(Q35182807)

7 August 2017

1 reference

title

Complex biotransformations catalyzed by radical S-adenosylmethionine enzymes (English)

1 reference

7 August 2017

Qi Zhang

1

1 reference

7 August 2017

Wen Liu

series ordinal

2

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7 August 2017

language of work or name

English

0 references

publication date

19 July 2011

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Journal of Biological Chemistry

7 August 2017

published in

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7 August 2017

volume

286

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7 August 2017

issue

35

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7 August 2017

page(s)

30245-30252

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Structural Basis for Methyl Transfer by a Radical SAM Enzyme

7 August 2017

cites work

1 reference

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13 July 2018

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A radically different mechanism for S-adenosylmethionine-dependent methyltransferases

13 July 2018

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Structural insights into radical generation by the radical SAM superfamily

13 July 2018

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RNA methylation by radical SAM enzymes RlmN and Cfr proceeds via methylene transfer and hydride shift

13 July 2018

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Radical-mediated enzymatic carbon chain fragmentation-recombination

13 July 2018

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Radicals from S-adenosylmethionine and their application to biosynthesis

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S-Adenosylmethionine-dependent radical-based modification of biological macromolecules

13 July 2018

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A "radical dance" in thiamin biosynthesis: mechanistic analysis of the bacterial hydroxymethylpyrimidine phosphate synthase.

13 July 2018

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Structures of apo and GTP-bound molybdenum cofactor biosynthesis protein MoaC from Thermus thermophilus HB8

13 July 2018

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13 July 2018

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Adenosyl radical: reagent and catalyst in enzyme reactions.

13 July 2018

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RlmN and Cfr are radical SAM enzymes involved in methylation of ribosomal RNA

13 July 2018

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13 July 2018

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Characterization and mechanistic studies of DesII: a radical S-adenosyl-L-methionine enzyme involved in the biosynthesis of TDP-D-desosamine

13 July 2018

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Nosiheptide biosynthesis featuring a unique indole side ring formation on the characteristic thiopeptide framework

13 July 2018

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The deazapurine biosynthetic pathway revealed: in vitro enzymatic synthesis of PreQ(0) from guanosine 5'-triphosphate in four steps

13 July 2018

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Ribosomally synthesized thiopeptide antibiotics targeting elongation factor Tu.

13 July 2018

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Control of radical chemistry in the AdoMet radical enzymes

13 July 2018

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Thiostrepton biosynthesis: prototype for a new family of bacteriocins

13 July 2018

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Thiopeptide biosynthesis featuring ribosomally synthesized precursor peptides and conserved posttranslational modifications

13 July 2018

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Protein residues that control the reaction trajectory in S-adenosylmethionine radical enzymes: mutagenesis of asparagine 153 and aspartate 155 in Escherichia coli biotin synthase

13 July 2018

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Unusual chemistry in the biosynthesis of the antibiotic chondrochlorens.

13 July 2018

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Reaction of AdoMet with ThiC generates a backbone free radical

13 July 2018

1 reference

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Reconstitution of ThiC in thiamine pyrimidine biosynthesis expands the radical SAM superfamily

13 July 2018

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Deciphering deazapurine biosynthesis: pathway for pyrrolopyrimidine nucleosides toyocamycin and sangivamycin

13 July 2018

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ThiC is an [Fe-S] cluster protein that requires AdoMet to generate the 4-amino-5-hydroxymethyl-2-methylpyrimidine moiety in thiamin synthesis

13 July 2018

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The methyltransferase YfgB/RlmN is responsible for modification of adenosine 2503 in 23S rRNA

13 July 2018

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13 July 2018

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Self-sacrifice in radical S-adenosylmethionine proteins

13 July 2018

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Identification of genes encoding tRNA modification enzymes by comparative genomics

13 July 2018

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Thiazole synthase from Escherichia coli: an investigation of the substrates and purified proteins required for activity in vitro.

13 July 2018

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S-adenosylmethionine as an oxidant: the radical SAM superfamily

13 July 2018

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13 July 2018

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The Cfr rRNA methyltransferase confers resistance to Phenicols, Lincosamides, Oxazolidinones, Pleuromutilins, and Streptogramin A antibiotics

13 July 2018

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Binding of 5'-GTP to the C-terminal FeS cluster of the radical S-adenosylmethionine enzyme MoaA provides insights into its mechanism

13 July 2018

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Structure, function, and formation of biological iron-sulfur clusters

13 July 2018

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13 July 2018

Thiopeptide antibiotics

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S-adenosylmethionine radical enzymes

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3162382

Crystal structure of the S-adenosylmethionine-dependent enzyme MoaA and its implications for molybdenum cofactor deficiency in humans

13 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3162382

A new perspective on thiamine catalysis

13 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3162382

AdoMet radical proteins--from structure to evolution--alignment of divergent protein sequences reveals strong secondary structure element conservation

13 July 2018

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Characterization of MOCS1A, an oxygen-sensitive iron-sulfur protein involved in human molybdenum cofactor biosynthesis

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3162382

Structural biology of enzymes of the thiamin biosynthesis pathway

13 July 2018

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Identification of four genes necessary for biosynthesis of the modified nucleoside queuosine

13 July 2018

1 reference

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S-Adenosylmethionine: a wolf in sheep's clothing, or a rich man's adenosylcobalamin?

13 July 2018

1 reference

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Radical catalysis in coenzyme B12-dependent isomerization (eliminating) reactions

13 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3162382

Radical carbon skeleton rearrangements: catalysis by coenzyme B12-dependent mutases

13 July 2018

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The generation of 5′-deoxyadenosyl radicals by adenosylmethionine-dependent radical enzymes

13 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3162382

Structural biology of enzymes involved in NAD and molybdenum cofactor biosynthesis

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3162382

Functionality of alternative splice forms of the first enzymes involved in human molybdenum cofactor biosynthesis

13 July 2018

1 reference

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The Mononuclear Molybdenum Enzymes.

13 July 2018

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Adenosylmethionine-dependent iron-sulfur enzymes: versatile clusters in a radical new role

13 July 2018

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Radical SAM, a novel protein superfamily linking unresolved steps in familiar biosynthetic pathways with radical mechanisms: functional characterization using new analysis and information visualization methods

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3162382

Insights into molybdenum cofactor deficiency provided by the crystal structure of the molybdenum cofactor biosynthesis protein MoaC

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3162382

Hypermodification of tRNA in Thermophilic archaea. Cloning, overexpression, and characterization of tRNA-guanine transglycosylase from Methanococcus jannaschii

13 July 2018

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Investigation of the early steps of molybdopterin biosynthesis in Escherichia coli through the use of in vivo labeling studies

13 July 2018

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Biosynthesis of the pyrimidine moiety of thiamine. A new route of pyrimidine biosynthesis involving purine intermediates

13 July 2018

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The biosynthesis of folic acid. 8. Purification and properties of the enzyme that catalyzes the production of formate from carbon atom 8 of guanosine triphosphate.

13 July 2018

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Formation of 2-methyltryptophan in the biosynthesis of thiostrepton: isolation of S-adenosylmethionine:tryptophan 2-methyltransferase

13 July 2018

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Spectroscopic approaches to elucidating novel iron-sulfur chemistry in the "radical-Sam" protein superfamily

13 July 2018

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Biosynthesis of the thiamin pyrimidine: the reconstitution of a remarkable rearrangement reaction

21 January 2018

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A connection between iron-sulfur cluster metabolism and the biosynthesis of 4-amino-5-hydroxymethyl-2-methylpyrimidine pyrophosphate in Salmonella enterica.

21 January 2018

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Biosynthesis of the modified peptide antibiotic nosiheptide in Streptomyces actuosus

21 January 2018

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Moving posttranslational modifications forward to biosynthesize the glycosylated thiopeptide nocathiacin I in Nocardia sp. ATCC202099.

21 January 2018

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[FeFe]-hydrogenase cyanide ligands derived from S-adenosylmethionine-dependent cleavage of tyrosine.

21 January 2018

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[FeFe]-hydrogenase maturation: HydG-catalyzed synthesis of carbon monoxide.

21 January 2018

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Biosynthesis of TDP-D-desosamine: identification of a strategy for C4 deoxygenation

21 January 2018

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Posttranscriptional modification of the central loop of domain V in Escherichia coli 23 S ribosomal RNA.

21 January 2018

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Chiral methyl groups: small is beautiful

21 January 2018

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Biosynthesis of the pyrrolopyrimidine nucleoside antibiotic, toyocamycin. VII. Origin of the pyrrole carbons and the cyano carbon

21 January 2018

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12 December 2020

Stereochemical course of the transmethylation catalyzed by catechol O-methyltransferase

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12 December 2020

The Radical SAM Superfamily

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12 December 2020

Lysine 2,3-aminomutase. Purification and properties of a pyridoxal phosphate and S-adenosylmethionine-activated enzyme

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Identifiers

DOI

10.1074/JBC.R111.272690

1 reference

7 August 2017

1 reference

7 August 2017

1 reference