(Q35183471)

7 August 2017

title

A systems biology investigation of neurodegenerative dementia reveals a pivotal role of autophagy (English)

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7 August 2017

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Laura Caberlotto

1

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7 August 2017

Thanh-Phuong Nguyen

series ordinal

2

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7 August 2017

publication date

7 June 2014

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7 August 2017

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7 August 2017

volume

8

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7 August 2017

page(s)

65

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Network analysis of neurodegenerative disease highlights a role of Toll-like receptor signaling.

7 August 2017

cites work

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28 July 2018

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28 July 2018

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Autophagy activation ameliorates neuronal pathogenesis of FTLD-U mice: a new light for treatment of TARDBP/TDP-43 proteinopathies

28 July 2018

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28 July 2018

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28 July 2018

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Long-term pioglitazone treatment improves learning and attenuates pathological markers in a mouse model of Alzheimer's disease

28 July 2018

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Roles of AMP-activated protein kinase in Alzheimer's disease.

28 July 2018

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Identification of common genetic modifiers of neurodegenerative diseases from an integrative analysis of diverse genetic screens in model organisms

28 July 2018

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28 July 2018

Autophagy in dementias

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Regulation of autophagy by neuropathological protein TDP-43.

28 July 2018

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28 July 2018

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28 July 2018

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28 July 2018

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Glycogen synthase kinase 3 inhibitors in the next horizon for Alzheimer's disease treatment

28 July 2018

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AMPK -> ULK1 -> autophagy

28 July 2018

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AMP-activated protein kinase: a potential player in Alzheimer's disease

28 July 2018

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Freeze-fracture replica immunolabelling reveals human WIPI-1 and WIPI-2 as membrane proteins of autophagosomes

28 July 2018

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Interactome networks and human disease

28 July 2018

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28 July 2018

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Microarray analysis of hippocampal CA1 neurons implicates early endosomal dysfunction during Alzheimer's disease progression

28 July 2018

1 reference

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Autophagy negatively regulates Wnt signalling by promoting Dishevelled degradation

28 July 2018

1 reference

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Network organization of the human autophagy system

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4077228

Lysosomal proteolysis and autophagy require presenilin 1 and are disrupted by Alzheimer-related PS1 mutations

28 July 2018

1 reference

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Negative regulation of Vps34 by Cdk mediated phosphorylation

28 July 2018

1 reference

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The Beclin 1-VPS34 complex--at the crossroads of autophagy and beyond

28 July 2018

1 reference

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The power of protein interaction networks for associating genes with diseases

28 July 2018

1 reference

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28 July 2018

The Beclin 1 interactome

1 reference

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Control of autophagy initiation by phosphoinositide 3-phosphatase Jumpy

28 July 2018

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28 July 2018

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Autophagy fights disease through cellular self-digestion

28 July 2018

1 reference

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Differentiating the dementias. Revisiting synucleinopathies and tauopathies

28 July 2018

1 reference

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Protein interactions in human genetic diseases.

28 July 2018

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Discovering functions and revealing mechanisms at molecular level from biological networks

28 July 2018

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Lysosomal system pathways: genes to neurodegeneration in Alzheimer's disease

28 July 2018

1 reference

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Autophagy and neurodegeneration.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4077228

Interface between tauopathies and synucleinopathies: A tale of two proteins

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4077228

Autophagy in cell death: an innocent convict?

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4077228

Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4077228

Online predicted human interaction database

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4077228

Metabolic/signal transduction hypothesis of Alzheimer's disease and other tauopathies

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4077228

Pioglitazone treatment activates AMP-activated protein kinase in rat liver and adipose tissue in vivo

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4077228

Gene expression profiles of cholinergic nucleus basalis neurons in Alzheimer's disease.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4077228

Stimulatory effect of vitamin C on autophagy in glial cells

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4077228

Accelerated amyloid deposition in the brains of transgenic mice coexpressing mutant presenilin 1 and amyloid precursor proteins

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4077228

Alteration in brain presenilin 1 mRNA expression in early onset familial Alzheimer's disease

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4077228

Lysosomal abnormalities in degenerating neurons link neuronal compromise to senile plaque development in Alzheimer disease

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4077228

AMP kinase activation mitigates dopaminergic dysfunction and mitochondrial abnormalities in Drosophila models of Parkinson's disease.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4077228

PP2A blockade inhibits autophagy and causes intraneuronal accumulation of ubiquitinated proteins

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4077228

Presenilins mediate efficient proteolysis via the autophagosome-lysosome system

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4077228

AMPK is abnormally activated in tangle- and pre-tangle-bearing neurons in Alzheimer’s disease and other tauopathies

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4077228

An okadaic acid-induced model of tauopathy and cognitive deficiency.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4077228

TARDBP mutations in frontotemporal lobar degeneration: frequency, clinical features, and disease course.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4077228

Autophagy was activated in injured astrocytes and mildly decreased cell survival following glucose and oxygen deprivation and focal cerebral ischemia

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4077228

Melatonin ameliorates Alzheimer-like pathological changes and spatial memory retention impairment induced by calyculin A.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4077228

GOrilla: a tool for discovery and visualization of enriched GO terms in ranked gene lists

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4077228

Neuroprotective effects of donepezil through inhibition of GSK-3 activity in amyloid-beta-induced neuronal cell death

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4077228

Protein interactions and disease: computational approaches to uncover the etiology of diseases.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4077228

The commonality of protein interaction networks determined in neurodegenerative disorders (NDDs).

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4077228

Structure of Atg5.Atg16, a complex essential for autophagy

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4077228

Predicting disease genes using protein-protein interactions.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4077228

Online Mendelian Inheritance in Man (OMIM), a knowledgebase of human genes and genetic disorders

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4077228

Presenilin mutations in familial Alzheimer disease and transgenic mouse models accelerate neuronal lysosomal pathology.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4077228

Functional and topological characterization of protein interaction networks

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4077228

Amino Acids and Insulin Control Autophagic Proteolysis through Different Signaling Pathways in Relation to mTOR in Isolated Rat Hepatocytes

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4077228

Autophagy as a regulated pathway of cellular degradation

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4077228

Distribution of active glycogen synthase kinase 3beta (GSK-3beta) in brains staged for Alzheimer disease neurofibrillary changes

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4077228

The impact of different presenilin 1 andpresenilin 2 mutations on amyloid deposition, neurofibrillary changes and neuronal loss in the familial Alzheimer's disease brain: evidence for other phenotype-modifying factors

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4077228

Properties of the endosomal-lysosomal system in the human central nervous system: disturbances mark most neurons in populations at risk to degenerate in Alzheimer's disease.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4077228

Effects of the tumour promoter okadaic acid on intracellular protein phosphorylation and metabolism

27 September 2018

1 reference

12 December 2020

Colocalization of lysosomal hydrolase and beta-amyloid in diffuse plaques of the cerebellum and striatum in Alzheimer's disease and Down's syndrome

1 reference

12 December 2020

Towards the global understanding of the autophagy regulatory network

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12 December 2020

Searching Online Mendelian Inheritance in Man (OMIM) for information for genetic loci involved in human disease

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12 December 2020

Identifiers

DOI

10.1186/1752-0509-8-65

1 reference

journals/bmcsb/CaberlottoN14

7 August 2017

DBLP publication ID

1 reference

DBLP Dataset 2021-01-02

28 January 2021

1 reference

7 August 2017

1 reference