(Q37988399)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22367557%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

title

Roles of AMP-activated protein kinase in Alzheimer's disease (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22367557%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

0 references

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22367557%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

author name string

Zhiyou Cai

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22367557%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

Keshen Li

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22367557%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

Sohel H Quazi

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22367557%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

Bin Zhao

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22367557%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

publication date

26 February 2012

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22367557%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

published in

NeuroMolecular Medicine

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22367557%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

volume

14

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22367557%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

issue

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22367557%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

page(s)

1-14

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22367557%20AND%20SRC:MED&resulttype=core&format=json

https://scigraph.springernature.com/pub.10.1007/s12017-012-8173-2

24 January 2020

exact match

0 references

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21 January 2018

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21 January 2018

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Family caregiving in dementia: the Asian perspective of a global problem

21 January 2018

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Impaired activation of AMP-kinase and fatty acid oxidation by globular adiponectin in cultured human skeletal muscle of obese type 2 diabetics

21 January 2018

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Antidiabetic drug metformin (GlucophageR) increases biogenesis of Alzheimer's amyloid peptides via up-regulating BACE1 transcription.

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21 January 2018

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21 January 2018

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21 January 2018

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Protection of synapses against Alzheimer's-linked toxins: insulin signaling prevents the pathogenic binding of Abeta oligomers

21 January 2018

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Potential predictors of hippocampal atrophy in Alzheimer's disease

21 January 2018

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The autophagy initiating kinase ULK1 is regulated via opposing phosphorylation by AMPK and mTOR

21 January 2018

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Protein kinase A is a target for aging and the aging heart

21 January 2018

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21 January 2018

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21 January 2018

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Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy state

21 January 2018

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21 January 2018

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Phosphorylation of microtubule-associated protein tau by stress-activated protein kinases

21 January 2018

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Hyperphosphorylation of microtubule-associated protein tau: a promising therapeutic target for Alzheimer disease

21 January 2018

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Leptin inhibits glycogen synthase kinase-3beta to prevent tau phosphorylation in neuronal cells

21 January 2018

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Leptin regulates tau phosphorylation and amyloid through AMPK in neuronal cells

21 January 2018

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LKB1/AMPK/mTOR signaling pathway in hematological malignancies: from metabolism to cancer cell biology.

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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AMPK activity and isoform protein expression are similar in muscle of obese subjects with and without type 2 diabetes

21 January 2018

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Receptor-mediated activation of ceramidase activity initiates the pleiotropic actions of adiponectin.

21 January 2018

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AMP-activated protein kinase activation increases phosphorylation of glycogen synthase kinase 3beta and thereby reduces cAMP-responsive element transcriptional activity and phosphoenolpyruvate carboxykinase C gene expression in the liver

21 January 2018

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Metformin suppresses azoxymethane-induced colorectal aberrant crypt foci by activating AMP-activated protein kinase

21 January 2018

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Genetic discoveries as the basis of personalized therapy: rosiglitazone treatment of Alzheimer's disease.

21 January 2018

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Clinical features and survival of 3R and 4R tauopathies presenting as behavioral variant frontotemporal dementia

21 January 2018

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LKB1, an upstream AMPK kinase, regulates glucose and lipid metabolism in cultured liver and muscle cells

21 January 2018

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TSC2 integrates Wnt and energy signals via a coordinated phosphorylation by AMPK and GSK3 to regulate cell growth

21 January 2018

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The role of mTOR inhibition in augmenting radiation induced autophagy

21 January 2018

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Increased risk of type 2 diabetes in Alzheimer disease

21 January 2018

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Systems biology of the autophagy-lysosomal pathway

21 January 2018

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Regulation of mitochondrial biogenesis

21 January 2018

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Nuclear translocation of AMPK-alpha1 potentiates striatal neurodegeneration in Huntington's disease

21 January 2018

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Reduced glucose transporter at the blood-brain barrier and in cerebral cortex in Alzheimer disease.

21 January 2018

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Disrupted energy metabolism and neuronal circuit dysfunction in cognitive impairment and Alzheimer's disease

21 January 2018

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Biguanide metformin acts on tau phosphorylation via mTOR/protein phosphatase 2A (PP2A) signaling

21 January 2018

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AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

21 January 2018

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AMP-activated protein kinase: a core signalling pathway in the heart.

21 January 2018

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AMP-activated protein kinase (AMPK) activating agents cause dephosphorylation of Akt and glycogen synthase kinase-3.

21 January 2018

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Cerebrospinal fluid beta-amyloid and tau proteins for the diagnosis of Alzheimer disease.

21 January 2018

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The role of AMP-activated protein kinase in obesity

21 January 2018

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DAP1, a novel substrate of mTOR, negatively regulates autophagy

21 January 2018

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Differences in lateral hemispheric asymmetries of glucose utilization between early- and late-onset Alzheimer-type dementia.

21 January 2018

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AMPK-mediated inhibition of mTOR kinase is circumvented during immediate-early times of human cytomegalovirus infection

21 January 2018

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Simian virus 40 small T antigen activates AMPK and triggers autophagy to protect cancer cells from nutrient deprivation

21 January 2018

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Melatonin Potentiates the Neuroprotective Properties of Resveratrol Against Beta-Amyloid-Induced Neurodegeneration by Modulating AMP-Activated Protein Kinase Pathways

21 January 2018

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AICAR (5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranoside) increases the production of toxic molecules and affects the profile of cytokines release in LPS-stimulated rat primary microglial cultures

21 January 2018

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PPARgamma agonists as new therapeutic agents for the treatment of Alzheimer's disease

21 January 2018

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Indirubins inhibit glycogen synthase kinase-3 beta and CDK5/p25, two protein kinases involved in abnormal tau phosphorylation in Alzheimer's disease. A property common to most cyclin-dependent kinase inhibitors?

21 January 2018

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The association of AMPK with ULK1 regulates autophagy

21 January 2018

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Post-stroke hypothermia provides neuroprotection through inhibition of AMP-activated protein kinase

21 January 2018

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Adenosine monophosphate activated protein kinase inhibition is protective in both sexes after experimental stroke

21 January 2018

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Effects of AMP-activated protein kinase in cerebral ischemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-012-8173-2

Neuroprotective effects of adenosine monophosphate-activated protein kinase inhibition and gene deletion in stroke

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-012-8173-2

Resveratrol modulates tumor cell proliferation and protein translation via SIRT1-dependent AMPK activation

21 January 2018

1 reference

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Brain aging and Aβ₁₋₄₂ neurotoxicity converge via deterioration in autophagy-lysosomal system: a conditional Drosophila model linking Alzheimer's neurodegeneration with aging

21 January 2018

1 reference

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A conserved mechanism of autoinhibition for the AMPK kinase domain: ATP-binding site and catalytic loop refolding as a means of regulation

21 January 2018

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Quercetin activates AMP-activated protein kinase by reducing PP2C expression protecting old mouse brain against high cholesterol-induced neurotoxicity.

21 January 2018

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Lifespan extension induced by AMPK and calcineurin is mediated by CRTC-1 and CREB

21 January 2018

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AMPK activates autophagy by phosphorylating ULK1.

21 January 2018

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Resveratrol promotes clearance of Alzheimer's disease amyloid-beta peptides.

21 January 2018

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The expanding TOR signaling network

21 January 2018

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AMP-activated protein kinase: 'a cup of tea' against cholesterol-induced neurotoxicity

21 January 2018

1 reference

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Cellular and molecular mechanisms underlying perturbed energy metabolism and neuronal degeneration in Alzheimer's and Parkinson's diseases.

21 January 2018

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Pharmacological inhibition of AMP-activated protein kinase provides neuroprotection in stroke

21 January 2018

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Topographical analysis of glucose metabolism, as measured with positron emission tomography, in dementia of the Alzheimer type: use of linear histograms

21 January 2018

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AMP activated protein kinase: a next generation target for total metabolic control.

21 January 2018

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Amyloid-beta(1-42), total tau, and phosphorylated tau as cerebrospinal fluid biomarkers for the diagnosis of Alzheimer disease.

21 January 2018

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Homologous posttranscriptional regulation of insulin-like growth factor-I receptor level via glycogen synthase kinase-3beta and mammalian target of rapamycin in adrenal chromaffin cells: effect on tau phosphorylation.

21 January 2018

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Alzheimer disease: amyloidogenesis, the presenilins and animal models.

21 January 2018

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Atypical antipsychotic drugs perturb AMPK-dependent regulation of hepatic lipid metabolism.

21 January 2018

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Protection against cognitive deficits and markers of neurodegeneration by long-term oral administration of melatonin in a transgenic model of Alzheimer disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-012-8173-2

Inhibition of Alzheimer beta-fibrillogenesis by melatonin

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-012-8173-2

mTOR-dependent signalling in Alzheimer's disease

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12017-012-8173-2

Expanding roles for AMP-activated protein kinase in neuronal survival and autophagy

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12017-012-8173-2

ER stress negatively regulates AKT/TSC/mTOR pathway to enhance autophagy

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12017-012-8173-2

Role of autophagy in the clearance of mutant huntingtin: a step towards therapy?

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12017-012-8173-2

Phosphorylation regulates tau interactions with Src homology 3 domains of phosphatidylinositol 3-kinase, phospholipase Cgamma1, Grb2, and Src family kinases

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12017-012-8173-2

Inhibition of BACE, a promising approach to Alzheimer's disease therapy

21 January 2018

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AMPK in the brain: its roles in energy balance and neuroprotection

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12017-012-8173-2

mTOR regulates autophagy-associated genes downstream of p73.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-012-8173-2

The mTOR pathway and its role in human genetic diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-012-8173-2

Alzheimer's disease beta-secretase BACE1 is not a neuron-specific enzyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-012-8173-2

AMP-activated protein kinase: a potential player in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-012-8173-2

Metformin and AMPK: an old drug and a new enzyme in the context of metabolic syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-012-8173-2

A patient with early Alzheimer's disease who showed improvement of cognitive function and cerebral perfusion by combined therapy of nilvadipine and PPAR gamma agonists

21 January 2018

1 reference

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Role of insulin signaling in the interaction between Alzheimer disease and diabetes mellitus: a missing link to therapeutic potential

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-012-8173-2

Red Wine Ingredient Resveratrol Protects from β-Amyloid Neurotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-012-8173-2

Modulation of amyloid precursor protein cleavage by cellular sphingolipids

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-012-8173-2

Tyrosine phosphorylation of tau by the SRC family kinases lck and fyn.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-012-8173-2

Glucose metabolism and Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-012-8173-2

Regulation of phosphorylation of tau by protein kinases in rat brain

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12017-012-8173-2

The autophagy-lysosomal degradation pathway: role in neurodegenerative disease and therapy.

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12017-012-8173-2

Comparison of the phosphorylation of microtubule-associated protein tau by non-proline dependent protein kinases

21 January 2018

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Rapid Alzheimer-like phosphorylation of tau by the synergistic actions of non-proline-dependent protein kinases and GSK-3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-012-8173-2

Inhibition of mTOR by rapamycin abolishes cognitive deficits and reduces amyloid-beta levels in a mouse model of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-012-8173-2

AMPK in Health and Disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-012-8173-2

[Cerebral glucose metabolism in presenile dementia of the Alzheimer type--follow-up of therapy with muscarinergic choline agonists]

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-012-8173-2

Molecular mechanisms linking diabetes mellitus and Alzheimer disease: beta-amyloid peptide, insulin signaling, and neuronal function

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-012-8173-2

Cerebrospinal fluid {beta}-amyloid 42 and tau proteins as biomarkers of Alzheimer-type pathologic changes in the brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-012-8173-2

AMP-activated protein kinase (AMPK) is a tau kinase, activated in response to amyloid β-peptide exposure.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-012-8173-2

AMP-Activated Protein Kinase in Metabolic Control and Insulin Signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-012-8173-2

The neurodegeneration mutant löchrig interferes with cholesterol homeostasis and Appl processing

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-012-8173-2

Beta-secretase (BACE) as a drug target for Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-012-8173-2

BACE1: the beta-secretase enzyme in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-012-8173-2

Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-012-8173-2

Liver AMP/ATP ratio and fructokinase expression are related to gender differences in AMPK activity and glucose intolerance in rats ingesting liquid fructose.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-012-8173-2

Novel synthetic small-molecule activators of AMPK as enhancers of autophagy and amyloid-β peptide degradation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-012-8173-2

AMPK is abnormally activated in tangle- and pre-tangle-bearing neurons in Alzheimer's disease and other tauopathies

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-012-8173-2

Therapeutic potential of resveratrol in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-012-8173-2

AMP-activated protein kinase signaling activation by resveratrol modulates amyloid-beta peptide metabolism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-012-8173-2

Targeting the AMPK pathway for the treatment of Type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-012-8173-2

The JNK pathway amplifies and drives subcellular changes in tau phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-012-8173-2

Tau fragmentation, aggregation and clearance: the dual role of lysosomal processing

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-012-8173-2

Role of melatonin in Alzheimer-like neurodegeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-012-8173-2

The role of insulin resistance in the pathogenesis of Alzheimer's disease: implications for treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-012-8173-2

Involvement of AMP-activated-protein-kinase (AMPK) in neuronal amyloidogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-012-8173-2

Neurofibrillary tangles of Alzheimer disease share antigenic determinants with the axonal microtubule-associated protein tau (tau)

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-012-8173-2

gamma-Secretase: characterization and implication for Alzheimer disease therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-012-8173-2

AMP-activated protein kinase (AMPK) activation and glycogen synthase kinase-3β (GSK-3β) inhibition induce Ca2+-independent deposition of tight junction components at the plasma membrane

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-012-8173-2

Role of AMP-activated protein kinase in mechanism of metformin action

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-012-8173-2

Cell cycle arrest in Metformin treated breast cancer cells involves activation of AMPK, downregulation of cyclin D1, and requires p27Kip1 or p21Cip1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-012-8173-2

Gamma-secretase as a pharmacological target in Alzheimer disease research: when, why and how?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-012-8173-2

Comparison of analytical platforms for cerebrospinal fluid measures of β-amyloid 1-42, total tau, and p-tau181 for identifying Alzheimer disease amyloid plaque pathology

21 January 2018

1 reference

12 December 2020

Rosiglitazone reduces fatty acid translocase and increases AMPK in skeletal muscle in aged rats: a possible mechanism to prevent high-fat-induced insulin resistance

1 reference

12 December 2020

Small-molecule activators of AMP-activated protein kinase (AMPK), RSVA314 and RSVA405, inhibit adipogenesis

1 reference

12 December 2020

Lysosome positioning coordinates mTORC1 activity and autophagy

1 reference

12 December 2020

AMP-activated protein kinase, super metabolic regulator

1 reference

12 December 2020

SREBP-1c, regulated by the insulin and AMPK signaling pathways, plays a role in nonalcoholic fatty liver disease

1 reference

12 December 2020

Apigenin, a chemopreventive bioflavonoid, induces AMP-activated protein kinase activation in human keratinocytes.

1 reference

12 December 2020

Networking with proline-directed protein kinases implicated in tau phosphorylation

1 reference

12 December 2020

Neuroglobin attenuates Alzheimer-like tau hyperphosphorylation by activating Akt signaling.

1 reference

12 December 2020

Caveolin induces cardioprotection through epigenetic regulation

1 reference

12 December 2020

AMP-activated protein kinase and metabolic control

1 reference

12 December 2020

Role of the beta-amyloid protein in Alzheimer's disease.

1 reference

12 December 2020

Régulation du métabolisme énergétique par l’AMPK

1 reference

12 December 2020

Role of insulin, adipocyte hormones, and nutrient-sensing pathways in regulating fuel metabolism and energy homeostasis: a nutritional perspective of diabetes, obesity, and cancer

1 reference

12 December 2020

AMPK as a cellular energy sensor and its function in the organism

1 reference

12 December 2020

Altered patterns of positron-emission tomography glucose metabolism in Alzheimer patients with microvascular white matter disease.

1 reference

12 December 2020

Progressive perturbations in cerebral energy metabolism after experimental whole-brain radiation in the therapeutic range

1 reference

12 December 2020

Role of AMPK in glucose and lipid metabolisms

1 reference

12 December 2020

[Diagnostic value of tau in cerebrospinal fluid in alzheimer disease]

1 reference

12 December 2020

Ethanol alters lipid profiles and phosphorylation status of AMP-activated protein kinase in the neonatal mouse brain

1 reference

12 December 2020

Dementia and insulin resistance in patients with diabetes mellitus

1 reference

12 December 2020

Hyperphosphorylation of tau and protein phosphatases in Alzheimer disease

1 reference

12 December 2020

Clinical features and pathogenesis of Alzheimer's disease: involvement of mitochondria and mitochondrial DNA.

1 reference

12 December 2020

Impaired brain glucose metabolism leads to Alzheimer neurofibrillary degeneration through a decrease in tau O-GlcNAcylation.

1 reference

12 December 2020

Rapid tyrosine phosphorylation of neuronal proteins including tau and focal adhesion kinase in response to amyloid-beta peptide exposure: involvement of Src family protein kinases.

1 reference

12 December 2020

mTOR signaling, function, novel inhibitors, and therapeutic targets.

1 reference

12 December 2020

An integrated and unifying hypothesis for the metabolic basis of sporadic Alzheimer's disease

1 reference

12 December 2020

Acute rosiglitazone treatment is cardioprotective against ischemia-reperfusion injury by modulating AMPK, Akt, and JNK signaling in nondiabetic mice.

1 reference

12 December 2020

Changes in blood glucose and insulin secretion in patients with senile dementia of Alzheimer type.

1 reference

12 December 2020

Phosphorylation of human tau protein by microtubule-associated kinases: GSK3beta and cdk5 are key participants

1 reference

12 December 2020

Phytic acid as a potential treatment for alzheimer's pathology: evidence from animal and in vitro models

1 reference

12 December 2020