(Q35197783)

7 August 2017

The role of the N-methyl-D-aspartate receptor in Alzheimer's disease: therapeutic potential (English)

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7 August 2017

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P Murali Doraiswamy

1

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7 August 2017

1 September 2003

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Current Neurology and Neuroscience Reports

7 August 2017

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7 August 2017

3

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7 August 2017

373-378

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7 August 2017

5

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https://scigraph.springernature.com/pub.10.1007/s11910-003-0019-8

7 August 2017

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cites work

Excitatory amino acids in synaptic transmission in the Schaffer collateral-commissural pathway of the rat hippocampus.

1 reference

https://api.crossref.org/works/10.1007%2FS11910-003-0019-8

Effects of memantine and MK-801 on NMDA-induced currents in cultured neurones and on synaptic transmission and LTP in area CA1 of rat hippocampal slices

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11910-003-0019-8

Excitotoxic neurodegeneration in Alzheimer disease. New hypothesis and new therapeutic strategies

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11910-003-0019-8

Effects of NMDA Modulation in Scopolamine Dementiaa

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11910-003-0019-8

d-Cycloserine enhances implicit memory in Alzheimer patients.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11910-003-0019-8

A preliminary study of D-cycloserine treatment in Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11910-003-0019-8

Milacemide: a placebo-controlled study in senile dementia of the Alzheimer type.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11910-003-0019-8

Safety and tolerability of the glutamate antagonist CGS 19755 (Selfotel) in patients with acute ischemic stroke. Results of a phase IIa randomized trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11910-003-0019-8

The association between quantitative measures of dementia and of senile change in the cerebral grey matter of elderly subjects.

21 January 2018

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12 December 2020

Evaluation of memantine for neuroprotection in dementia

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12 December 2020

Generation of aggregated beta-amyloid in the rat hippocampus impairs synaptic transmission and plasticity and causes memory deficits

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12 December 2020

Investigations of neurotoxicity and neuroprotection within the nucleus basalis of the rat.

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12 December 2020

Development and selective neurodegeneration in cell cultures from different hippocampal regions

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12 December 2020

Synapse loss in frontal cortex biopsies in Alzheimer's disease: correlation with cognitive severity.

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12 December 2020

CA1-specific N-methyl-D-aspartate receptor knockout mice are deficient in solving a nonspatial transverse patterning task

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12 December 2020

Thapsigargin blocks STP and LTP related calcium enhancements in hippocampal CA1 area

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12 December 2020

The N-methyl-D-aspartate receptor channel blockers memantine, MRZ 2/579 and other amino-alkyl-cyclohexanes antagonise 5-HT(3) receptor currents in cultured HEK-293 and N1E-115 cell systems in a non-competitive manner

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12 December 2020

D-cycloserine for Alzheimer's disease.

1 reference

12 December 2020

Tolerability of memantine in combination with cholinesterase inhibitors in dementia therapy

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12 December 2020

The excitatory amino acid antagonist D-CPP-ene (SDZ EAA-494) in patients with epilepsy

1 reference

12 December 2020

Memantine in severe dementia: results of the 9M-Best Study (Benefit and efficacy in severely demented patients during treatment with memantine).

1 reference

12 December 2020

Neuronal loss, neurofibrillary tangles and granulovacuolar degeneration in the hippocampus with ageing and dementia. A quantitative study

1 reference

12 December 2020

Memantine is a clinically well tolerated N-methyl-D-aspartate (NMDA) receptor antagonist--a review of preclinical data

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12 December 2020

The effects of milacemide on item and source memory

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12 December 2020

Neuroprotective and symptomatological action of memantine relevant for Alzheimer's disease--a unified glutamatergic hypothesis on the mechanism of action.

1 reference

12 December 2020

Memory enhancement: the search for mechanism-based drugs

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12 December 2020

Low affinity channel blocking (uncompetitive) NMDA receptor antagonists as therapeutic agents--toward an understanding of their favorable tolerability

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12 December 2020

MK-801, memantine and amantadine show neuroprotective activity in the nucleus basalis magnocellularis

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12 December 2020

Selective impairment of learning and blockade of long-term potentiation by an N-methyl-D-aspartate receptor antagonist, AP5

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12 December 2020

Rapid and reversible changes in dendrite morphology and synaptic efficacy following NMDA receptor activation: implication for a cellular defense against excitotoxicity.

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12 December 2020

Selective vulnerability of corticocortical and hippocampal circuits in aging and Alzheimer's disease

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12 December 2020

A hippocampal NR2B deficit can mimic age-related changes in long-term potentiation and spatial learning in the Fischer 344 rat.

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12 December 2020

beta-Amyloid peptide fragment 25-35 potentiates the calcium-dependent release of excitatory amino acids from depolarized hippocampal slices.

1 reference

12 December 2020

The role of excitotoxicity in neurodegenerative disease: implications for therapy

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12 December 2020

Alzheimer's disease: genes, proteins, and therapy

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12 December 2020

Glutamate transmission and toxicity in Alzheimer's disease

1 reference

12 December 2020

Alzheimer's disease: changes in hippocampal N-methyl-D-aspartate, quisqualate, neurotensin, adenosine, benzodiazepine, serotonin and opioid receptors--an autoradiographic study.

1 reference

12 December 2020

Neuroprotection by memantine against neurodegeneration induced by beta-amyloid(1-40).

1 reference

12 December 2020

Alzheimer's disease: cell-specific pathology isolates the hippocampal formation

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12 December 2020

Memantine in moderate-to-severe Alzheimer's disease

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12 December 2020

Beta-amyloid protein increases the vulnerability of cultured cortical neurons to excitotoxic damage

1 reference

12 December 2020

Neurodegeneration mediated by glutamate and beta-amyloid peptide: a comparison and possible interaction

1 reference

12 December 2020

D-cycloserine reverses the working memory impairment of hippocampal-lesioned rats in a spatial learning task

1 reference

12 December 2020

beta-amyloid neurotoxicity is mediated by a glutamate-triggered excitotoxic cascade in rat nucleus basalis

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12 December 2020

Psychotogenicity and N-methyl-D-aspartate receptor antagonism: implications for neuroprotective pharmacotherapy.

1 reference

12 December 2020

A double-blind, placebo-controlled multicentre study of memantine in mild to moderate vascular dementia (MMM500).

1 reference

12 December 2020

Resource utilisation and cost analysis of memantine in patients with moderate to severe Alzheimer's disease

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12 December 2020

A fresh look at the role of CaMKII in hippocampal synaptic plasticity and memory

1 reference

12 December 2020

Milacemide, a glycine prodrug, enhances performance of learning tasks in normal and amnestic rodents.

1 reference

12 December 2020

Efficacy and safety of memantine in patients with mild to moderate vascular dementia: a randomized, placebo-controlled trial (MMM 300).

1 reference

12 December 2020

Toying with memory in the hippocampus.

1 reference

12 December 2020

Formation of neurofibrillary tangles in P301l tau transgenic mice induced by Abeta 42 fibrils

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12 December 2020

Milacemide effects on the temporal inter-relationship of amino acids and monoamine metabolites in rat cerebrospinal fluid

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12 December 2020

Milacemide treatment in mice enhances acquisition of a Morris-type water maze task.

1 reference

12 December 2020

Excitatory amino acid binding sites in the hippocampal region of Alzheimer's disease and other dementias

1 reference

12 December 2020

Improved cognition in Alzheimer's disease with short-term D-cycloserine treatment.

1 reference

12 December 2020

beta-Amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity

1 reference

12 December 2020

10.1007/S11910-003-0019-8

Identifiers

DOI

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7 August 2017

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PubMed ID

12914679