(Q35197919)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21831832%20AND%20SRC:MED&resulttype=core&format=json

10 February 2020

title

Nucleotide pyrophosphatase employs a P-loop-like motif to enhance catalytic power and NDP/NTP discrimination (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21831832%20AND%20SRC:MED&resulttype=core&format=json

10 February 2020

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21831832%20AND%20SRC:MED&resulttype=core&format=json

10 February 2020

author name string

Ildikó Pécsi

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21831832%20AND%20SRC:MED&resulttype=core&format=json

10 February 2020

Judit E Szabó

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21831832%20AND%20SRC:MED&resulttype=core&format=json

10 February 2020

Scott D Adams

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21831832%20AND%20SRC:MED&resulttype=core&format=json

10 February 2020

James R Sellers

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21831832%20AND%20SRC:MED&resulttype=core&format=json

10 February 2020

Beáta G Vértessy

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21831832%20AND%20SRC:MED&resulttype=core&format=json

10 February 2020

Judit Tóth

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21831832%20AND%20SRC:MED&resulttype=core&format=json

10 February 2020

language of work or name

English

0 references

publication date

10 August 2011

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21831832%20AND%20SRC:MED&resulttype=core&format=json

10 February 2020

number of pages

6

1 reference

Proceedings of the National Academy of Sciences of the United States of America

inferred from page(s)

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21831832%20AND%20SRC:MED&resulttype=core&format=json

10 February 2020

volume

108

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21831832%20AND%20SRC:MED&resulttype=core&format=json

10 February 2020

issue

35

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21831832%20AND%20SRC:MED&resulttype=core&format=json

10 February 2020

page(s)

14437-14442

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21831832%20AND%20SRC:MED&resulttype=core&format=json

Aromatic stacking between nucleobase and enzyme promotes phosphate ester hydrolysis in dUTPase

10 February 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3167503

The Flexible Motif V of Epstein-Barr Virus Deoxyuridine 5'-Triphosphate Pyrophosphatase Is Essential for Catalysis

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3167503

Keeping uracil out of DNA: physiological role, structure and catalytic mechanism of dUTPases

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3167503

Active site of mycobacterial dUTPase: structural characteristics and a built-in sensor

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3167503

Mechanism of dTTP inhibition of the bifunctional dCTP deaminase:dUTPase encoded by Mycobacterium tuberculosis

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3167503

Methylene substitution at the alpha-beta bridging position within the phosphate chain of dUDP profoundly perturbs ligand accommodation into the dUTPase active site

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3167503

Active site closure facilitates juxtaposition of reactant atoms for initiation of catalysis by human dUTPase

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3167503

Flexible segments modulate co-folding of dUTPase and nucleocapsid proteins

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3167503

The crystal structure of a complex of Campylobacter jejuni dUTPase with substrate analogue sheds light on the mechanism and suggests the "basic module" for dimeric d(C/U)TPases

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3167503

Structural basis for recognition and catalysis by the bifunctional dCTP deaminase and dUTPase from Methanococcus jannaschii

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3167503

The Methanococcus jannaschii dCTP deaminase is a bifunctional deaminase and diphosphatase

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3167503

Homotrimeric dUTPases; structural solutions for specific recognition and hydrolysis of dUTP

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3167503

Kinetic properties and inhibition of the dimeric dUTPase-dUDPase from Leishmania major

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3167503

X-ray structures of the MgADP, MgATPgammaS, and MgAMPPNP complexes of the Dictyostelium discoideum myosin motor domain

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3167503

Flexible glycine rich motif of Escherichia coli deoxyuridine triphosphate nucleotidohydrolase is important for functional but not for structural integrity of the enzyme

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3167503

Characterization and mutational studies of equine infectious anemia virus dUTPase

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3167503

Human dUTP pyrophosphatase: uracil recognition by a beta hairpin and active sites formed by three separate subunits

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3167503

Kinetic characterization of dUTPase from Escherichia coli.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3167503

Active site comparisons highlight structural similarities between myosin and other P-loop proteins

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3167503

X-ray structures of the myosin motor domain of Dictyostelium discoideum complexed with MgADP.BeFx and MgADP.AlF4-

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3167503

Refined crystal structure of the triphosphate conformation of H-ras p21 at 1.35 A resolution: implications for the mechanism of GTP hydrolysis

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3167503

Glycine rich P-loop motif in deoxyuridine pyrophosphatase

28 July 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1013872108

The C-terminus of dUTPase: observation on flexibility using NMR.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1013872108

Crystal structure of the Mycobacterium tuberculosis dUTPase: insights into the catalytic mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1013872108

Molecular shape and prominent role of beta-strand swapping in organization of dUTPase oligomers

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1013872108

Kinetic mechanism of human dUTPase, an essential nucleotide pyrophosphatase enzyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1013872108

Structural insights into the catalytic mechanism of phosphate ester hydrolysis by dUTPase

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1013872108

The monomeric dUTPase from Epstein-Barr virus mimics trimeric dUTPases

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1013872108

Transient kinetics of ligand binding and role of the C-terminus in the dUTPase from equine infectious anemia virus

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1013872108

Structures of dCTP deaminase from Escherichia coli with bound substrate and product: reaction mechanism and determinants of mono- and bifunctionality for a family of enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1013872108

Kinetic properties and inhibition of the dimeric dUTPase-dUDPase fromCampylobacter jejuni

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1013872108

The difference between ADP-beryllium fluoride and ADP-aluminium fluoride complexes of the spin-labeled myosin subfragment 1

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21831832

12 December 2020

inferred from PubMed ID database lookup

The complete triphosphate moiety of non-hydrolyzable substrate analogues is required for a conformational shift of the flexible C-terminus in E. coli dUTP pyrophosphatase

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21831832

12 December 2020

inferred from PubMed ID database lookup

Oncogenic insertional mutations in the P-loop of Ras are overactive in MAP kinase signaling

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21831832

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1073/PNAS.1013872108

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21831832%20AND%20SRC:MED&resulttype=core&format=json

10 February 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21831832%20AND%20SRC:MED&resulttype=core&format=json

10 February 2020

PubMed publication ID

21831832

1 reference