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Novel anti-inflammatory therapy for Parkinson's disease.
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instance of
scholarly article
1 reference
stated in
Europe PubMed Central
PubMed publication ID
12915048
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12915048%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 November 2019
review article
1 reference
stated in
Europe PubMed Central
title
Novel anti-inflammatory therapy for Parkinson's disease
(English)
1 reference
stated in
Europe PubMed Central
PubMed publication ID
12915048
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12915048%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 November 2019
main subject
inflammation
0 references
Parkinson's disease
1 reference
based on heuristic
inferred from title
author
Jau-Shyong Hong
series ordinal
4
1 reference
stated in
Europe PubMed Central
PubMed publication ID
12915048
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12915048%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 November 2019
author name string
Hui Ming Gao
series ordinal
1
1 reference
stated in
Europe PubMed Central
PubMed publication ID
12915048
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12915048%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 November 2019
Bin Liu
series ordinal
2
1 reference
stated in
Europe PubMed Central
PubMed publication ID
12915048
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12915048%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 November 2019
Wangqin Zhang
series ordinal
3
1 reference
stated in
Europe PubMed Central
PubMed publication ID
12915048
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12915048%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 November 2019
publication date
1 August 2003
1 reference
stated in
Europe PubMed Central
PubMed publication ID
12915048
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12915048%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 November 2019
published in
Trends in Pharmacological Sciences
1 reference
stated in
Europe PubMed Central
PubMed publication ID
12915048
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12915048%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 November 2019
volume
24
1 reference
stated in
Europe PubMed Central
PubMed publication ID
12915048
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12915048%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 November 2019
issue
8
1 reference
stated in
Europe PubMed Central
PubMed publication ID
12915048
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12915048%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 November 2019
page(s)
395-401
1 reference
stated in
Europe PubMed Central
PubMed publication ID
12915048
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12915048%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 November 2019
cites work
Evidence of active nerve cell degeneration in the substantia nigra of humans years after 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine exposure
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900176-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Reactive microglia are positive for HLA-DR in the substantia nigra of Parkinson's and Alzheimer's disease brains
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900176-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Inducible nitric oxide synthase stimulates dopaminergic neurodegeneration in the MPTP model of Parkinson disease
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900176-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mice deficient in TNF receptors are protected against dopaminergic neurotoxicity: implications for Parkinson's disease
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900176-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Microglia: a sensor for pathological events in the CNS
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900176-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Distinct role for microglia in rotenone-induced degeneration of dopaminergic neurons.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900176-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Neuroinflammation of the nigrostriatal pathway during progressive 6-OHDA dopamine degeneration in rats monitored by immunohistochemistry and PET imaging.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900176-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Lipopolysaccharide intranigral injection induces inflammatory reaction and damage in nigrostriatal dopaminergic system
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900176-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Regional difference in susceptibility to lipopolysaccharide-induced neurotoxicity in the rat brain: role of microglia
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900176-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The single intranigral injection of LPS as a new model for studying the selective effects of inflammatory reactions on dopaminergic system
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900176-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Blockade of microglial activation is neuroprotective in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson disease.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900176-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Minocycline prevents nigrostriatal dopaminergic neurodegeneration in the MPTP model of Parkinson's disease
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900176-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Inhibition of the cyclooxygenase isoenzymes COX-1 and COX-2 provide neuroprotection in the MPTP-mouse model of Parkinson's disease
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900176-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Minocycline inhibits microglial activation and protects nigral cells after 6-hydroxydopamine injection into mouse striatum
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900176-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Inflammation in neurodegenerative disease--a double-edged sword
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900176-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Brain repair
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900176-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Brain repair--new avenues to an eternal dream?
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900176-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The role of glial cells in Parkinson's disease
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900176-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Role of microglia in inflammation-mediated neurodegenerative diseases: mechanisms and strategies for therapeutic intervention.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900176-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cytokines in inflammatory brain lesions: helpful and harmful
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900176-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Degeneration of neuronal cells due to oxidative stress--microglial contribution
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900176-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Microglial activation-mediated delayed and progressive degeneration of rat nigral dopaminergic neurons: relevance to Parkinson's disease.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900176-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
NADPH oxidase mediates oxidative stress in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900176-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Critical role of microglial NADPH oxidase-derived free radicals in the in vitro MPTP model of Parkinson's disease.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900176-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Synergistic dopaminergic neurotoxicity of the pesticide rotenone and inflammogen lipopolysaccharide: relevance to the etiology of Parkinson's disease.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900176-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Deficiency of inducible nitric oxide synthase protects against MPTP toxicity in vivo
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900176-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Heterogeneity in the distribution and morphology of microglia in the normal adult mouse brain
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900176-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Lipopolysaccharide (LPS)-induced dopamine cell loss in culture: roles of tumor necrosis factor-alpha, interleukin-1beta, and nitric oxide
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900176-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Dysfunction of rat forebrain astrocytes in culture alters cytokine and neurotrophic factor release
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900176-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The role of interleukin-1, interleukin-6, and glia in inducing growth of neuronal terminal arbors in mice.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900176-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Increased vulnerability of dopaminergic neurons in MPTP-lesioned interleukin-6 deficient mice
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900176-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Intranigral infusion of interleukin-1beta activates astrocytes and protects from subsequent 6-hydroxydopamine neurotoxicity.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900176-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Role of TNF-alpha receptors in mice intoxicated with the parkinsonian toxin MPTP.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900176-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Immune function of astrocytes
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900176-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
In vivo gene delivery of glial cell line--derived neurotrophic factor for Parkinson's disease
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900176-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Direct brain infusion of glial cell line-derived neurotrophic factor in Parkinson disease
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900176-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Experimental models of Parkinson's disease
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900176-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cyclooxygenase-2-deficient mice are resistant to 1-methyl-4-phenyl1, 2, 3, 6-tetrahydropyridine-induced damage of dopaminergic neurons in the substantia nigra.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900176-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Chronic systemic pesticide exposure reproduces features of Parkinson's disease
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900176-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Selective microglial activation in the rat rotenone model of Parkinson's disease
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900176-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Increase in level of tumor necrosis factor (TNF)-alpha in 6-hydroxydopamine-lesioned striatum in rats without influence of systemic L-DOPA on the TNF-alpha induction
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900176-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The inflammatory reaction following 1-methyl-4-phenyl-1,2,3, 6-tetrahydropyridine intoxication in mouse
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900176-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The degenerative effect of a single intranigral injection of LPS on the dopaminergic system is prevented by dexamethasone, and not mimicked by rh-TNF-alpha, IL-1beta and IFN-gamma
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900176-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Aspirin and salicylate protect against MPTP-induced dopamine depletion in mice
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900176-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Non-steroidal anti-inflammatory drug sodium salicylate, but not diclofenac or celecoxib, protects against 1-methyl-4-phenyl pyridinium-induced dopaminergic neurotoxicity in rats
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900176-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cyclooxygenase-2 is instrumental in Parkinson's disease neurodegeneration
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900176-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cyclooxygenase-2 inhibitor ns-398 protects neuronal cultures from lipopolysaccharide-induced neurotoxicity
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900176-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cyclooxygenase and 5-lipoxygenase inhibitors protect against mononuclear phagocyte neurotoxicity
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900176-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Inflammation, autotoxicity and Alzheimer disease
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900176-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A subset of NSAIDs lower amyloidogenic Abeta42 independently of cyclooxygenase activity
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900176-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Naloxone prevents microglia-induced degeneration of dopaminergic substantia nigra neurons in adult rats
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900176-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Dextromethorphan protects dopaminergic neurons against inflammation-mediated degeneration through inhibition of microglial activation.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900176-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Silymarin protects dopaminergic neurons against lipopolysaccharide-induced neurotoxicity by inhibiting microglia activation.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900176-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Minocycline, a tetracycline derivative, is neuroprotective against excitotoxicity by inhibiting activation and proliferation of microglia.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900176-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A tetracycline derivative, minocycline, reduces inflammation and protects against focal cerebral ischemia with a wide therapeutic window
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900176-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Minocycline reduces traumatic brain injury-mediated caspase-1 activation, tissue damage, and neurological dysfunction
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900176-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Epidermal immunization by a needle-free powder delivery technology: Immunogenicity of influenza vaccine and protection in mice
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900176-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Minocycline inhibits cytochrome c release and delays progression of amyotrophic lateral sclerosis in mice
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900176-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Minocycline and other tetracycline derivatives: a neuroprotective strategy in Parkinson's disease and Huntington's disease
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900176-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Neuroprotective effect of vasoactive intestinal peptide (VIP) in a mouse model of Parkinson's disease by blocking microglial activation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900176-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identifiers
DOI
10.1016/S0165-6147(03)00176-7
1 reference
stated in
Europe PubMed Central
PubMed publication ID
12915048
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12915048%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 November 2019
PubMed publication ID
12915048
1 reference
stated in
Europe PubMed Central
PubMed publication ID
12915048
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12915048%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 November 2019
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