(Q35199407)

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SMAD3 negatively regulates serum irisin and skeletal muscle FNDC5 and peroxisome proliferator-activated receptor γ coactivator 1-α (PGC-1α) during exercise

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

7 August 2017

SMAD3 negatively regulates serum irisin and skeletal muscle FNDC5 and peroxisome proliferator-activated receptor γ coactivator 1-α (PGC-1α) during exercise. (English)

1 reference

Europe PubMed Central

PubMed publication ID

7 August 2017

author name string

Joseph P Tiano

1

1 reference

Europe PubMed Central

PubMed publication ID

7 August 2017

Danielle A Springer

2

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Europe PubMed Central

PubMed publication ID

7 August 2017

Sushil G Rane

3

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Europe PubMed Central

PubMed publication ID

7 August 2017

language of work or name

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publication date

3 February 2015

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Europe PubMed Central

PubMed publication ID

7 August 2017

Journal of Biological Chemistry

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Europe PubMed Central

PubMed publication ID

7 August 2017

290

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Europe PubMed Central

PubMed publication ID

7 August 2017

12

1 reference

Europe PubMed Central

PubMed publication ID

7 August 2017

7671-7684

1 reference

Europe PubMed Central

PubMed publication ID

7 August 2017

describes a project that uses

1 reference

Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4367270/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

Activation of human brown adipose tissue by a β3-adrenergic receptor agonist.

1 reference

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Obesity- and aging-induced excess of central transforming growth factor-β potentiates diabetic development via an RNA stress response

1 reference

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13 July 2018

Irisin and FGF21 are cold-induced endocrine activators of brown fat function in humans

1 reference

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13 July 2018

Irisin as a muscle-derived hormone stimulating thermogenesis--a critical update.

1 reference

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13 July 2018

Myostatin induces insulin resistance via Casitas B-lineage lymphoma b (Cblb)-mediated degradation of insulin receptor substrate 1 (IRS1) protein in response to high calorie diet intake

1 reference

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An antibody blocking activin type II receptors induces strong skeletal muscle hypertrophy and protects from atrophy

1 reference

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13 July 2018

Irisin stimulates browning of white adipocytes through mitogen-activated protein kinase p38 MAP kinase and ERK MAP kinase signaling

1 reference

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Exercise induces hippocampal BDNF through a PGC-1α/FNDC5 pathway

1 reference

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13 July 2018

Evidence against a beneficial effect of irisin in humans

1 reference

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Smad3 induces atrogin-1, inhibits mTOR and protein synthesis, and promotes muscle atrophy in vivo.

1 reference

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13 July 2018

Myostatin knockout drives browning of white adipose tissue through activating the AMPK-PGC1α-Fndc5 pathway in muscle

1 reference

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13 July 2018

A PGC-1α isoform induced by resistance training regulates skeletal muscle hypertrophy

1 reference

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1 reference

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TGF-β suppresses the expression of genes related to mitochondrial function in lung A549 cells

1 reference

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13 July 2018

FNDC5 and irisin in humans: I. Predictors of circulating concentrations in serum and plasma and II. mRNA expression and circulating concentrations in response to weight loss and exercise

1 reference

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13 July 2018

Beige adipocytes are a distinct type of thermogenic fat cell in mouse and human

1 reference

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13 July 2018

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1 reference

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13 July 2018

A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis

1 reference

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1 reference

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13 July 2018

Myostatin induces degradation of sarcomeric proteins through a Smad3 signaling mechanism during skeletal muscle wasting

1 reference

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13 July 2018

White to brown fat phenotypic switch induced by genetic and environmental activation of a hypothalamic-adipocyte axis

1 reference

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1 reference

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13 July 2018

Acute loading and aging effects on myostatin pathway biomarkers in human skeletal muscle after three sequential bouts of resistance exercise

1 reference

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The roles of transforming growth factor-β and Smad3 signaling in adipocyte differentiation and obesity

1 reference

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Regulation of PGC-1α, a nodal regulator of mitochondrial biogenesis

1 reference

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13 July 2018

Smad3 deficiency in mice protects against insulin resistance and obesity induced by a high-fat diet

1 reference

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C/EBPβ controls exercise-induced cardiac growth and protects against pathological cardiac remodeling

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Identification of inducible brown adipocyte progenitors residing in skeletal muscle and white fat.

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A negative feedback control of transforming growth factor-beta signaling by glycogen synthase kinase 3-mediated Smad3 linker phosphorylation at Ser-204.

1 reference

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Identification and importance of brown adipose tissue in adult humans

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Transforming growth factor-beta/Smad3 signaling regulates insulin gene transcription and pancreatic islet beta-cell function

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Smad7 promotes and enhances skeletal muscle differentiation

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1 reference

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TGF-beta inhibits muscle differentiation through functional repression of myogenic transcription factors by Smad3

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13 July 2018

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13 July 2018

Irisin in response to exercise in humans with and without metabolic syndrome.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4367270

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Effects of obesity, diabetes and exercise on Fndc5 gene expression and irisin release in human skeletal muscle and adipose tissue: in vivo and in vitro studies.

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1 reference

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Adult epicardial fat exhibits beige features

1 reference

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Functional thermogenic beige adipogenesis is inducible in human neck fat.

1 reference

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26 September 2018

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1 reference

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Myostatin inhibits brown adipocyte differentiation via regulation of Smad3-mediated β-catenin stabilization.

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High-intensity exercise causes greater irisin response compared with low-intensity exercise under similar energy consumption

1 reference

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Prevalence of obesity, type II diabetes mellitus, hyperlipidemia, and hypertension in the United States: findings from the GE Centricity Electronic Medical Record database

1 reference

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A transient elevated irisin blood concentration in response to prolonged, moderate aerobic exercise in young men and women

1 reference

https://pubmed.ncbi.nlm.nih.gov/25648888

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inferred from PubMed ID database lookup

An adjustable-current swimming pool for the evaluation of endurance capacity of mice

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inferred from PubMed ID database lookup

Increased Smad signaling and reduced MRF expression in skeletal muscle from obese subjects

1 reference

https://pubmed.ncbi.nlm.nih.gov/25648888

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inferred from PubMed ID database lookup

The effects of acute and chronic exercise on PGC-1α, irisin and browning of subcutaneous adipose tissue in humans

1 reference

https://pubmed.ncbi.nlm.nih.gov/25648888

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based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1074/JBC.M114.617399

1 reference

Europe PubMed Central

PubMed publication ID

7 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

7 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

7 August 2017

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