(Q34265667)

1 August 2017

Muscles, exercise and obesity: skeletal muscle as a secretory organ (English)

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1 August 2017

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Bente Klarlund Pedersen

object named as

Bente K Pedersen

series ordinal

1

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author name string

Mark A Febbraio

series ordinal

2

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1 August 2017

3 April 2012

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Nature Reviews Endocrinology

1 August 2017

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1 August 2017

8

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1 August 2017

8

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1 August 2017

457-465

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https://scigraph.springernature.com/pub.10.1038/nrendo.2012.49

1 August 2017

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cites work

Adipsin: a circulating serine protease homolog secreted by adipose tissue and sciatic nerve

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2012.49

Positional cloning of the mouse obese gene and its human homologue

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2012.49

Adipose tissue: from lipid storage compartment to endocrine organ

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2012.49

Adiponectin in health and disease: evaluation of adiponectin-targeted drug development strategies

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2012.49

Metabolic responses to reduced daily steps in healthy nonexercising men.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2012.49

A 2-wk reduction of ambulatory activity attenuates peripheral insulin sensitivity

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2012.49

Waging war on physical inactivity: using modern molecular ammunition against an ancient enemy

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2012.49

Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2012.49

Association of physical activity with all-cause and cardiovascular mortality: a systematic review and meta-analysis.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2012.49

Physical activity and colon cancer prevention: a meta-analysis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2012.49

Physical activity and breast cancer: a systematic review.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2012.49

Physical activity in the prevention and amelioration of osteoporosis in women : interaction of mechanical, hormonal and dietary factors

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2012.49

Humoral nature of the hypoglycemic factor of muscular work

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2012.49

Searching for the exercise factor: is IL-6 a candidate?

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2012.49

Hormonal and metabolic responses to electrically induced cycling during epidural anesthesia in humans.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2012.49

Long-term adaptation to electrically induced cycle training in severe spinal cord injured individuals.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2012.49

Computational reconstruction of the human skeletal muscle secretome

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2012.49

Comparative proteomic analysis of the insulin-induced L6 myotube secretome

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2012.49

Dynamics of the skeletal muscle secretome during myoblast differentiation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2012.49

Does it matter which exercise? A randomized control trial of exercise for low back pain

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2012.49

The diseasome of physical inactivity--and the role of myokines in muscle--fat cross talk

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2012.49

Adipokines, myokines and cardiovascular disease

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2012.49

Muscle as an endocrine organ: focus on muscle-derived interleukin-6.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2012.49

Role of myokines in exercise and metabolism

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2012.49

The anti-inflammatory effect of exercise: its role in diabetes and cardiovascular disease control

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2012.49

Regulation of skeletal muscle mass in mice by a new TGF-beta superfamily member

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2012.49

Clinical, agricultural, and evolutionary biology of myostatin: a comparative review

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2012.49

Myostatin, activin receptor IIb, and follistatin-like-3 gene expression are altered in adipose tissue and skeletal muscle of obese mice

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2012.49

Myostatin modulates adipogenesis to generate adipocytes with favorable metabolic effects

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2012.49

Myostatin inhibition in muscle, but not adipose tissue, decreases fat mass and improves insulin sensitivity

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2012.49

Transgenic expression of myostatin propeptide prevents diet-induced obesity and insulin resistance

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2012.49

Myostatin Knockout in Mice Increases Myogenesis and Decreases Adipogenesis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2012.49

Suppression of body fat accumulation in myostatin-deficient mice

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2012.49

Expression and function of myostatin in obesity, diabetes, and exercise adaptation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2012.49

Increased secretion and expression of myostatin in skeletal muscle from extremely obese women.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2012.49

Exercise induces a marked increase in plasma follistatin: evidence that follistatin is a contraction-induced hepatokine

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2012.49

Cytokines and chemokines are both expressed by human myoblasts: possible relevance for the immune pathogenesis of muscle inflammation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2012.49

Constitutive and cytokine-induced production of interleukin-6 by human myoblasts

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2012.49

Differential regulation of IL-6 and TNF-alpha via calcineurin in human skeletal muscle cells.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2012.49

Interleukin-6 is an essential regulator of satellite cell-mediated skeletal muscle hypertrophy

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2012.49

IL-7 is expressed and secreted by human skeletal muscle cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2012.49

Elevated NF-κB activation is conserved in human myocytes cultured from obese type 2 diabetic patients and attenuated by AMP-activated protein kinase

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2012.49

Influence of mode and carbohydrate on the cytokine response to heavy exertion

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2012.49

Carbohydrate and the cytokine response to 2.5 h of running

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2012.49

Bicycle exercise enhances plasma IL-6 but does not change IL-1 alpha, IL-1 beta, IL-6, or TNF-alpha pre-mRNA in BMNC

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2012.49

Effect of prolonged, submaximal exercise and carbohydrate ingestion on monocyte intracellular cytokine production in humans

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2012.49

Circulating monocytes are not the source of elevations in plasma IL-6 and TNF-alpha levels after prolonged running.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2012.49

Hepatosplanchnic clearance of interleukin-6 in humans during exercise

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2012.49

Transcriptional activation of the IL-6 gene in human contracting skeletal muscle: influence of muscle glycogen content.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2012.49

IL-6 and TNF-alpha expression in, and release from, contracting human skeletal muscle

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2012.49

Skeletal myocytes are a source of interleukin-6 mRNA expression and protein release during contraction: evidence of fiber type specificity.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2012.49

Increase in interstitial interleukin-6 of human skeletal muscle with repetitive low-force exercise

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2012.49

Production of interleukin-6 in contracting human skeletal muscles can account for the exercise-induced increase in plasma interleukin-6.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2012.49

Effect of exercise, training, and glycogen availability on IL-6 receptor expression in human skeletal muscle

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2012.49

Interleukin-6 production in contracting human skeletal muscle is influenced by pre-exercise muscle glycogen content

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2012.49

Muscular interleukin-6 and its role as an energy sensor

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2012.49

Interleukin-6 regulation of AMP-activated protein kinase. Potential role in the systemic response to exercise and prevention of the metabolic syndrome

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2012.49

The metabolic role of IL-6 produced during exercise: is IL-6 an exercise factor?

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2012.49

Glucose ingestion attenuates interleukin-6 release from contracting skeletal muscle in humans

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2012.49

Effects of training duration on substrate turnover and oxidation during exercise

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2012.49

Endurance training reduces the contraction-induced interleukin-6 mRNA expression in human skeletal muscle

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2012.49

Interleukin-6 increases insulin-stimulated glucose disposal in humans and glucose uptake and fatty acid oxidation in vitro via AMP-activated protein kinase

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2012.49

Cytokine regulation of skeletal muscle fatty acid metabolism: effect of interleukin-6 and tumor necrosis factor-alpha

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2012.49

Interleukin-6 stimulates lipolysis and fat oxidation in humans

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2012.49

AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2012.49

Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2012.49

CNTF reverses obesity-induced insulin resistance by activating skeletal muscle AMPK.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2012.49

AMPK expression and phosphorylation are increased in rodent muscle after chronic leptin treatment

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2012.49

Cytokine Regulation of AMPK signalling

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2012.49

Interleukin-6-deficient mice develop mature-onset obesity

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2012.49

Interleukin-6 is a novel factor mediating glucose homeostasis during skeletal muscle contraction

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2012.49

Acute interleukin-6 administration does not impair muscle glucose uptake or whole-body glucose disposal in healthy humans

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2012.49

Interleukin-6 production in human subcutaneous abdominal adipose tissue: the effect of exercise

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2012.49

IL-6 selectively stimulates fat metabolism in human skeletal muscle

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2012.49

Skeletal muscle as an immunogenic organ

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2012.49

The anti-inflammatory effect of exercise

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2012.49

T cell activation-associated hepatic injury: mediation by tumor necrosis factors and protection by interleukin 6.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2012.49

Exercise and IL-6 infusion inhibit endotoxin-induced TNF-alpha production in humans.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2012.49

IL-6 enhances plasma IL-1ra, IL-10, and cortisol in humans

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2012.49

Induction of the CXCL1 (KC) chemokine in mouse astrocytes by infection with the murine encephalomyelitis virus of Theiler

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2012.49

Expression of the chemokine N51/KC in the thymus and epidermis of transgenic mice results in marked infiltration of a single class of inflammatory cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2012.49

The CXC chemokine receptor 2, CXCR2, is the putative receptor for ELR+ CXC chemokine-induced angiogenic activity

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2012.49

Autocrine IL-6 regulates GRO-alpha production in thymic epithelial cells.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2012.49

Exercise-induced liver chemokine CXCL-1 expression is linked to muscle-derived interleukin-6 expression.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2012.49

Muscle cytokine mRNA changes after 2.5 h of cycling: influence of carbohydrate

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2012.49

Purification of a murine leukemia inhibitory factor from Krebs ascites cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2012.49

Interleukin-6-type cytokine signalling through the gp130/Jak/STAT pathway

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2012.49

The unsolved enigmas of leukemia inhibitory factor

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2012.49

Exercise induces expression of leukaemia inhibitory factor in human skeletal muscle

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2012.49

The biological roles of exercise-induced cytokines: IL-6, IL-8, and IL-15.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2012.49

Interleukin-15 mediates reciprocal regulation of adipose and muscle mass: a potential role in body weight control

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2012.49

Interleukin-15 stimulates adiponectin secretion by 3T3-L1 adipocytes: evidence for a skeletal muscle-to-fat signaling pathway

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2012.49

Association between interleukin-15 and obesity: interleukin-15 as a potential regulator of fat mass

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2012.49

Fast/Glycolytic muscle fiber growth reduces fat mass and improves metabolic parameters in obese mice

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2012.49

Follistatin-like 1, a secreted muscle protein, promotes endothelial cell function and revascularization in ischemic tissue through a nitric-oxide synthase-dependent mechanism

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2012.49

Follistatin-like 1 is an Akt-regulated cardioprotective factor that is secreted by the heart

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2012.49

FGF21 is an Akt-regulated myokine

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2012.49

Fibroblast growth factor-21 is induced in human skeletal muscles by hyperinsulinemia

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2012.49

Role of exercise-induced brain-derived neurotrophic factor production in the regulation of energy homeostasis in mammals

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2012.49

Calprotectin is released from human skeletal muscle tissue during exercise.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2012.49

Erythropoietin over-expression protects against diet-induced obesity in mice through increased fat oxidation in muscles

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2012.49

IL-4 acts as a myoblast recruitment factor during mammalian muscle growth

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2012.49

A role for myokines in muscle-bone interactions

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2012.49

A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2012.49

Quantitative analysis of the secretion of the MCP family of chemokines by muscle cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2012.49

Proteomic identification of secreted proteins from human skeletal muscle cells and expression in response to strength training

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2012.49

Human IL6 enhances leptin action in mice

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2012.49

Interleukin-6 signaling in liver-parenchymal cells suppresses hepatic inflammation and improves systemic insulin action

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2012.49

Ciliary neurotrophic factor prevents acute lipid-induced insulin resistance by attenuating ceramide accumulation and phosphorylation of c-Jun N-terminal kinase in peripheral tissues

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2012.49

Recombinant variant of ciliary neurotrophic factor for weight loss in obese adults: a randomized, dose-ranging study

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2012.49

Bimodal effect on pancreatic β-cells of secretory products from normal or insulin-resistant human skeletal muscle

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2012.49

Interleukin-6 enhances insulin secretion by increasing glucagon-like peptide-1 secretion from L cells and alpha cells.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2012.49

Exercise-induced muscle-derived cytokines inhibit mammary cancer cell growth

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2012.49

Role of muscle-derived growth factors in bone formation

31 March 2020

1 reference

12 December 2020

The role of interleukin-6 in insulin resistance, body fat distribution and energy balance

1 reference

12 December 2020

Interleukin-15 mediates reciprocal regulation of adipose and muscle mass: a potential role in body weight control

1 reference

12 December 2020

Correlations and interactions in the production of interleukin-6 (IL-6), IL-1, and tumor necrosis factor (TNF) in human blood mononuclear cells: IL-6 suppresses IL-1 and TNF.

1 reference

12 December 2020

CXC chemokines in angiogenesis.

1 reference

12 December 2020

The CXC chemokines, IL-8 and IP-10, regulate angiogenic activity in idiopathic pulmonary fibrosis.

1 reference

12 December 2020

Interleukin-6 in acute exercise and training: what is the biological relevance?

1 reference

12 December 2020

Leukaemia inhibitory factor--an exercise-induced myokine.

1 reference

12 December 2020

Acute IL-6 treatment increases fatty acid turnover in elderly humans in vivo and in tissue culture in vitro

1 reference

12 December 2020

Identifiers

DOI

10.1038/NRENDO.2012.49

1 reference

1 August 2017

1 reference

PubMed ID

22473333