(Q35205925)

7 August 2017

title

Hypothalamic agouti-related peptide neurons and the central melanocortin system are crucial mediators of leptin's antidiabetic actions (English)

1 reference

7 August 2017

author name string

Gabriel H M Gonçalves

1

1 reference

7 August 2017

Wenjing Li

2

1 reference

7 August 2017

Adriana V C-G Garcia

3

1 reference

7 August 2017

Mariana S Figueiredo

4

1 reference

7 August 2017

Christian Bjørbæk

5

1 reference

7 August 2017

publication date

9 May 2014

1 reference

7 August 2017

1 reference

7 August 2017

volume

7

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7 August 2017

issue

4

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7 August 2017

page(s)

1093-1103

1 reference

Leptin engages a hypothalamic neurocircuitry to permit survival in the absence of insulin

7 August 2017

cites work

1 reference

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13 July 2018

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Leptin action in the ventromedial hypothalamic nucleus is sufficient, but not necessary, to normalize diabetic hyperglycemia

13 July 2018

1 reference

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Leptin revisited: its mechanism of action and potential for treating diabetes

13 July 2018

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Direct leptin action on POMC neurons regulates glucose homeostasis and hepatic insulin sensitivity in mice

13 July 2018

1 reference

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Leptin action on GABAergic neurons prevents obesity and reduces inhibitory tone to POMC neurons

13 July 2018

1 reference

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Loss of agouti-related peptide does not significantly impact the phenotype of murine POMC deficiency

13 July 2018

1 reference

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Melanocortin-4 receptors expressed by cholinergic neurons regulate energy balance and glucose homeostasis

13 July 2018

1 reference

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Antidiabetic effects of IGFBP2, a leptin-regulated gene

13 July 2018

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Loss of GABAergic signaling by AgRP neurons to the parabrachial nucleus leads to starvation

13 July 2018

1 reference

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A functional melanocortin system may be required for chronic CNS-mediated antidiabetic and cardiovascular actions of leptin

13 July 2018

1 reference

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Leptin-dependent control of glucose balance and locomotor activity by POMC neurons.

13 July 2018

1 reference

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Synaptic release of GABA by AgRP neurons is required for normal regulation of energy balance

13 July 2018

1 reference

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Collective and individual functions of leptin receptor modulated neurons controlling metabolism and ingestion

13 July 2018

1 reference

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Double leptin and melanocortin-4 receptor gene mutations have an additive effect on fat mass and are associated with reduced effects of leptin on weight loss and food intake

13 July 2018

1 reference

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Anatomy and regulation of the central melanocortin system

13 July 2018

1 reference

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Leptin reverses insulin resistance and hepatic steatosis in patients with severe lipodystrophy

13 July 2018

1 reference

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Selective deletion of leptin receptor in neurons leads to obesity

13 July 2018

1 reference

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Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4369586

Obesity and the regulation of energy balance

13 July 2018

1 reference

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Central nervous system control of food intake

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4369586

Antagonism of central melanocortin receptors in vitro and in vivo by agouti-related protein

13 July 2018

1 reference

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Attenuation of the obesity syndrome of ob/ob mice by the loss of neuropeptide Y.

13 July 2018

1 reference

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Abnormal splicing of the leptin receptor in diabetic mice

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4369586

Evidence that the diabetes gene encodes the leptin receptor: identification of a mutation in the leptin receptor gene in db/db mice

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4369586

Specificity of leptin action on elevated blood glucose levels and hypothalamic neuropeptide Y gene expression in ob/ob mice

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4369586

Positional cloning of the mouse obese gene and its human homologue

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4369586

Effects of the obese gene product on body weight regulation in ob/ob mice

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4369586

Obese and diabetes: Two mutant genes causing diabetes-obesity syndromes in mice

13 July 2018

1 reference

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Rapid versus delayed stimulation of feeding by the endogenously released AgRP neuron mediators GABA, NPY, and AgRP.

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4369586

Divergent regulation of proopiomelanocortin neurons by leptin in the nucleus of the solitary tract and in the arcuate hypothalamic nucleus

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4369586

Leptin directly activates SF1 neurons in the VMH, and this action by leptin is required for normal body-weight homeostasis

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4369586

Divergence of melanocortin pathways in the control of food intake and energy expenditure

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4369586

The hypothalamic arcuate nucleus: a key site for mediating leptin's effects on glucose homeostasis and locomotor activity

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4369586

Leptin receptor signaling in POMC neurons is required for normal body weight homeostasis

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4369586

Orexigen-sensitive NPY/AgRP pacemaker neurons in the hypothalamic arcuate nucleus

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4369586

Role of Signal Transducer and Activator of Transcription 3 in Regulation of Hypothalamic Proopiomelanocortin Gene Expression by Leptin

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4369586

Leptin-replacement therapy for lipodystrophy.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4369586

Leptin reverses insulin resistance and diabetes mellitus in mice with congenital lipodystrophy.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4369586

Microinjection of leptin into the ventromedial hypothalamus increases glucose uptake in peripheral tissues in rats

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4369586

Coexpression of Agrp and NPY in fasting-activated hypothalamic neurons

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4369586

Heterogeneity in the neuropeptide Y-containing neurons of the rat arcuate nucleus: GABAergic and non-GABAergic subpopulations

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4369586

Sensitivity to leptin and susceptibility to seizures of mice lacking neuropeptide Y

26 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24813890

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.CELREP.2014.04.010

1 reference

7 August 2017

1 reference

7 August 2017

1 reference