(Q35209894)

7 August 2017

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title

Membrane dynamics, cholesterol homeostasis, and Alzheimer's disease (English)

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7 August 2017

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Neelima B Chauhan

1

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PubMed ID

12951356

7 August 2017

language of work or name

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1 September 2003

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Journal of Lipid Research

7 August 2017

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7 August 2017

44

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7 August 2017

11

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7 August 2017

2019-2029

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The fluid mosaic model of the structure of cell membranes

7 August 2017

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R300010-JLR200

Protein conformation in cell membrane preparations as studied by optical rotatory dispersion and circular dichroism

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R300010-JLR200

On the interactions of lipids and proteins in the red blood cell membrane

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R300010-JLR200

Modulation of phospholipid acyl chain order by cholesterol. A solid-state 2H nuclear magnetic resonance study

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R300010-JLR200

Functional rafts in cell membranes

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R300010-JLR200

Functions of lipid rafts in biological membranes

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R300010-JLR200

Lipid sorting in epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R300010-JLR200

Lipid polarity and sorting in epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R300010-JLR200

The state of lipid rafts: from model membranes to cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R300010-JLR200

Lipid rafts at postsynaptic sites: distribution, function and linkage to postsynaptic density

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R300010-JLR200

Cross-talk between caveolae and glycosylphosphatidylinositol-rich domains.

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R300010-JLR200

Cholesterol metabolism in the brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R300010-JLR200

Lipid traffic in animal cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R300010-JLR200

Evidence for segregation of sphingomyelin and cholesterol during formation of COPI-coated vesicles

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R300010-JLR200

Role of membrane organization and membrane domains in endocytic lipid trafficking

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R300010-JLR200

Cholesterol modulates membrane traffic along the endocytic pathway in sphingolipid-storage diseases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R300010-JLR200

Flotillin-1-enriched lipid raft domains accumulate on maturing phagosomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R300010-JLR200

Caveolins, liquid-ordered domains, and signal transduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R300010-JLR200

Lipid rafts and signal transduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R300010-JLR200

Role of sphingomyelinase and ceramide in modulating rafts: do biophysical properties determine biologic outcome?

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R300010-JLR200

SNARE proteins are highly enriched in lipid rafts in PC12 cells: implications for the spatial control of exocytosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R300010-JLR200

Flotillas of lipid rafts fore and aft.

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R300010-JLR200

Lipid domain structure of the plasma membrane revealed by patching of membrane components

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R300010-JLR200

Essential role of caveolae in interleukin-6- and insulin-like growth factor I-triggered Akt-1-mediated survival of multiple myeloma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R300010-JLR200

Loss of caveolae, vascular dysfunction, and pulmonary defects in caveolin-1 gene-disrupted mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R300010-JLR200

Caveolin-deficient mice: insights into caveolar function human disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R300010-JLR200

VIP21/caveolin is a cholesterol-binding protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R300010-JLR200

Caveolins, a family of scaffolding proteins for organizing "preassembled signaling complexes" at the plasma membrane

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R300010-JLR200

Cholesterol-dependent retention of GPI-anchored proteins in endosomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R300010-JLR200

Cholesterol and Alzheimer's disease: is there a link?

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R300010-JLR200

Human apolipoprotein E N-terminal domain displacement of apolipophorin III from insect low density lipophorin creates a receptor-competent hybrid lipoprotein

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R300010-JLR200

Apolipoprotein E in animal models of CNS injury and in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R300010-JLR200

Origin of cholesterol in myelin

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R300010-JLR200

Apolipoprotein E: cholesterol transport protein with expanding role in cell biology

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R300010-JLR200

Secretory processing of amyloid precursor protein is inhibited by increase in cellular cholesterol content

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R300010-JLR200

Identification, biogenesis, and localization of precursors of Alzheimer's disease A4 amyloid protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R300010-JLR200

Normal and abnormal biology of the beta-amyloid precursor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R300010-JLR200

The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R300010-JLR200

Targeting of cell-surface beta-amyloid precursor protein to lysosomes: alternative processing into amyloid-bearing fragments.

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R300010-JLR200

Isolation and quantification of soluble Alzheimer's beta-peptide from biological fluids

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R300010-JLR200

Amyloid precursor protein is localized in growing neurites of neonatal rat brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R300010-JLR200

Regulation of amyloid precursor protein cleavage.

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R300010-JLR200

"Secretase," Alzheimer amyloid protein precursor secreting enzyme is not sequence-specific

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R300010-JLR200

Exact cleavage site of Alzheimer amyloid precursor in neuronal PC-12 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R300010-JLR200

Beta-amyloid precursor protein cleavage by a membrane-bound protease

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R300010-JLR200

Cholesterol modulates alpha-secretase cleavage of amyloid precursor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R300010-JLR200

Acyl-coenzyme A: cholesterol acyltransferase modulates the generation of the amyloid beta-peptide

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R300010-JLR200

Cholesterol depletion inhibits the generation of beta-amyloid in hippocampal neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R300010-JLR200

Simvastatin strongly reduces levels of Alzheimer's disease beta -amyloid peptides Abeta 42 and Abeta 40 in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R300010-JLR200

Low cholesterol stimulates the nonamyloidogenic pathway by its effect on the alpha -secretase ADAM 10.

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R300010-JLR200

The role of cholesterol in the biosynthesis of beta-amyloid

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R300010-JLR200

Hypercholesterolemia accelerates the Alzheimer's amyloid pathology in a transgenic mouse model

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R300010-JLR200

A detergent-insoluble membrane compartment contains A beta in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R300010-JLR200

Axonal amyloid precursor protein expressed by neurons in vitro is present in a membrane fraction with caveolae-like properties.

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R300010-JLR200

Cholesterol-dependent formation of GM1 ganglioside-bound amyloid beta-protein, an endogenous seed for Alzheimer amyloid

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R300010-JLR200

GM1 ganglioside-bound amyloid beta-protein (A beta): a possible form of preamyloid in Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R300010-JLR200

Membrane disruption by Alzheimer beta-amyloid peptides mediated through specific binding to either phospholipids or gangliosides. Implications for neurotoxicity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R300010-JLR200

A receptor-mediated pathway for cholesterol homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R300010-JLR200

Cholesterol synthesis and lipoprotein reuptake during synaptic remodelling in hippocampus in adult rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R300010-JLR200

Differential effects of apolipoproteins E3 and E4 on neuronal growth in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R300010-JLR200

Neurodegeneration in the central nervous system of apoE-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R300010-JLR200

Alterations in apolipoprotein E expression during aging and neurodegeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R300010-JLR200

Apolipoprotein E gene mapping and expression: localization of the structural gene to human chromosome 19 and expression of ApoE mRNA in lipoprotein- and non-lipoprotein-producing tissues.

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R300010-JLR200

Novel role for apolipoprotein E in the central nervous system. Modulation of sulfatide content

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R300010-JLR200

Apolipoprotein E mRNA is abundant in the brain and adrenals, as well as in the liver, and is present in other peripheral tissues of rats and marmosets

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R300010-JLR200

Apolipoprotein E associated with astrocytic glia of the central nervous system and with nonmyelinating glia of the peripheral nervous system

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R300010-JLR200

Apolipoprotein E is present in hippocampal neurons without neurofibrillary tangles in Alzheimer's disease and in age-matched controls.

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R300010-JLR200

Neurodegeneration and cognitive impairment in apoE-deficient mice is ameliorated by infusion of recombinant apoE.

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R300010-JLR200

Memory deficits and cholinergic impairments in apolipoprotein E-deficient mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R300010-JLR200

Severe learning deficits in apolipoprotein E-knockout mice in a water maze task.

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R300010-JLR200

Apolipoprotein E, plaques, tangles and cholinergic dysfunction in Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R300010-JLR200

Lack of apolipoprotein E dramatically reduces amyloid beta-peptide deposition.

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R300010-JLR200

Expression of human apolipoprotein E reduces amyloid-beta deposition in a mouse model of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R300010-JLR200

Opposite roles of apolipoprotein E in normal brains and in Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R300010-JLR200

Behavioral phenotyping of GFAP-apoE3 and -apoE4 transgenic mice: apoE4 mice show profound working memory impairments in the absence of Alzheimer's-like neuropathology

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R300010-JLR200

Human and murine ApoE markedly alters A beta metabolism before and after plaque formation in a mouse model of Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R300010-JLR200

Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R300010-JLR200

Apolipoprotein E and Alzheimer disease: an update on genetic and functional analyses

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R300010-JLR200

Apolipoprotein E immunoreactivity in neurons and neurofibrillary degeneration of aged non-demented and Alzheimer's disease patients.

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R300010-JLR200

Increased amyloid beta-peptide deposition in cerebral cortex as a consequence of apolipoprotein E genotype in late-onset Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R300010-JLR200

Neurotoxic effects of apolipoprotein E4 are mediated via dysregulation of calcium homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R300010-JLR200

Altered expression of synaptic proteins occurs early during progression of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R300010-JLR200

Apolipoprotein E4: an allele associated with many diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R300010-JLR200

Apolipoprotein-E gene polymorphism and lipid profiles in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R300010-JLR200

Cholesterol is increased in the exofacial leaflet of synaptic plasma membranes of human apolipoprotein E4 knock-in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R300010-JLR200

Stimulation of inflammatory responses in vitro and in vivo by lipophilic HMG-CoA reductase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R300010-JLR200

Statins and the risk of dementia

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R300010-JLR200

Decreased prevalence of Alzheimer disease associated with 3-hydroxy-3-methyglutaryl coenzyme A reductase inhibitors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R300010-JLR200

The impact of the use of statins on the prevalence of dementia and the progression of cognitive impairment.

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R300010-JLR200

Use of lipid-lowering agents, indication bias, and the risk of dementia in community-dwelling elderly people.

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R300010-JLR200

In vivo and in vitro blood-brain barrier transport of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R300010-JLR200

Brain membrane cholesterol domains, aging and amyloid beta-peptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R300010-JLR200

Myopathy induced by HMG-CoA reductase inhibitors in rabbits: a pathological, electrophysiological, and biochemical study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R300010-JLR200

Coronary artery disease, hypertension, ApoE, and cholesterol: a link to Alzheimer's disease?

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R300010-JLR200

Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R300010-JLR200

Midlife vascular risk factors and Alzheimer's disease in later life: longitudinal, population based study

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R300010-JLR200

Amyloid beta-peptide stimulates nitric oxide production in astrocytes through an NFkappaB-dependent mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R300010-JLR200

Differential regulation of NO availability from macrophages and endothelial cells by the garlic component S-allyl cysteine

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R300010-JLR200

Beneficial effects of aged garlic extract on learning and memory impairment in the senescence-accelerated mouse.

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R300010-JLR200

SNAREs are concentrated in cholesterol-dependent clusters that define docking and fusion sites for exocytosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R300010-JLR200

Extraction of cholesterol with methyl-beta-cyclodextrin perturbs formation of clathrin-coated endocytic vesicles

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R300010-JLR200

Acute cholesterol depletion inhibits clathrin-coated pit budding

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R300010-JLR200

Lipid rafts are enriched in arachidonic acid and plasmenylethanolamine and their composition is independent of caveolin-1 expression: a quantitative electrospray ionization/mass spectrometric analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R300010-JLR200

Controlling cytoskeleton structure by phosphoinositide-protein interactions: phosphoinositide binding protein domains and effects of lipid packing.

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R300010-JLR200

Phosphatidylinositol 4,5-bisphosphate functions as a second messenger that regulates cytoskeleton-plasma membrane adhesion

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R300010-JLR200

New EMBO members' review: actin cytoskeleton regulation through modulation of PI(4,5)P(2) rafts

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R300010-JLR200

Localized biphasic changes in phosphatidylinositol-4,5-bisphosphate at sites of phagocytosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R300010-JLR200

A critical review of brain cholesterol metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R300010-JLR200

The Presence of Amyloid β-Protein in the Detergent-Insoluble Membrane Compartment of Human Neuroblastoma Cells†

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R300010-JLR200

Cholesterol-dependent Generation of a Seeding Amyloid β-Protein in Cell Culture

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R300010-JLR200

21 January 2018

Digging into caveolae

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R300010-JLR200

Caveolae: from a morphological point of view

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R300010-JLR200

Transmembrane distribution of sterol in the human erythrocyte

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R300010-JLR200

Human very low density lipoprotein apolipoprotein E isoprotein polymorphism is explained by genetic variation and posttranslational modification

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R300010-JLR200

Astrocytes synthesize apolipoprotein E and metabolize apolipoprotein E-containing lipoproteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R300010-JLR200

Acetoacetylated lipoproteins used to distinguish fibroblasts from macrophages in vitro by fluorescence microscopy

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R300010-JLR200

Apolipoprotein E expression at neuromuscular junctions in mouse, rat and human skeletal muscle

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R300010-JLR200

Apolipoprotein E immunoreactivity within neurofibrillary tangles: relationship to Tau and PHF in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R300010-JLR200

Plasma levels of amyloid beta proteins did not differ between subjects taking statins and those not taking statins

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R300010-JLR200

Inhibition of cholesterol and fatty acid biosynthesis in liver enzymes and chicken hepatocytes by polar fractions of garlic

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R300010-JLR200

Influence of minor plant constituents on porcine hepatic lipid metabolism. Impact on serum lipids

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R300010-JLR200

Effect of aged garlic extract on caspase-3 activity, in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R300010-JLR200

10.1194/JLR.R300010-JLR200

21 January 2018

Identifiers

DOI

1 reference

7 August 2017

1 reference

PubMed ID

12951356