(Q35209979)

7 August 2017

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title

Cancer susceptibility in the mouse: genetics, biology and implications for human cancer (English)

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7 August 2017

1

Peter Demant

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7 August 2017

1 September 2003

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7 August 2017

Nature Reviews Genetics

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7 August 2017

4

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7 August 2017

721-734

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7 August 2017

9

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https://scigraph.springernature.com/pub.10.1038/nrg1157

7 August 2017

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Animal models of tumor-suppressor genes.

21 January 2018

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Conditional mouse models of sporadic cancer

21 January 2018

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High constant incidence in twins and other relatives of women with breast cancer.

21 January 2018

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Environmental and heritable factors in the causation of cancer--analyses of cohorts of twins from Sweden, Denmark, and Finland

21 January 2018

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A comprehensive model for familial breast cancer incorporating BRCA1, BRCA2 and other genes

21 January 2018

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Familial Risks, Early-Onset Breast Cancer, and BRCA1 and BRCA2 Germline Mutations

21 January 2018

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Cancer resistance genes in mice: models for the study of tumour modifiers

21 January 2018

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The genetics and genomics of cancer

21 January 2018

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Genomic approaches to identification of tumour-susceptibility genes using mouse models.

21 January 2018

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Studying complex biological systems using multifactorial perturbation.

21 January 2018

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Map Manager QTX, cross-platform software for genetic mapping

21 January 2018

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Analysing complex genetic traits with chromosome substitution strains

21 January 2018

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Genome-tagged mice (GTM): two sets of genome-wide congenic strains

21 January 2018

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Fine mapping of trypanosomiasis resistance loci in murine advanced intercross lines.

21 January 2018

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High-resolution mapping of quantitative trait loci in outbred mice

21 January 2018

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A method for fine mapping quantitative trait loci in outbred animal stocks

21 January 2018

1 reference

Genetic dissection of complex and quantitative traits: from fantasy to reality via a community effort

21 January 2018

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Multiple cross and inbred strain haplotype mapping of complex-trait candidate genes

21 January 2018

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Identification of Stk6/STK15 as a candidate low-penetrance tumor-susceptibility gene in mouse and human

21 January 2018

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Complexity of lung cancer modifiers: mapping of thirty genes and twenty-five interactions in half of the mouse genome.

21 January 2018

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Principles for the buffering of genetic variation

21 January 2018

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A bioinformatics-based strategy identifies c-Myc and Cdc25A as candidates for the Apmt mammary tumor latency modifiers

21 January 2018

1 reference

Ptprj is a candidate for the mouse colon-cancer susceptibility locus Scc1 and is frequently deleted in human cancers

21 January 2018

1 reference

Genetic control of susceptibility to experimental Lyme arthritis is polygenic and exhibits consistent linkage to multiple loci on chromosome 5 in four independent mouse crosses.

21 January 2018

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Mouse genetic model for clinical and immunological heterogeneity of leishmaniasis.

21 January 2018

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Gli and hedgehog in cancer: tumours, embryos and stem cells.

21 January 2018

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LOH of PTPRJ occurs early in colorectal cancer and is associated with chromosomal loss of 18q12-21.

21 January 2018

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Rat protein tyrosine phosphatase eta suppresses the neoplastic phenotype of retrovirally transformed thyroid cells through the stabilization of p27(Kip1).

21 January 2018

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A mutant receptor tyrosine phosphatase, CD148, causes defects in vascular development

21 January 2018

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The intestinal epithelium and its neoplasms: genetic, cellular and tissue interactions

21 January 2018

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Colorectal cancer in mice genetically deficient in the mucin Muc2

21 January 2018

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Polyclonal structure of intestinal adenomas in ApcMin/+ mice with concomitant loss of Apc+ from all tumor lineages

21 January 2018

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21 January 2018

Inflammation and cancer

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A subset of skin tumor modifier loci determines survival time of tumor-bearing mice.

21 January 2018

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Genetic linkage of nuclear morphology of mouse lung tumors to the Kras-2 locus

21 January 2018

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Bleomycin hydrolase and a genetic locus within the MHC affect risk for pulmonary fibrosis in mice

21 January 2018

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Fine mapping of colon tumor susceptibility (Scc) genes in the mouse, different from the genes known to be somatically mutated in colon cancer

21 January 2018

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Genetic analysis of colon cancer susceptibility in mice.

21 January 2018

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At least four loci and gender are associated with susceptibility to the chemical induction of lung adenomas in A/J x BALB/c mice.

21 January 2018

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A male germ cell tumor-susceptibility-determining locus, pgct1, identified on murine chromosome 13

21 January 2018

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Two genes abrogate the inhibition of murine hepatocarcinogenesis by ovarian hormones

21 January 2018

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Multiple loci affect genetic predisposition to hepatocarcinogenesis in mice.

21 January 2018

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Genetic and epigenetic resistance of SL/Ni mice to lymphomas.

21 January 2018

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Taking the study of cancer cell survival to a new dimension

21 January 2018

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Cancer modeling in the modern era: progress and challenges

31 March 2020

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Polygenic susceptibility to breast cancer and implications for prevention

31 March 2020

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The future of association studies of common cancers

31 March 2020

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Cancer as a complex genetic trait: tumor susceptibility in humans and mouse models

31 March 2020

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MHC and non-MHC genes in lung tumor susceptibility in the mouse: implications for the study of the different lung tumor types and their cell of origin

31 March 2020

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The generation of a library of PCR-analyzed microsatellite variants for genetic mapping of the mouse genome

31 March 2020

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A genetic map of the mouse with 4,006 simple sequence length polymorphisms

31 March 2020

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Complex interactions of new quantitative trait loci, Sluc1, Sluc2, Sluc3, and Sluc4, that influence the susceptibility to lung cancer in the mouse

31 March 2020

1 reference

On the power of experimental designs for the detection of linkage between marker loci and quantitative loci in crosses between inbred lines

31 March 2020

1 reference

Experimental strategies for the genetic dissection of complex traits in animal models

31 March 2020

1 reference

Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results

31 March 2020

1 reference

Recombinant-inbred strains. An aid to finding identity, linkage, and function of histocompatibility and other genes

31 March 2020

1 reference

Recombinant congenic strains--a new tool for analyzing genetic traits determined by more than one gene

31 March 2020

1 reference

Genetic composition of the recombinant congenic strains

31 March 2020

1 reference

Susceptibility to testicular germ-cell tumours in a 129.MOLF-Chr 19 chromosome substitution strain

31 March 2020

1 reference

Gene interaction and single gene effects in colon tumour susceptibility in mice

31 March 2020

1 reference

Three loci modify growth of a transgene-induced mammary tumor: suppression of proliferation associated with decreased microvessel density

31 March 2020

1 reference

Who's afraid of epistasis?

31 March 2020

1 reference

Genetic identification of Mom-1, a major modifier locus affecting Min-induced intestinal neoplasia in the mouse

31 March 2020

1 reference

The secretory phospholipase A2 gene is a candidate for the Mom1 locus, a major modifier of ApcMin-induced intestinal neoplasia

31 March 2020

1 reference

Secretory phospholipase Pla2g2a confers resistance to intestinal tumorigenesis

31 March 2020

1 reference

The Mom1AKR intestinal tumor resistance region consists of Pla2g2a and a locus distal to D4Mit64

31 March 2020

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A strong candidate gene for the Papg1 locus on mouse chromosome 4 affecting lung tumor progression

31 March 2020

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31 March 2020

The Hallmarks of Cancer

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Polyclonal origin of colonic adenomas in an XO/XY patient with FAP.

31 March 2020

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MHC-controlled susceptibility to C3H-MTV-induced mouse mammary tumors is predominantly systemic rather than local.

31 March 2020

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Genetics of quantitative and qualitative aspects of lung tumorigenesis in the mouse: multiple interacting Susceptibility to lung cancer (Sluc) genes with large effects

31 March 2020

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Colorectal adenoma to carcinoma progression follows multiple pathways of chromosomal instability

31 March 2020

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Genetic heterogeneity of angiogenesis in mice.

31 March 2020

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Three-dimensional patterns of lung tumor growth: association with tumor heterogeneity

31 March 2020

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A major susceptibility locus to murine lung carcinogenesis maps on chromosome 6.

31 March 2020

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Genetic mapping of a pulmonary adenoma resistance locus (Par1) in mouse

31 March 2020

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Multiple genes in the H-2 complex affect differently the number and growth rate of transplacentally induced lung tumours in mice

31 March 2020

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Assignment of a locus for mouse lung tumor susceptibility to proximal chromosome 19.

31 March 2020

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An epistatic interaction controls the latency of a transgene-induced mammary tumor

31 March 2020

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Distinct genetic loci control development of benign and malignant skin tumours in mice.

31 March 2020

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Genetic mapping of tumor susceptibility genes involved in mouse plasmacytomagenesis

31 March 2020

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Association of a murine chromosome 9 locus (Psl1) with susceptibility to mouse skin tumor promotion by 12-O-tetradecanoylphorbol-13-acetate

31 March 2020

1 reference

Genetic control of hepatocarcinogenesis in C3H mice

31 March 2020

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T lymphomagenesis is determined by a dominant host gene thymic lymphoma susceptible mouse-1 (TLSM-1) in mouse models

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRG1157

1 reference

7 August 2017

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PubMed ID

12951573