(Q35215613)

7 August 2017

N-alpha-acetylation of α-synuclein increases its helical folding propensity, GM1 binding specificity and resistance to aggregation (English)

1 reference

7 August 2017

1 reference

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25075858%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

4

Dennis J Selkoe

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25075858%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

author name string

Nora C Kim

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25075858%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

Eric S Luth

series ordinal

3

1 reference

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31 May 2020

language of work or name

English

0 references

publication date

30 July 2014

1 reference

7 August 2017

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25075858%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

volume

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25075858%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

page(s)

e103727

1 reference

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31 May 2020

issue

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25075858%20AND%20SRC:MED&resulttype=core&format=json

Creative Commons Attribution 4.0 International

31 May 2020

copyright license

start time

30 July 2014

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

N-terminal acetylation stabilizes N-terminal helicity in lipid- and micelle-bound α-synuclein and increases its affinity for physiological membranes.

1 reference

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Properties of native brain α-synuclein

13 July 2018

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α-Synuclein senses lipid packing defects and induces lateral expansion of lipids leading to membrane remodeling

13 July 2018

1 reference

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Solid-state ¹³C NMR reveals annealing of raft-like membranes containing cholesterol by the intrinsically disordered protein α-Synuclein

13 July 2018

1 reference

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α-Synuclein can inhibit SNARE-mediated vesicle fusion through direct interactions with lipid bilayers

13 July 2018

1 reference

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Exploring the accessible conformations of N-terminal acetylated α-synuclein

13 July 2018

1 reference

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In vivo cross-linking reveals principally oligomeric forms of α-synuclein and β-synuclein in neurons and non-neural cells

13 July 2018

1 reference

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A randomized, controlled, delayed start trial of GM1 ganglioside in treated Parkinson's disease patients

13 July 2018

1 reference

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Monomeric synucleins generate membrane curvature

13 July 2018

1 reference

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Characterization of semisynthetic and naturally Nα-acetylated α-synuclein in vitro and in intact cells: implications for aggregation and cellular properties of α-synuclein

13 July 2018

1 reference

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Deficiency of ganglioside GM1 correlates with Parkinson's disease in mice and humans.

13 July 2018

1 reference

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Impact of N-terminal acetylation of α-synuclein on its random coil and lipid binding properties

13 July 2018

1 reference

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N-Terminal acetylation is critical for forming α-helical oligomer of α-synuclein

13 July 2018

1 reference

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α-Synuclein in central nervous system and from erythrocytes, mammalian cells, and Escherichia coli exists predominantly as disordered monomer

13 July 2018

1 reference

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A soluble α-synuclein construct forms a dynamic tetramer

13 July 2018

1 reference

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α-Synuclein occurs physiologically as a helically folded tetramer that resists aggregation

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4116227

Identification of novel α-synuclein isoforms in human brain tissue by using an online nanoLC-ESI-FTICR-MS method

13 July 2018

1 reference

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Mice lacking major brain gangliosides develop parkinsonism

13 July 2018

1 reference

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Targeted amino-terminal acetylation of recombinant proteins in E. coli

13 July 2018

1 reference

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The N-terminus of the intrinsically disordered protein α-synuclein triggers membrane binding and helix folding

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4116227

13 July 2018

1 reference

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Multiple tight phospholipid-binding modes of alpha-synuclein revealed by solution NMR spectroscopy

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4116227

The first N-terminal amino acids of alpha-synuclein are essential for alpha-helical structure formation in vitro and membrane binding in yeast

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4116227

Curvature dynamics of alpha-synuclein familial Parkinson disease mutants: molecular simulations of the micelle- and bilayer-bound forms

13 July 2018

1 reference

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Molecular anatomy of a trafficking organelle

13 July 2018

1 reference

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Dystonia and parkinsonism in GM1 type 3 gangliosidosis

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4116227

Helix periodicity, topology, and dynamics of membrane-associated alpha-synuclein

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4116227

Thermodynamics of lipid-peptide interactions

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4116227

A gene atlas of the mouse and human protein-encoding transcriptomes

13 July 2018

1 reference

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Interaction of human alpha-Synuclein and Parkinson's disease variants with phospholipids. Structural analysis using site-directed mutagenesis.

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4116227

Both familial Parkinson's disease mutations accelerate alpha-synuclein aggregation

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4116227

Stabilization of alpha-synuclein secondary structure upon binding to synthetic membranes

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4116227

Titration calorimetry of lipid-peptide interactions

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4116227

NACP, a protein implicated in Alzheimer's disease and learning, is natively unfolded

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4116227

Fluorometric determination of amyloid fibrils in vitro using the fluorescent dye, thioflavin T1.

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4116227

Parameters of helix-coil transition theory for alanine-based peptides of varying chain lengths in water

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4116227

GM1 specifically interacts with alpha-synuclein and inhibits fibrillation

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4116227

Phosphorylation of Ser-129 is the dominant pathological modification of alpha-synuclein in familial and sporadic Lewy body disease

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4116227

Binding of alpha-synuclein affects the lipid packing in bilayers of small vesicles

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4116227

Neural activity controls the synaptic accumulation of alpha-synuclein.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4116227

Lipid rafts mediate the synaptic localization of alpha-synuclein.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4116227

Alpha-synuclein has a high affinity for packing defects in a bilayer membrane: a thermodynamics study.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4116227

Lipid binding inhibits alpha-synuclein fibril formation

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4116227

Defective membrane interactions of familial Parkinson's disease mutant A30P alpha-synuclein

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4116227

Accelerated in vitro fibril formation by a mutant alpha-synuclein linked to early-onset Parkinson disease.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4116227

alpha-Synuclein membrane interactions and lipid specificity

26 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25075858

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

GM1 ganglioside in Parkinson's disease: Results of a five year open study

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25075858

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1371/JOURNAL.PONE.0103727

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25075858%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25075858%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25075858%20AND%20SRC:MED&resulttype=core&format=json