(Q35216655)

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Design, synthesis, and biological evaluation of 14-heteroaromatic-substituted naltrexone derivatives: pharmacological profile switch from mu opioid receptor selectivity to mu/kappa opioid receptor dual selectivity

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scholarly article

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Europe PubMed Central

PubMed publication ID

7 August 2017

Design, synthesis, and biological evaluation of 14-heteroaromatic-substituted naltrexone derivatives: pharmacological profile switch from mu opioid receptor selectivity to mu/kappa opioid receptor dual selectivity (English)

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7 August 2017

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2 June 2020

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Yunyun Yuan

1

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2 June 2020

Orgil Elbegdorj

3

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2 June 2020

Lindsey C K Aschenbach

4

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2 June 2020

Guo Li

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2 June 2020

David L Stevens

6

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2 June 2020

Krista L Scoggins

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2 June 2020

William L Dewey

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2 June 2020

Dana E Selley

9

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2 June 2020

Yan Zhang

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2 June 2020

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7 November 2013

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7 August 2017

Journal of Medicinal Chemistry

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2 June 2020

56

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2 June 2020

22

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2 June 2020

9156-9169

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2 June 2020

Design, synthesis, and biological evaluation of 17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6β-[(4'-pyridyl)carboxamido]morphinan derivatives as peripheral selective μ opioid receptor Agents

1 reference

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Opiate addiction and cocaine addiction: underlying molecular neurobiology and genetics

1 reference

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Maintenance medication for opiate addiction: the foundation of recovery

1 reference

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13 July 2018

Characterization of 6α- and 6β-N-heterocyclic substituted naltrexamine derivatives as novel leads to development of mu opioid receptor selective antagonists

1 reference

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13 July 2018

κ-opioid receptor/dynorphin system: genetic and pharmacotherapeutic implications for addiction

1 reference

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13 July 2018

6β-N-heterocyclic substituted naltrexamine derivative NAP as a potential lead to develop peripheral mu opioid receptor selective antagonists

1 reference

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Structure of the δ-opioid receptor bound to naltrindole

1 reference

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13 July 2018

Structure of the human κ-opioid receptor in complex with JDTic

1 reference

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13 July 2018

Crystal structure of the µ-opioid receptor bound to a morphinan antagonist

1 reference

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13 July 2018

Oral naltrexone maintenance treatment for opioid dependence

1 reference

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13 July 2018

The role of the dynorphin-kappa opioid system in the reinforcing effects of drugs of abuse

1 reference

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Identification of a novel "almost neutral" micro-opioid receptor antagonist in CHO cells expressing the cloned human mu-opioid receptor

1 reference

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13 July 2018

A review of opioid dependence treatment: pharmacological and psychosocial interventions to treat opioid addiction

1 reference

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13 July 2018

The dynorphin/kappa opioid system as a modulator of stress-induced and pro-addictive behaviors

1 reference

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13 July 2018

Opioid dependence treatment: options in pharmacotherapy

1 reference

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13 July 2018

14 beta-O-cinnamoylnaltrexone and related dihydrocodeinones are mu opioid receptor partial agonists with predominant antagonist activity

1 reference

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13 July 2018

Design, synthesis, and biological evaluation of 6alpha- and 6beta-N-heterocyclic substituted naltrexamine derivatives as mu opioid receptor selective antagonists

1 reference

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13 July 2018

Stress-induced reinstatement of cocaine seeking is mediated by the kappa opioid system

1 reference

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13 July 2018

Enzymatic synthesis of optically active tertiary alcohols: expanding the biocatalysis toolbox.

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13 July 2018

The addiction liability of methadon (amidone, dolophine, 10820) and its use in the treatment of the morphine abstinence syndrome

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13 July 2018

Pharmacological evidence for a motivational role of kappa-opioid systems in ethanol dependence

1 reference

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13 July 2018

Structural determinants of opioid activity in derivatives of 14-aminomorphinones: effect of substitution in the aromatic ring of cinnamoylaminomorphinones and codeinones

1 reference

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13 July 2018

Injectable, sustained-release naltrexone for the treatment of opioid dependence: a randomized, placebo-controlled trial

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13 July 2018

Some narcotic antagonists in the benzomorphan series

1 reference

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13 July 2018

Kappa opioid receptor antagonism and prodynorphin gene disruption block stress-induced behavioral responses

1 reference

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13 July 2018

Synthesis and biological evaluation of 14-alkoxymorphinans. 18. N-substituted 14-phenylpropyloxymorphinan-6-ones with unanticipated agonist properties: extending the scope of common structure-activity relationships

1 reference

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13 July 2018

Disruption of the kappa-opioid receptor gene in mice enhances sensitivity to chemical visceral pain, impairs pharmacological actions of the selective kappa-agonist U-50,488H and attenuates morphine withdrawal

1 reference

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13 July 2018

Dopamine release in the nucleus accumbens during heroin self-administration is modulated by kappa opioid receptors: an in vivo fast-cyclic voltammetry study

1 reference

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1 reference

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Naltrexone treatment of heroin addiction: efficacy and safety in a double-blind dosage comparison

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The irreversible narcotic antagonistic and reversible agonistic properties of the fumaramate methyl ester derivative of naltrexone

1 reference

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Synthesis and biological evaluation of 14-alkoxymorphinans. 2. (-)-N-(cyclopropylmethyl)-4,14-dimethoxymorphinan-6-one, a selective mu opioid receptor antagonist.

1 reference

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Clinical Experience with Naltrexone

1 reference

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1 reference

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Opioid receptor selectivity profile change via isosterism for 14-O-substituted naltrexone derivatives

1 reference

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1 reference

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1 reference

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12 December 2020

based on heuristic

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Methocinnamox is a potent, long-lasting, and selective antagonist of morphine-mediated antinociception in the mouse: comparison with clocinnamox, beta-funaltrexamine, and beta-chlornaltrexamine

1 reference

https://pubmed.ncbi.nlm.nih.gov/24144240

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Naloxone hyperalgesia and stress-induced analgesia in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/24144240

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacological characterization in vivo of the novel opiate, beta-funaltrexamine

1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Naltrexone treatment of opiate-dependent persons

1 reference

https://pubmed.ncbi.nlm.nih.gov/24144240

12 December 2020

based on heuristic

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10.1021/JM4012214

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24144240%20AND%20SRC:MED&resulttype=core&format=json

2 June 2020

PMC publication ID

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24144240%20AND%20SRC:MED&resulttype=core&format=json

2 June 2020

PubMed publication ID

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24144240%20AND%20SRC:MED&resulttype=core&format=json

2 June 2020

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