(Q35230791)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25163684%20AND%20SRC:MED&resulttype=core&format=json

14 March 2020

title

Identification of potent inhibitors of the Trypanosoma brucei methionyl-tRNA synthetase via high-throughput orthogonal screening (English)

1 reference

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14 March 2020

0 references

2

1 reference

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14 March 2020

Cho Yeow Koh

7

1 reference

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14 March 2020

14

Wim G J Hol

1 reference

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14 March 2020

author name string

Laura Pedró-Rosa

1

1 reference

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14 March 2020

Ranae M Ranade

3

1 reference

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14 March 2020

Christina Eberhart

4

1 reference

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14 March 2020

Franck Madoux

5

1 reference

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14 March 2020

J Robert Gillespie

6

1 reference

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14 March 2020

Steven Brown

8

1 reference

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14 March 2020

Jacqueline Lohse

9

1 reference

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14 March 2020

Christophe L M Verlinde

10

1 reference

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14 March 2020

Erkang Fan

11

1 reference

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14 March 2020

Thomas Bannister

12

1 reference

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14 March 2020

Louis Scampavia

13

1 reference

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14 March 2020

Timothy Spicer

15

1 reference

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14 March 2020

Peter Hodder

16

1 reference

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14 March 2020

publication date

27 August 2014

1 reference

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Journal of Biomolecular Screening

14 March 2020

published in

1 reference

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14 March 2020

volume

20

1 reference

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14 March 2020

issue

1

1 reference

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14 March 2020

page(s)

122-130

1 reference

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Structures of Trypanosoma brucei methionyl-tRNA synthetase with urea-based inhibitors provide guidance for drug design against sleeping sickness

14 March 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4378865

A multiple aminoacyl-tRNA synthetase complex that enhances tRNA-aminoacylation in African trypanosomes

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4378865

Distinct States of Methionyl-tRNA Synthetase Indicate Inhibitor Binding by Conformational Selection

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4378865

Urea-based inhibitors of Trypanosoma brucei methionyl-tRNA synthetase: selectivity and in vivo characterization.

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4378865

Selective inhibitors of methionyl-tRNA synthetase have potent activity against Trypanosoma brucei Infection in Mice

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4378865

An ultra-high throughput cell-based screen for wee1 degradation inhibitors

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4378865

From one amino acid to another: tRNA-dependent amino acid biosynthesis

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4378865

Control of neglected tropical diseases

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4378865

Drugs for bad bugs: confronting the challenges of antibacterial discovery

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4378865

Prospects for aminoacyl-tRNA synthetase inhibitors as new antimicrobial agents

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4378865

Characterization of the human mitochondrial methionyl-tRNA synthetase

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4378865

Structural basis for the recognition of isoleucyl-adenylate and an antibiotic, mupirocin, by isoleucyl-tRNA synthetase

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4378865

Genomics-based identification of targets in pathogenic bacteria for potential therapeutic and diagnostic use.

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4378865

A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4378865

Continuous cultivation of Trypanosoma brucei blood stream forms in a medium containing a low concentration of serum protein without feeder cell layers

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4378865

Adenosine triphosphate consumption by bacterial arginyl-transfer ribonucleic acid synthetases

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4378865

Human African trypanosomiasis

13 July 2018

2 references

https://api.crossref.org/works/10.1177%2F1087057114548832

21 January 2018

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4378865

Potent and selective inhibitors of bacterial methionyl tRNA synthetase derived from an oxazolone-dipeptide scaffold

15 November 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057114548832

Potent and selective inhibitors of Staphylococcus epidermidis tryptophanyl-tRNA synthetase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057114548832

Determining appropriate substrate conversion for enzymatic assays in high-throughput screening

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057114548832

21 January 2018

Identifiers

DOI

10.1177/1087057114548832

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25163684%20AND%20SRC:MED&resulttype=core&format=json

14 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25163684%20AND%20SRC:MED&resulttype=core&format=json

14 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25163684%20AND%20SRC:MED&resulttype=core&format=json