(Q35237519)

English

Non-lineage/stage-restricted effects of a gain-of-function mutation in tyrosine phosphatase Ptpn11 (Shp2) on malignant transformation of hematopoietic cells

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

7 August 2017

Non-lineage/stage-restricted effects of a gain-of-function mutation in tyrosine phosphatase Ptpn11 (Shp2) on malignant transformation of hematopoietic cells (English)

1 reference

Europe PubMed Central

PubMed publication ID

7 August 2017

author name string

Dan Xu

1

1 reference

Europe PubMed Central

PubMed publication ID

7 August 2017

Xia Liu

2

1 reference

Europe PubMed Central

PubMed publication ID

7 August 2017

Wen-Mei Yu

3

1 reference

Europe PubMed Central

PubMed publication ID

7 August 2017

Howard J Meyerson

4

1 reference

Europe PubMed Central

PubMed publication ID

7 August 2017

Caiying Guo

5

1 reference

Europe PubMed Central

PubMed publication ID

7 August 2017

Stanton L Gerson

6

1 reference

Europe PubMed Central

PubMed publication ID

7 August 2017

Cheng-Kui Qu

7

1 reference

Europe PubMed Central

PubMed publication ID

7 August 2017

language of work or name

0 references

publication date

19 September 2011

1 reference

Europe PubMed Central

PubMed publication ID

7 August 2017

Journal of Experimental Medicine

1 reference

Europe PubMed Central

PubMed publication ID

7 August 2017

208

1 reference

Europe PubMed Central

PubMed publication ID

7 August 2017

10

1 reference

Europe PubMed Central

PubMed publication ID

7 August 2017

1977-1988

1 reference

Europe PubMed Central

PubMed publication ID

7 August 2017

Kit-Shp2-Kit signaling acts to maintain a functional hematopoietic stem and progenitor cell pool

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3182060

27 July 2018

Essential role for Ptpn11 in survival of hematopoietic stem and progenitor cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3182060

27 July 2018

A germline gain-of-function mutation in Ptpn11 (Shp-2) phosphatase induces myeloproliferative disease by aberrant activation of hematopoietic stem cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3182060

27 July 2018

Leukemogenic Ptpn11 causes fatal myeloproliferative disorder via cell-autonomous effects on multiple stages of hematopoiesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3182060

27 July 2018

Flow-cytometric phosphoprotein analysis reveals agonist and temporal differences in responses of murine hematopoietic stem/progenitor cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3182060

27 July 2018

Protein tyrosine phosphatases in the JAK/STAT pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3182060

27 July 2018

The RAS/MAPK syndromes: novel roles of the RAS pathway in human genetic disorders

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3182060

27 July 2018

Multi-genetic events collaboratively contribute to Pten-null leukaemia stem-cell formation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3182060

27 July 2018

Unique and independent roles for MLL in adult hematopoietic stem cells and progenitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3182060

27 July 2018

FoxOs are critical mediators of hematopoietic stem cell resistance to physiologic oxidative stress

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3182060

27 July 2018

Protein tyrosine phosphatases: from genes, to function, to disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3182060

27 July 2018

Pten dependence distinguishes haematopoietic stem cells from leukaemia-initiating cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3182060

27 July 2018

PTPN11 (Shp2) mutations in LEOPARD syndrome have dominant negative, not activating, effects

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3182060

27 July 2018

Diversity and functional consequences of germline and somatic PTPN11 mutations in human disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3182060

27 July 2018

SLAM family receptors distinguish hematopoietic stem and progenitor cells and reveal endothelial niches for stem cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3182060

27 July 2018

Diverse biochemical properties of Shp2 mutants. Implications for disease phenotypes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3182060

27 July 2018

The mutational spectrum of PTPN11 in juvenile myelomonocytic leukemia and Noonan syndrome/myeloproliferative disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3182060

27 July 2018

Functional analysis of leukemia-associated PTPN11 mutations in primary hematopoietic cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3182060

27 July 2018

Activating mutations of the noonan syndrome-associated SHP2/PTPN11 gene in human solid tumors and adult acute myelogenous leukemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3182060

27 July 2018

Cell-cycle checkpoints and cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3182060

27 July 2018

Chromosome segregation and genomic stability

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3182060

27 July 2018

Noonan syndrome-associated SHP2/PTPN11 mutants cause EGF-dependent prolonged GAB1 binding and sustained ERK2/MAPK1 activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3182060

27 July 2018

Specificity in signal transduction: from phosphotyrosine-SH2 domain interactions to complex cellular systems

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3182060

27 July 2018

Similar MLL-associated leukemias arising from self-renewing stem cells and short-lived myeloid progenitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3182060

27 July 2018

Catalytic-dependent and -independent roles of SHP-2 tyrosine phosphatase in interleukin-3 signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3182060

27 July 2018

Spatial and temporal patterns of ERK signaling during mouse embryogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3182060

27 July 2018

Blocking the function of tyrosine phosphatase SHP-2 by targeting its Src homology 2 domains

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3182060

27 July 2018

The 'Shp'ing news: SH2 domain-containing tyrosine phosphatases in cell signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3182060

27 July 2018

A highly efficient recombineering-based method for generating conditional knockout mutations

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3182060

27 July 2018

Mutations in PTPN11, encoding the protein tyrosine phosphatase SHP-2, cause Noonan syndrome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3182060

27 July 2018

Requirement of Shp-2 tyrosine phosphatase in lymphoid and hematopoietic cell development

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3182060

27 July 2018

Nf1 and Gmcsf interact in myeloid leukemogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3182060

27 July 2018

Genetic evidence that Shp-2 tyrosine phosphatase is a signal enhancer of the epidermal growth factor receptor in mammals

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3182060

27 July 2018

Biased suppression of hematopoiesis and multiple developmental defects in chimeric mice containing Shp-2 mutant cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3182060

27 July 2018

Nf1 regulates hematopoietic progenitor cell growth and ras signaling in response to multiple cytokines

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3182060

27 July 2018

Revealing mechanisms for SH2 domain mediated regulation of the protein tyrosine phosphatase SHP-2.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3182060

27 July 2018

Crystal structure of the tyrosine phosphatase SHP-2

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3182060

27 July 2018

A deletion mutation in the SH2-N domain of Shp-2 severely suppresses hematopoietic cell development

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3182060

27 July 2018

Abnormal mesoderm patterning in mouse embryos mutant for the SH2 tyrosine phosphatase Shp-2.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3182060

27 July 2018

Spatial constraints on the recognition of phosphoproteins by the tandem SH2 domains of the phosphatase SH-PTP2

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3182060

27 July 2018

A new function for a phosphotyrosine phosphatase: linking GRB2-Sos to a receptor tyrosine kinase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3182060

27 July 2018

Protein-tyrosine-phosphatase SHPTP2 couples platelet-derived growth factor receptor beta to Ras

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3182060

27 July 2018

Inducible gene targeting in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3182060

27 July 2018

Mouse model of Noonan syndrome reveals cell type- and gene dosage-dependent effects of Ptpn11 mutation

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20110450

21 January 2018

Human somatic PTPN11 mutations induce hematopoietic-cell hypersensitivity to granulocyte-macrophage colony-stimulating factor

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20110450

21 January 2018

Wnt signaling in the niche enforces hematopoietic stem cell quiescence and is necessary to preserve self-renewal in vivo.

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20110450

21 January 2018

PTPN11 mutations in pediatric patients with acute myeloid leukemia: results from the Children's Cancer Group

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20110450

21 January 2018

Mutations in PTPN11 implicate the SHP-2 phosphatase in leukemogenesis

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20110450

21 January 2018

Prognostic, therapeutic, and mechanistic implications of a mouse model of leukemia evoked by Shp2 (PTPN11) mutations.

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20110450

21 January 2018

Acute myeloid leukemia induced by graded reduction of a lineage-specific transcription factor, PU.1.

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20110450

21 January 2018

Chromosomal passengers: conducting cell division

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20110450

21 January 2018

ZIP codes for delivering SH2 domains

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20110450

21 January 2018

Somatic mutations in PTPN11 in juvenile myelomonocytic leukemia, myelodysplastic syndromes and acute myeloid leukemia

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20110450

21 January 2018

Genetic evidence for lineage-related and differentiation stage-related contribution of somatic PTPN11 mutations to leukemogenesis in childhood acute leukemia

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20110450

21 January 2018

Maintaining the ribosomal reading frame: the influence of the E site during translational regulation of release factor 2.

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20110450

21 January 2018

An Shp2/SFK/Ras/Erk signaling pathway controls trophoblast stem cell survival

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20110450

21 January 2018

Effects of a leukemia-associated gain-of-function mutation of SHP-2 phosphatase on interleukin-3 signaling

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20110450

21 January 2018

Structure and specificity of the SH2 domain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3182060

26 September 2018

TEL-AML1 Corrupts Hematopoietic Stem Cells to Persist in the Bone Marrow and Initiate Leukemia

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20110450

21 January 2018

Modeling of C/EBPα Mutant Acute Myeloid Leukemia Reveals a Common Expression Signature of Committed Myeloid Leukemia-Initiating Cells

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20110450

21 January 2018

PTEN maintains haematopoietic stem cells and acts in lineage choice and leukaemia prevention

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20110450

21 January 2018

Lineage infidelity in acute leukemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/21930766

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hematopoietic stem cell quiescence maintained by p21cip1/waf1

1 reference

https://pubmed.ncbi.nlm.nih.gov/21930766

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

MLL-GAS7 transforms multipotent hematopoietic progenitors and induces mixed lineage leukemias in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/21930766

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1084/JEM.20110450

1 reference

Europe PubMed Central

PubMed publication ID

7 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

7 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

7 August 2017

ResearchGate publication ID

0 references

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