(Q35251779)

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Evolutionary Action Score of TP53 Identifies High-Risk Mutations Associated with Decreased Survival and Increased Distant Metastases in Head and Neck Cancer.

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25634208%20AND%20SRC:MED&resulttype=core&format=json

29 February 2020

Evolutionary Action Score of TP53 Identifies High-Risk Mutations Associated with Decreased Survival and Increased Distant Metastases in Head and Neck Cancer (English)

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25634208%20AND%20SRC:MED&resulttype=core&format=json

29 February 2020

Stephanie C Hicks

6

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29 February 2020

Curtis R Pickering

8

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29 February 2020

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Marek Kimmel

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29 February 2020

Olivier Lichtarge

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Olivier Lichtarge

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29 February 2020

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David M Neskey

1

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29 February 2020

Abdullah A Osman

2

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29 February 2020

Thomas J Ow

3

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29 February 2020

Panagiotis Katsonis

4

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29 February 2020

Thomas McDonald

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29 February 2020

Teng-Kuei Hsu

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29 February 2020

Alexandra Ward

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29 February 2020

Ameeta Patel

10

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29 February 2020

John S Yordy

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29 February 2020

Heath D Skinner

12

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29 February 2020

Uma Giri

13

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29 February 2020

Daisuke Sano

14

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29 February 2020

Michael D Story

15

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29 February 2020

Beth M Beadle

16

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29 February 2020

Adel K El-Naggar

17

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29 February 2020

Merrill S Kies

18

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29 February 2020

William N William

19

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29 February 2020

Carlos Caulin

20

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29 February 2020

Mitchell Frederick

21

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29 February 2020

Jeffrey N Myers

23

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29 February 2020

language of work or name

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publication date

29 January 2015

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29 February 2020

Cancer Research

1 reference

Europe PubMed Central

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29 February 2020

75

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29 February 2020

7

1 reference

Europe PubMed Central

PMC publication ID

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29 February 2020

1527-1536

1 reference

Europe PubMed Central

PMC publication ID

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29 February 2020

A formal perturbation equation between genotype and phenotype determines the Evolutionary Action of protein-coding variations on fitness

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4383697

12 July 2018

Multi-tiered genomic analysis of head and neck cancer ties TP53 mutation to 3p loss

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4383697

12 July 2018

Prediction and experimental validation of enzyme substrate specificity in protein structures

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4383697

12 July 2018

Serine substitution of proline at codon 151 of TP53 confers gain of function activity leading to anoikis resistance and tumor progression of head and neck cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4383697

12 July 2018

Integrative genomic characterization of oral squamous cell carcinoma identifies frequent somatic drivers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4383697

12 July 2018

p53 mutations in cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4383697

12 July 2018

Assembly and initial characterization of a panel of 85 genomically validated cell lines from diverse head and neck tumor sites.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4383697

12 July 2018

Exome sequencing of head and neck squamous cell carcinoma reveals inactivating mutations in NOTCH1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4383697

12 July 2018

The mutational landscape of head and neck squamous cell carcinoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4383697

12 July 2018

Prognostic significance of truncating TP53 mutations in head and neck squamous cell carcinoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4383697

12 July 2018

Global cancer statistics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4383697

12 July 2018

Targeted molecular therapy of head and neck squamous cell carcinoma with the tyrosine kinase inhibitor vandetanib in a mouse model

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4383697

12 July 2018

Evolution: a guide to perturb protein function and networks

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4383697

12 July 2018

Evolutionary trace annotation of protein function in the structural proteome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4383697

12 July 2018

When mutants gain new powers: news from the mutant p53 field.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4383697

12 July 2018

Xenograft models of head and neck cancers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4383697

12 July 2018

TP53 mutations and survival in squamous-cell carcinoma of the head and neck.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4383697

12 July 2018

Cancer-derived p53 mutants suppress p53-target gene expression--potential mechanism for gain of function of mutant p53.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4383697

12 July 2018

Impact of mutant p53 functional properties on TP53 mutation patterns and tumor phenotype: lessons from recent developments in the IARC TP53 database

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4383697

12 July 2018

Global cancer statistics, 2002

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4383697

12 July 2018

A family of evolution-entropy hybrid methods for ranking protein residues by importance.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4383697

12 July 2018

Mutant p53 exerts a dominant negative effect by preventing wild-type p53 from binding to the promoter of its target genes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4383697

12 July 2018

Understanding the function-structure and function-mutation relationships of p53 tumor suppressor protein by high-resolution missense mutation analysis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4383697

12 July 2018

p53 mutation and locoregional treatment failure in head and neck squamous cell carcinoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4383697

12 July 2018

An evolutionary trace method defines binding surfaces common to protein families

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4383697

12 July 2018

Gain of function mutations in p53.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4383697

12 July 2018

Experimental Study of Metastases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4383697

12 July 2018

Amino acid substitution matrices from protein blocks

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4383697

12 July 2018

TP53 DNA contact mutations are selectively associated with allelic loss and have a strong clinical impact in head and neck cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/25634208

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lack of correlation between p53-dependent transcriptional activity and the ability to induce apoptosis among 179 mutant p53s

1 reference

https://pubmed.ncbi.nlm.nih.gov/25634208

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structural clusters of evolutionary trace residues are statistically significant and common in proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/25634208

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1158/0008-5472.CAN-14-2735

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25634208%20AND%20SRC:MED&resulttype=core&format=json

29 February 2020

PMC publication ID

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Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25634208%20AND%20SRC:MED&resulttype=core&format=json

29 February 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

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29 February 2020

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