(Q38069463)

28 August 2017

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title

p53 mutations in cancer (English)

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28 August 2017

2

Karen H Vousden

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28 August 2017

Patricia A J Muller

1

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28 August 2017

1 January 2013

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28 August 2017

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28 August 2017

15

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28 August 2017

2-8

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28 August 2017

1

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https://scigraph.springernature.com/pub.10.1038/ncb2641

28 August 2017

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cites work

Restoration of DNA-binding and growth-suppressive activity of mutant forms of p53 via a PCAF-mediated acetylation pathway

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12 December 2020

Inhibition of p53 DNA binding function by the MDM2 protein acidic domain

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12 December 2020

Mutant p53 gain-of-function induces epithelial-mesenchymal transition through modulation of the miR-130b-ZEB1 axis.

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12 December 2020

TAp73 knockout shows genomic instability with infertility and tumor suppressor functions

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12 December 2020

Integrity of the N-terminal transcription domain of p53 is required for mutant p53 interference with drug-induced apoptosis

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12 December 2020

Mutant p53 oncogenic functions are sustained by Plk2 kinase through an autoregulatory feedback loop.

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12 December 2020

Conformational and molecular basis for induction of apoptosis by a p53 C-terminal peptide in human cancer cells

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12 December 2020

Mutant p53 drives invasion in breast tumors through up-regulation of miR-155.

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12 December 2020

p63 is a suppressor of tumorigenesis and metastasis interacting with mutant p53.

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12 December 2020

Crystal structure of a p53 tumor suppressor-DNA complex: understanding tumorigenic mutations

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12 December 2020

Gain of function mutations in p53.

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12 December 2020

Mutant p53 gain-of-function in cancer

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12 December 2020

Mutant p53 cooperates with ETS and selectively up-regulates human MDR1 not MRP1.

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12 December 2020

Interference with the p53 family network contributes to the gain of oncogenic function of mutant p53 in hepatocellular carcinoma

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12 December 2020

Gain of function of mutant p53: the mutant p53/NF-Y protein complex reveals an aberrant transcriptional mechanism of cell cycle regulation

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12 December 2020

Mutant p53 protein localized in the cytoplasm inhibits autophagy

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12 December 2020

Oncogenic mutations of the p53 tumor suppressor: the demons of the guardian of the genome.

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12 December 2020

Ser392 phosphorylation regulates the oncogenic function of mutant p53.

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12 December 2020

Gain-of-function p53 mutants have widespread genomic locations partially overlapping with p63.

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12 December 2020

Mutant p53 drives multinucleation and invasion through a process that is suppressed by ANKRD11.

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12 December 2020

A Pin1/mutant p53 axis promotes aggressiveness in breast cancer

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12 December 2020

Gain of function of mutant p53 by coaggregation with multiple tumor suppressors

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12 December 2020

Restoration of the growth suppression function of mutant p53 by a synthetic peptide derived from the p53 C-terminal domain

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12 December 2020

A subset of tumor-derived mutant forms of p53 down-regulate p63 and p73 through a direct interaction with the p53 core domain

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12 December 2020

Mutant p53 drives invasion by promoting integrin recycling

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12 December 2020

Mutant p53 enhances MET trafficking and signalling to drive cell scattering and invasion

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12 December 2020

A common gain of function of p53 cancer mutants in inducing genetic instability

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12 December 2020

Loss of p63 and its microRNA-205 target results in enhanced cell migration and metastasis in prostate cancer

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12 December 2020

Differential activation of target cellular promoters by p53 mutants with impaired apoptotic function

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12 December 2020

p53 and Sp1 interact and cooperate in the tumor necrosis factor-induced transcriptional activation of the HIV-1 long terminal repeat

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12 December 2020

Mutation at Ser392 specifically sensitizes mutant p53H175 to mdm2-mediated degradation.

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12 December 2020

Tumor predisposition in mice mutant for p63 and p73: evidence for broader tumor suppressor functions for the p53 family

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12 December 2020

Family feud in chemosensitvity: p73 and mutant p53.

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12 December 2020

Blinded by the Light: The Growing Complexity of p53

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12 December 2020

p73 function is inhibited by tumor-derived p53 mutants in mammalian cells.

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12 December 2020

Reactivation of mutant p53 through interaction of a C-terminal peptide with the core domain.

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12 December 2020

Transcriptional activities of mutant p53: when mutations are more than a loss

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12 December 2020

A dominant negative form of p63 inhibits apoptosis in a p53-independent manner

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12 December 2020

The C-terminus of mutant p53 is necessary for its ability to interfere with growth arrest or apoptosis

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12 December 2020

Mutant p53 forms a complex with Sp1 on HIV-LTR DNA.

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12 December 2020

The oncogenic roles of p53 mutants in mouse models

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12 December 2020

Specific interaction of mutant p53 with regions of matrix attachment region DNA elements (MARs) with a high potential for base-unpairing

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12 December 2020

Regulation of p53 stability by Mdm2

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12 December 2020

Blockage of NF-kappaB induces serine 15 phosphorylation of mutant p53 by JNK kinase in prostate cancer cells.

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12 December 2020

SAHA shows preferential cytotoxicity in mutant p53 cancer cells by destabilizing mutant p53 through inhibition of the HDAC6-Hsp90 chaperone axis

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12 December 2020

p53 gain-of-function cancer mutants induce genetic instability by inactivating ATM.

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12 December 2020

Discrimination of DNA binding sites by mutant p53 proteins

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12 December 2020

Dissecting the role of p53 phosphorylation in homologous recombination provides new clues for gain-of-function mutants

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12 December 2020

Allele-specific p53 mutant reactivation

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12 December 2020

Aberrant expression of the p53 oncoprotein is a common feature of a wide spectrum of human malignancies

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12 December 2020

When mutants gain new powers: news from the mutant p53 field.

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12 December 2020

Kinetic mechanism of p53 oncogenic mutant aggregation and its inhibition

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12 December 2020

Mutant p53 proteins: between loss and gain of function

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12 December 2020

SCH529074, a small molecule activator of mutant p53, which binds p53 DNA binding domain (DBD), restores growth-suppressive function to mutant p53 and interrupts HDM2-mediated ubiquitination of wild type p53

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12 December 2020

Mdm2 promotes the rapid degradation of p53

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12 December 2020

p53 mutants induce transcription of NF-κB2 in H1299 cells through CBP and STAT binding on the NF-κB2 promoter and gain of function activity

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12 December 2020

Identification of GRO1 as a critical determinant for mutant p53 gain of function

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12 December 2020

p53 represses Sp1 DNA binding and HIV-LTR directed transcription

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12 December 2020

Transactivation-dependent and -independent regulation of p73 stability

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12 December 2020

Small-molecule RETRA suppresses mutant p53-bearing cancer cells through a p73-dependent salvage pathway.

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12 December 2020

Modulation of the vitamin D3 response by cancer-associated mutant p53

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12 December 2020

Addition of fresh medium induces cell cycle and conformation changes in p53, a tumour suppressor protein

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12 December 2020

DeltaNp73 transcription factors modulate cell survival and tumor development.

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12 December 2020

Isoform-specific p73 knockout mice reveal a novel role for delta Np73 in the DNA damage response pathway

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12 December 2020

Mutant p53 attenuates the SMAD-dependent transforming growth factor beta1 (TGF-beta1) signaling pathway by repressing the expression of TGF-beta receptor type II

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12 December 2020

Mutant p53 disrupts mammary tissue architecture via the mevalonate pathway

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12 December 2020

ChIP-on-chip analysis of in vivo mutant p53 binding to selected gene promoters.

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12 December 2020

TopBP1 mediates mutant p53 gain of function through NF-Y and p63/p73.

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12 December 2020

Re-oxygenation causes hypoxic tumor regression through restoration of p53 wild-type conformation and post-translational modifications

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12 December 2020

Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas

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12 December 2020

'Gain of function' phenotype of tumor-derived mutant p53 requires the oligomerization/nonsequence-specific nucleic acid-binding domain

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12 December 2020

Various p53 mutant proteins differently regulate the Ras circuit to induce a cancer-related gene signature

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12 December 2020

Mutant p53 cooperates with ETS2 to promote etoposide resistance

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12 December 2020

Mutant p53 uses p63 as a molecular chaperone to alter gene expression and induce a pro-invasive secretome

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12 December 2020

Thermodynamic stability of wild-type and mutant p53 core domain

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12 December 2020

Induction of Sp1-p53 DNA-binding heterocomplexes during granulocyte/macrophage colony-stimulating factor-dependent proliferation in human erythroleukemia cell line TF-1.

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12 December 2020

ΔNp63 knockout mice reveal its indispensable role as a master regulator of epithelial development and differentiation

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12 December 2020

Diacylglycerol kinase α controls RCP-dependent integrin trafficking to promote invasive migration.

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12 December 2020

Mutant p53 interactome identifies nardilysin as a p53R273H-specific binding partner that promotes invasion

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12 December 2020

p73-mediated chemosensitivity: a preferential target of oncogenic mutant p53.

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12 December 2020

Mutant p53: an oncogenic transcription factor

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12 December 2020

Histone deacetylase inhibitors suppress mutant p53 transcription via histone deacetylase 8.

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12 December 2020

A Mutant-p53/Smad complex opposes p63 to empower TGFbeta-induced metastasis

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12 December 2020

A peptide that binds and stabilizes p53 core domain: chaperone strategy for rescue of oncogenic mutants

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12 December 2020

Mutant p53 gain of function in two mouse models of Li-Fraumeni syndrome

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12 December 2020

Targeted rescue of a destabilized mutant of p53 by an in silico screened drug

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12 December 2020

Multiple stress signals activate mutant p53 in vivo

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12 December 2020

Mutant p53 aggregates into prion-like amyloid oligomers and fibrils: implications for cancer.

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12 December 2020

Posttranslational phosphorylation of mutant p53 protein in tumor development

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12 December 2020

TAp63 suppresses metastasis through coordinate regulation of Dicer and miRNAs

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12 December 2020

Pharmacological rescue of mutant p53 conformation and function

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12 December 2020

Physical interaction with human tumor-derived p53 mutants inhibits p63 activities.

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12 December 2020

A MicroRNA targeting dicer for metastasis control

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12 December 2020

Transcription regulation by mutant p53.

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12 December 2020

Gain of function of a p53 hot spot mutation in a mouse model of Li-Fraumeni syndrome.

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12 December 2020

PRIMA-1 reactivates mutant p53 by covalent binding to the core domain

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12 December 2020

MDM2 binding induces a conformational change in p53 that is opposed by heat-shock protein 90 and precedes p53 proteasomal degradation

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12 December 2020

A gain of function p53 mutant promotes both genomic instability and cell survival in a novel p53-null mammary epithelial cell model

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12 December 2020

The inherent instability of mutant p53 is alleviated by Mdm2 or p16INK4a loss

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12 December 2020

The role of mutant p53 in human cancer

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12 December 2020

Oncogenomic Approaches in Exploring Gain of Function of Mutant p53.

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12 December 2020

Impact of mutant p53 functional properties on TP53 mutation patterns and tumor phenotype: lessons from recent developments in the IARC TP53 database

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12 December 2020

Identifiers

DOI

10.1038/NCB2641

1 reference

PubMed ID

23263379

Dimensions Publication ID

28 August 2017

0 references

1 reference

PubMed ID

23263379