(Q33795918)

English

SCH529074, a small molecule activator of mutant p53, which binds p53 DNA binding domain (DBD), restores growth-suppressive function to mutant p53 and interrupts HDM2-mediated ubiquitination of wild type p53

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scholarly article

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Europe PubMed Central

PubMed publication ID

29 July 2017

SCH529074, a small molecule activator of mutant p53, which binds p53 DNA binding domain (DBD), restores growth-suppressive function to mutant p53 and interrupts HDM2-mediated ubiquitination of wild type p53 (English)

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

protein ubiquitination

1 reference

based on heuristic

inferred from title

author name string

Mark Demma

1

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

Eugene Maxwell

2

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

Robert Ramos

3

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

Lianzhu Liang

4

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

Cheng Li

5

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

David Hesk

6

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

Randall Rossman

7

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

Alan Mallams

8

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

Ronald Doll

9

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

Ming Liu

10

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

Cynthia Seidel-Dugan

11

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

W Robert Bishop

12

1 reference

Europe PubMed Central

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29 July 2017

Bimalendu Dasmahapatra

13

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

language of work or name

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publication date

2 February 2010

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Europe PubMed Central

PubMed publication ID

29 July 2017

number of pages

15

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Journal of Biological Chemistry

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Europe PubMed Central

PubMed publication ID

29 July 2017

285

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Europe PubMed Central

PubMed publication ID

29 July 2017

14

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

10198-10212

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

PRIMA-1 reactivates mutant p53 by covalent binding to the core domain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856225

4 July 2018

The proline-rich domain in p63 is necessary for the transcriptional and apoptosis-inducing activities of TAp63

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856225

4 July 2018

Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856225

4 July 2018

Restoration of p53 function leads to tumour regression in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856225

4 July 2018

p73-dependent induction of 14-3-3sigma increases the chemo-sensitivity of drug-resistant human breast cancers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856225

4 July 2018

Solution structure of p53 core domain: structural basis for its instability

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856225

4 July 2018

A global map of p53 transcription-factor binding sites in the human genome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856225

4 July 2018

Repression of the MSP/MST-1 gene contributes to the antiapoptotic gain of function of mutant p53

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856225

4 July 2018

Proteomic identification of heat shock protein 90 as a candidate target for p53 mutation reactivation by PRIMA-1 in breast cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856225

4 July 2018

Comparative analysis of inducible expression systems in transient transfection studies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856225

4 July 2018

CP-31398, a novel p53-stabilizing agent, induces p53-dependent and p53-independent glioma cell death

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856225

4 July 2018

Rescue of mutants of the tumor suppressor p53 in cancer cells by a designed peptide

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856225

4 July 2018

Crystal structure of a superstable mutant of human p53 core domain. Insights into the mechanism of rescuing oncogenic mutations

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856225

4 July 2018

Drug discovery and p53.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856225

4 July 2018

p53 has a direct apoptogenic role at the mitochondria

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856225

4 July 2018

Stabilization of p53 by CP-31398 inhibits ubiquitination without altering phosphorylation at serine 15 or 20 or MDM2 binding.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856225

4 July 2018

Differences in the ubiquitination of p53 by Mdm2 and the HPV protein E6.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856225

4 July 2018

The promise and obstacle of p53 as a cancer therapeutic agent

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856225

4 July 2018

Assessing TP53 status in human tumours to evaluate clinical outcome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856225

4 July 2018

Rescuing the function of mutant p53.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856225

4 July 2018

Restoration of the tumor suppressor function to mutant p53 by a low-molecular-weight compound.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856225

4 July 2018

Biogenesis of p53 involves cotranslational dimerization of monomers and posttranslational dimerization of dimers. Implications on the dominant negative effect

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856225

4 July 2018

A peptide that binds and stabilizes p53 core domain: chaperone strategy for rescue of oncogenic mutants

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856225

4 July 2018

The effects of wild-type p53 tumor suppressor activity and mutant p53 gain-of-function on cell growth

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856225

4 July 2018

Binding of c-Myc to chromatin mediates mitogen-induced acetylation of histone H4 and gene activation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856225

4 July 2018

Surfing the p53 network

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856225

4 July 2018

Quantitative analysis of residual folding and DNA binding in mutant p53 core domain: definition of mutant states for rescue in cancer therapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856225

4 July 2018

Mechanism of rescue of common p53 cancer mutations by second-site suppressor mutations

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856225

4 July 2018

The p53 gene family

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856225

4 July 2018

SUMO-1 modification activates the transcriptional response of p53

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856225

4 July 2018

Mdm2 binds p73 alpha without targeting degradation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856225

4 July 2018

Reactivation of mutant p53 through interaction of a C-terminal peptide with the core domain.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856225

4 July 2018

Semirational design of active tumor suppressor p53 DNA binding domain with enhanced stability

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856225

4 July 2018

Thermodynamic stability of wild-type and mutant p53 core domain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856225

4 July 2018

Structural aspects of the p53 protein in relation to gene evolution: a second look.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856225

4 July 2018

Crystal structure of a p53 tumor suppressor-DNA complex: understanding tumorigenic mutations

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856225

4 July 2018

Microinjection of monoclonal antibody PAb421 into human SW480 colorectal carcinoma cells restores the transcription activation function to mutant p53.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856225

4 July 2018

Conformational changes in p53 analysed using new antibodies to the core DNA binding domain of the protein.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856225

4 July 2018

Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856225

4 July 2018

Activating mutations in p53 produce a common conformational effect. A monoclonal antibody specific for the mutant form

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856225

4 July 2018

The p53 stabilizing compound CP-31398 induces apoptosis by activating the intrinsic Bax/mitochondrial/caspase-9 pathway.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.083469

21 January 2018

High thermostability and lack of cooperative DNA binding distinguish the p63 core domain from the homologous tumor suppressor p53.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.083469

21 January 2018

The conformationally flexible S9-S10 linker region in the core domain of p53 contains a novel MDM2 binding site whose mutation increases ubiquitination of p53 in vivo

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.083469

21 January 2018

Comparison of the human and worm p53 structures suggests a way for enhancing stability

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.083469

21 January 2018

Structural distortion of p53 by the mutation R249S and its rescue by a designed peptide: implications for "mutant conformation".

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.083469

21 January 2018

Hdmx and Mdm2 can repress transcription activation by p53 but not by p63.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.083469

21 January 2018

Kinetic Instability of p53 Core Domain Mutants

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.083469

21 January 2018

CP-31398 restores DNA-binding activity to mutant p53 in vitro but does not affect p53 homologs p63 and p73

1 reference

https://pubmed.ncbi.nlm.nih.gov/20124408

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Direct measurement of the binding of RAS to neurofibromin using a scintillation proximity assay

1 reference

https://pubmed.ncbi.nlm.nih.gov/20124408

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dual-site regulation of MDM2 E3-ubiquitin ligase activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/20124408

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of p53 nuclear export through sequential changes in conformation and ubiquitination

1 reference

https://pubmed.ncbi.nlm.nih.gov/20124408

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacological rescue of mutant p53 conformation and function

1 reference

https://pubmed.ncbi.nlm.nih.gov/20124408

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1074/JBC.M109.083469

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

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