(Q43690426)

25 November 2017

title

High thermostability and lack of cooperative DNA binding distinguish the p63 core domain from the homologous tumor suppressor p53. (English)

1 reference

25 November 2017

Klein C

1

1 reference

25 November 2017

Georges G

2

1 reference

25 November 2017

Künkele KP

3

1 reference

25 November 2017

Huber R

4

1 reference

25 November 2017

Engh RA

5

1 reference

25 November 2017

Hansen S

6

1 reference

25 November 2017

language of work or name

English

0 references

publication date

26 July 2001

1 reference

Journal of Biological Chemistry

25 November 2017

number of pages

12

1 reference

based on heuristic

inferred from page(s)

published in

1 reference

25 November 2017

volume

276

1 reference

25 November 2017

issue

40

1 reference

25 November 2017

page(s)

37390-37401

1 reference

p53 mutations in human cancers

25 November 2017

cites work

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103801200

p53, the cellular gatekeeper for growth and division

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103801200

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103801200

A novel protein with strong homology to the tumor suppressor p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103801200

Cloning and functional analysis of human p51, which structurally and functionally resembles p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103801200

A new human p53 homologue

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103801200

p63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing, and dominant-negative activities

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103801200

AIS is an oncogene amplified in squamous cell carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103801200

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103801200

p73 is a simian [correction of human] p53-related protein that can induce apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103801200

Monoallelically expressed gene related to p53 at 1p36, a region frequently deleted in neuroblastoma and other human cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103801200

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103801200

Regulation and function of the p53-related proteins: same family, different rules

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103801200

From p63 to p53 across p73.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103801200

P63 and P73: P53 mimics, menaces and more

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103801200

Identification and classification of p53-regulated genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103801200

p63 is a p53 homologue required for limb and epidermal morphogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103801200

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103801200

p63 is essential for regenerative proliferation in limb, craniofacial and epithelial development

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103801200

Heterozygous germline mutations in the p53 homolog p63 are the cause of EEC syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103801200

p73-deficient mice have neurological, pheromonal and inflammatory defects but lack spontaneous tumours

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103801200

Structural aspects of the p53 protein in relation to gene evolution: a second look.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103801200

Solution structure of a conserved C-terminal domain of p73 with structural homology to the SAM domain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103801200

Structure of the C-terminal sterile alpha-motif (SAM) domain of human p73 alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103801200

Structure, function and regulation of p63 and p73.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103801200

An anti-apoptotic role for the p53 family member, p73, during developmental neuron death

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103801200

Crystal structure of a p53 tumor suppressor-DNA complex: understanding tumorigenic mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103801200

Crystal structure of the mouse p53 core DNA-binding domain at 2.7 A resolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103801200

A proteolytic fragment from the central region of p53 has marked sequence-specific DNA-binding activity when generated from wild-type but not from oncogenic mutant p53 protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103801200

Thermodynamic stability of wild-type and mutant p53 core domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103801200

Hot-spot mutants of p53 core domain evince characteristic local structural changes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103801200

Quantitative analysis of residual folding and DNA binding in mutant p53 core domain: definition of mutant states for rescue in cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103801200

Four p53 DNA-binding domain peptides bind natural p53-response elements and bend the DNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103801200

Genetic selection of intragenic suppressor mutations that reverse the effect of common p53 cancer mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103801200

Mechanism of rescue of common p53 cancer mutations by second-site suppressor mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103801200

Semirational design of active tumor suppressor p53 DNA binding domain with enhanced stability

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103801200

In vitro evolution of thermostable p53 variants

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103801200

Structure and function in the p53 family

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103801200

Gapped BLAST and PSI-BLAST: a new generation of protein database search programs

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103801200

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103801200

Spectroscopic Determination of Tryptophan and Tyrosine in Proteins*

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103801200

Regulation of the specific DNA binding function of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103801200

Definition of a consensus binding site for p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103801200

Quantitative analysis of protein far UV circular dichroism spectra by neural networks

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103801200

Determination and analysis of urea and guanidine hydrochloride denaturation curves

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103801200

Engineered disulfide bonds as probes of the folding pathway of barnase: increasing the stability of proteins against the rate of denaturation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103801200

Structure of the p53 tumor suppressor bound to the ankyrin and SH3 domains of 53BP2

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103801200

Improvements in protein secondary structure prediction by an enhanced neural network

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103801200

Prediction of protein secondary structure by combining nearest-neighbor algorithms and multiple sequence alignments

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103801200

p53 domains: identification and characterization of two autonomous DNA-binding regions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103801200

Interaction of p53 with its consensus DNA-binding site

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103801200

Architectural accommodation in the complex of four p53 DNA binding domain peptides with the p21/waf1/cip1 DNA response element

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103801200

Role of cysteine residues in regulation of p53 function

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103801200

Redox signalling and transition metals in the control of the p53 pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103801200

A simple method for displaying the hydropathic character of a protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103801200

Correlation between stability of a protein and its dipeptide composition: a novel approach for predicting in vivo stability of a protein from its primary sequence

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103801200

A transcriptionally active DNA-binding site for human p53 protein complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103801200

Solution structure of the tetrameric minimum transforming domain of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103801200

Refined solution structure of the oligomerization domain of the tumour suppressor p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103801200

Crystal structure of the tetramerization domain of the p53 tumor suppressor at 1.7 angstroms

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103801200

How p53 binds DNA as a tetramer

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103801200

NPAT links cyclin E-Cdk2 to the regulation of replication-dependent histone gene transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103801200

Allosteric regulation of the thermostability and DNA binding activity of human p53 by specific interacting proteins. CRC Cell Transformation Group

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103801200

Stability and stabilization of globular proteins in solution

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103801200

p53 associates with and targets Delta Np63 into a protein degradation pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103801200

Two Distinct Mechanisms Regulate the Levels of a Cellular Tumor Antigen, p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103801200

UV Irradiation Stimulates Levels of p53 Cellular Tumor Antigen in Nontransformed Mouse Cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103801200

Mdm2 promotes the rapid degradation of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103801200

Regulation of p53 stability by Mdm2

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103801200

Regulation of p53 stability

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103801200

A subset of tumor-derived mutant forms of p53 down-regulate p63 and p73 through a direct interaction with the p53 core domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103801200

A new generation of information retrieval tools for biologists: the example of the ExPASy WWW server

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103801200

Dictionary of protein secondary structure: pattern recognition of hydrogen-bonded and geometrical features

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103801200

CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103801200

Physical and Functional Interaction between p53 Mutants and Different Isoforms of p73

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103801200

MDM2 and MDMX can interact differently with ARF and members of the p53 family

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103801200

The DNA-binding domain of p53 contains the four conserved regions and the major mutation hot spots

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103801200

Structure-based rescue of common tumor-derived p53 mutants

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103801200

Molecular evolution of the thermosensitive PAb1620 epitope of human p53 by DNA shuffling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103801200

Pharmacological rescue of mutant p53 conformation and function

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103801200

p73 function is inhibited by tumor-derived p53 mutants in mammalian cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103801200

The tumor suppressor protein p53 requires a cofactor to activate transcriptionally the human BAX promoter

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103801200

Signaling to p53: breaking the MDM2-p53 circuit

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103801200

21 January 2018

Identifiers

DOI

10.1074/JBC.M103801200

1 reference

25 November 2017

1 reference