(Q35101871)

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Drug discovery and p53.

scientific article

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scholarly article

1 reference

Europe PubMed Central

6 August 2017

1 reference

Europe PubMed Central

Drug discovery and p53. (English)

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Europe PubMed Central

6 August 2017

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based on heuristic

inferred from title

author name string

David P Lane

1

1 reference

Europe PubMed Central

6 August 2017

Ted R Hupp

2

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Europe PubMed Central

6 August 2017

language of work or name

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based on heuristic

inferred from title

publication date

1 April 2003

1 reference

Europe PubMed Central

6 August 2017

Drug Discovery Today

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Europe PubMed Central

6 August 2017

8

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Europe PubMed Central

6 August 2017

347-355

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Europe PubMed Central

6 August 2017

8

1 reference

Europe PubMed Central

6 August 2017

Surfing the p53 network

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https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902669-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902669-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Cancer. p53, guardian of the genome

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https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902669-2

7 January 2021

based on heuristic

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The evolution of diverse biological responses to DNA damage: insights from yeast and p53.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902669-2

7 January 2021

based on heuristic

inferred from DOI database lookup

PDK1-dependent activation of atypical PKC leads to degradation of the p21 tumour modifier protein.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902669-2

7 January 2021

based on heuristic

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Cell-cycle arrest and inhibition of Cdk4 activity by small peptides based on the carboxy-terminal domain of p21WAF1

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https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902669-2

7 January 2021

based on heuristic

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In vitro and in vivo antitumor properties of the cyclin dependent kinase inhibitor CYC202 (R-roscovitine)

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https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902669-2

7 January 2021

based on heuristic

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Synergistic activation of p53-dependent transcription by two cooperating damage recognition pathways

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902669-2

7 January 2021

based on heuristic

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Highly potent p21(WAF1)-derived peptide inhibitors of CDK-mediated pRb phosphorylation: delineation and structural insight into their interactions with cyclin A

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902669-2

7 January 2021

based on heuristic

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T antigen is bound to a host protein in SY40-transformed cells

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902669-2

7 January 2021

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Characterization of a 54K Dalton cellular SV40 tumor antigen present in SV40-transformed cells and uninfected embryonal carcinoma cells

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902669-2

7 January 2021

based on heuristic

inferred from DOI database lookup

The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902669-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Inhibiting the p53-MDM2 interaction: an important target for cancer therapy

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902669-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Mutant p53 gain of function: differential effects of different p53 mutants on resistance of cultured cells to chemotherapy

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902669-2

7 January 2021

based on heuristic

inferred from DOI database lookup

p53 mutations in colorectal cancer

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902669-2

7 January 2021

based on heuristic

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Specific interaction between the p53 cellular tumour antigen and major heat shock proteins

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902669-2

7 January 2021

based on heuristic

inferred from DOI database lookup

The physical association of multiple molecular chaperone proteins with mutant p53 is altered by geldanamycin, an hsp90-binding agent

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902669-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Cotranslation of activated mutant p53 with wild type drives the wild-type p53 protein into the mutant conformation

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902669-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Aggregation of huntingtin in yeast varies with the length of the polyglutamine expansion and the expression of chaperone proteins

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902669-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Presenilin-1 mutations downregulate the signalling pathway of the unfolded-protein response

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902669-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Hsp90 as a capacitor of phenotypic variation

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902669-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Hsp90 inhibitors as novel cancer chemotherapeutic agents

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902669-2

7 January 2021

based on heuristic

inferred from DOI database lookup

The p53 protein is an unusually shaped tetramer that binds directly to DNA.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902669-2

7 January 2021

based on heuristic

inferred from DOI database lookup

DNA-dependent acetylation of p53 by the transcription coactivator p300.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902669-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Recognition of DNA by p53 Core Domain and Location of Intermolecular Contacts of Cooperative Binding

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902669-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Regulation of p53 protein function through alterations in protein-folding pathways

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902669-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Rescuing the function of mutant p53.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902669-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Latent and active p53 are identical in conformation

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902669-2

7 January 2021

based on heuristic

inferred from DOI database lookup

p53 latency – out of the blind alley

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902669-2

7 January 2021

based on heuristic

inferred from DOI database lookup

A peptide that binds and stabilizes p53 core domain: chaperone strategy for rescue of oncogenic mutants

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902669-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Increased and altered DNA binding of human p53 by S and G2/M but not G1 cyclin-dependent kinases

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902669-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Presence of a potent transcription activating sequence in the p53 protein

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902669-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Human p53 phosphorylation mimic, S392E, increases nonspecific DNA affinity and thermal stability

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902669-2

7 January 2021

based on heuristic

inferred from DOI database lookup

p53 contains large unstructured regions in its native state

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902669-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Active site-directed protein regulation

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902669-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Activation of the cryptic DNA binding function of mutant forms of p53.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902669-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Characterization of baculovirus recombinant wild-type p53. Dimerization of p53 is required for high-affinity DNA binding and cysteine oxidation inhibits p53 DNA binding

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902669-2

7 January 2021

based on heuristic

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Interaction of p53 with its consensus DNA-binding site

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902669-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Stoichiometric phosphorylation of human p53 at Ser315 stimulates p53-dependent transcription

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902669-2

7 January 2021

based on heuristic

inferred from DOI database lookup

p53 Latency. C-terminal domain prevents binding of p53 core to target but not to nonspecific DNA sequences.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902669-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Restoration of transcriptional activity of p53 mutants in human tumour cells by intracellular expression of anti-p53 single chain Fv fragments

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902669-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Thermodynamic stability of wild-type and mutant p53 core domain

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902669-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Crystal structure of a p53 tumor suppressor-DNA complex: understanding tumorigenic mutations

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902669-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Allosteric effects of DNA on transcriptional regulators

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902669-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Small peptides activate the latent sequence-specific DNA binding function of p53.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902669-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Differential post-translational modification of the tumour suppressor proteins Rb and p53 modulate the rates of radiation-induced apoptosis in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902669-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Allosteric activation of latent p53 tetramers

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902669-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Intrinsically unstructured proteins: re-assessing the protein structure-function paradigm

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902669-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Insights into the structure and dynamics of unfolded proteins from nuclear magnetic resonance

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902669-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Correcting temperature-sensitive protein folding defects

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902669-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Pharmacological rescue of mutant p53 conformation and function

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902669-2

7 January 2021

based on heuristic

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Characterization of the p53-rescue drug CP-31398 in vitro and in living cells.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902669-2

7 January 2021

based on heuristic

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Stabilization of p53 by CP-31398 inhibits ubiquitination without altering phosphorylation at serine 15 or 20 or MDM2 binding.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902669-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Mutant p53-dependent growth suppression distinguishes PRIMA-1 from known anticancer drugs: a statistical analysis of information in the National Cancer Institute database.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902669-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Restoration of the tumor suppressor function to mutant p53 by a low-molecular-weight compound.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902669-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Co-chaperones Bag-1, Hop and Hsp40 regulate Hsc70 and Hsp90 interactions with wild-type or mutant p53.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902669-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Hsp70 interactions with the p53 tumour suppressor protein

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902669-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Molecular chaperones in the cytosol: from nascent chain to folded protein

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902669-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Geldanamycin activates a heat shock response and inhibits huntingtin aggregation in a cell culture model of Huntington's disease

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902669-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Mutant conformation of p53 translated in vitro or in vivo requires functional HSP90.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902669-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Alteration of p53 conformation and induction of apoptosis in a murine erythroleukemia cell line by dimethylsulfoxide

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902669-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Distinct residues of human p53 implicated in binding to DNA, simian virus 40 large T antigen, 53BP1, and 53BP2.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902669-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Inhibition of p53-dependent transcription by BOX-I phospho-peptide mimetics that bind to p300.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902669-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Transcriptional regulation by p53 through intrinsic DNA/chromatin binding and site-directed cofactor recruitment.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902669-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

10.1016/S1359-6446(03)02669-2

1 reference

Europe PubMed Central

6 August 2017

1 reference

Europe PubMed Central

6 August 2017

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