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p53 latency – out of the blind alley
scientific article published on 01 December 2002
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1 reference
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Europe PubMed Central
PubMed publication ID
12468230
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12468230%20AND%20SRC:MED&resulttype=core&format=json
retrieved
15 December 2019
title
p53 latency--out of the blind alley
(English)
1 reference
stated in
Europe PubMed Central
PubMed publication ID
12468230
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12468230%20AND%20SRC:MED&resulttype=core&format=json
retrieved
15 December 2019
author
Georgy Bakalkin
series ordinal
5
1 reference
stated in
Europe PubMed Central
PubMed publication ID
12468230
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12468230%20AND%20SRC:MED&resulttype=core&format=json
retrieved
15 December 2019
author name string
Tatiana Yakovleva
series ordinal
1
1 reference
stated in
Europe PubMed Central
PubMed publication ID
12468230
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12468230%20AND%20SRC:MED&resulttype=core&format=json
retrieved
15 December 2019
Aladdin Pramanik
series ordinal
2
1 reference
stated in
Europe PubMed Central
PubMed publication ID
12468230
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12468230%20AND%20SRC:MED&resulttype=core&format=json
retrieved
15 December 2019
Lars Terenius
series ordinal
3
1 reference
stated in
Europe PubMed Central
PubMed publication ID
12468230
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12468230%20AND%20SRC:MED&resulttype=core&format=json
retrieved
15 December 2019
Tomas J Ekström
series ordinal
4
1 reference
stated in
Europe PubMed Central
PubMed publication ID
12468230
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12468230%20AND%20SRC:MED&resulttype=core&format=json
retrieved
15 December 2019
publication date
1 December 2002
1 reference
stated in
Europe PubMed Central
PubMed publication ID
12468230
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12468230%20AND%20SRC:MED&resulttype=core&format=json
retrieved
15 December 2019
number of pages
7
1 reference
based on heuristic
inferred from page(s)
published in
Trends in Biochemical Sciences
1 reference
stated in
Europe PubMed Central
PubMed publication ID
12468230
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12468230%20AND%20SRC:MED&resulttype=core&format=json
retrieved
15 December 2019
volume
27
1 reference
stated in
Europe PubMed Central
PubMed publication ID
12468230
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12468230%20AND%20SRC:MED&resulttype=core&format=json
retrieved
15 December 2019
issue
12
1 reference
stated in
Europe PubMed Central
PubMed publication ID
12468230
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12468230%20AND%20SRC:MED&resulttype=core&format=json
retrieved
15 December 2019
page(s)
612-618
1 reference
stated in
Europe PubMed Central
PubMed publication ID
12468230
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12468230%20AND%20SRC:MED&resulttype=core&format=json
retrieved
15 December 2019
cites work
p53: puzzle and paradigm
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0968-0004%2802%2902209-0
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7 January 2021
based on heuristic
inferred from DOI database lookup
Mechanisms of switching on p53: a role for covalent modification?
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0968-0004%2802%2902209-0
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7 January 2021
based on heuristic
inferred from DOI database lookup
Regulation of the p53 tumor suppressor protein
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0968-0004%2802%2902209-0
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7 January 2021
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inferred from DOI database lookup
Maintenance of genomic integrity by p53: complementary roles for activated and non-activated p53.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0968-0004%2802%2902209-0
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7 January 2021
based on heuristic
inferred from DOI database lookup
Small peptides activate the latent sequence-specific DNA binding function of p53.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0968-0004%2802%2902209-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
DNA damage-induced apoptosis requires the DNA-dependent protein kinase, and is mediated by the latent population of p53.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0968-0004%2802%2902209-0
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7 January 2021
based on heuristic
inferred from DOI database lookup
Activation of p53 sequence-specific DNA bindingby short single strands of DNA requires the p53 C-terminus
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0968-0004%2802%2902209-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Restoration of the growth suppression function of mutant p53 by a synthetic peptide derived from the p53 C-terminal domain
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0968-0004%2802%2902209-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Reactivation of mutant p53 through interaction of a C-terminal peptide with the core domain.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0968-0004%2802%2902209-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identification of an additional negative regulatory region for p53 sequence-specific DNA binding
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0968-0004%2802%2902209-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Conformational and molecular basis for induction of apoptosis by a p53 C-terminal peptide in human cancer cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0968-0004%2802%2902209-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Latent and active p53 are identical in conformation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0968-0004%2802%2902209-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A peptide that binds and stabilizes p53 core domain: chaperone strategy for rescue of oncogenic mutants
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0968-0004%2802%2902209-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
NMR spectroscopy reveals the solution dimerization interface of p53 core domains bound to their consensus DNA
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0968-0004%2802%2902209-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
p53 Latency. C-terminal domain prevents binding of p53 core to target but not to nonspecific DNA sequences.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0968-0004%2802%2902209-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Carbamylation decreases the cytotoxicity but not the drug-carrier properties of polylysines
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0968-0004%2802%2902209-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cytotoxic effects of dynorphins through nonopioid intracellular mechanisms.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0968-0004%2802%2902209-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The carboxyl-terminal domain of the p53 protein regulates sequence-specific DNA binding through its nonspecific nucleic acid-binding activity
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0968-0004%2802%2902209-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Reciprocal interference between the sequence-specific core and nonspecific C-terminal DNA binding domains of p53: implications for regulation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0968-0004%2802%2902209-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Allosteric activation of latent p53 tetramers
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0968-0004%2802%2902209-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
p53 binds single-stranded DNA ends and catalyzes DNA renaturation and strand transfer.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0968-0004%2802%2902209-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
p53 binds single-stranded DNA ends through the C-terminal domain and internal DNA segments via the middle domain
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0968-0004%2802%2902209-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The C-terminal domain of p53 recognizes DNA damaged by ionizing radiation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0968-0004%2802%2902209-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
High affinity insertion/deletion lesion binding by p53. Evidence for a role of the p53 central domain
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0968-0004%2802%2902209-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Binding of p53 and its core domain to supercoiled DNA.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0968-0004%2802%2902209-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Crystal structure of a p53 tumor suppressor-DNA complex: understanding tumorigenic mutations
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0968-0004%2802%2902209-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Architectural accommodation in the complex of four p53 DNA binding domain peptides with the p21/waf1/cip1 DNA response element
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0968-0004%2802%2902209-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The N terminus of p53 regulates its dissociation from DNA.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0968-0004%2802%2902209-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Transcriptional regulation by p53 through intrinsic DNA/chromatin binding and site-directed cofactor recruitment.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0968-0004%2802%2902209-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Specific interaction of p53 with target binding sites is determined by DNA conformation and is regulated by the C-terminal domain
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0968-0004%2802%2902209-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Chromatin immunoprecipitation analysis fails to support the latency model for regulation of p53 DNA binding activity in vivo
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0968-0004%2802%2902209-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
DNA-conformation is an important determinant of sequence-specific DNA binding by tumor suppressor p53
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0968-0004%2802%2902209-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Influence of promoter DNA topology on sequence-specific DNA binding and transactivation by tumor suppressor p53.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0968-0004%2802%2902209-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Generation of superhelical torsion by ATP-dependent chromatin remodeling activities
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0968-0004%2802%2902209-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Specificity of gene regulation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0968-0004%2802%2902209-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cooperation between complexes that regulate chromatin structure and transcription
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0968-0004%2802%2902209-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Allosteric effects of Pit-1 DNA sites on long-term repression in cell type specification
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0968-0004%2802%2902209-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Transcriptional repression by p53 through direct binding to a novel DNA element
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0968-0004%2802%2902209-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The gene encoding p202, an interferon-inducible negative regulator of the p53 tumor suppressor, is a target of p53-mediated transcriptional repression
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0968-0004%2802%2902209-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Transcriptional repression of the anti-apoptotic survivin gene by wild type p53.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0968-0004%2802%2902209-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Acetylation of p53 activates transcription through recruitment of coactivators/histone acetyltransferases
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0968-0004%2802%2902209-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Transcriptional regulation of the mdm2 oncogene by p53 requires TRRAP acetyltransferase complexes
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0968-0004%2802%2902209-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
hADA3 is required for p53 activity
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0968-0004%2802%2902209-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Human SIR2 deacetylates p53 and antagonizes PML/p53-induced cellular senescence
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0968-0004%2802%2902209-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The corepressor mSin3a interacts with the proline-rich domain of p53 and protects p53 from proteasome-mediated degradation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0968-0004%2802%2902209-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Transcriptional repression by wild-type p53 utilizes histone deacetylases, mediated by interaction with mSin3a.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0968-0004%2802%2902209-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
DNA intersegment transfer, how steroid receptors search for a target site
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0968-0004%2802%2902209-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Structure of BamHI bound to nonspecific DNA: a model for DNA sliding
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0968-0004%2802%2902209-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Dynamic interactions of p53 with DNA in solution by time-lapse atomic force microscopy
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0968-0004%2802%2902209-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Pharmacological rescue of mutant p53 conformation and function
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0968-0004%2802%2902209-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Restoration of the tumor suppressor function to mutant p53 by a low-molecular-weight compound.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0968-0004%2802%2902209-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Characterization of the p53-rescue drug CP-31398 in vitro and in living cells.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0968-0004%2802%2902209-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A chemical inhibitor of p53 that protects mice from the side effects of cancer therapy
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0968-0004%2802%2902209-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identifiers
DOI
10.1016/S0968-0004(02)02209-0
1 reference
stated in
Europe PubMed Central
PubMed publication ID
12468230
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12468230%20AND%20SRC:MED&resulttype=core&format=json
retrieved
15 December 2019
PubMed publication ID
12468230
1 reference
stated in
Europe PubMed Central
PubMed publication ID
12468230
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12468230%20AND%20SRC:MED&resulttype=core&format=json
retrieved
15 December 2019
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