(Q74631439)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11606582%20AND%20SRC:MED&resulttype=core&format=json

12 November 2019

title

NMR spectroscopy reveals the solution dimerization interface of p53 core domains bound to their consensus DNA (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11606582%20AND%20SRC:MED&resulttype=core&format=json

12 November 2019

0 references

0 references

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11606582%20AND%20SRC:MED&resulttype=core&format=json

12 November 2019

author name string

Klein C

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11606582%20AND%20SRC:MED&resulttype=core&format=json

12 November 2019

Planker E

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11606582%20AND%20SRC:MED&resulttype=core&format=json

12 November 2019

Kessler H

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11606582%20AND%20SRC:MED&resulttype=core&format=json

12 November 2019

Künkele KP

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11606582%20AND%20SRC:MED&resulttype=core&format=json

12 November 2019

Lang K

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11606582%20AND%20SRC:MED&resulttype=core&format=json

12 November 2019

Hansen S

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11606582%20AND%20SRC:MED&resulttype=core&format=json

12 November 2019

Schwaiger M

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11606582%20AND%20SRC:MED&resulttype=core&format=json

12 November 2019

language of work or name

English

0 references

publication date

17 October 2001

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11606582%20AND%20SRC:MED&resulttype=core&format=json

Journal of Biological Chemistry

12 November 2019

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11606582%20AND%20SRC:MED&resulttype=core&format=json

12 November 2019

volume

276

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11606582%20AND%20SRC:MED&resulttype=core&format=json

12 November 2019

issue

52

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11606582%20AND%20SRC:MED&resulttype=core&format=json

12 November 2019

page(s)

49020-49027

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11606582%20AND%20SRC:MED&resulttype=core&format=json

New approaches to understanding p53 gene tumor mutation spectra

12 November 2019

cites work

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M107516200

p53, the cellular gatekeeper for growth and division

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M107516200

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M107516200

21 January 2018

Surfing the p53 network

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M107516200

P63 and P73: P53 mimics, menaces and more

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M107516200

Structure and function in the p53 family

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M107516200

Definition of a consensus binding site for p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M107516200

A transcriptionally active DNA-binding site for human p53 protein complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M107516200

Crystal structure of a p53 tumor suppressor-DNA complex: understanding tumorigenic mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M107516200

Interaction of p53 with its consensus DNA-binding site

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M107516200

Solution structure of the tetrameric minimum transforming domain of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M107516200

Refined solution structure of the oligomerization domain of the tumour suppressor p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M107516200

Crystal structure of the tetramerization domain of the p53 tumor suppressor at 1.7 angstroms

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M107516200

How p53 binds DNA as a tetramer

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M107516200

A proteolytic fragment from the central region of p53 has marked sequence-specific DNA-binding activity when generated from wild-type but not from oncogenic mutant p53 protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M107516200

The DNA-binding domain of p53 contains the four conserved regions and the major mutation hot spots

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M107516200

Four p53 DNA-binding domain peptides bind natural p53-response elements and bend the DNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M107516200

Thermodynamic stability of wild-type and mutant p53 core domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M107516200

Quantitative analysis of residual folding and DNA binding in mutant p53 core domain: definition of mutant states for rescue in cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M107516200

Crystal structure of the mouse p53 core DNA-binding domain at 2.7 A resolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M107516200

Hot-spot mutants of p53 core domain evince characteristic local structural changes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M107516200

Strategies for manipulating the p53 pathway in the treatment of human cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M107516200

Structure-based rescue of common tumor-derived p53 mutants

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M107516200

Genetic selection of intragenic suppressor mutations that reverse the effect of common p53 cancer mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M107516200

Mechanism of rescue of common p53 cancer mutations by second-site suppressor mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M107516200

Semirational design of active tumor suppressor p53 DNA binding domain with enhanced stability

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M107516200

In vitro evolution of thermostable p53 variants

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M107516200

Molecular evolution of the thermosensitive PAb1620 epitope of human p53 by DNA shuffling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M107516200

Allosteric activation of latent p53 tetramers

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M107516200

Small peptides activate the latent sequence-specific DNA binding function of p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M107516200

Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M107516200

Restoration of the growth suppression function of mutant p53 by a synthetic peptide derived from the p53 C-terminal domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M107516200

Reactivation of mutant p53: a new strategy for cancer therapy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M107516200

Conformational and molecular basis for induction of apoptosis by a p53 C-terminal peptide in human cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M107516200

Pharmacological rescue of mutant p53 conformation and function

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M107516200

p53 domains: identification and characterization of two autonomous DNA-binding regions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M107516200

Architectural accommodation in the complex of four p53 DNA binding domain peptides with the p21/waf1/cip1 DNA response element

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M107516200

p53-induced DNA bending and twisting: p53 tetramer binds on the outer side of a DNA loop and increases DNA twisting

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M107516200

Modeling multi-component protein-DNA complexes: the role of bending and dimerization in the complex of p53 dimers with DNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M107516200

Evolutionary conservation and somatic mutation hotspot maps of p53: correlation with p53 protein structural and functional features.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M107516200

Structure of the p53 tumor suppressor bound to the ankyrin and SH3 domains of 53BP2

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M107516200

High-level expression of recombinant genes in Escherichia coli is dependent on the availability of the dnaY gene product

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M107516200

Advances in refolding of proteins produced in E. coli

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M107516200

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M107516200

Spectroscopic Determination of Tryptophan and Tyrosine in Proteins*

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M107516200

Regulation of the specific DNA binding function of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M107516200

Gradient-tailored excitation for single-quantum NMR spectroscopy of aqueous solutions

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M107516200

Efficient simulation of coherence transfer pathway selection by phase cycling and pulsed field gradients in NMR

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M107516200

Characterization of Ligand Binding by Saturation Transfer Difference NMR Spectroscopy

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M107516200

The N terminus of the murine p53 tumour suppressor is an independent regulatory domain affecting activation and thermostability

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M107516200

Identification of an additional negative regulatory region for p53 sequence-specific DNA binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M107516200

Reactivation of mutant p53 through interaction of a C-terminal peptide with the core domain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M107516200

Attenuated T2 relaxation by mutual cancellation of dipole-dipole coupling and chemical shift anisotropy indicates an avenue to NMR structures of very large biological macromolecules in solution

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M107516200

NMR identification of protein surfaces using paramagnetic probes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M107516200

p53 domains: structure, oligomerization, and transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M107516200

Principles of protein-protein interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M107516200

Structure of the negative regulatory domain of p53 bound to S100B(betabeta)

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M107516200

Assignment of 1H(N), 15N, 13C(alpha), 13CO and 13C(beta) resonances in a 67 kDa p53 dimer using 4D-TROSY NMR spectroscopy

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M107516200

Latent and active p53 are identical in conformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M107516200

Phosphorylation of the C-terminal sites of human p53 reduces non-sequence-specific DNA binding as modeled with synthetic peptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M107516200

The C-terminus of p53: the more you learn the less you know

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M107516200

Reciprocal interference between the sequence-specific core and nonspecific C-terminal DNA binding domains of p53: implications for regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M107516200

Protein-DNA binding correlates with structural thermostability for the full-length human p53 protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M107516200

p53 Latency. C-terminal domain prevents binding of p53 core to target but not to nonspecific DNA sequences.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M107516200

Transcriptional regulation by p53 through intrinsic DNA/chromatin binding and site-directed cofactor recruitment.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M107516200

Evidence for a distinct inhibitory factor in the regulation of p53 functional activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M107516200

Protein-DNA interactions: A structural analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M107516200

High thermostability and lack of cooperative DNA binding distinguish the p63 core domain from the homologous tumor suppressor p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M107516200

Filling in the blanks in the p53 protein structure

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M107516200

How loops, beta sheets, and alpha helices help us to understand p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M107516200

High-resolution structure of the oligomerization domain of p53 by multidimensional NMR

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M107516200

The p53 protein is an unusually shaped tetramer that binds directly to DNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M107516200

Crystal structure of lac repressor core tetramer and its implications for DNA looping

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M107516200

Mechanisms of differential activation of target gene promoters by p53 hinge domain mutants with impaired apoptotic function

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M107516200

p53 DNA binding can be modulated by factors that alter the conformational equilibrium

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M107516200

Sequence-specific transcriptional activation is essential for growth suppression by p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M107516200

Structure and functionality of a designed p53 dimer

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M107516200

Synergistic transcriptional activation of the MCK promoter by p53: tetramers link separated DNA response elements by DNA looping

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M107516200

Local Structural Elements in the Mostly Unstructured Transcriptional Activation Domain of Human p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M107516200

The alpha-helical FXXPhiPhi motif in p53: TAF interaction and discrimination by MDM2

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M107516200

21 January 2018

Identifiers

DOI

10.1074/JBC.M107516200

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11606582%20AND%20SRC:MED&resulttype=core&format=json

12 November 2019

1 reference