(Q24530763)

4 July 2017

title

A peptide that binds and stabilizes p53 core domain: chaperone strategy for rescue of oncogenic mutants (English)

1 reference

4 July 2017

0 references

9

Alan R Fersht

Alan R

Fersht

1 reference

4 July 2017

Lars O Hansson

2

Lars O

Hansson

1 reference

19 October 2023

Stefan Rüdiger

8

Stefan

Rüdiger

1 reference

19 October 2023

Dmitry B Veprintsev

3

Dmitry B

Veprintsev

1 reference

19 October 2023

Assaf Friedler

1

Assaf

Friedler

1 reference

4 July 2017

Stefan M V Freund

4

Stefan M V

Freund

1 reference

4 July 2017

Thomas M Rippin

5

Thomas M

Rippin

1 reference

4 July 2017

Penka V Nikolova

6

Penka V

Nikolova

1 reference

4 July 2017

Mark R Proctor

7

Mark R

Proctor

1 reference

4 July 2017

language of work or name

English

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publication date

8 January 2002

1 reference

4 July 2017

number of pages

6

1 reference

Proceedings of the National Academy of Sciences of the United States of America

inferred from page(s)

published in

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4 July 2017

volume

99

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4 July 2017

issue

2

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4 July 2017

page(s)

937-942

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ASPP proteins specifically stimulate the apoptotic function of p53

4 July 2017

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=117409

Proapoptotic p53-interacting protein 53BP2 is induced by UV irradiation but suppressed by p53

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=117409

Stimulation of p53-mediated transcriptional activation by the p53-binding proteins, 53BP1 and 53BP2

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=117409

Thermodynamic stability of wild-type and mutant p53 core domain

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=117409

Structure of the p53 tumor suppressor bound to the ankyrin and SH3 domains of 53BP2

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=117409

Two cellular proteins that bind to wild-type but not mutant p53

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=117409

Crystal structure of a p53 tumor suppressor-DNA complex: understanding tumorigenic mutations

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=117409

SWISS-MODEL and the Swiss-PdbViewer: an environment for comparative protein modeling

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=117409

Rescuing the function of mutant p53.

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=117409

Strategies for manipulating the p53 pathway in the treatment of human cancer.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=117409

Quantitative analysis of residual folding and DNA binding in mutant p53 core domain: definition of mutant states for rescue in cancer therapy

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=117409

p53 and human cancer: the first ten thousand mutations.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=117409

Hot-spot mutants of p53 core domain evince characteristic local structural changes.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=117409

Reactivation of mutant p53 through interaction of a C-terminal peptide with the core domain.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=117409

Identification of an additional negative regulatory region for p53 sequence-specific DNA binding

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=117409

The carboxyl-terminal domain of the p53 protein regulates sequence-specific DNA binding through its nonspecific nucleic acid-binding activity

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=117409

Regulation of the sequence-specific DNA binding function of p53 by protein kinase C and protein phosphatases

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=117409

Competition BIAcore for measuring true affinities: large differences from values determined from binding kinetics.

27 September 2017

1 reference

Crossref

https://api.crossref.org/works/10.1073%2FPNAS.241629998

Small peptides activate the latent sequence-specific DNA binding function of p53.

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1073%2FPNAS.241629998

Pharmacological rescue of mutant p53 conformation and function

21 January 2018

1 reference

12 December 2020

Restoration of the transcription activation function to mutant p53 in human cancer cells

1 reference

12 December 2020

Restoration of the growth suppression function of mutant p53 by a synthetic peptide derived from the p53 C-terminal domain

1 reference

12 December 2020

Conformational and molecular basis for induction of apoptosis by a p53 C-terminal peptide in human cancer cells

1 reference

12 December 2020

Identifiers

DOI

10.1073/PNAS.241629998

1 reference

release_omiradygnzcsrbpyy3bak6dl2m

4 July 2017

0 references

0 references

PMC publication ID

117409

0 references

1 reference