(Q36661775)

15 August 2017

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title

Mutant p53 proteins: between loss and gain of function (English)

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15 August 2017

Sabrina Strano

1

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15 August 2017

Stefania Dell'Orso

2

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15 August 2017

Adriana Maria Mongiovi

3

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15 August 2017

Olimpia Monti

4

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15 August 2017

Eleonora Lapi

5

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15 August 2017

Silvia Di Agostino

6

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15 August 2017

Giulia Fontemaggi

7

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15 August 2017

Giovanni Blandino

8

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15 August 2017

language of work or name

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1 May 2007

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15 August 2017

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15 August 2017

volume

29

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15 August 2017

issue

5

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15 August 2017

page(s)

488-496

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Li-Fraumeni syndrome – a molecular and clinical review

15 August 2017

cites work

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Li-Fraumeni syndrome: a p53 family affair

21 January 2018

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p53 mutation, but not p53 overexpression, correlates with survival in head and neck squamous cell carcinoma

21 January 2018

1 reference

A prospective phase II trial of ONYX-015 adenovirus and chemotherapy in recurrent squamous cell carcinoma of the head and neck (the Baylor experience).

21 January 2018

1 reference

Cancer. p53, guardian of the genome

21 January 2018

1 reference

7 January 2021

T antigen is bound to a host protein in SY40-transformed cells

1 reference

7 January 2021

Decision making by p53: life, death and cancer

1 reference

7 January 2021

p53, the cellular gatekeeper for growth and division

1 reference

7 January 2021

Characterization of a 54K Dalton cellular SV40 tumor antigen present in SV40-transformed cells and uninfected embryonal carcinoma cells

1 reference

7 January 2021

Ubiquitination, phosphorylation and acetylation: the molecular basis for p53 regulation

1 reference

7 January 2021

Regulation of p53 responses by post-translational modifications

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7 January 2021

MDM2--master regulator of the p53 tumor suppressor protein

1 reference

7 January 2021

p53 mutations in human cancers

1 reference

7 January 2021

Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas, and other neoplasms

1 reference

7 January 2021

Assessing TP53 status in human tumours to evaluate clinical outcome

1 reference

7 January 2021

Gain of function of a p53 hot spot mutation in a mouse model of Li-Fraumeni syndrome.

1 reference

7 January 2021

Mutant p53 gain of function in two mouse models of Li-Fraumeni syndrome

1 reference

7 January 2021

The effects of wild-type p53 tumor suppressor activity and mutant p53 gain-of-function on cell growth

1 reference

7 January 2021

A transgenic mouse model for mammary carcinogenesis.

1 reference

7 January 2021

Gain of function mutations in p53.

1 reference

7 January 2021

Physical interaction with Yes-associated protein enhances p73 transcriptional activity

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7 January 2021

Transcriptional activities of mutant p53: when mutations are more than a loss

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7 January 2021

Modulation of gene expression by tumor-derived p53 mutants

1 reference

7 January 2021

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

1 reference

7 January 2021

Mutant p53 gain of function: differential effects of different p53 mutants on resistance of cultured cells to chemotherapy

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7 January 2021

Tumor spectrum analysis in p53-mutant mice

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7 January 2021

p53 mutation heterogeneity in cancer

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7 January 2021

Hot-spot mutants of p53 core domain evince characteristic local structural changes.

1 reference

7 January 2021

Change of Conformation of the DNA-binding Domain of p53 Is the Only Key Element for Binding of and Interference with p73

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7 January 2021

Crystal structure of a p53 tumor suppressor-DNA complex: understanding tumorigenic mutations

1 reference

7 January 2021

Mutations in the p53 gene occur in diverse human tumour types

1 reference

7 January 2021

Mdm2 promotes the rapid degradation of p53

1 reference

7 January 2021

Escape from therapy-induced accelerated cellular senescence in p53-null lung cancer cells and in human lung cancers.

1 reference

7 January 2021

Integrity of the N-terminal transcription domain of p53 is required for mutant p53 interference with drug-induced apoptosis

1 reference

7 January 2021

Comparison of the effect of mutant and wild-type p53 on global gene expression

1 reference

7 January 2021

Transactivation of the EGR1 gene contributes to mutant p53 gain of function

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7 January 2021

p73 function is inhibited by tumor-derived p53 mutants in mammalian cells.

1 reference

7 January 2021

A subset of tumor-derived mutant forms of p53 down-regulate p63 and p73 through a direct interaction with the p53 core domain

1 reference

7 January 2021

Interaction of c-Abl and p73alpha and their collaboration to induce apoptosis

1 reference

7 January 2021

The tyrosine kinase c-Abl regulates p73 in apoptotic response to cisplatin-induced DNA damage

1 reference

7 January 2021

p73 is regulated by tyrosine kinase c-Abl in the apoptotic response to DNA damage

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7 January 2021

Chemosensitivity linked to p73 function

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7 January 2021

Physical interaction with human tumor-derived p53 mutants inhibits p63 activities.

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7 January 2021

p63 and p73 are required for p53-dependent apoptosis in response to DNA damage

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7 January 2021

P63 and P73: P53 mimics, menaces and more

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7 January 2021

A common polymorphism acts as an intragenic modifier of mutant p53 behaviour

1 reference

7 January 2021

Inactivate the remaining p53 allele or the alternate p73? Preferential selection of the Arg72 polymorphism in cancers with recessive p53 mutants but not transdominant mutants

1 reference

7 January 2021

p53 polymorphism influences response in cancer chemotherapy via modulation of p73-dependent apoptosis

1 reference

7 January 2021

Estimates of the worldwide frequency of sixteen major cancers in 1980

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7 January 2021

Cancer statistics, 2002

1 reference

7 January 2021

Association between cigarette smoking and mutation of the p53 gene in squamous-cell carcinoma of the head and neck

1 reference

7 January 2021

TP53 and head and neck neoplasms

1 reference

7 January 2021

Emerging molecular markers of cancer.

1 reference

7 January 2021

p53 gene mutations in sequential oral epithelial dysplasias and squamous cell carcinomas

1 reference

7 January 2021

Biochemopreventive therapy for patients with premalignant lesions of the head and neck and p53 gene expression.

1 reference

7 January 2021

p53 expression and cell proliferation as prognostic factors in laryngeal squamous cell carcinoma

1 reference

7 January 2021

TP53 DNA contact mutations are selectively associated with allelic loss and have a strong clinical impact in head and neck cancer

1 reference

7 January 2021

p53 gene status as a predictor of tumor response to induction chemotherapy of patients with locoregionally advanced squamous cell carcinomas of the head and neck

1 reference

7 January 2021

p53 alterations predict tumor response to neoadjuvant chemotherapy in head and neck squamous cell carcinoma: a prospective series.

1 reference

7 January 2021

Adenovirus-mediated p53 gene transfer in patients with advanced recurrent head and neck squamous cell carcinoma

1 reference

7 January 2021

Induction chemotherapy with cisplatin and 5-fluorouracil followed by chemoradiotherapy or radiotherapy alone in the treatment of locoregionally advanced resectable cancers of the larynx and hypopharynx: results of single-center study of 45 patients

1 reference

7 January 2021

Analysis of p53 serum antibodies in patients with head and neck squamous cell carcinoma

1 reference

7 January 2021

Restoration of the growth suppression function of mutant p53 by a synthetic peptide derived from the p53 C-terminal domain

1 reference

7 January 2021

Restoration of the tumor suppressor function to mutant p53 by a low-molecular-weight compound.

1 reference

7 January 2021

A peptide that binds and stabilizes p53 core domain: chaperone strategy for rescue of oncogenic mutants

1 reference

7 January 2021

Rescue of mutants of the tumor suppressor p53 in cancer cells by a designed peptide

1 reference

7 January 2021

ASPP1 and ASPP2: common activators of p53 family members

1 reference

7 January 2021

Blockage by adenovirus E4orf6 of transcriptional activation by the p53 tumor suppressor

1 reference

7 January 2021

An adenovirus mutant that replicates selectively in p53-deficient human tumor cells

1 reference

7 January 2021

ONYX-015 selectivity and the p14ARF pathway

1 reference

7 January 2021

Loss of p14ARF in tumor cells facilitates replication of the adenovirus mutant dl1520 (ONYX-015).

1 reference

7 January 2021

a controlled trial of intratumoral ONYX-015, a selectively-replicating adenovirus, in combination with cisplatin and 5-fluorouracil in patients with recurrent head and neck cancer

1 reference

7 January 2021

Identifiers

DOI

10.1002/HED.20531

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15 August 2017

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