(Q35418068)

8 August 2017

title

Intramuscular injection of AAV8 in mice and macaques is associated with substantial hepatic targeting and transgene expression (English)

1 reference

8 August 2017

James M Wilson

12

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author name string

Jenny A Greig

1

1 reference

8 August 2017

Hui Peng

2

1 reference

8 August 2017

Jason Ohlstein

3

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8 August 2017

C Angelica Medina-Jaszek

4

1 reference

8 August 2017

Omua Ahonkhai

5

1 reference

8 August 2017

Anne Mentzinger

6

1 reference

8 August 2017

Rebecca L Grant

7

1 reference

8 August 2017

Soumitra Roy

8

1 reference

8 August 2017

Shu-Jen Chen

9

1 reference

8 August 2017

Peter Bell

10

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8 August 2017

Anna P Tretiakova

11

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8 August 2017

language of work or name

English

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publication date

13 November 2014

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8 August 2017

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8 August 2017

volume

9

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8 August 2017

issue

11

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8 August 2017

page(s)

e112268

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Creative Commons Attribution 4.0 International

8 August 2017

copyright license

start time

13 November 2014

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

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Application of mutated miR-206 target sites enables skeletal muscle-specific silencing of transgene expression of cardiotropic AAV9 vectors.

12 July 2018

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12 July 2018

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Muscle-directed gene therapy for hemophilia B with more efficient and less immunogenic AAV vectors.

12 July 2018

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MicroRNA-restricted transgene expression in the retina

12 July 2018

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Inflammation promotes the loss of adeno-associated virus-mediated transgene expression in mouse liver.

12 July 2018

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12 July 2018

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Liver-specific microRNA-122 target sequences incorporated in AAV vectors efficiently inhibits transgene expression in the liver

12 July 2018

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12 July 2018

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12 July 2018

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12 July 2018

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Broad and potent neutralizing antibodies from an African donor reveal a new HIV-1 vaccine target

12 July 2018

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Sustained transgene expression despite T lymphocyte responses in a clinical trial of rAAV1-AAT gene therapy

12 July 2018

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Tolerance induction to cytoplasmic beta-galactosidase by hepatic AAV gene transfer: implications for antigen presentation and immunotoxicity

12 July 2018

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Hepatic regulatory T cells and Kupffer cells are crucial mediators of systemic T cell tolerance to antigens targeting murine liver.

12 July 2018

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Vector-mediated gene transfer engenders long-lived neutralizing activity and protection against SIV infection in monkeys

12 July 2018

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Stable knockdown of microRNA in vivo by lentiviral vectors

12 July 2018

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Construction and analysis of compact muscle-specific promoters for AAV vectors

12 July 2018

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miRNAs get an early start on translational silencing

12 July 2018

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12 July 2018

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Induction and role of regulatory CD4+CD25+ T cells in tolerance to the transgene product following hepatic in vivo gene transfer

12 July 2018

1 reference

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Muscle-specific microRNA miR-206 promotes muscle differentiation

12 July 2018

1 reference

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Endogenous microRNA regulation suppresses transgene expression in hematopoietic lineages and enables stable gene transfer

12 July 2018

1 reference

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Prevention of cytotoxic T lymphocyte responses to factor IX-expressing hepatocytes by gene transfer-induced regulatory T cells

12 July 2018

1 reference

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A microRNA polycistron as a potential human oncogene

12 July 2018

1 reference

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Safety and efficacy of factor IX gene transfer to skeletal muscle in murine and canine hemophilia B models by adeno-associated viral vector serotype 1.

12 July 2018

1 reference

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Induction of immune tolerance to coagulation factor IX antigen by in vivo hepatic gene transfer

12 July 2018

1 reference

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New microRNAs from mouse and human

12 July 2018

1 reference

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AAV-mediated factor IX gene transfer to skeletal muscle in patients with severe hemophilia B.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4230988

Sustained expression of therapeutic level of factor IX in hemophilia B dogs by AAV-mediated gene therapy in liver

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4230988

Characterization of a macaque recombinant monoclonal antibody that binds to a CD4-induced epitope and neutralizes simian immunodeficiency virus

12 July 2018

1 reference

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Evidence for gene transfer and expression of factor IX in haemophilia B patients treated with an AAV vector.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4230988

Simian immunodeficiency virus (SIV) envelope-specific Fabs with high-level homologous neutralizing activity: recovery from a long-term-nonprogressor SIV-infected macaque

12 July 2018

1 reference

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Stable gene transfer and expression of human blood coagulation factor IX after intramuscular injection of recombinant adeno-associated virus

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4230988

Gene delivery to skeletal muscle results in sustained expression and systemic delivery of a therapeutic protein

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4230988

microRNA122-regulated transgene expression increases specificity of cardiac gene transfer upon intravenous delivery of AAV9 vectors

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4230988

Worldwide epidemiology of neutralizing antibodies to adeno-associated viruses.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4230988

Muscle as a target for supplementary factor IX gene transfer

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4230988

Analysis of tumors arising in male B6C3F1 mice with and without AAV vector delivery to liver.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4230988

Biology of AAV serotype vectors in liver-directed gene transfer to nonhuman primates.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4230988

An optimized protocol for detection of E. coli beta-galactosidase in lung tissue following gene transfer.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4230988

Sustained correction of disease in naive and AAV2-pretreated hemophilia B dogs: AAV2/8-mediated, liver-directed gene therapy

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4230988

Long-term pharmacologically regulated expression of erythropoietin in primates following AAV-mediated gene transfer.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4230988

Induction of antigen-specific CD4+ T-cell anergy and deletion by in vivo viral gene transfer

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4230988

Intramuscular administration of recombinant adeno-associated virus 2 alpha-1 antitrypsin (rAAV-SERPINA1) vectors in a nonhuman primate model: safety and immunologic aspects

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4230988

Influence of vector dose on factor IX-specific T and B cell responses in muscle-directed gene therapy

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4230988

Sustained phenotypic correction of hemophilia B dogs with a factor IX null mutation by liver-directed gene therapy

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4230988

Long-term correction of canine hemophilia B by gene transfer of blood coagulation factor IX mediated by adeno-associated viral vector

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4230988

Safety and Efficacy of Regional Intravenous (RI) Versus Intramuscular (IM) Delivery of rAAV1 and rAAV8 to Nonhuman Primate Skeletal Muscle.

26 September 2018

1 reference

Crossref

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0112268

10.1371/JOURNAL.PONE.0112268

21 January 2018

Identifiers

DOI

1 reference

release_zd6jk3epnrhfdjmsjnvfcevgyy

8 August 2017

0 references

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/zd6jk3epnrhfdjmsjnvfcevgyy

mapped directly with Wikidata item

24 November 2022

based on heuristic

PMC publication ID

4230988

1 reference

8 August 2017

1 reference