(Q35423470)

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5-aza-2'-deoxycytidine activates iron uptake and heme biosynthesis by increasing c-Myc nuclear localization and binding to the E-boxes of transferrin receptor 1 (TfR1) and ferrochelatase (Fech) genes.

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21903580%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

5-aza-2'-deoxycytidine activates iron uptake and heme biosynthesis by increasing c-Myc nuclear localization and binding to the E-boxes of transferrin receptor 1 (TfR1) and ferrochelatase (Fech) genes (English)

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21903580%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

Gregory J Anderson

5

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12 February 2020

11

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12 February 2020

author name string

Bo Ning

1

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12 February 2020

Gang Liu

2

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12 February 2020

Yuanyuan Liu

3

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12 February 2020

Xiufen Su

4

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12 February 2020

Xin Zheng

6

1 reference

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21903580%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

Yanzhong Chang

7

1 reference

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21903580%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

Mingzhou Guo

8

1 reference

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21903580%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

Yuanfang Liu

9

1 reference

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12 February 2020

Yuliang Zhao

10

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12 February 2020

language of work or name

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publication date

7 September 2011

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12 February 2020

Journal of Biological Chemistry

1 reference

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21903580%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

286

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21903580%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

43

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21903580%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

37196-37206

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21903580%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

Therapy with azanucleosides for myelodysplastic syndromes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3199467

12 July 2018

A global role for KLF1 in erythropoiesis revealed by ChIP-seq in primary erythroid cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3199467

12 July 2018

New clues to the molecular pathogenesis of myelodysplastic syndromes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3199467

12 July 2018

Epigenetic regulation affects N-myc downstream-regulated gene 1 expression indirectly in pancreatic cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3199467

12 July 2018

Relationship of differential gene expression profiles in CD34+ myelodysplastic syndrome marrow cells to disease subtype and progression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3199467

12 July 2018

5-Aza-2'-deoxycytidine sensitizes busulfan-resistant myeloid leukemia cells by regulating expression of genes involved in cell cycle checkpoint and apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3199467

12 July 2018

Early epigenetic changes and DNA damage do not predict clinical response in an overlapping schedule of 5-azacytidine and entinostat in patients with myeloid malignancies.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3199467

12 July 2018

Efficacy of azacitidine compared with that of conventional care regimens in the treatment of higher-risk myelodysplastic syndromes: a randomised, open-label, phase III study

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3199467

12 July 2018

DNA methylation landscapes: provocative insights from epigenomics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3199467

12 July 2018

In vivo transcriptional regulation of N-Myc target genes is controlled by E-box methylation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3199467

12 July 2018

Myelodysplastic syndrome.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3199467

12 July 2018

Induction of gene expression by 5-Aza-2'-deoxycytidine in acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS) but not epithelial cells by DNA-methylation-dependent and -independent mechanisms

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3199467

12 July 2018

Global regulation of erythroid gene expression by transcription factor GATA-1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3199467

12 July 2018

Genomic targets of the human c-Myc protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3199467

12 July 2018

Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3199467

12 July 2018

c-MYC: more than just a matter of life and death

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3199467

12 July 2018

c-Myc represses and Miz-1 activates the murine natural resistance-associated protein 1 promoter

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3199467

12 July 2018

Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3199467

12 July 2018

Coordinated regulation of iron-controlling genes, H-ferritin and IRP2, by c-MYC

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3199467

12 July 2018

c-Myc target genes involved in cell growth, apoptosis, and metabolism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3199467

12 July 2018

Pathogenesis, etiology and epidemiology of myelodysplastic syndromes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3199467

12 July 2018

Tissue-specific regulation of iron metabolism and heme synthesis: distinct control mechanisms in erythroid cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3199467

12 July 2018

Regulation of the erythroid Kruppel-like factor (EKLF) gene promoter by the erythroid transcription factor GATA-1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3199467

12 July 2018

Lethal beta-thalassaemia in mice lacking the erythroid CACCC-transcription factor EKLF

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3199467

12 July 2018

Dependence of globin gene expression in mouse erythroleukemia cells on the NF-E2 heterodimer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3199467

12 July 2018

Transcription factor GATA-1 permits survival and maturation of erythroid precursors by preventing apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3199467

12 July 2018

Hemin does not cause commitment of murine erythroleukemia (MEL) cells to terminal differentiation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3199467

12 July 2018

Hypomethylation of DNA during differentiation of Friend erythroleukemia cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3199467

12 July 2018

Acquisition of iron from transferrin regulates reticulocyte heme synthesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3199467

12 July 2018

5-Azacytidine acts directly on both erythroid precursors and progenitors to increase production of fetal hemoglobin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3199467

12 July 2018

CpG-rich islands and the function of DNA methylation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3199467

12 July 2018

Demethylation of a hypermethylated P15/INK4B gene in patients with myelodysplastic syndrome by 5-Aza-2'-deoxycytidine (decitabine) treatment

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.258129

21 January 2018

Activation of transferrin receptor 1 by c-Myc enhances cellular proliferation and tumorigenesis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.258129

21 January 2018

Circadian rhythm of transferrin receptor 1 gene expression controlled by c-Myc in colon cancer-bearing mice

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.258129

21 January 2018

Myelodysplastic Syndromes

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.258129

21 January 2018

Myelodysplastic syndromes

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.258129

21 January 2018

Inhibition of DNA methyltransferase and induction of Friend erythroleukemia cell differentiation by 5-azacytidine and 5-aza-2'-deoxycytidine

1 reference

https://pubmed.ncbi.nlm.nih.gov/21903580

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

5-Aza-2'-deoxycytidine induces terminal differentiation of leukemic blasts from patients with acute myeloid leukemias

1 reference

https://pubmed.ncbi.nlm.nih.gov/21903580

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Control of heme synthesis during Friend cell differentiation: role of iron and transferrin

1 reference

https://pubmed.ncbi.nlm.nih.gov/21903580

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reduction site of transferrin-dependent and transferrin-independent iron in cultured human fibroblasts

1 reference

https://pubmed.ncbi.nlm.nih.gov/21903580

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Safety and clinical activity of the combination of 5-azacytidine, valproic acid, and all-trans retinoic acid in acute myeloid leukemia and myelodysplastic syndrome

1 reference

https://pubmed.ncbi.nlm.nih.gov/21903580

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Microarray-based classifiers and prognosis models identify subgroups with distinct clinical outcomes and high risk of AML transformation of myelodysplastic syndrome

1 reference

https://pubmed.ncbi.nlm.nih.gov/21903580

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1074/JBC.M111.258129

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21903580%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21903580%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21903580%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

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