(Q35516107)

English

Activation and desensitization induce distinct conformational changes at the extracellular-transmembrane domain interface of the glycine receptor

scientific article published on 14 September 2011

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scholarly article

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Europe PubMed Central

PubMed publication ID

8 August 2017

Activation and desensitization induce distinct conformational changes at the extracellular-transmembrane domain interface of the glycine receptor (English)

1 reference

Europe PubMed Central

PubMed publication ID

8 August 2017

transmembrane protein

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desensitization

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inferred from title

author name string

Qian Wang

1

1 reference

Europe PubMed Central

PubMed publication ID

8 August 2017

Joseph W Lynch

2

1 reference

Europe PubMed Central

PubMed publication ID

8 August 2017

language of work or name

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publication date

14 September 2011

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Europe PubMed Central

PubMed publication ID

8 August 2017

Journal of Biological Chemistry

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Europe PubMed Central

PubMed publication ID

8 August 2017

286

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Europe PubMed Central

PubMed publication ID

8 August 2017

44

1 reference

Europe PubMed Central

PubMed publication ID

8 August 2017

38814-38824

1 reference

Europe PubMed Central

PubMed publication ID

8 August 2017

Ligand- and Subunit-specific Conformational Changes in the Ligand-binding Domain and the TM2-TM3 Linker of α1 β2 γ2 GABAA Receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3207466

12 July 2018

Binding, activation and modulation of Cys-loop receptors.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3207466

12 July 2018

Conformational changes in the nicotinic acetylcholine receptor during gating and desensitization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3207466

12 July 2018

X-ray structure, symmetry and mechanism of an AMPA-subtype glutamate receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3207466

12 July 2018

The gating isomerization of neuromuscular acetylcholine receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3207466

12 July 2018

Gating of nicotinic ACh receptors: latest insights into ligand binding and function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3207466

12 July 2018

An epilepsy-related region in the GABA(A) receptor mediates long-distance effects on GABA and benzodiazepine binding sites

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3207466

12 July 2018

Magnitude of a conformational change in the glycine receptor beta1-beta2 loop is correlated with agonist efficacy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3207466

12 July 2018

Gating mechanisms in Cys-loop receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3207466

12 July 2018

Ligand-specific conformational changes in the alpha1 glycine receptor ligand-binding domain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3207466

12 July 2018

Native glycine receptor subtypes and their physiological roles

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3207466

12 July 2018

The interface between extracellular and transmembrane domains of homomeric Cys-loop receptors governs open-channel lifetime and rate of desensitization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3207466

12 July 2018

Illuminating the structure and function of Cys-loop receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3207466

12 July 2018

Establishing an ion pair interaction in the homomeric rho1 gamma-aminobutyric acid type A receptor that contributes to the gating pathway.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3207466

12 July 2018

Structural aspects of AMPA receptor activation, desensitization and deactivation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3207466

12 July 2018

Measurement of conformational changes accompanying desensitization in an ionotropic glutamate receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3207466

12 July 2018

Recent advances in Cys-loop receptor structure and function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3207466

12 July 2018

A role for the beta 1-beta 2 loop in the gating of 5-HT3 receptors.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3207466

12 July 2018

A unified view of the role of electrostatic interactions in modulating the gating of Cys loop receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3207466

12 July 2018

Shedding light on membrane proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3207466

12 July 2018

Desensitization of nicotinic ACh receptors: shaping cholinergic signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3207466

12 July 2018

Molecular dynamics simulation links conformation of a pore-flanking region to hyperekplexia-related dysfunction of the inhibitory glycine receptor.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3207466

12 July 2018

A fluorophore attached to nicotinic acetylcholine receptor beta M2 detects productive binding of agonist to the alpha delta site

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3207466

12 July 2018

Kinetic determinants of agonist action at the recombinant human glycine receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3207466

12 July 2018

Altered kinetics and benzodiazepine sensitivity of a GABAA receptor subunit mutation [gamma 2(R43Q)] found in human epilepsy.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3207466

12 July 2018

Mechanism of glutamate receptor desensitization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3207466

12 July 2018

Point mutation in the first transmembrane region of the beta 2 subunit of the gamma--aminobutyric acid type A receptor alters desensitization kinetics of gamma--aminobutyric acid- and anesthetic-induced channel gating

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3207466

12 July 2018

Crystal structure of an ACh-binding protein reveals the ligand-binding domain of nicotinic receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3207466

12 July 2018

Desensitization of neuronal nicotinic acetylcholine receptors conferred by N-terminal segments of the beta 2 subunit

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3207466

12 July 2018

Structural determinants of fast desensitization and desensitization-deactivation coupling in GABAa receptors.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3207466

12 July 2018

Acetylcholine receptor channel structure in the resting, open, and desensitized states probed with the substituted-cysteine-accessibility method

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3207466

12 July 2018

The impact of receptor desensitization on fast synaptic transmission

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3207466

12 July 2018

Identification of intracellular and extracellular domains mediating signal transduction in the inhibitory glycine receptor chloride channel

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3207466

12 July 2018

A kinetic mechanism for nicotinic acetylcholine receptors based on multiple allosteric transitions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3207466

12 July 2018

An amino acid exchange in the second transmembrane segment of a neuronal nicotinic receptor causes partial epilepsy by altering its desensitization kinetics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3207466

12 July 2018

A novel hyperekplexia-causing mutation in the pre-transmembrane segment 1 of the human glycine receptor alpha1 subunit reduces membrane expression and impairs gating by agonists.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.273631

21 January 2018

Aromatic residues at position 55 of rat alpha7 nicotinic acetylcholine receptors are critical for maintaining rapid desensitization

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.273631

21 January 2018

Rapid desensitization of the rat α7 nAChR is facilitated by the presence of a proline residue in the outer β-sheet.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.273631

21 January 2018

Conformational variability of the glycine receptor M2 domain in response to activation by different agonists

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.273631

21 January 2018

Site-specific fluorescence reveals distinct structural changes with GABA receptor activation and antagonism

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.273631

21 January 2018

Distinct conformational changes in activated agonist-bound and agonist-free glycine receptor subunits

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.273631

21 January 2018

Principal pathway coupling agonist binding to channel gating in nicotinic receptors

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.273631

21 January 2018

Acetylcholine receptor gating at extracellular transmembrane domain interface: the "pre-M1" linker

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.273631

21 January 2018

Transducing agonist binding to channel gating involves different interactions in 5-HT3 and GABAC receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/21917927

12 December 2020

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10.1074/JBC.M111.273631

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Europe PubMed Central

PubMed publication ID

8 August 2017

release_b4p3klmz3fgovpre7bsqs2rfii

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https://api.fatcat.wiki/v0/release/b4p3klmz3fgovpre7bsqs2rfii

24 November 2022

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Europe PubMed Central

PubMed publication ID

8 August 2017

PubMed publication ID

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Europe PubMed Central

PubMed publication ID

8 August 2017

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