(Q35542021)

8 August 2017

1 reference

title

Trefoil factors: initiators of mucosal healing (English)

1 reference

8 August 2017

1 reference

13 March 2024

author name string

Douglas Taupin

series ordinal

1

1 reference

8 August 2017

Daniel K. Podolsky

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14506475

13 March 2024

language of work or name

English

1 reference

National Center for Biotechnology Information

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=14506475

13 March 2024

publication date

1 September 2003

1 reference

full work available at URL

8 August 2017

https://www.nature.com/articles/nrm1203.pdf

file format

Portable Document Format

1 reference

https://www.nature.com/articles/nrm1203

13 March 2024

1 reference

Nature Reviews Molecular Cell Biology

13 March 2024

published in

1 reference

8 August 2017

volume

4

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8 August 2017

issue

9

1 reference

8 August 2017

page(s)

721-732

1 reference

Cutaneous wound healing: an update

8 August 2017

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Rho proteins play a critical role in cell migration during the early phase of mucosal restitution

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The trefoil peptide family

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31 March 2020

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31 March 2020

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Augmented intestinal trefoil factor (TFF3) and loss of pS2 (TFF1) expression precedes metaplastic differentiation of gastric epithelium.

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31 March 2020

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31 March 2020

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The mouse one P-domain (pS2) and two P-domain (mSP) genes exhibit distinct patterns of expression.

31 March 2020

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31 March 2020

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31 March 2020

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TFF2/SP-deficient mice show decreased gastric proliferation, increased acid secretion, and increased susceptibility to NSAID injury

31 March 2020

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Identification and characterization of rat intestinal trefoil factor: tissue- and cell-specific member of the trefoil protein family

31 March 2020

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Ultrastructural co-localization of TFF3-peptide and oxytocin in the neural lobe of the porcine pituitary

31 March 2020

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Trefoil factor family domain peptides in the human respiratory tract

31 March 2020

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31 March 2020

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Experimental ulceration leads to sequential expression of spasmolytic polypeptide, intestinal trefoil factor, epidermal growth factor and transforming growth factor alpha mRNAs in rat stomach.

31 March 2020

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Specificity of gene regulation

31 March 2020

1 reference

Identification of a goblet cell-specific enhancer element in the rat intestinal trefoil factor gene promoter bound by a goblet cell nuclear protein

31 March 2020

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A silencer inhibitor confers specific expression of intestinal trefoil factor in gobletlike cell lines

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31 March 2020

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Identification and characterization of the MUC2 (human intestinal mucin) gene 5'-flanking region: promoter activity in cultured cells

31 March 2020

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Biosynthesis of human colonic mucin: Muc2 is the prominent secretory mucin

31 March 2020

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Autoinduction of the trefoil factor 2 (TFF2) promoter requires an upstream cis-acting element

31 March 2020

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Interaction of a liver-specific factor with an enhancer 4.8 kilobases upstream of the phosphoenolpyruvate carboxykinase gene

31 March 2020

1 reference

Developmental competence of the gut endoderm: genetic potentiation by GATA and HNF3/fork head proteins

31 March 2020

1 reference

Hepatocyte nuclear factor 3 (winged helix domain) activates trefoil factor gene TFF1 through a binding motif adjacent to the TATAA box.

31 March 2020

1 reference

Mouse Trefoil factor genes: genomic organization, sequences and methylation analyses

31 March 2020

1 reference

GATA-6: a zinc finger transcription factor that is expressed in multiple cell lineages derived from lateral mesoderm

31 March 2020

1 reference

The zinc finger-containing transcription factors GATA-4, -5, and -6. Ubiquitously expressed regulators of tissue-specific gene expression.

31 March 2020

1 reference

Transcription factor GATA-6 activates expression of gastroprotective trefoil genes TFF1 and TFF2.

31 March 2020

1 reference

Interaction of a gene-specific transcription factor with the adenovirus major late promoter upstream of the TATA box region.

31 March 2020

1 reference

Ubiquitous expression of the 43- and 44-kDa forms of transcription factor USF in mammalian cells

31 March 2020

1 reference

Gastroprotective peptide trefoil factor family 2 gene is activated by upstream stimulating factor but not by c-Myc in gastrointestinal cancer cells.

31 March 2020

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The trefoil gene family are coordinately expressed immediate-early genes: EGF receptor- and MAP kinase-dependent interregulation

31 March 2020

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Reciprocal regulation of gastrointestinal homeostasis by SHP2 and STAT-mediated trefoil gene activation in gp130 mutant mice

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Histone deacetylase inhibitors stimulate mitochondrial HMG-CoA synthase gene expression via a promoter proximal Sp1 site.

31 March 2020

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Trichostatin A Induces Morphological Changes and Gelsolin Expression by Inhibiting Histone Deacetylase in Human Carcinoma Cell Lines

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

1 reference

Epidermal growth factor receptor-stimulated intestinal epithelial cell migration requires phospholipase C activity

31 March 2020

1 reference

Role of epidermal growth factor receptor in basal and stimulated colonic epithelial cell migration in vitro

31 March 2020

1 reference

Regulation of cell motility by mitogen-activated protein kinase

31 March 2020

1 reference

Trefoil peptides promote epithelial migration through a transforming growth factor beta-independent pathway

31 March 2020

1 reference

Receptor binding of pancreatic spasmolytic polypeptide in intestinal mucosal cells and membranes

31 March 2020

1 reference

Immunoprecipitation and characterization of a binding protein specific for the peptide, intestinal trefoil factor

31 March 2020

1 reference

pS2/TFF1 interacts directly with the VWFC cysteine-rich domains of mucins

31 March 2020

1 reference

Isolation and characterization of putative trefoil peptide receptors

31 March 2020

1 reference

31 March 2020

1 reference

Effect of trefoil factors on the viscoelastic properties of mucus gels

31 March 2020

1 reference

Intestinal trefoil factor induces decay-accelerating factor expression and enhances the protective activities against complement activation in intestinal epithelial cells

31 March 2020

1 reference

Intestinal trefoil factor confers colonic epithelial resistance to apoptosis

31 March 2020

1 reference

Rho, rac, and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia

31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

1 reference

31 March 2020

1 reference

Induction of scattering and cellular invasion by trefoil peptides in src- and RhoA-transformed kidney and colonic epithelial cells

31 March 2020

1 reference

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31 March 2020

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Varying cecal bacterial loads influences colitis and gastritis in HLA-B27 transgenic rats

31 March 2020

1 reference

Tolerance exists towards resident intestinal flora but is broken in active inflammatory bowel disease (IBD)

31 March 2020

1 reference

Nods: a family of cytosolic proteins that regulate the host response to pathogens

31 March 2020

1 reference

The trefoil peptides TFF2 and TFF3 are expressed in rat lymphoid tissues and participate in the immune response

31 March 2020

1 reference

Trefoil peptide TFF2 (spasmolytic polypeptide) potently accelerates healing and reduces inflammation in a rat model of colitis

31 March 2020

1 reference

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31 March 2020

1 reference

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31 March 2020

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31 March 2020

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Protein kinase C and ERK activation are required for TFF-peptide-stimulated bronchial epithelial cell migration and tumor necrosis factor-alpha-induced interleukin-6 (IL-6) and IL-8 secretion

31 March 2020

1 reference

Novel inhibitors of cytokine-induced IkappaBalpha phosphorylation and endothelial cell adhesion molecule expression show anti-inflammatory effects in vivo

31 March 2020

1 reference

Synergistic interaction between hypergastrinemia and Helicobacter infection in a mouse model of gastric cancer

31 March 2020

1 reference

DNA hypermethylation at the pS2 promoter region is associated with early stage of stomach carcinogenesis

31 March 2020

1 reference

The trefoil factor 1 participates in gastrointestinal cell differentiation by delaying G1-S phase transition and reducing apoptosis

31 March 2020

1 reference

A novel 25 bp tandem repeat within the human trefoil peptide gene TFF2 in 21q22.3: polymorphism and mammalian evolution

31 March 2020

1 reference

Variable distribution of TFF2 (Spasmolysin) alleles in Europeans does not indicate predisposition to gastric cancer

31 March 2020

1 reference

Expression of intestinal trefoil factor mRNA is downregulated during progression of colorectal carcinomas

31 March 2020

1 reference

Overexpression of intestinal trefoil factor in human colon carcinoma cells reduces cellular growth in vitro and in vivo

31 March 2020

1 reference

Oral trefoil peptides protect against ethanol- and indomethacin-induced gastric injury in rats

31 March 2020

1 reference

Human spasmolytic polypeptide is a cytoprotective agent that stimulates cell migration

31 March 2020

1 reference

Characterization of radiation-induced apoptosis in the small intestine and its biological implications

31 March 2020

1 reference

The effects of keratinocyte growth factor in preclinical models of mucositis

31 March 2020

1 reference

1H NMR-based determination of the secondary structure of porcine pancreatic spasmolytic polypeptide: one of a new family of "trefoil" motif containing cell growth factors

31 March 2020

1 reference

Crystal structure of a disulfide-linked "trefoil" motif found in a large family of putative growth factors

31 March 2020

1 reference

Metabolism of oral trefoil factor 2 (TFF2) and the effect of oral and parenteral TFF2 on gastric and duodenal ulcer healing in the rat.

31 March 2020

1 reference

Effect of ectopic expression of rat trefoil factor family 3 (intestinal trefoil factor) in the jejunum of transgenic mice

31 March 2020

1 reference

Dimerization of human pS2 (TFF1) plays a key role in its protective/healing effects

31 March 2020

1 reference

Combined intestinal trefoil factor and epidermal growth factor is prophylactic against indomethacin-induced gastric damage in the rat

31 March 2020

1 reference

Role of spasmolytic polypeptide in healing of stress-induced gastric lesions in rats

31 March 2020

1 reference

Oral human spasmolytic polypeptide protects against aspirin-induced gastric injury in rats.

31 March 2020

1 reference

Intestinal trefoil factor controls the expression of the adenomatous polyposis coli-catenin and the E-cadherin-catenin complexes in human colon carcinoma cells

31 March 2020

1 reference

Trefoil factor family-peptides promote migration of human bronchial epithelial cells: synergistic effect with epidermal growth factor

31 March 2020

1 reference

Trefoil peptides promote restitution of wounded corneal epithelial cells

31 March 2020

1 reference

Trefoil peptide protection of intestinal epithelial barrier function: cooperative interaction with mucin glycoprotein

31 March 2020

1 reference

The trefoil peptide TFF1 inhibits the growth of the human gastric adenocarcinoma cell line AGS.

31 March 2020

1 reference

Trefoil peptides as proangiogenic factors in vivo and in vitro: implication of cyclooxygenase-2 and EGF receptor signaling

31 March 2020

1 reference

Transgenic mice that overexpress the human trefoil peptide pS2 have an increased resistance to intestinal damage.

31 March 2020

1 reference

31 March 2020

1

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DK Podolsky

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Trefoil Peptide Gene Expression in Gastrointestinal Epithelial Cells in Inflammatory Bowel Disease

13 March 2024

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13 March 2024

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13 March 2024

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13 March 2024

Identifiers

DOI

10.1038/NRM1203

1 reference

8 August 2017

1 reference