(Q35548123)

English

Probing the mechanistic consequences of 5-fluorine substitution on cytidine nucleotide analogue incorporation by HIV-1 reverse transcriptase

scientific article published on May 2003

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scholarly article

1 reference

Europe PubMed Central

8 August 2017

1 reference

Europe PubMed Central

Probing the mechanistic consequences of 5-fluorine substitution on cytidine nucleotide analogue incorporation by HIV-1 reverse transcriptase (English)

1 reference

Europe PubMed Central

8 August 2017

Raymond F. Schinazi

2

object named as

Raymond F Schinazi

1 reference

Europe PubMed Central

8 August 2017

7

object named as

Chung K Chu

1 reference

Europe PubMed Central

8 August 2017

1

object named as

Adrian S Ray

1 reference

Europe PubMed Central

8 August 2017

5

object named as

Junxing Shi

1 reference

Europe PubMed Central

8 August 2017

Eisuke Murakami

3

object named as

Eisuke Murakami

1 reference

Europe PubMed Central

8 August 2017

Aravind Basavapathruni

4

object named as

Aravind Basavapathruni

1 reference

Europe PubMed Central

8 August 2017

6

object named as

Suzana M Zorca

1 reference

Europe PubMed Central

8 August 2017

author name string

Karen S Anderson

8

1 reference

Europe PubMed Central

8 August 2017

publication date

1 May 2003

1 reference

Europe PubMed Central

8 August 2017

Antiviral Chemistry & Chemotherapy

1 reference

Europe PubMed Central

8 August 2017

14

1 reference

Europe PubMed Central

8 August 2017

3

1 reference

Europe PubMed Central

8 August 2017

115-125

1 reference

Europe PubMed Central

8 August 2017

Selective assays for thymidine kinase 1 and 2 and deoxycytidine kinase and their activities in extracts from human cells and tissues.

1 reference

https://api.crossref.org/works/10.1177%2F095632020301400301

21 January 2018

A single side chain prevents Escherichia coli DNA polymerase I (Klenow fragment) from incorporating ribonucleotides

1 reference

https://api.crossref.org/works/10.1177%2F095632020301400301

21 January 2018

van der Waals Volumes and Radii

1 reference

https://api.crossref.org/works/10.1177%2F095632020301400301

21 January 2018

High-level resistance to (-) enantiomeric 2'-deoxy-3'-thiacytidine in vitro is due to one amino acid substitution in the catalytic site of human immunodeficiency virus type 1 reverse transcriptase

1 reference

https://api.crossref.org/works/10.1177%2F095632020301400301

21 January 2018

Analysis of mutations at positions 115 and 116 in the dNTP binding site of HIV-1 reverse transcriptase.

1 reference

https://api.crossref.org/works/10.1177%2F095632020301400301

21 January 2018

Inhibition of hepatitis C virus RNA replication by 2'-modified nucleoside analogs

1 reference

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21 January 2018

Synthesis and comparative evaluation of two antiviral agents: beta-L-Fd4C and beta-D-Fd4C.

1 reference

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21 January 2018

An exonucleolytic activity of human apurinic/apyrimidinic endonuclease on 3' mispaired DNA

1 reference

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21 January 2018

A novel action of human apurinic/apyrimidinic endonuclease: excision of L-configuration deoxyribonucleoside analogs from the 3' termini of DNA.

1 reference

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21 January 2018

Comparative activity of 2',3'-saturated and unsaturated pyrimidine and purine nucleosides against human immunodeficiency virus type 1 in peripheral blood mononuclear cells

1 reference

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21 January 2018

HIV population dynamics in vivo: implications for genetic variation, pathogenesis, and therapy

1 reference

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21 January 2018

Structure and functional implications of the polymerase active site region in a complex of HIV-1 RT with a double-stranded DNA template-primer and an antibody Fab fragment at 2.8 A resolution

1 reference

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21 January 2018

Inhibition of human immunodeficiency virus type 1 reverse transcriptase by the 5'-triphosphate beta enantiomers of cytidine analogs

1 reference

https://api.crossref.org/works/10.1177%2F095632020301400301

21 January 2018

Mechanistic studies comparing the incorporation of (+) and (-) isomers of 3TCTP by HIV-1 reverse transcriptase

1 reference

https://api.crossref.org/works/10.1177%2F095632020301400301

21 January 2018

Mechanistic studies examining the efficiency and fidelity of DNA synthesis by the 3TC-resistant mutant (184V) of HIV-1 reverse transcriptase

1 reference

https://api.crossref.org/works/10.1177%2F095632020301400301

21 January 2018

An analysis of the catalytic cycle of HIV-1 reverse transcriptase: opportunities for chemotherapeutic intervention based on enzyme inhibition

1 reference

https://api.crossref.org/works/10.1177%2F095632020301400301

21 January 2018

The role of steric hindrance in 3TC resistance of human immunodeficiency virus type-1 reverse transcriptase.

1 reference

https://api.crossref.org/works/10.1177%2F095632020301400301

21 January 2018

HIV-1 resistance profile of the novel nucleoside reverse transcriptase inhibitor beta-D-2',3'-dideoxy-2',3'-didehydro-5-fluorocytidine (Reverset).

1 reference

https://api.crossref.org/works/10.1177%2F095632020301400301

21 January 2018

3'-substituted 2',3'-dideoxynucleoside analogues as potential anti-HIV (HTLV-III/LAV) agents

1 reference

https://api.crossref.org/works/10.1177%2F095632020301400301

21 January 2018

Structure of a covalently trapped catalytic complex of HIV-1 reverse transcriptase: implications for drug resistance

1 reference

https://api.crossref.org/works/10.1177%2F095632020301400301

21 January 2018

Toxicity of antiviral nucleoside analogs and the human mitochondrial DNA polymerase.

1 reference

https://api.crossref.org/works/10.1177%2F095632020301400301

21 January 2018

Choosing the right sugar: how polymerases select a nucleotide substrate

1 reference

https://api.crossref.org/works/10.1177%2F095632020301400301

21 January 2018

RNA dependent DNA replication fidelity of HIV-1 reverse transcriptase: evidence of discrimination between DNA and RNA substrates

1 reference

https://api.crossref.org/works/10.1177%2F095632020301400301

21 January 2018

Asymmetric synthesis of 1,3-dioxolane-pyrimidine nucleosides and their anti-HIV activity

1 reference

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21 January 2018

1,3-dioxolanylpurine nucleosides (2R,4R) and (2R,4S) with selective anti-HIV-1 activity in human lymphocytes

1 reference

https://api.crossref.org/works/10.1177%2F095632020301400301

21 January 2018

Phosphorylation of pyrimidine deoxynucleoside analog diphosphates: selective phosphorylation of L-nucleoside analog diphosphates by 3-phosphoglycerate kinase

1 reference

https://api.crossref.org/works/10.1177%2F095632020301400301

21 January 2018

Interactions between drug resistance mutations in human immunodeficiency virus type 1 reverse transcriptase

1 reference

https://api.crossref.org/works/10.1177%2F095632020301400301

21 January 2018

Synthesis and anti-HIV and anti-HBV activities of 2'-fluoro-2', 3'-unsaturated L-nucleosides

1 reference

https://api.crossref.org/works/10.1177%2F095632020301400301

21 January 2018

Structure-activity relationships of 2'-fluoro-2',3'-unsaturated D-nucleosides as anti-HIV-1 agents

1 reference

https://api.crossref.org/works/10.1177%2F095632020301400301

21 January 2018

Understanding the mode of action of L-nucleosides as antiviral agents: a molecular modeling approach

1 reference

https://api.crossref.org/works/10.1177%2F095632020301400301

21 January 2018

Molecular modeling approach to understanding the mode of action of L-nucleosides as antiviral agents

1 reference

https://api.crossref.org/works/10.1177%2F095632020301400301

21 January 2018

Crystal structures of a ddATP-, ddTTP-, ddCTP, and ddGTP- trapped ternary complex of Klentaq1: insights into nucleotide incorporation and selectivity

1 reference

https://api.crossref.org/works/10.1177%2F095632020301400301

21 January 2018

Antiviral activity of 2',3'-dideoxy-beta-L-5-fluorocytidine (beta-L-FddC) and 2',3'-dideoxy-beta-L-cytidine (beta-L-ddC) against hepatitis B virus and human immunodeficiency virus type 1 in vitro

1 reference

https://api.crossref.org/works/10.1177%2F095632020301400301

21 January 2018

Design and synthesis of 2',3'-dideoxy-2',3'-didehydro-beta-L-cytidine (beta-L-d4C) and 2',3'-dideoxy 2',3'-didehydro-beta-L-5-fluorocytidine (beta-L-Fd4C), two exceptionally potent inhibitors of human hepatitis B virus (HBV) and potent inhibitors of

1 reference

https://api.crossref.org/works/10.1177%2F095632020301400301

21 January 2018

Acid-stable 2'-fluoro purine dideoxynucleosides as active agents against HIV

1 reference

https://api.crossref.org/works/10.1177%2F095632020301400301

21 January 2018

Fluorinated nucleosides

1 reference

https://api.crossref.org/works/10.1177%2F095632020301400301

21 January 2018

Interactions of enantiomers of 2',3'-didehydro-2',3'-dideoxy-fluorocytidine with wild type and M184V mutant HIV-1 reverse transcriptase

1 reference

https://api.crossref.org/works/10.1177%2F095632020301400301

21 January 2018

Insights into the molecular mechanism of inhibition and drug resistance for HIV-1 RT with carbovir triphosphate

1 reference

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21 January 2018

Structures of HIV-1 reverse transcriptase with pre- and post-translocation AZTMP-terminated DNA.

1 reference

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21 January 2018

Lamivudine (3TC) resistance in HIV-1 reverse transcriptase involves steric hindrance with beta-branched amino acids

1 reference

https://api.crossref.org/works/10.1177%2F095632020301400301

21 January 2018

Activities of the four optical isomers of 2',3'-dideoxy-3'-thiacytidine (BCH-189) against human immunodeficiency virus type 1 in human lymphocytes

1 reference

https://api.crossref.org/works/10.1177%2F095632020301400301

21 January 2018

Pure nucleoside enantiomers of beta-2',3'-dideoxycytidine analogs are selective inhibitors of hepatitis B virus in vitro

1 reference

https://api.crossref.org/works/10.1177%2F095632020301400301

21 January 2018

Characterization of human immunodeficiency viruses resistant to oxathiolane-cytosine nucleosides

1 reference

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21 January 2018

Selective inhibition of human immunodeficiency viruses by racemates and enantiomers of cis-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine

1 reference

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21 January 2018

DPC 817: a cytidine nucleoside analog with activity against zidovudine- and lamivudine-resistant viral variants

1 reference

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21 January 2018

In vitro and in vivo activity of 1-O-hexadecylpropanediol-3-phospho-ganciclovir and 1-O-hexadecylpropanediol-3-phospho-penciclovir in cytomegalovirus and herpes simplex virus infections.

1 reference

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21 January 2018

Rapid changes in human immunodeficiency virus type 1 RNA load and appearance of drug-resistant virus populations in persons treated with lamivudine (3TC).

1 reference

https://api.crossref.org/works/10.1177%2F095632020301400301

21 January 2018

Synthesis and biological evaluation of 2',3'-didehydro-2',3'- dideoxy-5-fluorocytidine (D4FC) analogues: discovery of carbocyclic nucleoside triphosphates with potent inhibitory activity against HIV-1 reverse transcriptase

1 reference

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21 January 2018

Ribonucleoside Analogue That Blocks Replication of Bovine Viral Diarrhea and Hepatitis C Viruses in Culture

1 reference

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21 January 2018

Rapid in vitro selection of human immunodeficiency virus type 1 resistant to 3'-thiacytidine inhibitors due to a mutation in the YMDD region of reverse transcriptase

1 reference

https://api.crossref.org/works/10.1177%2F095632020301400301

21 January 2018

Effect of anti-HIV 2'-beta-fluoro-2',3'-dideoxynucleoside analogs on the cellular content of mitochondrial DNA and on lactate production.

1 reference

https://api.crossref.org/works/10.1177%2F095632020301400301

21 January 2018

Mechanism of inhibition of the human immunodeficiency virus type 1 reverse transcriptase by d4TTP: an equivalent incorporation efficiency relative to the natural substrate dTTP

1 reference

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21 January 2018

Nucleosides. 123. Synthesis of antiviral nucleosides: 5-substituted 1-(2-deoxy-2-halogeno-.beta.-D-arabinofuranosyl)cytosines and -uracils. Some structure-activity relationships

1 reference

https://api.crossref.org/works/10.1177%2F095632020301400301

21 January 2018

Identifiers

10.1177/095632020301400301

1 reference

Europe PubMed Central

8 August 2017

1 reference

Europe PubMed Central

8 August 2017

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