(Q35549296)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25622091%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

title

Inhibition of PAD4 activity is sufficient to disrupt mouse and human NET formation (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25622091%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25622091%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

Kimberly Martinod

19

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25622091%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

Daniel J Slade

25

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25622091%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

Gerard Drewes

29

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25622091%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

30

Denisa D Wagner

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25622091%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

11

Chun-Wa Chung

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25622091%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

author name string

Huw D Lewis

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25622091%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

John Liddle

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25622091%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

Jim E Coote

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25622091%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

Stephen J Atkinson

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25622091%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

Michael D Barker

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25622091%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

Kevin L Bicker

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25622091%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

Ryan P Bingham

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25622091%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

Matthew Campbell

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25622091%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

Yu Hua Chen

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25622091%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

Peter D Craggs

12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25622091%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

Rob P Davis

13

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25622091%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

Dirk Eberhard

14

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25622091%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

Gerard Joberty

15

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25622091%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

Kenneth E Lind

16

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25622091%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

Kelly Locke

17

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25622091%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

Claire Maller

18

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25622091%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

Chris Patten

20

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25622091%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

Oxana Polyakova

21

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25622091%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

Cecil E Rise

22

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25622091%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

Martin Rüdiger

23

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25622091%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

Robert J Sheppard

24

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25622091%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

Pamela Thomas

26

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25622091%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

Jim Thorpe

27

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25622091%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

Gang Yao

28

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25622091%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

Paul R Thompson

31

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25622091%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

Rab K Prinjha

32

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25622091%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

David M Wilson

33

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25622091%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

publication date

26 January 2015

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25622091%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

published in

Nature Chemical Biology

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25622091%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

volume

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25622091%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

issue

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25622091%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

page(s)

189-191

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25622091%20AND%20SRC:MED&resulttype=core&format=json

describes a project that uses

28 February 2020

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4397581/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

exact match

https://scigraph.springernature.com/pub.10.1038/nchembio.1735

0 references

cites work

A FluoPol-ABPP PAD2 high-throughput screen identifies the first calcium site inhibitor targeting the PADs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4397581

Erosive rheumatoid arthritis is associated with antibodies that activate PAD4 by increasing calcium sensitivity

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4397581

Cancers predispose neutrophils to release extracellular DNA traps that contribute to cancer-associated thrombosis

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4397581

Exploiting structure similarity in refinement: automated NCS and target-structure restraints in BUSTER

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4397581

Synthesis and Screening of a Haloacetamidine Containing Library To Identify PAD4 Selective Inhibitors

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4397581

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4397581

Getting physical in drug discovery II: the impact of chromatographic hydrophobicity measurements and aromaticity

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4397581

Netting neutrophils induce endothelial damage, infiltrate tissues, and expose immunostimulatory molecules in systemic lupus erythematosus.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4397581

Autodeimination of protein arginine deiminase 4 alters protein-protein interactions but not activity

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4397581

REFMAC5 for the refinement of macromolecular crystal structures

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4397581

PAD4 is essential for antibacterial innate immunity mediated by neutrophil extracellular traps

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4397581

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4397581

Impairment of neutrophil extracellular trap degradation is associated with lupus nephritis

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4397581

Features and development of Coot

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4397581

Coordination of PAD4 and HDAC2 in the regulation of p53-target gene expression

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4397581

PHENIX: a comprehensive Python-based system for macromolecular structure solution

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4397581

Protein arginine deiminase 4 (PAD4): Current understanding and future therapeutic potential

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4397581

Design, synthesis and selection of DNA-encoded small-molecule libraries

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4397581

Regulation of p53 target gene expression by peptidylarginine deiminase 4

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4397581

Quantitative chemical proteomics reveals mechanisms of action of clinical ABL kinase inhibitors

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4397581

Platelet TLR4 activates neutrophil extracellular traps to ensnare bacteria in septic blood

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4397581

Novel cell death program leads to neutrophil extracellular traps

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4397581

Inhibitors and inactivators of protein arginine deiminase 4: functional and structural characterization.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4397581

A fluoroacetamidine-based inactivator of protein arginine deiminase 4: design, synthesis, and in vitro and in vivo evaluation

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4397581

Kinetic characterization of protein arginine deiminase 4: a transcriptional corepressor implicated in the onset and progression of rheumatoid arthritis

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4397581

Neutrophil extracellular traps kill bacteria

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4397581

A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4397581

Crystal structure and mechanism of human L-arginine:glycine amidinotransferase: a mitochondrial enzyme involved in creatine biosynthesis

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4397581

Neutrophils from vasculitis patients exhibit an increased propensity for activation by anti-neutrophil cytoplasmic antibodies.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4397581

Neutrophil histone modification by peptidylarginine deiminase 4 is critical for deep vein thrombosis in mice.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4397581

Anticancer peptidylarginine deiminase (PAD) inhibitors regulate the autophagy flux and the mammalian target of rapamycin complex 1 activity.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4397581

Activation of the Raf-MEK-ERK pathway is required for neutrophil extracellular trap formation.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4397581

Substrate specificity and kinetic studies of PADs 1, 3, and 4 identify potent and selective inhibitors of protein arginine deiminase 3.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4397581

Structural basis for Ca(2+)-induced activation of human PAD4

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4397581

Fluorogenic reaction and specific microdetermination of ammonia

26 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25622091

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NCHEMBIO.1735

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25622091%20AND%20SRC:MED&resulttype=core&format=json

release_rhl4hwcytndmtkxncivqbnobrm

28 February 2020

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/rhl4hwcytndmtkxncivqbnobrm

mapped directly with Wikidata item

24 November 2022

based on heuristic

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25622091%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

1 reference