(Q35550073)

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The translation inhibitor silvestrol exhibits direct anti-tumor activity while preserving innate and adaptive immunity against EBV-driven lymphoproliferative disease

scientific article published on February 2015

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scholarly article

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Europe PubMed Central

PubMed publication ID

8 August 2017

The translation inhibitor silvestrol exhibits direct anti-tumor activity while preserving innate and adaptive immunity against EBV-driven lymphoproliferative disease (English)

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Europe PubMed Central

PubMed publication ID

8 August 2017

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object named as

A Douglas Kinghorn

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8 August 2017

author name string

John T Patton

1

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8 August 2017

Mark E Lustberg

2

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8 August 2017

Gerard Lozanski

3

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8 August 2017

Sabrina L Garman

4

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8 August 2017

William H Towns

5

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8 August 2017

Callie M Drohan

6

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8 August 2017

Amy Lehman

7

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8 August 2017

Xiaoli Zhang

8

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8 August 2017

Brad Bolon

9

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8 August 2017

Li Pan

10

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8 August 2017

Michael R Grever

12

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8 August 2017

David M Lucas

13

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8 August 2017

Robert A Baiocchi

14

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8 August 2017

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publication date

1 February 2015

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8 August 2017

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8 August 2017

6

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8 August 2017

5

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Europe PubMed Central

PubMed publication ID

8 August 2017

2693-2708

1 reference

Europe PubMed Central

PubMed publication ID

8 August 2017

Therapeutic potential of the translation inhibitor silvestrol in hepatocellular cancer

1 reference

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Evidence for a functionally relevant rocaglamide binding site on the eIF4A-RNA complex

1 reference

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12 July 2018

Silvestrol exhibits significant in vivo and in vitro antileukemic activities and inhibits FLT3 and miR-155 expressions in acute myeloid leukemia

1 reference

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Dual targeting of the cyclin/Rb/E2F and mitochondrial pathways in mantle cell lymphoma with the translation inhibitor silvestrol.

1 reference

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Epstein-Barr virus: an important vaccine target for cancer prevention

1 reference

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12 July 2018

Characterization of silvestrol pharmacokinetics in mice using liquid chromatography-tandem mass spectrometry

1 reference

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Visualization and quantification of cytotoxicity mediated by antibodies using imaging flow cytometry.

1 reference

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12 July 2018

EBV and HIV-Related Lymphoma

1 reference

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Age-related EBV-associated lymphoproliferative disorders in the Western population: a spectrum of reactive lymphoid hyperplasia and lymphoma

1 reference

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Epstein-Barr virus LMP1 activates EGFR, STAT3, and ERK through effects on PKCdelta

1 reference

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Combination anti-CD74 (milatuzumab) and anti-CD20 (rituximab) monoclonal antibody therapy has in vitro and in vivo activity in mantle cell lymphoma

1 reference

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A new model of Epstein-Barr virus infection reveals an important role for early lytic viral protein expression in the development of lymphomas

1 reference

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A Therapeutic Approach to Nasopharyngeal Carcinomas by DNAzymes Targeting EBV LMP-1 Gene

1 reference

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12 July 2018

Evaluation of LMP1 of Epstein-Barr virus as a therapeutic target by its inhibition

1 reference

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12 July 2018

The interplay between Epstein-Barr virus and the immune system: a rationale for adoptive cell therapy of EBV-related disorders

1 reference

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Chemotherapy enhances tumor cell susceptibility to CTL-mediated killing during cancer immunotherapy in mice

1 reference

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12 July 2018

Synergistic effect of inhibiting translation initiation in combination with cytotoxic agents in acute myelogenous leukemia cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4413611

12 July 2018

Antitumor activity and mechanism of action of the cyclopenta[b]benzofuran, silvestrol

1 reference

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12 July 2018

The novel plant-derived agent silvestrol has B-cell selective activity in chronic lymphocytic leukemia and acute lymphoblastic leukemia in vitro and in vivo

1 reference

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12 July 2018

Chronic lymphocytic leukemia T cells show impaired immunological synapse formation that can be reversed with an immunomodulating drug

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4413611

12 July 2018

Therapeutic suppression of translation initiation modulates chemosensitivity in a mouse lymphoma model

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4413611

12 July 2018

Epstein-Barr virus latent membrane protein 1 induces expression of the epidermal growth factor receptor through effects on Bcl-3 and STAT3.

1 reference

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12 July 2018

EBV latent membrane protein 1 activates Akt, NFkappaB, and Stat3 in B cell lymphomas

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4413611

12 July 2018

Silvestrol, a potential anticancer rocaglate derivative from Aglaia foveolata, induces apoptosis in LNCaP cells through the mitochondrial/apoptosome pathway without activation of executioner caspase-3 or -7.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4413611

12 July 2018

Silencing of LMP1 induces cell cycle arrest and enhances chemosensitivity through inhibition of AKT signaling pathway in EBV-positive nasopharyngeal carcinoma cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4413611

12 July 2018

Antibody-dependent cellular cytotoxicity mediated by cetuximab against lung cancer cell lines

1 reference

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12 July 2018

Latent membrane protein 1 regulates STAT1 through NF-kappaB-dependent interferon secretion in Epstein-Barr virus-immortalized B cells

1 reference

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12 July 2018

Selective efficacy of depsipeptide in a xenograft model of Epstein-Barr virus-positive lymphoproliferative disorder.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4413611

12 July 2018

Silvestrol and episilvestrol, potential anticancer rocaglate derivatives from Aglaia silvestris

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4413611

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A positive autoregulatory loop of LMP1 expression and STAT activation in epithelial cells latently infected with Epstein-Barr virus.

1 reference

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Epstein-Barr virus latent membrane protein 1 (LMP1) activates the phosphatidylinositol 3-kinase/Akt pathway to promote cell survival and induce actin filament remodeling

1 reference

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Generating CTLs against the subdominant Epstein-Barr virus LMP1 antigen for the adoptive immunotherapy of EBV-associated malignancies

1 reference

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Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

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GM-CSF and IL-2 induce specific cellular immunity and provide protection against Epstein-Barr virus lymphoproliferative disorder

1 reference

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Antisense to the Epstein-Barr virus (EBV)-encoded latent membrane protein 1 (LMP-1) sensitizes EBV-immortalized B cells to transforming growth factor-beta and chemotherapeutic agents

1 reference

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1 reference

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hu-PBL-SCID mice: an in vivo model of Epstein-Barr virus-dependent lymphoproliferative disease

1 reference

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Latent membrane protein 1 of Epstein-Barr virus mimics a constitutively active receptor molecule.

1 reference

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Low-dose interleukin 2 prevents the development of Epstein-Barr virus (EBV)-associated lymphoproliferative disease in scid/scid mice reconstituted i.p. with EBV-seropositive human peripheral blood lymphocytes

1 reference

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1 reference

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Epstein-Barr virus-induced human B-cell lymphomas in SCID mice reconstituted with human peripheral blood leukocytes

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Synthesis of biotinylated episilvestrol: highly selective targeting of the translation factors eIF4AI/II.

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Silvestrol regulates G2/M checkpoint genes independent of p53 activity.

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1 reference

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12 December 2020

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Identifiers

10.18632/ONCOTARGET.2098

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PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

8 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

8 August 2017

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