(Q35551884)

English

Cyclic lactam hybrid α-MSH/Agouti-related protein (AGRP) analogues with nanomolar range binding affinities at the human melanocortin receptors

scientific article published on 13 March 2011

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

8 August 2017

Cyclic lactam hybrid α-MSH/Agouti-related protein (AGRP) analogues with nanomolar range binding affinities at the human melanocortin receptors (English)

1 reference

Europe PubMed Central

PubMed publication ID

8 August 2017

author name string

Alexander V Mayorov

1

1 reference

Europe PubMed Central

PubMed publication ID

8 August 2017

Minying Cai

2

1 reference

Europe PubMed Central

PubMed publication ID

8 August 2017

Erin S Palmer

3

1 reference

Europe PubMed Central

PubMed publication ID

8 August 2017

Dustin K Tanaka

4

1 reference

Europe PubMed Central

PubMed publication ID

8 August 2017

James P Cain

5

1 reference

Europe PubMed Central

PubMed publication ID

8 August 2017

Matthew M Dedek

6

1 reference

Europe PubMed Central

PubMed publication ID

8 August 2017

Bahar Tan

7

1 reference

Europe PubMed Central

PubMed publication ID

8 August 2017

Dev Trivedi

8

1 reference

Europe PubMed Central

PubMed publication ID

8 August 2017

Victor J Hruby

9

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Europe PubMed Central

PubMed publication ID

8 August 2017

language of work or name

0 references

publication date

13 March 2011

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Europe PubMed Central

PubMed publication ID

8 August 2017

Bioorganic & Medicinal Chemistry Letters

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Europe PubMed Central

PubMed publication ID

8 August 2017

21

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Europe PubMed Central

PubMed publication ID

8 August 2017

10

1 reference

Europe PubMed Central

PubMed publication ID

8 August 2017

3099-3102

1 reference

Europe PubMed Central

PubMed publication ID

8 August 2017

Solid-phase peptide head-to-side chain cyclodimerization: Discovery of C2-symmetric cyclic lactam hybrid α-melanocyte-stimulating hormone (MSH)/agouti-signaling protein (ASIP) analogues with potent activities at the human melanocortin receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3216836

12 July 2018

Substitution of arginine with proline and proline derivatives in melanocyte-stimulating hormones leads to selectivity for human melanocortin 4 receptor

1 reference

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Alpha-melanocyte-stimulating hormone and related tripeptides: biochemistry, antiinflammatory and protective effects in vitro and in vivo, and future perspectives for the treatment of immune-mediated inflammatory diseases

1 reference

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12 July 2018

Targeting melanocortin receptors: an approach to treat weight disorders and sexual dysfunction

1 reference

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Designing drugs for the treatment of female sexual dysfunction

1 reference

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12 July 2018

Melanocortin receptors, melanotropic peptides and penile erection

1 reference

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12 July 2018

Design, synthesis and biological evaluation of ligands selective for the melanocortin-3 receptor

1 reference

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12 July 2018

Novel selective human melanocortin-3 receptor ligands: use of the 4-amino-1,2,4,5-tetrahydro-2-benzazepin-3-one (Aba) scaffold

1 reference

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12 July 2018

Studies on the physiological functions of the melanocortin system

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3216836

12 July 2018

Development of cyclic gamma-MSH analogues with selective hMC3R agonist and hMC3R/hMC5R antagonist activities

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3216836

12 July 2018

Current trends in the structure-activity relationship studies of the endogenous agouti-related protein (AGRP) melanocortin receptor antagonist

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3216836

12 July 2018

Design of cyclic and other templates for potent and selective peptide alpha-MSH analogues

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3216836

12 July 2018

Chimeras of the agouti-related protein: insights into agonist and antagonist selectivity of melanocortin receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3216836

12 July 2018

Design of novel melanotropin agonists and antagonists with high potency and selectivity for human melanocortin receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3216836

12 July 2018

Novel 3D pharmacophore of alpha-MSH/gamma-MSH hybrids leads to selective human MC1R and MC3R analogues

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3216836

12 July 2018

Chimeric NDP-MSH and MTII melanocortin peptides with agouti-related protein (AGRP) Arg-Phe-Phe amino acids possess agonist melanocortin receptor activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3216836

12 July 2018

Identification of putative agouti-related protein(87-132)-melanocortin-4 receptor interactions by homology molecular modeling and validation using chimeric peptide ligands

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3216836

12 July 2018

Biological and conformational study of beta-substituted prolines in MT-II template: steric effects leading to human MC5 receptor selectivity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3216836

12 July 2018

Melanocortin ligands: 30 years of structure-activity relationship (SAR) studies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3216836

12 July 2018

Solution structures of cyclic melanocortin agonists and antagonists by NMR.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3216836

12 July 2018

Melanocortin-5 receptor deficiency promotes defensive behavior in male mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3216836

12 July 2018

Recent developments in our understanding of melanocortin system in the regulation of food intake

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3216836

12 July 2018

Discovery and in vivo evaluation of new melanocortin-4 receptor-selective peptides.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3216836

12 July 2018

Elongation studies of the human agouti-related protein (AGRP) core decapeptide (Yc[CRFFNAFC]Y) results in antagonism at the mouse melanocortin-3 receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3216836

12 July 2018

The melanocortin-1 receptor gene mediates female-specific mechanisms of analgesia in mice and humans

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3216836

12 July 2018

Design, pharmacology, and NMR structure of a minimized cystine knot with agouti-related protein activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3216836

12 July 2018

High-resolution NMR structure of the chemically-synthesized melanocortin receptor binding domain AGRP(87-132) of the agouti-related protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3216836

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Neuropathic pain: a possible role for the melanocortin system?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3216836

12 July 2018

Molecular interaction of Agouti protein and Agouti-related protein with human melanocortin receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3216836

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Synthetic melanotropic peptide initiates erections in men with psychogenic erectile dysfunction: double-blind, placebo controlled crossover study

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3216836

12 July 2018

Melanocortin receptor binding determinants in the agouti protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3216836

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Exocrine gland dysfunction in MC5-R-deficient mice: evidence for coordinated regulation of exocrine gland function by melanocortin peptides

1 reference

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Antagonism of central melanocortin receptors in vitro and in vivo by agouti-related protein

1 reference

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12 July 2018

Role of melanocortinergic neurons in feeding and the agouti obesity syndrome

1 reference

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Molecular cloning, expression, and gene localization of a fourth melanocortin receptor

1 reference

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Binding and cAMP studies of melanotropin peptides with the cloned human peripheral melanocortin receptor, hMC1R.

1 reference

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Agouti protein is an antagonist of the melanocyte-stimulating-hormone receptor

1 reference

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Cyclic lactam alpha-melanotropin analogues of Ac-Nle4-cyclo[Asp5, D-Phe7,Lys10] alpha-melanocyte-stimulating hormone-(4-10)-NH2 with bulky aromatic amino acids at position 7 show high antagonist potency and selectivity at specific melanocortin recep

1 reference

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4-Norleucine, 7-D-phenylalanine-alpha-melanocyte-stimulating hormone: a highly potent alpha-melanotropin with ultralong biological activity

1 reference

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Anti-microbial action of melanocortin peptides and identification of a novel X-Pro-D/L-Val sequence in Gram-positive and Gram-negative bacteria

1 reference

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Central receptors mediating the cardiovascular actions of melanocyte stimulating hormones

1 reference

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26 September 2018

Exploring the stereostructural requirements of peptide ligands for the melanocortin receptors

1 reference

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alpha-Melanocyte-stimulating hormone inhibits lipopolysaccharide-induced tumor necrosis factor-alpha production in leukocytes by modulating protein kinase A, p38 kinase, and nuclear factor kappa B signaling pathways.

1 reference

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alpha-Melanotropin: the minimal active sequence in the frog skin bioassay

1 reference

https://pubmed.ncbi.nlm.nih.gov/21486697

12 December 2020

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10.1016/J.BMCL.2011.03.019

1 reference

Europe PubMed Central

PubMed publication ID

8 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

8 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

8 August 2017

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