(Q35552842)

8 August 2017

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title

Antinociception and the new COX inhibitors: research approaches and clinical perspectives (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6741672&resulttype=core&format=json

12 May 2020

1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6741672&resulttype=core&format=json

12 May 2020

author name string

E Alfonso Romero-Sandoval

series ordinal

2

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6741672&resulttype=core&format=json

12 May 2020

Gema Gaitan

series ordinal

3

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6741672&resulttype=core&format=json

12 May 2020

Javier Mazario

series ordinal

4

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6741672&resulttype=core&format=json

12 May 2020

language of work or name

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1 January 2003

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CNS Neuroscience & Therapeutics

8 August 2017

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6741672&resulttype=core&format=json

12 May 2020

volume

9

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6741672&resulttype=core&format=json

12 May 2020

issue

3

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6741672&resulttype=core&format=json

12 May 2020

page(s)

227-252

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6741672&resulttype=core&format=json

In Vivo Antithrombotic Effects of a Nitric Oxide-Releasing Aspirin Derivative, NCX-4016

12 May 2020

cites work

1 reference

12 December 2020

Characterization of rofecoxib as a cyclooxygenase-2 isoform inhibitor and demonstration of analgesia in the dental pain model

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12 December 2020

Selective COX-2 inhibitors: is the water becoming muddy?

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12 December 2020

Celecoxib, a COX-2--specific inhibitor: the clinical data

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12 December 2020

Effects of specific inhibition of cyclooxygenase-2 on sodium balance, hemodynamics, and vasoactive eicosanoids

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12 December 2020

Gastrointestinal safety of nitric oxide-derived aspirin is related to inhibition of ICE-like cysteine proteases in rats

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12 December 2020

COX 2-selective NSAIDs: biology, promises, and concerns

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12 December 2020

Cyclooxygenase-2 specificity and its clinical implications

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12 December 2020

Rofecoxib [Vioxx, MK-0966; 4-(4'-methylsulfonylphenyl)-3-phenyl-2-(5H)-furanone]: a potent and orally active cyclooxygenase-2 inhibitor. Pharmacological and biochemical profiles

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12 December 2020

Synergistic antiallodynic effects of spinal morphine with ketorolac and selective COX1- and COX2-inhibitors in nerve-injured rats☆

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12 December 2020

NO-aspirins: a class of new anti-inflammatory and antithrombotic agents.

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12 December 2020

A randomized trial comparing the effect of rofecoxib, a cyclooxygenase 2-specific inhibitor, with that of ibuprofen on the gastroduodenal mucosa of patients with osteoarthritis. Rofecoxib Osteoarthritis Endoscopy Study Group

1 reference

12 December 2020

Celecoxib, a selective cyclooxygenase-2 inhibitor for the treatment of rheumatoid arthritis and osteoarthritis

1 reference

12 December 2020

Treatment of osteoarthritis with celecoxib, a cyclooxygenase-2 inhibitor: a randomized controlled trial

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12 December 2020

Comparison of rofecoxib and celecoxib, two cyclooxygenase-2 inhibitors, in postoperative dental pain: a randomized, placebo- and active-comparator-controlled clinical trial

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12 December 2020

Anti-inflammatory and upper gastrointestinal effects of celecoxib in rheumatoid arthritis: a randomized controlled trial

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12 December 2020

Celecoxib versus diclofenac in long-term management of rheumatoid arthritis: randomised double-blind comparison.

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12 December 2020

Distribution and expression of cyclooxygenase (COX) isoenzymes, their physiological roles, and the categorization of nonsteroidal anti-inflammatory drugs (NSAIDs).

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12 December 2020

Effects of nonsteroidal anti-inflammatory drugs on renal function: focus on cyclooxygenase-2-selective inhibition

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12 December 2020

Cyclo-oxygenase-inhibitors increase morphine effects on mesolimbic dopamine neurons

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12 December 2020

NO-aspirin protects from T cell–mediated liver injury by inhibiting caspase-dependent processing of Th1-like cytokines

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12 December 2020

A comparison of the anti-inflammatory and anti-nociceptive activity of nitroaspirin and aspirin

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12 December 2020

COX-1, COX-2, and COX-3 and the future treatment of chronic inflammatory disease

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12 December 2020

Wind-up of spinal cord neurones and pain sensation: much ado about something?

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12 December 2020

Myocardial protection by the nitroderivative of aspirin, NCX 4016: in vitro and in vivo experiments in the rabbit.

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12 December 2020

Rheumatoid arthritis. New disease-modifying and anti-inflammatory drugs

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12 December 2020

Selective cyclo-oxygenase-2 inhibition with celecoxib elevates blood pressure and promotes leukocyte adherence

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12 December 2020

Rofecoxib, a specific inhibitor of cyclooxygenase 2, with clinical efficacy comparable with that of diclofenac sodium: results of a one-year, randomized, clinical trial in patients with osteoarthritis of the knee and hip. Rofecoxib Phase III Protoco

1 reference

12 December 2020

COX-2 inhibitors and dental pain control.

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12 December 2020

Effects of celecoxib and naproxen on renal function in the elderly

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12 December 2020

Prevention of pulmonary thromboembolism by NCX 4016, a nitric oxide-releasing aspirin

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12 December 2020

COX-2 selective nonsteroidal anti-Inflammatory drugs: do they really offer any advantages?

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12 December 2020

NO-naproxen modulates inflammation, nociception and downregulates T cell response in rat Freund's adjuvant arthritis

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12 December 2020

A review of the pharmacokinetic and pharmacodynamic factors in the potentiation of the antinociceptive effect of nonsteroidal anti-inflammatory drugs by caffeine

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12 December 2020

Nitroparacetamol exhibits anti-inflammatory and anti-nociceptive activity

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12 December 2020

Gastrointestinal toxicity with celecoxib vs nonsteroidal anti-inflammatory drugs for osteoarthritis and rheumatoid arthritis: the CLASS study: A randomized controlled trial. Celecoxib Long-term Arthritis Safety Study

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12 December 2020

Management of Inflammatory Pain with Selective COX-2 Inhibitors: Promises and Facts

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12 December 2020

Antiinflammatory and analgesic efficacy of COX-2 specific inhibition: from investigational trials to clinical experience.

1 reference

12 December 2020

Nitrosothiol esters of diclofenac: synthesis and pharmacological characterization as gastrointestinal-sparing prodrugs

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12 December 2020

Comparison of upper gastrointestinal toxicity of rofecoxib and naproxen in patients with rheumatoid arthritis. VIGOR Study Group

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12 December 2020

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12 December 2020

A comparison of the effect of nitroparacetamol and paracetamol on liver injury

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12 December 2020

Cyclooxygenase inhibition and thrombogenicity

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12 December 2020

Nitric oxide: a novel link between synaptic and nonsynaptic transmission

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12 December 2020

Prostaglandins and cyclooxygenases [correction of cycloxygenases] in the spinal cord

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12 December 2020

The dual effect of a nitric oxide donor in nociception.

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12 December 2020

Renal safety and tolerability of celecoxib, a novel cyclooxygenase-2 inhibitor

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12 December 2020

NO-releasing NSAIDs are caspase inhibitors

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12 December 2020

Clinical pharmacokinetics of dexketoprofen

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12 December 2020

Cyclooxygenase-1 vs. cyclooxygenase-2 inhibitors in the induction of antinociception in rodent withdrawal reflexes.

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12 December 2020

Early-morning administration of dexketoprofen-trometamol in morning stiffness induced by nodal osteoarthritis of the hands.

1 reference

12 December 2020

Understanding NSAIDs: from aspirin to COX-2

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12 December 2020

New issues about nitric oxide and its effects on the gastrointestinal tract

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12 December 2020

Interaction between the antinociceptive effect of ketoprofen and adrenergic modulatory systems

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12 December 2020

Upper gastrointestinal safety evaluation of parecoxib sodium, a new parenteral cyclooxygenase-2-specific inhibitor, compared with ketorolac, naproxen, and placebo

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12 December 2020

Subeffective doses of dexketoprofen trometamol enhance the potency and duration of fentanyl antinociception

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12 December 2020

A NO-releasing derivative of acetaminophen spares the liver by acting at several checkpoints in the Fas pathway.

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12 December 2020

Nitric-oxide releasing molecules: a new class of drugs with several major indications

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12 December 2020

Valdecoxib is more efficacious than rofecoxib in relieving pain associated with oral surgery

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12 December 2020

NCX-701 (nitroparacetamol) is an effective antinociceptive agent in rat withdrawal reflexes and wind-up.

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12 December 2020

An evidence-based evaluation of the gastrointestinal safety of coxibs

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12 December 2020

Cyclooxygenase-2 inhibition and renal physiology

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12 December 2020

Cardiovascular pharmacology of nonselective nonsteroidal anti-inflammatory drugs and coxibs: clinical considerations

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12 December 2020

Selective cyclooxygenase-2 (COX-2) inhibitors and potential risk of cardiovascular events.

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12 December 2020

Colon cancer prevention with NO-releasing NSAIDs

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12 December 2020

[A critical evaluation of side effect data on COX-2 inhibitors].

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12 December 2020

The analgesic efficacy of valdecoxib vs. oxycodone/acetaminophen after oral surgery

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12 December 2020

COX-3, a cyclooxygenase-1 variant inhibited by acetaminophen and other analgesic/antipyretic drugs: cloning, structure, and expression

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12 December 2020

Modulation of NSAID-induced antinociceptive and anti-inflammatory effects by alpha2-adrenoceptor agonists with gastroprotective effects

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12 December 2020

Nitric oxide donors increase mucus gel thickness in rat stomach.

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12 December 2020

Human cyclooxygenase-2 cDNA

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12 December 2020

Lipopolysaccharide induces prostaglandin H synthase-2 in alveolar macrophages

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12 December 2020

Pure enantiomers of 2-arylpropionic acids: tools in pain research and improved drugs in rheumatology

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12 December 2020

Intravenous Diclofenac Coupled with PCA Fentanyl for Pain Relief after Total Hip Replacement

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12 December 2020

A serum- and glucocorticoid-regulated 4-kilobase mRNA encodes a cyclooxygenase-related protein

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12 December 2020

Expression of a mitogen-responsive gene encoding prostaglandin synthase is regulated by mRNA splicing

1 reference

12 December 2020

Double-blind comparison of the morphine sparing effect of continuous and intermittent i.m. administration of ketorolac.

1 reference

12 December 2020

Opioids activate both an inward rectifier and a novel voltage-gated potassium conductance in the hippocampal formation

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12 December 2020

Comparison of long-term safety of ketorolac tromethamine and aspirin in the treatment of chronic pain

1 reference

12 December 2020

Copper complexes offer a physiological approach to treatment of chronic diseases

1 reference

12 December 2020

Evidence for a role of the NMDA receptor in the frequency dependent potentiation of deep rat dorsal horn nociceptive neurones following C fibre stimulation

1 reference

12 December 2020

Evidence for involvement of N-methylaspartate receptors in 'wind-up' of class 2 neurones in the dorsal horn of the rat.

1 reference

12 December 2020

Tizanidine and ibuprofen in acute low-back pain: results of a double-blind multicentre study in general practice

1 reference

12 December 2020

On steroid-saving drug combinations in carrageenin paw edema and adjuvant arthritis

1 reference

12 December 2020

The morphine sparing effect of ketorolac tromethamine. A study of a new, parenteral non-steroidal anti-inflammatory agent after abdominal surgery.

1 reference

12 December 2020

Comparison of intramuscular ketorolac tromethamine and morphine sulfate for analgesia of pain after major surgery

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12 December 2020

Anti-inflammatory and PG inhibitory effects of phenacetin and acetaminophen

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12 December 2020

Relief of pain by oral medications. A controlled evaluation of analgesic combinations

1 reference

12 December 2020

Effects of Caffeine on the Absorption and Analgesic Efficacy of Paracetamol in Rats

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12 December 2020

Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs

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12 December 2020

Double-blind controlled trial of indomethacin as an adjunct to narcotic analgesia after major abdominal surgery

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12 December 2020

A comparison of the anti-inflammatory effects of copper aspirinate and other copper salts in the rat and guinea pig

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12 December 2020

The anti-inflammatory, analgesic and antipyretic activities of non-narcotic analgesic drug mixtures in rats.

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12 December 2020

Renal abnormalities and an altered inflammatory response in mice lacking cyclooxygenase II.

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12 December 2020

Prostaglandin E2 stimulates glutamate release from synaptosomes of rat spinal cord

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12 December 2020

A nitric oxide-releasing nonsteroidal anti-inflammatory drug accelerates gastric ulcer healing in rats

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12 December 2020

Combination of intramuscular Ketorolac and low dose epidural morphine for the relief of post-caesarean pain.

1 reference

12 December 2020

Plasma concentrations and pharmacokinetic parameters of nitrofenac using a simple and sensitive HPLC method

1 reference

12 December 2020

Anti-inflammatory potency and gastrointestinal toxicity of a new compound, nitronaproxen.

1 reference

12 December 2020

Non-steroidal anti-inflammatory drugs and spinal nociceptive processing

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12 December 2020

Comparison of morphine and ketorolac for intravenous patient-controlled analgesia in postoperative cancer patients

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12 December 2020

Pharmacological and biochemical demonstration of the role of cyclooxygenase 2 in inflammation and pain

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12 December 2020

Ketorolac potentiates morphine antinociception during visceral nociception in the rat.

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12 December 2020

Novel nonsteroidal anti-inflammatory drug derivatives with markedly reduced ulcerogenic properties in the rat

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12 December 2020

Pharmacology of the spinal action of ketorolac, morphine, ST-91, U50488H, and L-PIA on the formalin test and an isobolographic analysis of the NSAID interaction

1 reference

12 December 2020

Thirteenth Gaddum Memorial Lecture. Neuronal and endothelium-derived mediators in the modulation of the gastric microcirculation: integrity in the balance

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12 December 2020

Is copper pro- or anti-inflammatory? A reconciling view and a novel approach for the use of copper in the control of inflammation

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12 December 2020

Prostaglandin synthase 2 gene disruption causes severe renal pathology in the mouse.

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12 December 2020

Prostaglandin synthase 1 gene disruption in mice reduces arachidonic acid-induced inflammation and indomethacin-induced gastric ulceration.

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12 December 2020

Anti-thrombotic effects of a nitric oxide-releasing, gastric-sparing aspirin derivative

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12 December 2020

Supraspinal influences on the facilitation of rat nociceptive reflexes induced by carrageenan monoarthritis

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12 December 2020

In vitro study of the anti-aggregating activity of two nitroderivatives of acetylsalicylic acid.

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12 December 2020

Enhanced effects of co-administered dexamethasone and diclofenac on inflammatory pain processing and associated spinal c-Fos expression in the rat.

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12 December 2020

Reversal by naloxone of the spinal antinociceptive actions of a systemically-administered NSAID.

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12 December 2020

The excitatory and inhibitory modulation of primary afferent fibre-evoked responses of ventral roots in the neonatal rat spinal cord exerted by nitric oxide

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12 December 2020

Exacerbation of inflammation-associated colonic injury in rat through inhibition of cyclooxygenase-2.

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12 December 2020

Preclinical and clinical development of dexketoprofen

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12 December 2020

NO-naproxen vs. naproxen: ulcerogenic, analgesic and anti-inflammatory effects

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12 December 2020

Synthesis and biological evaluation of the 1,5-diarylpyrazole class of cyclooxygenase-2 inhibitors: identification of 4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benze nesulfonamide (SC-58635, celecoxib).

1 reference

12 December 2020

Biochemical and pharmacological profile of a tetrasubstituted furanone as a highly selective COX-2 inhibitor

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12 December 2020

Copper(II) interactions with nonsteroidal antiinflammatory agents. II. Anthranilic acid as a potential. OH-inactivating ligand.

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12 December 2020

How opioids inhibit GABA-mediated neurotransmission.

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12 December 2020

Prostanoids synthesized by cyclo-oxygenase isoforms in rat spinal cord and their contribution to the development of neuronal hyperexcitability

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12 December 2020

Central and peripheral actions of the NSAID ketoprofen on spinal cord nociceptive reflexes.

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12 December 2020

Reduction of shock-induced gastric damage by a nitric oxide-releasing aspirin derivative: role of neutrophils

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12 December 2020

Differential effects of inhibition of isoforms of cyclooxygenase (COX-1, COX-2) in chronic inflammation.

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12 December 2020

Altered nociception, analgesia and aggression in mice lacking the receptor for substance P

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12 December 2020

Enhancement of opioid inhibition of GABAergic synaptic transmission by cyclo-oxygenase inhibitors in rat periaqueductal grey neurones

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12 December 2020

Mechanism of enhancement of intestinal ulcerogenicity of S-aryl propionic acids by their R-enantiomers in the rat

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12 December 2020

Cyclooxygenase 1 contributes to inflammatory responses in rats and mice: implications for gastrointestinal toxicity

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12 December 2020

Effect of nitric oxide-releasing aspirin derivative on gastric functional and ulcerogenic responses in rats: comparison with plain aspirin

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12 December 2020

Differential effects of inhibitors of cyclooxygenase (cyclooxygenase 1 and cyclooxygenase 2) in acute inflammation

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12 December 2020

Peripheral and/or central effects of racemic-, S(+)- and R(-)-flurbiprofen on inflammatory nociceptive processes: a c-Fos protein study in the rat spinal cord

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12 December 2020

Pharmacological analysis of cyclooxygenase-1 in inflammation

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12 December 2020

The NSAID dexketoprofen trometamol is as potent as mu-opioids in the depression of wind-up and spinal cord nociceptive reflexes in normal rats.

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12 December 2020

Analgesic, antiinflammatory, and antipyretic effects of S(+)-ketoprofen in vivo

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12 December 2020

Intestinal ulcerogenic effect of S(+)-ketoprofen in the rat

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12 December 2020

Pharmacokinetics of dexketoprofen trometamol in healthy volunteers after single and repeated oral doses.

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12 December 2020

Clinical comparison of dexketoprofen trometamol, ketoprofen, and placebo in postoperative dental pain.

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12 December 2020

Clinical comparison of dexketoprofen trometamol and dipyrone in postoperative dental pain.

1 reference

12 December 2020

Comparison of dexketoprofen trometamol and ketoprofen in the treatment of osteoarthritis of the knee

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12 December 2020

1 reference

12 December 2020

10.1111/J.1527-3458.2003.TB00251.X

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6741672&resulttype=core&format=json

12 May 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6741672&resulttype=core&format=json

12 May 2020

1 reference