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UBR1 promotes protein kinase quality control and sensitizes cells to Hsp90 inhibition.
scientific article published on 29 September 2011
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scholarly article
1 reference
stated in
Europe PubMed Central
PMC publication ID
3221935
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21983172%20AND%20SRC:MED&resulttype=core&format=json
retrieved
14 February 2020
title
UBR1 promotes protein kinase quality control and sensitizes cells to Hsp90 inhibition
(English)
1 reference
stated in
Europe PubMed Central
PMC publication ID
3221935
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21983172%20AND%20SRC:MED&resulttype=core&format=json
retrieved
14 February 2020
main subject
quality control
0 references
geldanamycin
1 reference
stated in
ChEBI release 2020-05-28
ChEBI ID
5292
author
Maria A Theodoraki
series ordinal
2
1 reference
stated in
Europe PubMed Central
PMC publication ID
3221935
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21983172%20AND%20SRC:MED&resulttype=core&format=json
retrieved
14 February 2020
author name string
Rasheda Sultana
series ordinal
1
1 reference
stated in
Europe PubMed Central
PMC publication ID
3221935
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21983172%20AND%20SRC:MED&resulttype=core&format=json
retrieved
14 February 2020
Avrom J Caplan
series ordinal
3
1 reference
stated in
Europe PubMed Central
PMC publication ID
3221935
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21983172%20AND%20SRC:MED&resulttype=core&format=json
retrieved
14 February 2020
language of work or name
English
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publication date
29 September 2011
1 reference
stated in
Europe PubMed Central
PMC publication ID
3221935
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21983172%20AND%20SRC:MED&resulttype=core&format=json
retrieved
14 February 2020
published in
Experimental Cell Research
1 reference
stated in
Europe PubMed Central
PMC publication ID
3221935
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21983172%20AND%20SRC:MED&resulttype=core&format=json
retrieved
14 February 2020
volume
318
1 reference
stated in
Europe PubMed Central
PMC publication ID
3221935
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21983172%20AND%20SRC:MED&resulttype=core&format=json
retrieved
14 February 2020
issue
1
1 reference
stated in
Europe PubMed Central
PMC publication ID
3221935
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21983172%20AND%20SRC:MED&resulttype=core&format=json
retrieved
14 February 2020
page(s)
53-60
1 reference
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Europe PubMed Central
PMC publication ID
3221935
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21983172%20AND%20SRC:MED&resulttype=core&format=json
retrieved
14 February 2020
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Threonine 22 phosphorylation attenuates Hsp90 interaction with cochaperones and affects its chaperone activity
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Ubr1 and Ubr2 function in a quality control pathway for degradation of unfolded cytosolic proteins
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Hsp90 inhibitor PU-H71, a multimodal inhibitor of malignancy, induces complete responses in triple-negative breast cancer models
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Degradation of misfolded protein in the cytoplasm is mediated by the ubiquitin ligase Ubr1.
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Akt and CHIP coregulate tau degradation through coordinated interactions
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Silencing of HSP90 cochaperone AHA1 expression decreases client protein activation and increases cellular sensitivity to the HSP90 inhibitor 17-allylamino-17-demethoxygeldanamycin
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Deficiency of UBR1, a ubiquitin ligase of the N-end rule pathway, causes pancreatic dysfunction, malformations and mental retardation (Johanson-Blizzard syndrome)
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A family of mammalian E3 ubiquitin ligases that contain the UBR box motif and recognize N-degrons
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CHIP (carboxyl terminus of Hsc70-interacting protein) promotes basal and geldanamycin-induced degradation of estrogen receptor-alpha
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Chaperone-dependent E3 ubiquitin ligase CHIP mediates a degradative pathway for c-ErbB2/Neu
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27 July 2018
Akt forms an intracellular complex with heat shock protein 90 (Hsp90) and Cdc37 and is destabilized by inhibitors of Hsp90 function
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27 July 2018
The co-chaperone CHIP regulates protein triage decisions mediated by heat-shock proteins
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DT-Diaphorase expression and tumor cell sensitivity to 17-allylamino, 17-demethoxygeldanamycin, an inhibitor of heat shock protein 90
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Mammalian p50Cdc37 is a protein kinase-targeting subunit of Hsp90 that binds and stabilizes Cdk4
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Impaired neurogenesis and cardiovascular development in mice lacking the E3 ubiquitin ligases UBR1 and UBR2 of the N-end rule pathway.
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26 September 2018
Formation of 17-allylamino-demethoxygeldanamycin (17-AAG) hydroquinone by NAD(P)H:quinone oxidoreductase 1: role of 17-AAG hydroquinone in heat shock protein 90 inhibition
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26 September 2018
C-terminal Hsp-interacting protein slows androgen receptor synthesis and reduces its rate of degradation
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26 September 2018
Drug-induced ubiquitylation and degradation of ErbB receptor tyrosine kinases: implications for cancer therapy
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26 September 2018
The Hsc70 co-chaperone CHIP targets immature CFTR for proteasomal degradation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3221935
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26 September 2018
Chaperone functions of the E3 ubiquitin ligase CHIP.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.YEXCR.2011.09.010
retrieved
7 January 2021
Identifiers
DOI
10.1016/J.YEXCR.2011.09.010
1 reference
stated in
Europe PubMed Central
PMC publication ID
3221935
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21983172%20AND%20SRC:MED&resulttype=core&format=json
retrieved
14 February 2020
PMC publication ID
3221935
1 reference
stated in
Europe PubMed Central
PMC publication ID
3221935
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21983172%20AND%20SRC:MED&resulttype=core&format=json
retrieved
14 February 2020
PubMed publication ID
21983172
1 reference
stated in
Europe PubMed Central
PMC publication ID
3221935
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21983172%20AND%20SRC:MED&resulttype=core&format=json
retrieved
14 February 2020
ResearchGate publication ID
51702762
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