(Q35572426)

8 August 2017

title

Inhibition of PKCδ reduces cisplatin-induced nephrotoxicity without blocking chemotherapeutic efficacy in mouse models of cancer (English)

1 reference

8 August 2017

1 reference

Robert O Messing

6

1 reference

ORCID Public Data File 2021

author name string

Navjotsingh Pabla

1

1 reference

8 August 2017

Guie Dong

2

1 reference

8 August 2017

Man Jiang

3

1 reference

8 August 2017

Shuang Huang

4

1 reference

8 August 2017

M Vijay Kumar

5

1 reference

8 August 2017

Zheng Dong

7

1 reference

8 August 2017

language of work or name

English

0 references

publication date

1 July 2011

1 reference

Journal of Clinical Investigation

8 August 2017

published in

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8 August 2017

volume

121

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8 August 2017

issue

7

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8 August 2017

page(s)

2709-2722

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Mechanisms of Cisplatin nephrotoxicity

8 August 2017

cites work

1 reference

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siRNA targeted to p53 attenuates ischemic and cisplatin-induced acute kidney injury

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Regulation of mitochondrial dynamics in acute kidney injury in cell culture and rodent models

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The copper transporter Ctr1 contributes to cisplatin uptake by renal tubular cells during cisplatin nephrotoxicity

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12 July 2018

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Regulation and pathological role of p53 in cisplatin nephrotoxicity

12 July 2018

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Migration of renal carcinoma cells is dependent on protein kinase Cdelta via beta1 integrin and focal adhesion kinase

12 July 2018

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Prevention of cisplatin nephrotoxicity: state of the art and recommendations from the European Society of Clinical Pharmacy Special Interest Group on Cancer Care

12 July 2018

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12 July 2018

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TLR4 signaling mediates inflammation and tissue injury in nephrotoxicity

12 July 2018

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ATR-Chk2 signaling in p53 activation and DNA damage response during cisplatin-induced apoptosis

12 July 2018

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Sustained pharmacological inhibition of deltaPKC protects against hypertensive encephalopathy through prevention of blood-brain barrier breakdown in rats

12 July 2018

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Protein kinase Cdelta and apoptosis

12 July 2018

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Rottlerin: an inappropriate and ineffective inhibitor of PKCdelta

12 July 2018

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Activation and involvement of p53 in cisplatin-induced nephrotoxicity

12 July 2018

1 reference

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Bak regulates mitochondrial morphology and pathology during apoptosis by interacting with mitofusins.

12 July 2018

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Biochemical mechanisms of cisplatin cytotoxicity

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223835

Regulation of PUMA-alpha by p53 in cisplatin-induced renal cell apoptosis.

12 July 2018

1 reference

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Protein kinase C delta regulates Ser46 phosphorylation of p53 tumor suppressor in the apoptotic response to DNA damage

12 July 2018

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Impact of PKCdelta on estrogen receptor localization and activity in breast cancer cells

12 July 2018

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Cellular processing of platinum anticancer drugs

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223835

p38 MAP kinase inhibition ameliorates cisplatin nephrotoxicity in mice.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223835

Distinctive activation mechanisms and functions for protein kinase Cdelta

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223835

Role of p53 in cisplatin-induced tubular cell apoptosis: dependence on p53 transcriptional activity

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223835

Neutrophil protein kinase Cdelta as a mediator of stroke-reperfusion injury.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223835

Cisplatin-induced cell death is EGFR/src/ERK signaling dependent in mouse proximal tubule cells

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223835

The enigmatic protein kinase Cdelta: complex roles in cell proliferation and survival

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223835

Involvement of protein kinase C-delta in DNA damage-induced apoptosis.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223835

Cisplatin: mode of cytotoxic action and molecular basis of resistance

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223835

Induction of cIAP-2 in Human Colon Cancer Cells through PKCδ/NF-κB

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223835

Cell cycle regulation: repair and regeneration in acute renal failure

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223835

The isoform-specific regulation of apoptosis by protein kinase C.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223835

Regulation of cell apoptosis by protein kinase c delta

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223835

Generation of a syngeneic mouse model to study the effects of vascular endothelial growth factor in ovarian carcinoma.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223835

TNF-alpha mediates chemokine and cytokine expression and renal injury in cisplatin nephrotoxicity

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223835

Protein kinase C-alpha and ERK1/2 mediate mitochondrial dysfunction, decreases in active Na+ transport, and cisplatin-induced apoptosis in renal cells

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223835

Curing metastatic testicular cancer

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223835

Manganese superoxide dismutase attenuates Cisplatin-induced renal injury: importance of superoxide.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223835

Opposing cardioprotective actions and parallel hypertrophic effects of delta PKC and epsilon PKC.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223835

Heme oxygenase-1 gene ablation or expression modulates cisplatin-induced renal tubular apoptosis.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223835

Induction of p21WAF1/CIP1/SDI1 in kidney tubule cells affects the course of cisplatin-induced acute renal failure

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223835

Proteolytic activation of protein kinase C delta by an ICE/CED 3-like protease induces characteristics of apoptosis

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223835

The phosphoinositide-3 kinase gamma-Akt pathway mediates renal tubular injury in cisplatin nephrotoxicity

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223835

Induction of apoptosis is driven by nuclear retention of protein kinase C delta.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223835

Involvement of the CDK2-E2F1 pathway in cisplatin cytotoxicity in vitro and in vivo.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223835

Protein kinase C delta enhances proliferation and survival of murine mammary cells.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223835

A pathophysiologic role for T lymphocytes in murine acute cisplatin nephrotoxicity

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223835

Mechanisms of apoptosis-induction by rottlerin: therapeutic implications for B-CLL.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223835

Protein kinase C delta induces apoptosis of vascular smooth muscle cells through induction of the tumor suppressor p53 by both p38-dependent and p38-independent mechanisms

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223835

p53-dependent caspase-2 activation in mitochondrial release of apoptosis-inducing factor and its role in renal tubular epithelial cell injury

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223835

Endoplasmic reticulum stress-associated caspase 12 mediates cisplatin-induced LLC-PK1 cell apoptosis.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223835

Caspase-1-deficient mice are protected against cisplatin-induced apoptosis and acute tubular necrosis

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223835

Protein kinase C delta mediates cerebral reperfusion injury in vivo.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223835

Cellular and molecular studies on cisplatin-induced apoptotic cell death in rat kidney

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223835

Protein kinase C delta is a prosurvival factor in human breast tumor cell lines

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223835

Altered protein kinase C (PKC) isoforms in non-small cell lung cancer cells: PKCdelta promotes cellular survival and chemotherapeutic resistance

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223835

Direct involvement of the receptor-mediated apoptotic pathways in cisplatin-induced renal tubular cell death

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223835

Cisplatin-induced renal cell apoptosis: caspase 3-dependent and -independent pathways

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223835

Cisplatin induces apoptosis in LLC-PK1 cells via activation of mitochondrial pathways.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223835

Induction of heme oxygenase in toxic renal injury: a protective role in cisplatin nephrotoxicity in the rat.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223835

Biochemical assays for multiple activation states of protein kinase C

26 September 2018

1 reference

12 December 2020

In vitro and in vivo evidence suggesting a role for iron in cisplatin-induced nephrotoxicity

1 reference

12 December 2020

Protein kinase C delta involvement in mammary tumor cell metastasis

1 reference

12 December 2020

MEK inhibitor, U0126, attenuates cisplatin-induced renal injury by decreasing inflammation and apoptosis

1 reference

12 December 2020

The pathological role of Bax in cisplatin nephrotoxicity

1 reference

12 December 2020

How to keep kidneys safe while shrinking tumors: the conundrum of cisplatin action

1 reference

12 December 2020

Identifiers

DOI

10.1172/JCI45586

1 reference

8 August 2017

1 reference

8 August 2017

1 reference