(Q35581474)

English

Pharmacokinetics (PK), pharmacodynamics (PD) and integrated PK/PD modeling of a novel long acting FGF21 clinical candidate PF-05231023 in diet-induced obese and leptin-deficient obese mice

scientific article published on 19 March 2015

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

Pharmacokinetics (PK), pharmacodynamics (PD) and integrated PK/PD modeling of a novel long acting FGF21 clinical candidate PF-05231023 in diet-induced obese and leptin-deficient obese mice (English)

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

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pharmacokinetics

1 reference

based on heuristic

inferred from title

pharmacodynamics

1 reference

based on heuristic

inferred from title

object named as

Roberto Calle

9

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author name string

Yan Weng

1

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

Jeffrey R Chabot

2

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

Barbara Bernardo

3

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

Qingyun Yan

4

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

Yimin Zhu

5

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

Martin B Brenner

6

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

Chandra Vage

7

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

Alison Logan

8

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

Saswata Talukdar

10

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Europe PubMed Central

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9 August 2017

language of work or name

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publication date

19 March 2015

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Europe PubMed Central

PubMed publication ID

9 August 2017

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Europe PubMed Central

PubMed publication ID

9 August 2017

10

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Europe PubMed Central

PubMed publication ID

9 August 2017

3

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

e0119104

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

copyright license

Creative Commons Attribution 4.0 International

19 March 2015

1 reference

April 2022 Public Data File from Crossref

copyright status

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FGF21 acts centrally to induce sympathetic nerve activity, energy expenditure, and weight loss.

1 reference

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12 July 2018

FGF21-based pharmacotherapy--potential utility for metabolic disorders

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12 July 2018

FGF21 mimetic shows therapeutic promise.

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LY2405319, an Engineered FGF21 Variant, Improves the Metabolic Status of Diabetic Monkeys

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1 reference

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Dynamics and Distribution of Klothoβ (KLB) and fibroblast growth factor receptor-1 (FGFR1) in living cells reveal the fibroblast growth factor-21 (FGF21)-induced receptor complex

1 reference

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12 July 2018

FGF21 regulates PGC-1α and browning of white adipose tissues in adaptive thermogenesis

1 reference

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12 July 2018

FGF21 analogs of sustained action enabled by orthogonal biosynthesis demonstrate enhanced antidiabetic pharmacology in rodents

1 reference

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12 July 2018

A guide to analysis of mouse energy metabolism

1 reference

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12 July 2018

Circulating FGF21 levels are progressively increased from the early to end stages of chronic kidney diseases and are associated with renal function in Chinese

1 reference

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FGF19 regulates cell proliferation, glucose and bile acid metabolism via FGFR4-dependent and independent pathways

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FGF21 reloaded: challenges of a rapidly growing field

1 reference

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Research resource: Comprehensive expression atlas of the fibroblast growth factor system in adult mouse.

1 reference

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1 reference

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Fibroblast growth factor 21: from pharmacology to physiology

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1 reference

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Different roles of N- and C- termini in the functional activity of FGF21

1 reference

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FGF21 N- and C-termini play different roles in receptor interaction and activation

1 reference

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Serum levels of the adipokine FGF21 depend on renal function

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Differential enzyme-linked immunosorbent assay and ligand-binding mass spectrometry for analysis of biotransformation of protein therapeutics: application to various FGF21 modalities

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Identifiers

10.1371/JOURNAL.PONE.0119104

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

2015PLoSO..1019104W

0 references

release_2axoufd5offn7icfextdsblt3m

1 reference

https://api.fatcat.wiki/v0/release/2axoufd5offn7icfextdsblt3m

24 November 2022

based on heuristic

mapped directly with Wikidata item

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

ResearchGate publication ID

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