(Q35582364)

9 August 2017

title

Replicative senescence of mesenchymal stem cells causes DNA-methylation changes which correlate with repressive histone marks (English)

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9 August 2017

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mesenchymal stem cell

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11

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9 August 2017

8

Norbert Pallua

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9 August 2017

Anne Schellenberg

1

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9 August 2017

Qiong Lin

2

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9 August 2017

Herdit Schüler

3

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9 August 2017

Carmen M Koch

4

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9 August 2017

Sylvia Joussen

5

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9 August 2017

Bernd Denecke

6

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9 August 2017

Gudrun Walenda

7

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9 August 2017

Christoph V Suschek

9

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9 August 2017

Martin Zenke

10

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9 August 2017

publication date

1 September 2011

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9 August 2017

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9 August 2017

volume

3

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9 August 2017

issue

9

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9 August 2017

page(s)

873-888

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Epigenetic dysregulation in mesenchymal stem cell aging and spontaneous differentiation

9 August 2017

cites work

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DNA methyltransferase controls stem cell aging by regulating BMI1 and EZH2 through microRNAs

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Specific age-associated DNA methylation changes in human dermal fibroblasts

12 July 2018

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CDK1-dependent phosphorylation of EZH2 suppresses methylation of H3K27 and promotes osteogenic differentiation of human mesenchymal stem cells

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A statistical framework for Illumina DNA methylation arrays

12 July 2018

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miRNAs regulate SIRT1 expression during mouse embryonic stem cell differentiation and in adult mouse tissues

12 July 2018

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MicroRNA profiling in human diploid fibroblasts uncovers miR-519 role in replicative senescence

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12 July 2018

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12 July 2018

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12 July 2018

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12 July 2018

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Age-associated epigenetic modifications in human DNA increase its immunogenicity

12 July 2018

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Human aging-associated DNA hypermethylation occurs preferentially at bivalent chromatin domains

12 July 2018

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Age-dependent DNA methylation of genes that are suppressed in stem cells is a hallmark of cancer.

12 July 2018

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Coordinated chromatin control: structural and functional linkage of DNA and histone methylation

12 July 2018

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Different facets of aging in human mesenchymal stem cells

12 July 2018

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Modeling of replicative senescence in hematopoietic development

12 July 2018

1 reference

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Replicative senescence-associated gene expression changes in mesenchymal stromal cells are similar under different culture conditions

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3227452

Histone deacetylase controls adult stem cell aging by balancing the expression of polycomb genes and jumonji domain containing 3

12 July 2018

1 reference

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Clinical-grade production of human mesenchymal stromal cells: occurrence of aneuploidy without transformation

12 July 2018

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DNA methylation pattern changes upon long-term culture and aging of human mesenchymal stromal cells

12 July 2018

1 reference

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Mesenchymal stem cells for clinical application

12 July 2018

1 reference

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Aging and replicative senescence have related effects on human stem and progenitor cells

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3227452

Pharmacologic inhibition of MEK and PI-3K converges on the mTOR/S6 pathway to decelerate cellular senescence

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3227452

Rapamycin decelerates cellular senescence

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3227452

Polycomb mediated epigenetic silencing and replication timing at the INK4a/ARF locus during senescence

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3227452

Linking DNA methylation and histone modification: patterns and paradigms

12 July 2018

1 reference

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The role of promoter CpG methylation in the epigenetic control of stem cell related genes during differentiation

12 July 2018

1 reference

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Genomewide analysis of PRC1 and PRC2 occupancy identifies two classes of bivalent domains

12 July 2018

1 reference

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Controversial issue: is it safe to employ mesenchymal stem cells in cell-based therapies?

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3227452

Histone methylation marks play important roles in predicting the methylation status of CpG islands

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3227452

Genome-scale DNA methylation maps of pluripotent and differentiated cells

12 July 2018

1 reference

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Long-term in vitro expansion alters the biology of adult mesenchymal stem cells

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3227452

Replicative senescence of mesenchymal stem cells: a continuous and organized process

12 July 2018

1 reference

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Mesenchymal stem cell preparations--comparing apples and oranges

12 July 2018

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Human embryonic stem cells: mechanisms to escape replicative senescence?

12 July 2018

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Dynamics of adipogenic promoter DNA methylation during clonal culture of human adipose stem cells to senescence

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3227452

Biological aging is no longer an unsolved problem

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3227452

Murine but not human mesenchymal stem cells generate osteosarcoma-like lesions in the lung

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3227452

The Polycomb group proteins bind throughout the INK4A-ARF locus and are disassociated in senescent cells

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3227452

Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement

12 July 2018

1 reference

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Aging of mesenchymal stem cell in vitro.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3227452

The Polycomb group gene Ezh2 prevents hematopoietic stem cell exhaustion

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3227452

An Alizarin red-based assay of mineralization by adherent cells in culture: comparison with cetylpyridinium chloride extraction

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3227452

The serial cultivation of human diploid cell strains

12 July 2018

1 reference

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TM4: a free, open-source system for microarray data management and analysis

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3227452

Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3227452

Stress-induced premature senescence: from biomarkers to likeliness of in vivo occurrence

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3227452

Significance analysis of microarrays applied to the ionizing radiation response

12 July 2018

1 reference

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Multilineage potential of adult human mesenchymal stem cells

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3227452

Replicative senescence: implications for in vivo aging and tumor suppression

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3227452

Oxidative DNA damage and senescence of human diploid fibroblast cells.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3227452

Identification of a specific telomere terminal transferase activity in Tetrahymena extracts

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3227452

Comparison of doubling numbers attained by cultured animal cells with life span of species

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3227452

Impact of individual platelet lysates on isolation and growth of human mesenchymal stromal cells

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3227452

Pitfalls in spontaneous in vitro transformation of human mesenchymal stem cells.

26 September 2018

1 reference

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Protocols to detect senescence-associated beta-galactosidase (SA-betagal) activity, a biomarker of senescent cells in culture and in vivo

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3227452

Epigenetic maintenance of stemness and malignancy in peripheral neuroectodermal tumors by EZH2.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3227452

Histone H3 modifications associated with differentiation and long-term culture of mesenchymal adipose stem cells

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3227452

Human bone marrow derived mesenchymal stem cells do not undergo transformation after long-term in vitro culture and do not exhibit telomere maintenance mechanisms.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3227452

Accelerated and safe expansion of human mesenchymal stromal cells in animal serum-free medium for transplantation and regenerative medicine.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3227452

Telomerase maintains telomere structure in normal human cells.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3227452

Telomerase can extend the proliferative capacity of human myoblasts, but does not lead to their immortalization.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3227452

Hayflick, his limit, and cellular ageing

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3227452

Proliferation kinetics and differentiation potential of ex vivo expanded human bone marrow stromal cells: Implications for their use in cell therapy

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3227452

Spontaneous Malignant Transformation of Human Mesenchymal Stem Cells Reflects Cross-Contamination: Putting the Research Field on Track - Letter

26 September 2018

1 reference

12 December 2020

Novel markers of mesenchymal stem cells defined by genome-wide gene expression analysis of stromal cells from different sources

1 reference

12 December 2020

Adipogenic differentiation of human mesenchymal stromal cells is down-regulated by microRNA-369-5p and up-regulated by microRNA-371

1 reference

12 December 2020

Expansion of adipose mesenchymal stromal cells is affected by human platelet lysate and plating density

1 reference

12 December 2020

DNA methylation decreases in aging but not in immortal cells

1 reference

12 December 2020

Comparative characteristics of mesenchymal stem cells from human bone marrow, adipose tissue, and umbilical cord blood

1 reference

12 December 2020

Cell specific differences between human adipose-derived and mesenchymal-stromal cells despite similar differentiation potentials

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12 December 2020

Identifiers

DOI

10.18632/AGING.100391

0 references

PMC publication ID

3227452

1 reference

9 August 2017

1 reference