(Q35590733)

9 August 2017

1 reference

title

Nitric oxide and arginine dysregulation: a novel pathway to pulmonary hypertension in hemolytic disorders (English)

1 reference

9 August 2017

main subject

pulmonary hypertension

1 reference

2

Mark T Gladwin

1 reference

9 August 2017

Gregory J Kato

3

0 references

author name string

Claudia R Morris

series ordinal

1

1 reference

9 August 2017

publication date

1 November 2008

1 reference

Current Molecular Medicine

9 August 2017

published in

1 reference

9 August 2017

volume

8

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9 August 2017

issue

7

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9 August 2017

page(s)

620-632

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Pulmonary hypertension and cor pulmonale during severe acute chest syndrome in sickle cell disease

9 August 2017

cites work

1 reference

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27 July 2018

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Relative systemic hypertension in patients with sickle cell disease is associated with risk of pulmonary hypertension and renal insufficiency

27 July 2018

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27 July 2018

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Platelet activation in patients with sickle disease, hemolysis-associated pulmonary hypertension, and nitric oxide scavenging by cell-free hemoglobin

27 July 2018

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Sickle cell lung disease and sudden death: a retrospective/prospective study of 21 autopsy cases and literature review

27 July 2018

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27 July 2018

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Hemodynamic and functional assessment of patients with sickle cell disease and pulmonary hypertension

27 July 2018

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Amplified expression profiling of platelet transcriptome reveals changes in arginine metabolic pathways in patients with sickle cell disease

27 July 2018

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Disruption of methylarginine metabolism impairs vascular homeostasis

27 July 2018

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Hemolysis in sickle cell mice causes pulmonary hypertension due to global impairment in nitric oxide bioavailability

27 July 2018

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Severity of pulmonary hypertension during vaso-occlusive pain crisis and exercise in patients with sickle cell disease

27 July 2018

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Deconstructing sickle cell disease: reappraisal of the role of hemolysis in the development of clinical subphenotypes

27 July 2018

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Clinical hemoglobinopathies: iron, lungs and new blood

27 July 2018

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Oxidative and nitrosative stress in pediatric pulmonary hypertension: roles of endothelin-1 and nitric oxide

27 July 2018

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Oxidative stress and inflammation in iron-overloaded patients with beta-thalassaemia or sickle cell disease.

27 July 2018

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Tetrahydrobiopterin and cardiovascular disease

27 July 2018

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Asymmetric dimethylarginine is an independent risk factor for coronary heart disease: results from the multicenter Coronary Artery Risk Determination investigating the Influence of ADMA Concentration (CARDIAC) study

27 July 2018

1 reference

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Cerebrovascular disease associated with sickle cell pulmonary hypertension

27 July 2018

1 reference

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Sickle cell leg ulcers: associations with haemolysis and SNPs in Klotho, TEK and genes of the TGF-beta/BMP pathway

27 July 2018

1 reference

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Splenectomy: a strong risk factor for pulmonary hypertension in patients with thalassaemia

27 July 2018

1 reference

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Endothelial nitric oxide synthase in vascular disease: from marvel to menace

27 July 2018

1 reference

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Abnormal pulmonary function in adults with sickle cell anemia

27 July 2018

1 reference

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National Heart, Lung, and Blood Institute guidelines and asthma management practices among inner-city pediatric primary care providers

27 July 2018

1 reference

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In vivo rates of erythrocyte glutathione synthesis in adults with sickle cell disease.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3230043

Arginase strongly impairs neuronal nitric oxide-mediated airway smooth muscle relaxation in allergic asthma

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3230043

Pulmonary hypertension in beta-thalassemia

27 July 2018

1 reference

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Cardiopulmonary complications of sickle cell disease: role of nitric oxide and hemolytic anemia

27 July 2018

1 reference

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Lactate dehydrogenase as a biomarker of hemolysis-associated nitric oxide resistance, priapism, leg ulceration, pulmonary hypertension, and death in patients with sickle cell disease

27 July 2018

1 reference

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Outcome of sickle cell anemia: a 4-decade observational study of 1056 patients

27 July 2018

1 reference

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The therapeutic potential of drugs targeting the arginase pathway in asthma

27 July 2018

1 reference

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Heart failure in beta-thalassemia syndromes: a decade of progress

27 July 2018

1 reference

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Levels of soluble endothelium-derived adhesion molecules in patients with sickle cell disease are associated with pulmonary hypertension, organ dysfunction, and mortality

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3230043

L-glutamine therapy reduces endothelial adhesion of sickle red blood cells to human umbilical vein endothelial cells

27 July 2018

1 reference

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Sildenafil therapy in patients with sickle cell disease and pulmonary hypertension

27 July 2018

1 reference

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Dysregulated arginine metabolism, hemolysis-associated pulmonary hypertension, and mortality in sickle cell disease

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3230043

Hemolysis-associated priapism in sickle cell disease

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3230043

Chronic sickle cell lung disease: new insights into the diagnosis, pathogenesis and treatment of pulmonary hypertension

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3230043

Asthma in the pediatric sickle cell patient with acute chest syndrome

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3230043

Pivotal role for endothelial tetrahydrobiopterin in pulmonary hypertension

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3230043

The clinical sequelae of intravascular hemolysis and extracellular plasma hemoglobin: a novel mechanism of human disease

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3230043

Asthma in children with sickle cell disease and its association with acute chest syndrome.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3230043

Hemolytic anemia-associated pulmonary hypertension in sickle cell disease

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3230043

The role of arginine in infection and sepsis

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3230043

Asthma is a risk factor for acute chest syndrome and cerebral vascular accidents in children with sickle cell disease

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3230043

Effect of fetal hemoglobin on microvascular regulation in sickle transgenic-knockout mice

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3230043

Sepsis: an arginine deficiency state?

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3230043

Redox function of tetrahydrobiopterin and effect of L-arginine on oxygen binding in endothelial nitric oxide synthase

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3230043

Arginine in asthma and lung inflammation

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3230043

Nitric oxide insufficiency and atherothrombosis

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3230043

L-Arginine transport in disease

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3230043

The endothelial biology of sickle cell disease: inflammation and a chronic vasculopathy

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3230043

Hypercoagulability in sickle cell disease: a curious paradox

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3230043

Correction of hypercoagulability and amelioration of pulmonary arterial hypertension by chronic blood transfusion in an asplenic hemoglobin E/beta-thalassemia patient

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3230043

Arginase and asthma: novel insights into nitric oxide homeostasis and airway hyperresponsiveness

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3230043

Erythrocyte adhesion in sickle cell disease.

27 July 2018

1 reference

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Dissection of experimental asthma with DNA microarray analysis identifies arginase in asthma pathogenesis

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3230043

Oxidation of tetrahydrobiopterin leads to uncoupling of endothelial cell nitric oxide synthase in hypertension

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3230043

The role of the NO axis and its therapeutic implications in pulmonary arterial hypertension

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3230043

An emerging role for nitric oxide in sickle cell disease vascular homeostasis and therapy

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3230043

Divergent nitric oxide bioavailability in men and women with sickle cell disease

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3230043

Cell-free hemoglobin limits nitric oxide bioavailability in sickle-cell disease

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3230043

Regulation of enzymes of the urea cycle and arginine metabolism

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3230043

Sickle cell vaso-occlusion: multistep and multicellular paradigm

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3230043

The hypercoagulable state in thalassemia

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3230043

Oxygen radical inhibition of nitric oxide-dependent vascular function in sickle cell disease

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3230043

Cardiac involvement in thalassemia intermedia: a multicenter study.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3230043

The transport activity of the human cationic amino acid transporter hCAT-1 is downregulated by activation of protein kinase C

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3230043

Endothelial dysfunction in patients with sickle cell disease is related to selective impairment of shear stress-mediated vasodilation

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3230043

Oxidative stress and induction of heme oxygenase-1 in the kidney in sickle cell disease

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3230043

Comment: the asymmetrical dimethylarginine/dimethylarginine dimethylaminohydrolase pathway in the regulation of nitric oxide generation

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3230043

Role of nitric oxide in the pathogenesis of chronic pulmonary hypertension

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3230043

Hypoxia/reoxygenation causes inflammatory response in transgenic sickle mice but not in normal mice

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3230043

Arginine nutrition in development, health and disease

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3230043

27 July 2018

The beta-thalassemias

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3230043

Arginine metabolism: nitric oxide and beyond

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3230043

Inducible nitric oxide: an autoregulatory feedback inhibitor of vascular inflammation

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3230043

Intestinal mucosal amino acid catabolism

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3230043

Peroxynitrite: a putative cytotoxin

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3230043

Nitric oxide and platelet function: implications for neonatology

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3230043

Natural history of blood pressure in sickle cell disease: risks for stroke and death associated with relative hypertension in sickle cell anemia.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3230043

Nitric oxide metabolite levels in acute vaso-occlusive sickle-cell crisis

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3230043

Nitric oxide synthase generates superoxide and nitric oxide in arginine-depleted cells leading to peroxynitrite-mediated cellular injury

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3230043

Nitric oxide: basic science and clinical applications

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3230043

The L-arginine-nitric oxide pathway

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3230043

Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3230043

Pathologic findings in 76 autopsy cases of thalassemia

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3230043

Reduced antioxidant capacity in paediatric patients with homozygous sickle cell disease.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3230043

Heme-dependent activation of soluble guanylate cyclase by nitric oxide: regulation of enzyme activity by porphyrins and metalloporphyrins

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3230043

Nitrogen metabolism in sickle cell anemia: free amino acids in plasma and urine.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3230043

Selenium, glutathione peroxidase and oxidative hemolysis in sickle cell disease

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3230043

27 July 2018

Update on thalassemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3230043

Ca2+/calmodulin-dependent formation of hydrogen peroxide by brain nitric oxide synthase

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3230043

Pulmonary thromboembolism in thalassemic patients

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3230043

Coagulation activation and inflammation in sickle cell disease-associated pulmonary hypertension.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3230043

Pulmonary hypertension in children and adolescents with sickle cell disease.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3230043

Asthma is associated with increased mortality in individuals with sickle cell anemia

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3230043

Asymmetrical dimethylarginine independently predicts total and cardiovascular mortality in individuals with angiographic coronary artery disease (the Ludwigshafen Risk and Cardiovascular Health study).

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3230043

Arginase activity is increased by thrombin: a mechanism for endothelial dysfunction in arterial thrombosis.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3230043

Morbidity and mortality in chronically transfused subjects with thalassemia and sickle cell disease: A report from the multi-center study of iron overload

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3230043

Circumstances of death in adult sickle cell disease patients.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3230043

N-terminal pro-brain natriuretic peptide levels and risk of death in sickle cell disease.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3230043

Pulmonary hypertension in patients with sickle cell disease: a longitudinal study.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3230043

Reversal of endothelial nitric oxide synthase uncoupling and up-regulation of endothelial nitric oxide synthase expression lowers blood pressure in hypertensive rats.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3230043

Regular transfusion lowers plasma free hemoglobin in children with sickle-cell disease at risk for stroke.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3230043

Elevation of tricuspid regurgitant jet velocity, a marker for pulmonary hypertension in children with sickle cell disease

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3230043

New strategies for the treatment of pulmonary hypertension in sickle cell disease : the rationale for arginine therapy

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3230043

Increased pulmonary artery pressures among adolescents with sickle cell disease

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3230043

Hemolysis-associated pulmonary hypertension in thalassemia

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3230043

Changing patterns of thalassemia worldwide

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3230043

Increased arginase activity in cystic fibrosis airways

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3230043

Thalassemia heart disease: a comparative evaluation of thalassemia major and thalassemia intermedia.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3230043

Asymmetrical dimethylarginine in idiopathic pulmonary arterial hypertension

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3230043

Increased levels and reduced catabolism of asymmetric and symmetric dimethylarginines in pulmonary hypertension

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3230043

Differential gene expression in pulmonary artery endothelial cells exposed to sickle cell plasma

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3230043

Critical role of endothelial cell activation in hypoxia-induced vasoocclusion in transgenic sickle mice.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3230043

Antioxidant deficit and enhanced susceptibility to oxidative damage in individuals with different forms of alpha-thalassaemia

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3230043

Plasma levels of asymmetric dimethylarginine (ADMA), an endogenous nitric oxide synthase inhibitor, are elevated in sickle cell disease

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3230043

Thrombin stimulates human endothelial arginase enzymatic activity via RhoA/ROCK pathway: implications for atherosclerotic endothelial dysfunction

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3230043

Pulmonary hypertension in sickle cell disease

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3230043

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3230043

Cardiac status in well-treated patients with thalassemia major

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3230043

Increased arginase II and decreased NO synthesis in endothelial cells of patients with pulmonary arterial hypertension

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3230043

Three different oxygen-induced radical species in endothelial nitric-oxide synthase oxygenase domain under regulation by L-arginine and tetrahydrobiopterin

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3230043

Decreased arginine bioavailability and increased serum arginase activity in asthma

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3230043

Evidence for a metabolic shift of arginine metabolism in sickle cell disease

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3230043

Oxidant-mediated impairment of nitric oxide signaling in sickle cell disease--mechanisms and consequences.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3230043

Pulmonary hypertension as a risk factor for death in patients with sickle cell disease

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3230043

Pulmonary hypertension in sickle cell disease.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3230043

Endothelial dysfunction in pulmonary hypertension

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3230043

Oxidative stress in severe pulmonary hypertension

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3230043

Lower airway obstruction, bronchial hyperresponsiveness, and primary pulmonary hypertension in children

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3230043

ADMA and oxidative stress

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3230043

Causes of death in sickle cell disease: an autopsy study

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3230043

Sickle cell anemia is associated with reduced nitric oxide bioactivity in peripheral conduit and resistance vessels

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3230043

Hemolytic anemia-associated pulmonary hypertension of sickle cell disease and the nitric oxide/arginine pathway

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3230043

Induction of arginase I and II in bleomycin-induced fibrosis of mouse lung

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3230043

Arginine therapy: a new treatment for pulmonary hypertension in sickle cell disease?

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3230043

L-arginine levels are diminished in adult acute vaso-occlusive sickle cell crisis in the emergency department

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3230043

Pulmonary hypertension in sickle cell disease: cardiac catheterization results and survival

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3230043

Reduced arginine availability and nitric oxide production.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3230043

Expression of the liver form of arginase in erythrocytes

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3230043

Pathobiology of pulmonary hypertension. The role of platelets and thrombosis

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3230043

Pulmonary hypertension, interstitial lung fibrosis, and lung iron deposition in thalassaemia major

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3230043

Antioxidant defense status of red blood cells of patients with beta-thalassemia and Ebeta-thalassemia

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3230043

Prevalence and reversibility of lower airway obstruction in children with sickle cell disease

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3230043

Patterns of arginine and nitric oxide in patients with sickle cell disease with vaso-occlusive crisis and acute chest syndrome

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3230043

Biologic and pharmacologic regulation of mammalian glutathione synthesis

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3230043

Role of L-arginine in the deficiency of nitric oxide and airway hyperreactivity after the allergen-induced early asthmatic reaction in guinea-pigs

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3230043

Thrombin stimulates vascular smooth muscle cell polyamine synthesis by inducing cationic amino acid transporter and ornithine decarboxylase gene expression

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3230043

Differential expression of arginase and iNOS in the lung in sepsis

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3230043

Oral L-glutamine therapy for sickle cell anemia: I. Subjective clinical improvement and favorable change in red cell NAD redox potential

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3230043

Pathogenesis and treatment of sickle cell disease

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3230043

Serum and urinary amino acid levels in sickle cell disease

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3230043

Human type II arginase: sequence analysis and tissue-specific expression

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3230043

Pulmonary hypertension and right heart failure in patients with beta-thalassemia intermedia.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3230043

Oral L-arginine inhibits platelet aggregation but does not enhance endothelium-dependent dilation in healthy young men.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3230043

Spontaneous oxygen radical generation by sickle erythrocytes.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3230043

Pulmonary hypertension associated with sickle cell disease: Clinical and laboratory endpoints and disease outcomes

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3230043

Distribution of pulmonary thromboembolic lesions in thalassemic patients

15 November 2018

1 reference

12 December 2020

Critical role of endothelial cell-derived nitric oxide synthase in sickle cell disease-induced microvascular dysfunction

1 reference

12 December 2020

Pulmonary hypertension in sickle cell disease

1 reference

12 December 2020

Renal nitric oxide synthases in transgenic sickle cell mice

1 reference

12 December 2020

Interplay between superoxide and nitric oxide in thalassemia and Fanconi's anemia

1 reference

12 December 2020

Pulmonary hypertension in thalassemia: association with platelet activation and hypercoagulable state

1 reference

12 December 2020

Relationship of glutathione levels and Heinz body formation to irreversibly sickled cells in sickle cell anemia

1 reference

12 December 2020

The release of nitric oxide and superoxide anion by neutrophils and mononuclear cells from patients with sickle cell anaemia

1 reference

12 December 2020

Arterial Blood Pressure in Adults With Sickle Cell Disease

1 reference

12 December 2020

Asymmetrical dimethylarginine inhibits shear stress-induced nitric oxide release and dilation and elicits superoxide-mediated increase in arteriolar tone

1 reference

12 December 2020

Depressed erythrocyte glutathione reductase activity in sickle cell disease

1 reference

12 December 2020

Is "relative" hypertension a risk factor for vaso-occlusive complications in sickle cell disease?

1 reference

12 December 2020

Thromboembolic events in beta thalassemia major: an Italian multicenter study

1 reference

12 December 2020

Pulmonary Arterial Hypertension

1 reference

12 December 2020

Temporal relationship of asthma to acute chest syndrome in sickle cell disease

1 reference

12 December 2020

Enhanced thrombin generation in children with sickle cell disease

1 reference

12 December 2020

Primary pulmonary hypertension

1 reference

12 December 2020

Pulmonary arterial hypertension in previously splenectomized patients with beta-thalassemic disorders

1 reference

12 December 2020

Pulmonary hypertension in patients with thalassemia major

1 reference

12 December 2020

Increased procoagulant activity of red blood cells from patients with homozygous sickle cell disease and beta-thalassemia

1 reference

12 December 2020

Pulmonary thrombotic arteriopathy in patients with sickle cell disease

1 reference

12 December 2020

Decreased reduced glutathione and glutathione reductase activity in subjects with hemoglobin C

1 reference

12 December 2020

A chronic hypercoagulable state in patients with beta-thalassaemia major is already present in childhood

1 reference

12 December 2020

The metabolites of nitric oxide in sickle-cell disease

1 reference

12 December 2020

Cardiorespiratory adjustments in chronic sickle cell anemia

1 reference

12 December 2020

Low blood pressure, decreased incidence of hypertension, and renal cardiac, and autonomic nervous system functions in patients with sickle cell syndromes

1 reference

12 December 2020

New NHLBI guidelines for the diagnosis and management of asthma. National Heart, Lung and Blood Institute

1 reference

12 December 2020

Immunohistochemical localization of hepatic nitric oxide synthase in normal and transgenic sickle cell mice: the effect of hypoxia

1 reference

12 December 2020

Impaired nitric oxide-mediated vasodilation in transgenic sickle mouse

1 reference

12 December 2020

Reperfusion injury pathophysiology in sickle transgenic mice

1 reference

12 December 2020

Increased oxidative stress in lambs with increased pulmonary blood flow and pulmonary hypertension: role of NADPH oxidase and endothelial NO synthase

1 reference

12 December 2020

Molecular Mechanism for Elevation of Asymmetric Dimethylarginine and Its Role for Hypertension in Chronic Kidney Disease

1 reference

12 December 2020

Lung Function in β-Thalassemia Patients: A Longitudinal Study

1 reference

12 December 2020

Activated monocytes in sickle cell disease: potential role in the activation of vascular endothelium and vaso-occlusion

1 reference

12 December 2020

Phosphatidylserine in the outer leaflet of red blood cells from beta-thalassemia patients may explain the chronic hypercoagulable state and thrombotic episodes

1 reference

12 December 2020

Mitochondrial arginase II modulates nitric-oxide synthesis through nonfreely exchangeable L-arginine pools in human endothelial cells

1 reference

12 December 2020

Clinical differences between children and adults with pulmonary hypertension and sickle cell disease

1 reference

12 December 2020

ENZYMATIC ACTIVITIES OF THE BLOOD SERUM IN THALASSEMIA AND IN THALASSODREPANOCYTOSIS

1 reference

12 December 2020

Sequential nitric oxide measurements during the emergency department treatment of acute vasoocclusive sickle cell crisis

1 reference

12 December 2020

The arginase activity of erythrocytes and leukocytes with particular reference to pernicious anemia and thalassemia major

1 reference

12 December 2020

Cardiopulmonary assessment in beta-thalassemia major

1 reference

12 December 2020

Asthma and acute chest in sickle-cell disease

1 reference

12 December 2020

Association of L-arginine transporters with fodrin: implications for hypoxic inhibition of arginine uptake

1 reference

12 December 2020

Arginase activity in erythrocytes of healthy and ill children

1 reference

12 December 2020

Pulmonary hypertension in thalassaemia major patients with normal left ventricular systolic function

1 reference

12 December 2020

Increased prevalence of iron-overload associated endocrinopathy in thalassaemia versus sickle-cell disease

1 reference

12 December 2020

Arginine therapy: a novel strategy to induce nitric oxide production in sickle cell disease

1 reference

12 December 2020

Pulmonary hypertension in sickle cell hemoglobinopathy: a clinicopathologic study of 20 cases

1 reference

12 December 2020

10.2174/156652408786241447

Identifiers

DOI

1 reference

9 August 2017

1 reference

9 August 2017

1 reference