(Q35598535)

English

The ellagic acid-derived gut microbiota metabolite, urolithin A, potentiates the anticancer effects of 5-fluorouracil chemotherapy on human colon cancer cells

scientific article published on May 2015

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scholarly article

1 reference

Europe PubMed Central

9 August 2017

The ellagic acid-derived gut microbiota metabolite, urolithin A, potentiates the anticancer effects of 5-fluorouracil chemotherapy on human colon cancer cells (English)

1 reference

Europe PubMed Central

9 August 2017

0 references

1 reference

based on heuristic

inferred from title

1 reference

based on heuristic

inferred from title

1 reference

based on heuristic

inferred from title

Juan Carlos Espín

5

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25857357%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

Antonio González-Sarrías

1

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25857357%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

João Tomé-Carneiro

2

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25857357%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

Francisco A Tomas-Barberan

4

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25857357%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

author name string

Andrea Bellesia

3

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25857357%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

publication date

1 May 2015

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Europe PubMed Central

9 August 2017

Food & Function

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Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25857357%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

6

1 reference

Europe PubMed Central

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8 June 2020

5

1 reference

Europe PubMed Central

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8 June 2020

1460-1469

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25857357%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012

1 reference

https://api.crossref.org/works/10.1039%2FC5FO00120J

21 January 2018

Metabolism of capecitabine, an oral fluorouracil prodrug: (19)F NMR studies in animal models and human urine

1 reference

https://api.crossref.org/works/10.1039%2FC5FO00120J

21 January 2018

Antitumor effect of 5-fluorouracil is enhanced by rosemary extract in both drug sensitive and resistant colon cancer cells.

1 reference

https://api.crossref.org/works/10.1039%2FC5FO00120J

21 January 2018

Polyphenolic compounds in chemoprevention of colon cancer - targets and signaling pathways

1 reference

https://api.crossref.org/works/10.1039%2FC5FO00120J

21 January 2018

Molecular mechanisms for chemoprevention of colorectal cancer by natural dietary compounds.

1 reference

https://api.crossref.org/works/10.1039%2FC5FO00120J

21 January 2018

Description of urolithin production capacity from ellagic acid of two human intestinal Gordonibacter species

1 reference

https://api.crossref.org/works/10.1039%2FC5FO00120J

21 January 2018

Ellagitannins, ellagic acid and vascular health.

1 reference

https://api.crossref.org/works/10.1039%2FC5FO00120J

21 January 2018

Iberian pig as a model to clarify obscure points in the bioavailability and metabolism of ellagitannins in humans.

1 reference

https://api.crossref.org/works/10.1039%2FC5FO00120J

21 January 2018

Dissimilar in vitro and in vivo effects of ellagic acid and its microbiota-derived metabolites, urolithins, on the cytochrome P450 1A1.

1 reference

https://api.crossref.org/works/10.1039%2FC5FO00120J

21 January 2018

UV and MS identification of Urolithins and Nasutins, the bioavailable metabolites of ellagitannins and ellagic acid in different mammals.

1 reference

https://api.crossref.org/works/10.1039%2FC5FO00120J

21 January 2018

Occurrence of urolithins, gut microbiota ellagic acid metabolites and proliferation markers expression response in the human prostate gland upon consumption of walnuts and pomegranate juice.

1 reference

https://api.crossref.org/works/10.1039%2FC5FO00120J

21 January 2018

Strawberry processing does not affect the production and urinary excretion of urolithins, ellagic acid metabolites, in humans.

1 reference

https://api.crossref.org/works/10.1039%2FC5FO00120J

21 January 2018

The potent in vitro antioxidant ellagitannins from pomegranate juice are metabolised into bioavailable but poor antioxidant hydroxy-6H-dibenzopyran-6-one derivatives by the colonic microflora of healthy humans

1 reference

https://api.crossref.org/works/10.1039%2FC5FO00120J

21 January 2018

Phase-II metabolism limits the antiproliferative activity of urolithins in human colon cancer cells

1 reference

https://api.crossref.org/works/10.1039%2FC5FO00120J

21 January 2018

Gene expression, cell cycle arrest and MAPK signalling regulation in Caco-2 cells exposed to ellagic acid and its metabolites, urolithins.

1 reference

https://api.crossref.org/works/10.1039%2FC5FO00120J

21 January 2018

Pomegranate ellagitannin-derived metabolites inhibit prostate cancer growth and localize to the mouse prostate gland

1 reference

https://api.crossref.org/works/10.1039%2FC5FO00120J

21 January 2018

Colon cancer chemopreventive activities of pomegranate ellagitannins and urolithins

1 reference

https://api.crossref.org/works/10.1039%2FC5FO00120J

21 January 2018

Walnut polyphenol metabolites, urolithins A and B, inhibit the expression of the prostate-specific antigen and the androgen receptor in prostate cancer cells

1 reference

https://api.crossref.org/works/10.1039%2FC5FO00120J

21 January 2018

Anti-inflammatory properties of a pomegranate extract and its metabolite urolithin-A in a colitis rat model and the effect of colon inflammation on phenolic metabolism.

1 reference

https://api.crossref.org/works/10.1039%2FC5FO00120J

21 January 2018

NF-kappaB-dependent anti-inflammatory activity of urolithins, gut microbiota ellagic acid-derived metabolites, in human colonic fibroblasts.

1 reference

https://api.crossref.org/works/10.1039%2FC5FO00120J

21 January 2018

Intestinal ellagitannin metabolites ameliorate cytokine-induced inflammation and associated molecular markers in human colon fibroblasts.

1 reference

https://api.crossref.org/works/10.1039%2FC5FO00120J

21 January 2018

Urolithins, ellagic acid-derived metabolites produced by human colonic microflora, exhibit estrogenic and antiestrogenic activities

1 reference

https://api.crossref.org/works/10.1039%2FC5FO00120J

21 January 2018

Modelling the possible bioactivity of ellagitannin-derived metabolites. In silico tools to evaluate their potential xenoestrogenic behavior

1 reference

https://api.crossref.org/works/10.1039%2FC5FO00120J

21 January 2018

Theoretical basis, experimental design, and computerized simulation of synergism and antagonism in drug combination studies

1 reference

https://api.crossref.org/works/10.1039%2FC5FO00120J

21 January 2018

5-Fluorouracil: mechanisms of action and clinical strategies

1 reference

https://api.crossref.org/works/10.1039%2FC5FO00120J

21 January 2018

Capecitabine: a review

1 reference

https://api.crossref.org/works/10.1039%2FC5FO00120J

21 January 2018

Combinations of plant polyphenols & anti-cancer molecules: a novel treatment strategy for cancer chemotherapy

1 reference

https://api.crossref.org/works/10.1039%2FC5FO00120J

21 January 2018

Effect of 5-fluorouracil on cell cycle regulatory proteins in human colon cancer cell line

1 reference

https://api.crossref.org/works/10.1039%2FC5FO00120J

21 January 2018

Inhibition of Fas expression by RNAi modulates 5-fluorouracil-induced apoptosis in HCT116 cells expressing wild-type p53.

1 reference

https://api.crossref.org/works/10.1039%2FC5FO00120J

21 January 2018

Increased cytotoxicity and bystander effect of 5-fluorouracil and 5-deoxy-5-fluorouridine in human colorectal cancer cells transfected with thymidine phosphorylase

1 reference

https://api.crossref.org/works/10.1039%2FC5FO00120J

21 January 2018

Synergistic inhibitory effects of curcumin and 5-fluorouracil on the growth of the human colon cancer cell line HT-29.

1 reference

https://api.crossref.org/works/10.1039%2FC5FO00120J

21 January 2018

Curcumin enhances the effects of 5-fluorouracil and oxaliplatin in mediating growth inhibition of colon cancer cells by modulating EGFR and IGF-1R.

1 reference

https://api.crossref.org/works/10.1039%2FC5FO00120J

21 January 2018

Curcumin enhances the effect of chemotherapy against colorectal cancer cells by inhibition of NF-κB and Src protein kinase signaling pathways

1 reference

https://api.crossref.org/works/10.1039%2FC5FO00120J

21 January 2018

Curcumin chemosensitizes 5-fluorouracil resistant MMR-deficient human colon cancer cells in high density cultures

1 reference

https://api.crossref.org/works/10.1039%2FC5FO00120J

21 January 2018

Effects of resveratrol analogs on cell cycle progression, cell cycle associated proteins and 5fluoro-uracil sensitivity in human derived colon cancer cells.

1 reference

https://api.crossref.org/works/10.1039%2FC5FO00120J

21 January 2018

Anti-cancer effects of naturally occurring compounds through modulation of signal transduction and miRNA expression in human colon cancer cells

1 reference

https://api.crossref.org/works/10.1039%2FC5FO00120J

21 January 2018

Resveratrol displays converse dose-related effects on 5-fluorouracil-evoked colon cancer cell apoptosis: the roles of caspase-6 and p53.

1 reference

https://api.crossref.org/works/10.1039%2FC5FO00120J

21 January 2018

Interaction between phenolics and gut microbiota: role in human health.

1 reference

https://api.crossref.org/works/10.1039%2FC5FO00120J

21 January 2018

Anticancer and anti-inflammatory effects of cysteine metabolites of the green tea polyphenol, (-)-epigallocatechin-3-gallate

1 reference

https://api.crossref.org/works/10.1039%2FC5FO00120J

21 January 2018

Clinical pharmacology of resveratrol and its metabolites in colorectal cancer patients.

1 reference

https://api.crossref.org/works/10.1039%2FC5FO00120J

21 January 2018

Prolonged biologically active colonic tissue levels of curcumin achieved after oral administration--a clinical pilot study including assessment of patient acceptability

1 reference

https://api.crossref.org/works/10.1039%2FC5FO00120J

21 January 2018

Resveratrol metabolites inhibit human metastatic colon cancer cells progression and synergize with chemotherapeutic drugs to induce cell death.

1 reference

https://api.crossref.org/works/10.1039%2FC5FO00120J

21 January 2018

Sulfate metabolites provide an intracellular pool for resveratrol generation and induce autophagy with senescence

1 reference

https://api.crossref.org/works/10.1039%2FC5FO00120J

21 January 2018

Metabolism of antioxidant and chemopreventive ellagitannins from strawberries, raspberries, walnuts, and oak-aged wine in humans: identification of biomarkers and individual variability

1 reference

https://api.crossref.org/works/10.1039%2FC5FO00120J

21 January 2018

Biological significance of urolithins, the gut microbial ellagic Acid-derived metabolites: the evidence so far

1 reference

https://api.crossref.org/works/10.1039%2FC5FO00120J

21 January 2018

Gastrointestinal microflora and mucins may play a critical role in the development of 5-Fluorouracil-induced gastrointestinal mucositis.

1 reference

https://api.crossref.org/works/10.1039%2FC5FO00120J

21 January 2018

Increased JNK1 signaling pathway is responsible for ABCG2-mediated multidrug resistance in human colon cancer

1 reference

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21 January 2018

Modulating drug resistance by targeting BCRP/ABCG2 using retrovirus-mediated RNA interference

1 reference

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21 January 2018

Multiple molecular mechanisms for multidrug resistance transporters

1 reference

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21 January 2018

The gut microbiota ellagic acid-derived metabolite urolithin A and its sulfate conjugate are substrates for the drug efflux transporter breast cancer resistance protein (ABCG2/BCRP).

1 reference

https://api.crossref.org/works/10.1039%2FC5FO00120J

21 January 2018

Targeted metabolic profiling of pomegranate polyphenols and urolithins in plasma, urine and colon tissues from colorectal cancer patients

1 reference

https://api.crossref.org/works/10.1039%2FC5FO00120J

21 January 2018

Ellagic Acid Metabolism by Human Gut Microbiota: Consistent Observation of Three Urolithin Phenotypes in Intervention Trials, Independent of Food Source, Age, and Health Status

1 reference

https://api.crossref.org/works/10.1039%2FC5FO00120J

21 January 2018

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