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Multiple molecular mechanisms for multidrug resistance transporters
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title
Multiple molecular mechanisms for multidrug resistance transporters
(English)
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main subject
multiple drug resistance
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author name string
Christopher F Higgins
series ordinal
1
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language of work or name
English
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publication date
12 April 2007
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published in
Nature
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volume
446
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page(s)
749-57
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issue
7137
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cites work
P-glycoprotein in the blood-brain barrier of mice influences the brain penetration and pharmacological activity of many drugs
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7 January 2021
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Phylogeny of multidrug transporters
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7 January 2021
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ABC Transporters: From Microorganisms to Man
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7 January 2021
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A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants
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7 January 2021
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Multidrug resistance in cancer: role of ATP-dependent transporters
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7 January 2021
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A bacterial antibiotic-resistance gene that complements the human multidrug-resistance P-glycoprotein gene
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A family of related ATP-binding subunits coupled to many distinct biological processes in bacteria
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7 January 2021
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Structure of the multidrug resistance P-glycoprotein to 2.5 nm resolution determined by electron microscopy and image analysis.
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7 January 2021
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Repacking of the transmembrane domains of P-glycoprotein during the transport ATPase cycle
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Three-dimensional structures of the mammalian multidrug resistance P-glycoprotein demonstrate major conformational changes in the transmembrane domains upon nucleotide binding
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Three-dimensional structure of P-glycoprotein: the transmembrane regions adopt an asymmetric configuration in the nucleotide-bound state.
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7 January 2021
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Structure of a bacterial multidrug ABC transporter
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7 January 2021
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The packing of the transmembrane segments of human multidrug resistance P-glycoprotein is revealed by disulfide cross-linking analysis.
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An atomic detail model for the human ATP binding cassette transporter P‐glycoprotein derived from disulphide cross‐ linking and homology modeling
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ATP binding to the motor domain from an ABC transporter drives formation of a nucleotide sandwich dimer
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7 January 2021
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The E. coli BtuCD structure: a framework for ABC transporter architecture and mechanism
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7 January 2021
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An inward-facing conformation of a putative metal-chelate-type ABC transporter
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7 January 2021
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The ATP switch model for ABC transporters
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7 January 2021
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Structural basis of energy transduction in the transport cycle of MsbA.
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7 January 2021
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Evidence for two nonidentical drug-interaction sites in the human P-glycoprotein
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7 January 2021
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Drug binding sites on P-glycoprotein are altered by ATP binding prior to nucleotide hydrolysis
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7 January 2021
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The vinblastine binding site adopts high- and low-affinity conformations during a transport cycle of P-glycoprotein
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7 January 2021
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Role of carboxylate residues adjacent to the conserved core Walker B motifs in the catalytic cycle of multidrug resistance protein 1 (ABCC1).
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7 January 2021
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The homodimeric ATP-binding cassette transporter LmrA mediates multidrug transport by an alternating two-site (two-cylinder engine) mechanism
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7 January 2021
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CFTR channel opening by ATP-driven tight dimerization of its nucleotide-binding domains
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7 January 2021
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Is the multidrug transporter a flippase?
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7 January 2021
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Multidrug resistance in Lactococcus lactis: evidence for ATP-dependent drug extrusion from the inner leaflet of the cytoplasmic membrane.
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7 January 2021
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Recent progress in understanding the mechanism of P-glycoprotein-mediated drug efflux.
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7 January 2021
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Communication between multiple drug binding sites on P-glycoprotein
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7 January 2021
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Positively cooperative sites for drug transport by P-glycoprotein with distinct drug specificities
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7 January 2021
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Evidence for two interacting ligand binding sites in human multidrug resistance protein 2 (ATP binding cassette C2).
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7 January 2021
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Interaction of LDS-751 and rhodamine 123 with P-glycoprotein: evidence for simultaneous binding of both drugs
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7 January 2021
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Dynamic movements of organelles containing Niemann-Pick C1 protein: NPC1 involvement in late endocytic events
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Hedgehog-mediated patterning of the mammalian embryo requires transporter-like function of dispatched
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7 January 2021
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Bypassing the periplasm: reconstitution of the AcrAB multidrug efflux pump of Escherichia coli
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7 January 2021
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Crystal structure of bacterial multidrug efflux transporter AcrB
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7 January 2021
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Crystal structures of a multidrug transporter reveal a functionally rotating mechanism.
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7 January 2021
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Structural Basis of Multiple Drug-Binding Capacity of the AcrB Multidrug Efflux Pump
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7 January 2021
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Structural asymmetry of AcrB trimer suggests a peristaltic pump mechanism.
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7 January 2021
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Crystal structure of the bacterial membrane protein TolC central to multidrug efflux and protein export
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7 January 2021
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Aminoglycosides are captured from both periplasm and cytoplasm by the AcrD multidrug efflux transporter of Escherichia coli
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7 January 2021
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Three-dimensional structure of the bacterial multidrug transporter EmrE shows it is an asymmetric homodimer
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7 January 2021
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Exploring the binding domain of EmrE, the smallest multidrug transporter
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7 January 2021
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On parallel and antiparallel topology of a homodimeric multidrug transporter.
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7 January 2021
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Identification and evolution of dual-topology membrane proteins
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7 January 2021
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A model for coupling of H(+) and substrate fluxes based on "time-sharing" of a common binding site
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7 January 2021
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Structure and mechanism of the lactose permease of Escherichia coli
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7 January 2021
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Structure and mechanism of the glycerol-3-phosphate transporter from Escherichia coli
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7 January 2021
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Structure of the multidrug transporter EmrD from Escherichia coli
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7 January 2021
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Promiscuity in the geometry of electrostatic interactions between the Escherichia coli multidrug resistance transporter MdfA and cationic substrates
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7 January 2021
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Energetics of wild-type and mutant multidrug resistance secondary transporter LmrP of Lactococcus lactis.
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https://api.crossref.org/works/10.1038%2FNATURE05630
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7 January 2021
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The secondary multidrug transporter LmrP contains multiple drug interaction sites.
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7 January 2021
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Alkalitolerance: a biological function for a multidrug transporter in pH homeostasis.
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7 January 2021
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Lactose permease as a paradigm for membrane transport proteins (Review).
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7 January 2021
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Structural basis of multidrug recognition by BmrR, a transcription activator of a multidrug transporter
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7 January 2021
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Mechanism of ligand recognition by BmrR, the multidrug-responding transcriptional regulator: mutational analysis of the ligand-binding site
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7 January 2021
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Structural mechanisms of QacR induction and multidrug recognition
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7 January 2021
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Structural mechanism of the simultaneous binding of two drugs to a multidrug-binding protein
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7 January 2021
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Mystery of multidrug transporters: the answer can be simple
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7 January 2021
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The structural basis of sequence-independent peptide binding by OppA protein
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7 January 2021
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The human nuclear xenobiotic receptor PXR: structural determinants of directed promiscuity
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7 January 2021
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The insect attractant 1-octen-3-ol is the natural ligand of bovine odorant-binding protein
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RETRACTED: Structure of MsbA from E. coli: a homolog of the multidrug resistance ATP binding cassette (ABC) transporters
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https://api.crossref.org/works/10.1038%2FNATURE05630
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7 January 2021
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Structure of the multidrug resistance efflux transporter EmrE from Escherichia coli
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https://api.crossref.org/works/10.1038%2FNATURE05630
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7 January 2021
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A General Theory of Membrane Transport From Studies of Bacteria
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7 January 2021
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Homozygous disruption of the murine mdr2 P-glycoprotein gene leads to a complete absence of phospholipid from bile and to liver disease
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https://api.crossref.org/works/10.1038%2FNATURE05630
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7 January 2021
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cDNA cloning of the hepatocyte canalicular isoform of the multidrug resistance protein, cMrp, reveals a novel conjugate export pump deficient in hyperbilirubinemic mutant rats
1 reference
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https://api.crossref.org/works/10.1038%2FNATURE05630
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7 January 2021
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Two highly similar multidrug transporters of Bacillus subtilis whose expression is differentially regulated
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7 January 2021
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Evidence for simultaneous binding of dissimilar substrates by the Escherichia coli multidrug transporter MdfA.
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https://api.crossref.org/works/10.1038%2FNATURE05630
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7 January 2021
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Cotransport of reduced glutathione with bile salts by MRP4 (ABCC4) localized to the basolateral hepatocyte membrane
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https://api.crossref.org/works/10.1038%2FNATURE05630
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7 January 2021
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Identifiers
DOI
10.1038/NATURE05630
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stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
1387619
Dimensions Publication ID
1020303794
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Fatcat ID
release_fo4lpjbip5gs5dqllnj45kvrbe
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Fatcat
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https://api.fatcat.wiki/v0/release/fo4lpjbip5gs5dqllnj45kvrbe
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24 November 2022
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OpenCitations bibliographic resource ID
1387619
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
1387619
PubMed ID
17429392
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
1387619
Springer Nature article ID
10.1038/nature05630
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