(Q35600811)

9 August 2017

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title

Altering immune tolerance therapeutically: the power of negative thinking (English)

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9 August 2017

Gérald J Prud'homme

1

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9 August 2017

publication date

4 December 2003

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Journal of Leukocyte Biology

9 August 2017

published in

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9 August 2017

volume

75

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9 August 2017

issue

4

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9 August 2017

page(s)

586-599

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The danger model: a renewed sense of self

9 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0803394

Innate immune recognition

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0803394

Lymphoproliferative disorders with early lethality in mice deficient in Ctla-4

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0803394

Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0803394

Biologic activity of cytotoxic T lymphocyte-associated antigen 4 antibody blockade in previously vaccinated metastatic melanoma and ovarian carcinoma patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0803394

Cancer regression and autoimmunity induced by cytotoxic T lymphocyte-associated antigen 4 blockade in patients with metastatic melanoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0803394

The inhibitory effects of transforming growth factor-beta-1 (TGF-beta1) in autoimmune diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0803394

Natural killer cells and their receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0803394

KIR: diverse, rapidly evolving receptors of innate and adaptive immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0803394

Macrophage regulation by Tyro 3 family receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0803394

NODs: intracellular proteins involved in inflammation and apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0803394

Foxp3 and natural regulatory T cells: key to a cell lineage?

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0803394

Regulation of cytokine receptor signaling by SOCS1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0803394

Control of the complement system.

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0803394

Immune inhibitory receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0803394

Surface receptors delivering opposite signals regulate the function of human NK cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0803394

Signaling pathways engaged by NK cell receptors: double concerto for activating receptors, inhibitory receptors and NK cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0803394

Aire regulates negative selection of organ-specific T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0803394

Autoimmune regulator: from loss of function to autoimmunity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0803394

Projection of an immunological self shadow within the thymus by the aire protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0803394

BTLA is a lymphocyte inhibitory receptor with similarities to CTLA-4 and PD-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0803394

Negative feedback of T cell activation through inhibitory adapters and costimulatory receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0803394

Targeting T cell costimulation in autoimmune disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0803394

The right place at the right time: novel B7 family members regulate effector T cell responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0803394

CTLA-4: new insights into its biological function and use in tumor immunotherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0803394

Complexities of CD28/B7: CTLA-4 costimulatory pathways in autoimmunity and transplantation

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0803394

CTLA-4-mediated inhibition in regulation of T cell responses: mechanisms and manipulation in tumor immunotherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0803394

B7-H1 is expressed by human endothelial cells and suppresses T cell cytokine synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0803394

Critical role of the programmed death-1 (PD-1) pathway in regulation of experimental autoimmune encephalomyelitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0803394

The programmed death-1 (PD-1) pathway regulates autoimmune diabetes in nonobese diabetic (NOD) mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0803394

Blockade of programmed death-1 engagement accelerates graft-versus-host disease lethality by an IFN-gamma-dependent mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0803394

Blockade of programmed death-1 ligands on dendritic cells enhances T cell activation and cytokine production

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0803394

Programmed death-1 targeting can promote allograft survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0803394

Involvement of PD-L1 on tumor cells in the escape from host immune system and tumor immunotherapy by PD-L1 blockade

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0803394

Molecular modeling and functional mapping of B7-H1 and B7-DC uncouple costimulatory function from PD-1 interaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0803394

Do B cells take advantage of 'missing self' recognition?

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0803394

Signaling mutations and autoimmunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0803394

Development of lupus-like autoimmune diseases by disruption of the PD-1 gene encoding an ITIM motif-carrying immunoreceptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0803394

Deficiency in CD22, a B cell-specific inhibitory receptor, is sufficient to predispose to development of high affinity autoantibodies

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0803394

Roles of the SHP-1 tyrosine phosphatase in the negative regulation of cell signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0803394

Loss of TACI causes fatal lymphoproliferation and autoimmunity, establishing TACI as an inhibitory BLyS receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0803394

TACI and BCMA are receptors for a TNF homologue implicated in B-cell autoimmune disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0803394

Cutting edge: a role for B lymphocyte stimulator in systemic lupus erythematosus

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0803394

Genetics of systemic autoimmunity in mouse models of lupus

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0803394

Defective clonal deletion and anergy induction in TCR transgenic lpr/lpr mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0803394

Enforced BCL2 expression in B-lymphoid cells prolongs antibody responses and elicits autoimmune disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0803394

Oral tolerance: immune mechanisms and the generation of Th3-type TGF-beta-secreting regulatory cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0803394

The role of IL-10 and TGF-beta in the differentiation and effector function of T regulatory cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0803394

Type 1 T-regulatory cells: their role in the control of immune responses.

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0803394

Colitogenic Th1 cells are present in the antigen-experienced T cell pool in normal mice: control by CD4+ regulatory T cells and IL-10.

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0803394

CD4+CD25+ T(R) cells suppress innate immune pathology through cytokine-dependent mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0803394

TGF-beta-dependent mechanisms mediate restoration of self-tolerance induced by antibodies to CD3 in overt autoimmune diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0803394

Regulation of murine inflammatory bowel disease by CD25+ and CD25- CD4+ glucocorticoid-induced TNF receptor family-related gene+ regulatory T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0803394

Synergism of cytotoxic T lymphocyte-associated antigen 4 blockade and depletion of CD25(+) regulatory T cells in antitumor therapy reveals alternative pathways for suppression of autoreactive cytotoxic T lymphocyte responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0803394

Unifying concepts in CD28, ICOS and CTLA4 co-receptor signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0803394

Engagement of cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) induces transforming growth factor beta (TGF-beta) production by murine CD4(+) T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0803394

TGF-beta: the missing link in CD4+CD25+ regulatory T cell-mediated immunosuppression

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0803394

Dual effect of CD85/leukocyte Ig-like receptor-1/Ig-like transcript 2 and CD152 (CTLA-4) on cytokine production by antigen-stimulated human T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0803394

Low CD86 expression in the nonobese diabetic mouse results in the impairment of both T cell activation and CTLA-4 up-regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0803394

CTLA-4 gene polymorphism at position 49 in exon 1 reduces the inhibitory function of CTLA-4 and contributes to the pathogenesis of Graves' disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0803394

Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0803394

Pinpointing when T cell costimulatory receptor CTLA-4 must be engaged to dampen diabetogenic T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0803394

Cytotoxic T Lymphocyte Antigen 4 (CD152) Regulates Self-Reactive T cells in BALB/c but not in the Autoimmune NOD Mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0803394

Role of the B7-CD28/CTLA-4 Pathway in Autoimmune Disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0803394

CTLA-4 exon 1 polymorphism in patients with autoimmune blood disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0803394

CTLA-4 in autoimmune diseases--a general susceptibility gene to autoimmunity?

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0803394

Abnormal expression of CTLA-4 by T cells from patients with myasthenia gravis: effect of an AT-rich gene sequence

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0803394

A regulatory polymorphism in PDCD1 is associated with susceptibility to systemic lupus erythematosus in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0803394

Association of the CTLA4 3' untranslated region polymorphism with the susceptibility to rheumatoid arthritis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0803394

Negative T cell costimulation and islet tolerance.

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0803394

A native soluble form of CTLA-4

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0803394

Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0803394

PD-L2 is a second ligand for PD-1 and inhibits T cell activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0803394

Autoimmune dilated cardiomyopathy in PD-1 receptor-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0803394

Tumor-associated B7-H1 promotes T-cell apoptosis: a potential mechanism of immune evasion

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0803394

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0803394

Evidence for a tumoral immune resistance mechanism based on tryptophan degradation by indoleamine 2,3-dioxygenase

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0803394

B7-H4, a molecule of the B7 family, negatively regulates T cell immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0803394

B7S1, a novel B7 family member that negatively regulates T cell activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0803394

B7x: a widely expressed B7 family member that inhibits T cell activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0803394

Does the immune system see tumors as foreign or self?

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0803394

Combination immunotherapy of B16 melanoma using anti-cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) and granulocyte/macrophage colony-stimulating factor (GM-CSF)-producing vaccines induces rejection of subcutaneous and metastatic tumors accomp

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0803394

CTLA-4 blockade synergizes with tumor-derived granulocyte-macrophage colony-stimulating factor for treatment of an experimental mammary carcinoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0803394

Pathogen-specific regulatory T cells provoke a shift in the Th1/Th2 paradigm in immunity to infectious diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0803394

Poxviruses and immune evasion

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0803394

Human cytomegalovirus escape from immune detection

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0803394

Yersinia enterocolitica evasion of the host innate immune response by V antigen-induced IL-10 production of macrophages is abrogated in IL-10-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0803394

Pathogen-specific T regulatory 1 cells induced in the respiratory tract by a bacterial molecule that stimulates interleukin 10 production by dendritic cells: a novel strategy for evasion of protective T helper type 1 responses by Bordetella pertussi

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0803394

Neisserial binding to CEACAM1 arrests the activation and proliferation of CD4+ T lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0803394

CD4+CD25+ regulatory T cells control Leishmania major persistence and immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0803394

Absence of CD4+CD25+ regulatory T cells is associated with a loss of regulation leading to increased pathology in Helicobacter pylori-infected mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0803394

CTLA-4 down-regulates the protective anticryptococcal cell-mediated immune response

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0803394

The dual role of CTLA-4 in Leishmania infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0803394

CTLA4-Ig: a novel immunosuppressive agent

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0803394

Anti-TNF alpha therapy of rheumatoid arthritis: what have we learned?

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0803394

Progress in human tumour immunology and immunotherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0803394

Blockade of T cell activation using a surface-linked single-chain antibody to CTLA-4 (CD152).

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0803394

Targeted engagement of CTLA-4 prevents autoimmune thyroiditis

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0803394

Immunoinhibitory DNA vaccine protects against autoimmune diabetes through cDNA encoding a selective CTLA-4 (CD152) ligand.

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0803394

Chimeric co-stimulatory molecules that selectively act through CD28 or CTLA-4 on human T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0803394

Identification of conserved amino acids in murine B7-1IgV domain critical for CTLA4/CD28:B7 interaction by site-directed mutagenesis: a novel structural model of the binding site.

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0803394

Identification of residues in the V domain of CD80 (B7-1) implicated in functional interactions with CD28 and CTLA4

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0803394

CTLA-4 gene polymorphisms in systemic lupus erythematosus: a highly significant association with a determinant in the promoter region

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0803394

Targeted delivery of anti-CTLA-4 antibody downregulates T cell function in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0803394

21 January 2018

Identifiers

DOI

10.1189/JLB.0803394

1 reference

9 August 2017

1 reference