(Q35603375)

9 August 2017

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title

The dark side of Ras: regulation of apoptosis (English)

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9 August 2017

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Adrienne D Cox

1

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PubMed ID

14663478

9 August 2017

Channing J Der

series ordinal

2

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PubMed ID

14663478

9 August 2017

language of work or name

English

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publication date

1 December 2003

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9 August 2017

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9 August 2017

22

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9 August 2017

56

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9 August 2017

8999-9006

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https://scigraph.springernature.com/pub.10.1038/sj.onc.1207111

9 August 2017

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cites work

Oncolytic activity of vesicular stomatitis virus is effective against tumors exhibiting aberrant p53, Ras, or myc function and involves the induction of apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207111

Reovirus-induced apoptosis is mediated by TRAIL

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207111

Rac1 protects epithelial cells against anoikis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207111

Bcl-2, via Its BH4 Domain, Blocks Apoptotic Signaling Mediated by Mitochondrial Ras

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207111

CREB is a regulatory target for the protein kinase Akt/PKB

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207111

A distinct class of dominant negative Ras mutants: cytosolic GTP-bound Ras effector domain mutants that inhibit Ras signaling and transformation and enhance cell adhesion

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207111

Disruption of epithelial cell-matrix interactions induces apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207111

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207111

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207111

Identification of Aurora kinases as RasGAP Src homology 3 domain-binding proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207111

Regulation of Bcl-xL: a little bit of this and a little bit of STAT.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207111

MST, a physiological caspase substrate, highly sensitizes apoptosis both upstream and downstream of caspase activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207111

RhoB is required to mediate apoptosis in neoplastically transformed cells after DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207111

D4-GDI, a substrate of CPP32, is proteolyzed during Fas-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207111

Oncogenic Ras sensitizes cells to apoptosis by Par-4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207111

Activated Ha-ras induces apoptosis by association with phosphorylated Bcl-2 in a mitogen-activated protein kinase-independent manner.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207111

Actin' up: RhoB in cancer and apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207111

Massive programmed cell death in intestinal epithelial cells induced by three-dimensional growth conditions: suppression by mutant c-H-ras oncogene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207111

Regulation of Raf by Akt controls growth and differentiation in vascular smooth muscle cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207111

The Ras branch of small GTPases: Ras family members don't fall far from the tree

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207111

Activated Ras prevents downregulation of Bcl-X(L) triggered by detachment from the extracellular matrix. A mechanism of Ras-induced resistance to anoikis in intestinal epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207111

p90(RSK) blocks bad-mediated cell death via a protein kinase C-dependent pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207111

Analysis of Ras-dependent signals that prevent caspase-3 activation and apoptosis induced by cytokine deprivation in hematopoietic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207111

A mouse homologue of the Drosophila tumor suppressor l(2)tid gene defines a novel Ras GTPase-activating protein (RasGAP)-binding protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207111

Cdc42 is a substrate for caspases and influences Fas-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207111

Ras uses the novel tumor suppressor RASSF1 as an effector to mediate apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207111

R-Ras promotes apoptosis caused by growth factor deprivation via a Bcl-2 suppressible mechanism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207111

Proteolytic cleavage of ras GTPase-activating protein during apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207111

Caspase-dependent cleavage of signaling proteins during apoptosis. A turn-off mechanism for anti-apoptotic signals

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207111

The Ras/phosphatidylinositol 3-kinase and Ras/ERK pathways function as independent survival modules each of which inhibits a distinct apoptotic signaling pathway in sympathetic neurons.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207111

The RasGAP N-terminal Fragment Generated by Caspase Cleavage Protects Cells in a Ras/PI3K/Akt-dependent Manner That Does Not Rely on NFκB Activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207111

Cell survival promoted by the Ras-MAPK signaling pathway by transcription-dependent and -independent mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207111

7 January 2021

Both farnesylated and geranylgeranylated RhoB inhibit malignant transformation and suppress human tumor growth in nude mice

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207111

7 January 2021

Essential role for oncogenic Ras in tumour maintenance

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207111

7 January 2021

Reovirus therapy of tumors with activated Ras pathway

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207111

7 January 2021

NF-kappaB blockade and oncogenic Ras trigger invasive human epidermal neoplasia.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207111

7 January 2021

Raf-induced effects on the differentiation and apoptosis of skeletal myoblasts are determined by the level of Raf signaling: abrogation of apoptosis by Raf is downstream of caspase 3 activation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207111

7 January 2021

Regulation of BAD phosphorylation at serine 112 by the Ras-mitogen-activated protein kinase pathway

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207111

7 January 2021

PI-3-kinase is an essential anti-apoptotic effector in the proliferative response of primary human epithelial cells to mutant RAS

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207111

7 January 2021

Vascular system defects and neuronal apoptosis in mice lacking ras GTPase-activating protein

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207111

7 January 2021

Mitogenic signaling mediated by oxidants in Ras-transformed fibroblasts

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207111

7 January 2021

Suppression of c-Myc-induced apoptosis by Ras signalling through PI(3)K and PKB.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207111

7 January 2021

Raf/MAPK and rapamycin-sensitive pathways mediate the anti-apoptotic function of p21Ras in IL-3-dependent hematopoietic cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207111

7 January 2021

Ras-GTPase activating protein inhibition specifically induces apoptosis of tumour cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207111

7 January 2021

Mice deficient in the Rac activator Tiam1 are resistant to Ras-induced skin tumours.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207111

7 January 2021

Requirement of NF-kappaB activation to suppress p53-independent apoptosis induced by oncogenic Ras.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207111

7 January 2021

Ras regulates sympathetic neuron survival by suppressing the p53-mediated cell death pathway

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207111

7 January 2021

The putative tumor suppressor RASSF1A homodimerizes and heterodimerizes with the Ras-GTP binding protein Nore1

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207111

7 January 2021

Opposing effects of Ras on p53: transcriptional activation of mdm2 and induction of p19ARF.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207111

7 January 2021

NF-kappaB is a target of AKT in anti-apoptotic PDGF signalling

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207111

7 January 2021

TC21 mediates transformation and cell survival via activation of phosphatidylinositol 3-kinase/Akt and NF-kappaB signaling pathway

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207111

7 January 2021

Rit, a non-lipid-modified Ras-related protein, transforms NIH3T3 cells without activating the ERK, JNK, p38 MAPK or PI3K/Akt pathways

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207111

7 January 2021

Matrix detachment induces caspase-dependent cytochrome c release from mitochondria: inhibition by PKB/Akt but not Raf signalling

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207111

7 January 2021

Ras/MEK signaling suppresses Myc-dependent apoptosis in cells transformed by c-myc and activated ras.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207111

7 January 2021

Antiapoptotic Cdc42 mutants are potent activators of cellular transformation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207111

7 January 2021

Bcl-2 targets the protein kinase Raf-1 to mitochondria

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207111

7 January 2021

Phosphorylation and regulation of Raf by Akt (protein kinase B)

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207111

7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1207111

1 reference

9 August 2017

1 reference

PubMed ID

14663478