(Q35605100)

English

Ensemble perspective for catalytic promiscuity: calorimetric analysis of the active site conformational landscape of a detoxification enzyme

scientific article published on 14 October 2011

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

Ensemble perspective for catalytic promiscuity: calorimetric analysis of the active site conformational landscape of a detoxification enzyme (English)

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

detoxification enzyme

1 reference

based on heuristic

inferred from title

author name string

Matthew T Honaker

1

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

Mauro Acchione

2

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

John P Sumida

3

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

William M Atkins

4

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

language of work or name

0 references

publication date

14 October 2011

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

Journal of Biological Chemistry

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

286

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

49

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

42770-42776

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

Stability of the domain interface contributes towards the catalytic function at the H-site of class alpha glutathione transferase A1-1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234982

27 July 2018

Enzyme promiscuity: a mechanistic and evolutionary perspective

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234982

27 July 2018

Multi-substrate-activity space and quasi-species in enzyme evolution: Ohno's dilemma, promiscuity and functional orthogonality

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234982

27 July 2018

Protein dynamism and evolvability.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234982

27 July 2018

Emergence of a novel highly specific and catalytically efficient enzyme from a naturally promiscuous glutathione transferase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234982

27 July 2018

The stereochemical course of 4-hydroxy-2-nonenal metabolism by glutathione S-transferases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234982

27 July 2018

A biological cosmos of parallel universes: does protein structural plasticity facilitate evolution?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234982

27 July 2018

Binding induced conformational changes of proteins correlate with their intrinsic fluctuations: a case study of antibodies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234982

27 July 2018

Antibody evolution constrains conformational heterogeneity by tailoring protein dynamics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234982

27 July 2018

Structural basis for ligand promiscuity in cytochrome P450 3A4.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234982

27 July 2018

New crystal structures of human glutathione transferase A1-1 shed light on glutathione binding and the conformation of the C-terminal helix

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234982

27 July 2018

Glutathione transferases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234982

27 July 2018

Predicting undesirable drug interactions with promiscuous proteins in silico

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234982

27 July 2018

A perspective on enzyme catalysis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234982

27 July 2018

Enzymes with extra talents: moonlighting functions and catalytic promiscuity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234982

27 July 2018

Antibody multispecificity mediated by conformational diversity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234982

27 July 2018

Catalytic and binding poly-reactivities shared by two unrelated proteins: The potential role of promiscuity in enzyme evolution

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234982

27 July 2018

Contribution of aromatic-aromatic interactions to the anomalous pK(a) of tyrosine-9 and the C-terminal dynamics of glutathione S-transferase A1-1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234982

27 July 2018

The C-terminus of glutathione S-transferase A1-1 is required for entropically-driven ligand binding

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234982

27 July 2018

Localization of the C-terminus of rat glutathione S-transferase A1-1: crystal structure of mutants W21F and W21F/F220Y

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234982

27 July 2018

The catalytic Tyr-9 of glutathione S-transferase A1-1 controls the dynamics of the C terminus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234982

27 July 2018

Thiol ester hydrolysis catalyzed by glutathione S-transferase A1-1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234982

27 July 2018

Human glutathione transferase A4-4: an alpha class enzyme with high catalytic efficiency in the conjugation of 4-hydroxynonenal and other genotoxic products of lipid peroxidation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234982

27 July 2018

The role of human glutathione transferases and epoxide hydrolases in the metabolism of xenobiotics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234982

27 July 2018

Structural analysis of human alpha-class glutathione transferase A1-1 in the apo-form and in complexes with ethacrynic acid and its glutathione conjugate

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234982

27 July 2018

X-ray crystal structures of cytosolic glutathione S-transferases. Implications for protein architecture, substrate recognition and catalytic function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234982

27 July 2018

Reversible conjugation of isothiocyanates with glutathione catalyzed by human glutathione transferases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234982

27 July 2018

Differential Scanning Calorimetry

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234982

27 July 2018

Glutathione S-transferases. The first enzymatic step in mercapturic acid formation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234982

27 July 2018

Protein binding specificity versus promiscuity.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.304386

21 January 2018

A quantitative index of substrate promiscuity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.304386

21 January 2018

Hub promiscuity in protein-protein interaction networks

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.304386

21 January 2018

Catalytic versus inhibitory promiscuity in cytochrome P450s: implications for evolution of new function

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.304386

21 January 2018

Catalytic promiscuity and the evolution of new enzymatic activities

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.304386

21 January 2018

The evolution of catalytic efficiency and substrate promiscuity in human theta class 1-1 glutathione transferase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.304386

21 January 2018

Differences in flexibility of active sites of cytochromes P450 probed by resonance Raman and UV-Vis absorption spectroscopy.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.304386

21 January 2018

Tertiary interactions stabilise the C-terminal region of human glutathione transferase A1-1: a crystallographic and calorimetric study.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.304386

21 January 2018

Human glutathione transferase A4-4 crystal structures and mutagenesis reveal the basis of high catalytic efficiency with toxic lipid peroxidation products

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.304386

21 January 2018

Redesign of substrate-selectivity determining modules of glutathione transferase A1-1 installs high catalytic efficiency with toxic alkenal products of lipid peroxidation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.304386

21 January 2018

Exploring protein-folding ensembles: a variable-barrier model for the analysis of equilibrium unfolding experiments.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.304386

21 January 2018

Ligand effects on the fluorescence properties of tyrosine-9 in alpha 1-1 glutathione S-transferase.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.304386

21 January 2018

Domain-domain interface packing at conserved Trp-20 in class alpha glutathione transferase impacts on protein stability.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.304386

21 January 2018

L-phenylalanine binding and domain organization in human phenylalanine hydroxylase: a differential scanning calorimetry study.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.304386

21 January 2018

Glutathione induces helical formation in the carboxy terminus of human glutathione transferase A1-1.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.304386

21 January 2018

A conserved N-capping motif contributes significantly to the stabilization and dynamics of the C-terminal region of class Alpha glutathione S-transferases.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.304386

21 January 2018

The Role of Human Glutathione Transferases and Epoxide Hydrolases in the Metabolism of Xenobiotics

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.304386

21 January 2018

Functional promiscuity correlates with conformational heterogeneity in A-class glutathione S-transferases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234982

25 September 2018

Conformational diversity and protein evolution--a 60-year-old hypothesis revisited

1 reference

https://pubmed.ncbi.nlm.nih.gov/22002059

12 December 2020

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inferred from PubMed ID database lookup

Human glutathione transferase catalysis of the formation of S-nitrosoglutathione from organic nitrites plus glutathione

1 reference

https://pubmed.ncbi.nlm.nih.gov/22002059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Stopped-flow kinetic analysis of the ligand-induced coil-helix transition in glutathione S-transferase A1-1: evidence for a persistent denatured state

1 reference

https://pubmed.ncbi.nlm.nih.gov/22002059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Direct Measurement of Barrier Heights in Protein Folding

1 reference

https://pubmed.ncbi.nlm.nih.gov/22002059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential epitope positioning within the germline antibody paratope enhances promiscuity in the primary immune response

1 reference

https://pubmed.ncbi.nlm.nih.gov/22002059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1074/JBC.M111.304386

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

ResearchGate publication ID

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