(Q35605433)

9 August 2017

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title

Regulating antigen-receptor gene assembly (English)

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9 August 2017

Mark S Schlissel

1

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9 August 2017

1 November 2003

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Nature Reviews Immunology

9 August 2017

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9 August 2017

3

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9 August 2017

11

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9 August 2017

890-899

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Somatic generation of antibody diversity

9 August 2017

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V(D)J recombination: molecular biology and regulation

21 January 2018

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The RAG proteins and V(D)J recombination: complexes, ends, and transposition

21 January 2018

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Cellular localization of immunoglobulins with different allotypic specificities in rabbit lymphoid tissues

21 January 2018

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Impairment of V(D)J recombination in double-strand break repair mutants

21 January 2018

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Accessibility control of antigen-receptor variable-region gene assembly: role of cis-acting elements

21 January 2018

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Developmentally controlled and tissue-specific expression of unrearranged VH gene segments

21 January 2018

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Transcription from the RAG1 locus marks the earliest lymphocyte progenitors in bone marrow

21 January 2018

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Two waves of recombinase gene expression in developing thymocytes

21 January 2018

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Down-regulation of RAG1 and RAG2 gene expression in preB cells after functional immunoglobulin heavy chain rearrangement

21 January 2018

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Engagement of the T-cell receptor during positive selection in the thymus down-regulates RAG-1 expression

21 January 2018

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Receptor editing in self-reactive bone marrow B cells

21 January 2018

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Receptor editing: an approach by autoreactive B cells to escape tolerance

21 January 2018

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Thymocyte Expression of RAG-1 and RAG-2: Termination by T Cell Receptor Cross-Linking

21 January 2018

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Secondary V(D)J recombination in B-1 cells

21 January 2018

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RAG reexpression and DNA recombination at T cell receptor loci in peripheral CD4+ T cells

21 January 2018

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Cell cycle regulation of V(D)J recombination-activating protein RAG-2.

21 January 2018

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The half-life of RAG-1 protein in precursor B cells is increased in the absence of RAG-2 expression

21 January 2018

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Cyclin A/CDK2 regulates V(D)J recombination by coordinating RAG-2 accumulation and DNA repair

21 January 2018

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Transposition mediated by RAG1 and RAG2 and its implications for the evolution of the immune system

21 January 2018

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Isolation and characterization of a TATA-less promoter for the human RAG-1 gene

21 January 2018

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Identification and characterization of the murine Rag1 promoter

21 January 2018

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Distinct factors regulate the murine RAG-2 promoter in B- and T-cell lines

21 January 2018

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Cooperative binding of c-Myb and Pax-5 activates the RAG-2 promoter in immature B cells

21 January 2018

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Lymphoid enhancer-binding factor-1 binds and activates the recombination-activating gene-2 promoter together with c-Myb and Pax-5 in immature B cells

21 January 2018

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c-Myb binds to a sequence in the proximal region of the RAG-2 promoter and is essential for promoter activity in T-lineage cells

21 January 2018

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RAG2 is regulated differentially in B and T cells by elements 5' of the promoter

21 January 2018

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Characterization of chromatin structure and enhancer elements for murine recombination activating gene-2.

21 January 2018

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A conserved transcriptional enhancer regulates RAG gene expression in developing B cells.

21 January 2018

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E2A proteins are required for proper B cell development and initiation of immunoglobulin gene rearrangements

21 January 2018

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Identification of a Coordinate Regulator of Interleukins 4, 13, and 5 by Cross-Species Sequence Comparisons

21 January 2018

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RAG-1 and RAG-2, adjacent genes that synergistically activate V(D)J recombination

21 January 2018

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E2A and EBF act in synergy with the V(D)J recombinase to generate a diverse immunoglobulin repertoire in nonlymphoid cells

21 January 2018

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Cell type-specific chromatin structure determines the targeting of V(D)J recombinase activity in vitro

21 January 2018

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Accessibility and the developmental regulation of V(D)J recombination

21 January 2018

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Essential roles of the kappa light chain intronic enhancer and 3' enhancer in kappa rearrangement and demethylation

21 January 2018

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Deletion of germline promoter PD beta 1 from the TCR beta locus causes hypermethylation that impairs D beta 1 recombination by multiple mechanisms.

21 January 2018

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Defect in rearrangement of the most 5' TCR-J alpha following targeted deletion of T early alpha (TEA): implications for TCR alpha locus accessibility.

21 January 2018

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Regulation of the TCRalpha repertoire by the survival window of CD4(+)CD8(+) thymocytes.

21 January 2018

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A developmental switch from TCR delta enhancer to TCR alpha enhancer function during thymocyte maturation.

21 January 2018

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In vivo occupancy of the kappa light chain enhancers in primary pro- and pre-B cells: a model for kappa locus activation

21 January 2018

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Induction of Ig light chain gene rearrangement in heavy chain-deficient B cells by activated Ras.

21 January 2018

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Control of B cell development by Ras-mediated activation of Raf.

21 January 2018

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The transcription factor early growth response 1 (Egr-1) advances differentiation of pre-B and immature B cells

21 January 2018

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Induction of germline transcription in the TCRgamma locus by Stat5: implications for accessibility control by the IL-7 receptor

21 January 2018

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Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals

21 January 2018

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Kappa chain monoallelic demethylation and the establishment of allelic exclusion

21 January 2018

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Differential accessibility at the kappa chain locus plays a role in allelic exclusion

21 January 2018

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A critical role for Dnmt1 and DNA methylation in T cell development, function, and survival.

21 January 2018

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Germ-line transcription and methylation status of the TCR-J alpha locus in its accessible configuration.

21 January 2018

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Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex

21 January 2018

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Nucleosome structure completely inhibits in vitro cleavage by the V(D)J recombinase

21 January 2018

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Accessibility of nucleosomal DNA to V(D)J cleavage is modulated by RSS positioning and HMG1.

21 January 2018

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Stimulation of V(D)J recombination by histone acetylation

21 January 2018

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Controlling the double helix

21 January 2018

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A role for histone acetylation in the developmental regulation of VDJ recombination.

21 January 2018

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Stepwise activation of the immunoglobulin mu heavy chain gene locus

21 January 2018

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Chromatin remodeling by the T cell receptor (TCR)-beta gene enhancer during early T cell development: Implications for the control of TCR-beta locus recombination

21 January 2018

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Ezh2 controls B cell development through histone H3 methylation and Igh rearrangement.

21 January 2018

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Translating the Histone Code

21 January 2018

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The V(D)J recombinational and transcriptional activities of the immunoglobulin heavy-chain intronic enhancer can be mediated through distinct protein-binding sites in a transgenic substrate

21 January 2018

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Regulation of V(D)J recombination: a dominant role for promoter positioning in gene segment accessibility

21 January 2018

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Pax5 is required for recombination of transcribed, acetylated, 5' IgH V gene segments

21 January 2018

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Nonequivalent nuclear location of immunoglobulin alleles in B lymphocytes.

21 January 2018

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Subnuclear compartmentalization of immunoglobulin loci during lymphocyte development

21 January 2018

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B cell development under the condition of allelic inclusion.

21 January 2018

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The "dispensable" portion of RAG2 is necessary for efficient V-to-DJ rearrangement during B and T cell development

21 January 2018

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Enhancers increase the probability but not the level of gene expression

21 January 2018

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Biallelic germline transcription at the kappa immunoglobulin locus

21 January 2018

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Crystal structure of the nucleosome core particle at 2.8 A resolution

21 January 2018

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Factors that influence formation of B cell repertoire

21 January 2018

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Mouse kappa light-chain recombination signal sequences mediate recombination more frequently than do those of lambda light chain

21 January 2018

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Recombination signal sequences restrict chromosomal V(D)J recombination beyond the 12/23 rule.

21 January 2018

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Mechanisms that direct ordered assembly of T cell receptor beta locus V, D, and J gene segments

21 January 2018

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The role of recombination signal sequences in the preferential joining by deletion in DH-JH recombination and in the ordered rearrangement of the IgH locus

21 January 2018

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Prospective estimation of recombination signal efficiency and identification of functional cryptic signals in the genome by statistical modeling

21 January 2018

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Aberrant rearrangements contribute significantly to the allelic exclusion of immunoglobulin gene expression

21 January 2018

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Asynchronous replication and allelic exclusion in the immune system

21 January 2018

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V(D)J recombination: a functional definition of the joining signals

21 January 2018

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Activation of immunoglobulin kappa gene rearrangement correlates with induction of germline kappa gene transcription

31 March 2020

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Reexpression of RAG-1 and RAG-2 genes in activated mature mouse B cells

31 March 2020

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V(D)J recombinase activity in a subset of germinal center B lymphocytes

31 March 2020

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RAG2:GFP Knockin Mice Reveal Novel Aspects of RAG2 Expression in Primary and Peripheral Lymphoid Tissues

31 March 2020

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A regulatory role for recombinase activating genes, RAG-1 and RAG-2, in T cell development

31 March 2020

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Functional analysis of the human RAG 2 promoter

31 March 2020

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Coordinate regulation of RAG1 and RAG2 by cell type-specific DNA elements 5' of RAG2

31 March 2020

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Differential roles of cytokine receptors in the development of epidermal gamma delta T cells

31 March 2020

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Histone acetylation and hSWI/SNF remodeling act in concert to stimulate V(D)J cleavage of nucleosomal DNA

31 March 2020

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Precursor B cells showing H chain allelic inclusion display allelic exclusion at the level of pre-B cell receptor surface expression

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRI1225

1 reference

9 August 2017

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PubMed ID

14668805