(Q35605442)

9 August 2017

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title

New targets for allergic rhinitis--a disease of civilization (English)

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9 August 2017

1

Stephen T Holgate

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9 August 2017

David Broide

2

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9 August 2017

1 November 2003

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Nature Reviews Drug Discovery

9 August 2017

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9 August 2017

2

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9 August 2017

11

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9 August 2017

902-914

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https://scigraph.springernature.com/pub.10.1038/nrd1224

9 August 2017

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21 January 2018

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Immunostimulatory sequence DNA linked to the Amb a 1 allergen promotes T(H)1 cytokine expression while downregulating T(H)2 cytokine expression in PBMCs from human patients with ragweed allergy.

21 January 2018

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Conjugation of immunostimulatory DNA to the short ragweed allergen amb a 1 enhances its immunogenicity and reduces its allergenicity

21 January 2018

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The pharmacological basis of anti-IgE therapy

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Effect of omalizumab on symptoms of seasonal allergic rhinitis: a randomized controlled trial.

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21 January 2018

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Interleukin-13: central mediator of allergic asthma

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

Interleukin-13 in asthma

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21 January 2018

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Effects of an interleukin-5 blocking monoclonal antibody on eosinophils, airway hyper-responsiveness, and the late asthmatic response.

21 January 2018

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Effect of SCH55700, a humanized anti-human interleukin-5 antibody, in severe persistent asthma: a pilot study.

21 January 2018

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Eosinophil's role remains uncertain as anti-interleukin-5 only partially depletes numbers in asthmatic airway.

21 January 2018

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Pathogenesis of murine experimental allergic rhinitis: a study of local and systemic consequences of IL-5 deficiency

21 January 2018

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Eotaxin but not MCP-3 induces eosinophil influx into nasal fluid in allergic patients.

21 January 2018

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Attenuation of interleukin 8-induced nasal inflammation by an inhibitor peptide

21 January 2018

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Intrinsic defect in T cell production of interleukin (IL)-13 in the absence of both IL-5 and eotaxin precludes the development of eosinophilia and airways hyperreactivity in experimental asthma

21 January 2018

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The effects of Mycobacterium vaccae on allergen-induced airway responses in atopic asthma.

21 January 2018

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Probiotics in primary prevention of atopic disease: a randomised placebo-controlled trial

21 January 2018

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No effect of oral treatment with an intestinal bacterial strain, Lactobacillus rhamnosus (ATCC 53103), on birch-pollen allergy: a placebo-controlled double-blind study.

21 January 2018

1 reference

Inhibition of pulmonary eosinophilia in P-selectin- and ICAM-1-deficient mice.

21 January 2018

1 reference

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21 January 2018

1 reference

Long-Term Protective and Antigen-Specific Effect of Heat-Killed Mycobacterium vaccae in a Murine Model of Allergic Pulmonary Inflammation

21 January 2018

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Suppression of airway eosinophilia by killed Mycobacterium vaccae-induced allergen-specific regulatory T-cells

21 January 2018

1 reference

Direct costs of allergic rhinitis in the United States: estimates from the 1996 Medical Expenditure Panel Survey

21 January 2018

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Treating allergic rhinitis in patients with comorbid asthma: the risk of asthma-related hospitalizations and emergency department visits

21 January 2018

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Cysteinyl leukotriene receptors

21 January 2018

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Expression of NPY Y1 and CGRP1 receptors in human nasal mucosa: implications in allergic rhinitis

21 January 2018

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Treatment of cat allergy with T-cell reactive peptides

21 January 2018

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Effect of T-cell peptides derived from Fel d 1 on allergic reactions and cytokine production in patients sensitive to cats: a randomised controlled trial

21 January 2018

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Immunostimulatory DNA inhibits IL-4-dependent IgE synthesis by human B cells

21 January 2018

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Soluble IL-4 receptor inhibits airway inflammation following allergen challenge in a mouse model of asthma

21 January 2018

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Recombinant humanized mAb-E25, an anti-IgE mAb, in birch pollen-induced seasonal allergic rhinitis

21 January 2018

1 reference

Efficacy of combination treatment with anti-IgE plus specific immunotherapy in polysensitized children and adolescents with seasonal allergic rhinitis

21 January 2018

1 reference

Uncovering new complexities in mast cell signaling

21 January 2018

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Interleukin-5 and eosinophils as therapeutic targets for asthma

21 January 2018

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Efficacy of soluble IL-4 receptor for the treatment of adults with asthma

21 January 2018

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Effect of anti-IL-4 and anti-IL-5 antibodies on allergic airway hyperresponsiveness in mice

21 January 2018

1 reference

The kinetics of allergen-induced eotaxin level in nasal lavage fluid: its key role in eosinophil recruitment in nasal mucosa

21 January 2018

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Could the risk of asthma and atopy be reduced by a vaccine that induces a strong T-helper type 1 response?

21 January 2018

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Effects of recombinant human interleukin-12 on eosinophils, airway hyper-responsiveness, and the late asthmatic response

21 January 2018

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Could asthma be worsened by stimulating the T-helper type 1 immune response?

21 January 2018

1 reference

Nasal allergen provocation induces adhesion molecule expression and tissue eosinophilia in upper and lower airways

21 January 2018

1 reference

A small-molecule, tight-binding inhibitor of the integrin alpha(4)beta(1) blocks antigen-induced airway responses and inflammation in experimental asthma in sheep

21 January 2018

1 reference

Next generation antihistamines: therapeutic rationale, accomplishments and advances

21 January 2018

1 reference

Efficacy and tolerability of montelukast alone or in combination with loratadine in seasonal allergic rhinitis: a multicenter, randomized, double-blind, placebo-controlled trial performed in the fall

31 March 2020

1 reference

Human mast cell tryptase: multiple cDNAs and genes reveal a multigene serine protease family

31 March 2020

1 reference

Recombinant human stem cell factor (kit ligand) promotes human mast cell and melanocyte hyperplasia and functional activation in vivo

31 March 2020

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Sensory, parasympathetic, and sympathetic neural influences in the nasal mucosa

31 March 2020

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Selective recruitment of eosinophils by substance P after repeated allergen exposure in allergic rhinitis

31 March 2020

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Increases in IL-12 messenger RNA+ cells accompany inhibition of allergen-induced late skin responses after successful grass pollen immunotherapy.

31 March 2020

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Peripheral T-cell tolerance induced in naive and primed mice by subcutaneous injection of peptides from the major cat allergen Fel d I

31 March 2020

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Immunostimulatory DNA sequences function as T helper-1-promoting adjuvants.

31 March 2020

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The late, but not early, asthmatic response is dependent on IL-5 and correlates with eosinophil infiltration

31 March 2020

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Generation of therapeutic antibody responses against IgE through vaccination

31 March 2020

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Increase in IL-8, IL-10, IL-13, and RANTES mRNA levels (in situ hybridization) in the nasal mucosa after nasal allergen provocation

31 March 2020

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A novel interleukin 13 (IL-13) antagonist that blocks the biological activity of human IL-13 in immune and nonimmune cells

31 March 2020

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Anti-interleukin-4 inhibits immunoglobulin E production in a murine model of atopic asthma

31 March 2020

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Eosinophil adhesion to nasal polyp endothelium is P-selectin-dependent

31 March 2020

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Alpha 4 integrin antagonists

31 March 2020

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Adhesion to fibronectin prolongs eosinophil survival.

31 March 2020

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Blockade of CD49d (alpha4 integrin) on intrapulmonary but not circulating leukocytes inhibits airway inflammation and hyperresponsiveness in a mouse model of asthma

31 March 2020

1 reference

Phosphodiesterase 4 inhibitors and the treatment of asthma: where are we now and where do we go from here?

31 March 2020

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The phosphodiesterase 4 inhibitor roflumilast is effective in the treatment of allergic rhinitis

31 March 2020

1 reference

31 March 2020

Identifiers

DOI

10.1038/NRD1224

1 reference

9 August 2017

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PubMed ID

14668811