(Q35611152)

English

Health Effects of Long-Term Rapamycin Treatment: The Impact on Mouse Health of Enteric Rapamycin Treatment from Four Months of Age throughout Life

scientific article published on 15 May 2015

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scholarly article

1 reference

Europe PubMed Central

9 August 2017

Health Effects of Long-Term Rapamycin Treatment: The Impact on Mouse Health of Enteric Rapamycin Treatment from Four Months of Age throughout Life (English)

1 reference

Europe PubMed Central

9 August 2017

1 reference

based on heuristic

inferred from title

Steven N. Austad

7

object named as

Steven N Austad

1 reference

Europe PubMed Central

9 August 2017

Arlan G. Richardson

6

object named as

Arlan Richardson

1 reference

Europe PubMed Central

9 August 2017

author name string

Kathleen E Fischer

1

1 reference

Europe PubMed Central

9 August 2017

Jonathan A L Gelfond

2

1 reference

Europe PubMed Central

9 August 2017

Vanessa Y Soto

3

1 reference

Europe PubMed Central

9 August 2017

Chul Han

4

1 reference

Europe PubMed Central

9 August 2017

Shinichi Someya

5

1 reference

Europe PubMed Central

9 August 2017

language of work or name

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publication date

15 May 2015

1 reference

Europe PubMed Central

9 August 2017

1 reference

Europe PubMed Central

9 August 2017

10

1 reference

Europe PubMed Central

9 August 2017

5

1 reference

Europe PubMed Central

9 August 2017

e0126644

1 reference

Europe PubMed Central

9 August 2017

copyright license

Creative Commons CC0 License

15 May 2015

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted, dedicated to the public domain by copyright holder

0 references

Mice fed rapamycin have an increase in lifespan associated with major changes in the liver transcriptome

1 reference

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Rapamycin-mediated lifespan increase in mice is dose and sex dependent and metabolically distinct from dietary restriction

1 reference

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Rapamycin extends murine lifespan but has limited effects on aging

1 reference

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Late-life rapamycin treatment reverses age-related heart dysfunction.

1 reference

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Rapamycin extends life and health in C57BL/6 mice

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Young and old genetically heterogeneous HET3 mice on a rapamycin diet are glucose intolerant but insulin sensitive.

1 reference

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Duration of rapamycin treatment has differential effects on metabolism in mice

1 reference

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Rapamycin extends life span of Rb1+/- mice by inhibiting neuroendocrine tumors

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Enteric-delivered rapamycin enhances resistance of aged mice to pneumococcal pneumonia through reduced cellular senescence

1 reference

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Chronic inhibition of mammalian target of rapamycin by rapamycin modulates cognitive and non-cognitive components of behavior throughout lifespan in mice

1 reference

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Rapamycin-induced insulin resistance is mediated by mTORC2 loss and uncoupled from longevity

1 reference

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Lifelong rapamycin administration ameliorates age-dependent cognitive deficits by reducing IL-1β and enhancing NMDA signaling

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Selective pharmacogenetic inhibition of mammalian target of Rapamycin complex I (mTORC1) blocks long-term synaptic plasticity and memory storage

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Sirt3 mediates reduction of oxidative damage and prevention of age-related hearing loss under caloric restriction

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Rapamycin, but not resveratrol or simvastatin, extends life span of genetically heterogeneous mice

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Inhibition of mTOR by rapamycin abolishes cognitive deficits and reduces amyloid-beta levels in a mouse model of Alzheimer's disease

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Molecular interplay between mammalian target of rapamycin (mTOR), amyloid-beta, and Tau: effects on cognitive impairments

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Age-related hearing loss in C57BL/6J mice is mediated by Bak-dependent mitochondrial apoptosis.

1 reference

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Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

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Rapamycin slows aging in mice

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https://pubmed.ncbi.nlm.nih.gov/25978367

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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1 reference

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1 reference

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based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1371/JOURNAL.PONE.0126644

1 reference

Europe PubMed Central

9 August 2017

2015PLoSO..1026644F

0 references

PMC publication ID

1 reference

Europe PubMed Central

9 August 2017

1 reference

Europe PubMed Central

9 August 2017

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