(Q35615371)

9 August 2017

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title

Rediscovering the sweet spot in drug discovery. (English)

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9 August 2017

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2

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9 August 2017

David Brown

1

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9 August 2017

1 December 2003

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9 August 2017

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9 August 2017

8

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9 August 2017

1067-1077

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9 August 2017

23

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Drug discovery: a historical perspective

9 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902902-7

7 January 2021

Stategic trends in the drug industry

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902902-7

7 January 2021

The emergence of the drug receptor theory

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https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902902-7

7 January 2021

The Sequence of the Human Genome

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902902-7

7 January 2021

Initial sequencing and analysis of the human genome

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https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902902-7

7 January 2021

A new paradigm for drug discovery: integrating clinical, genetic, genomic and molecular phenotype data to identify drug targets

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902902-7

7 January 2021

Fulfilling the promise: drug discovery in the post-genomic era.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902902-7

7 January 2021

Online Mendelian Inheritance in Man (OMIM), a knowledgebase of human genes and genetic disorders.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902902-7

7 January 2021

Pharmacogenetics and the practice of medicine

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902902-7

7 January 2021

Hit and lead generation: beyond high-throughput screening

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902902-7

7 January 2021

Assembly of Cell Regulatory Systems Through Protein Interaction Domains

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902902-7

7 January 2021

Integrated genomic and proteomic analyses of a systematically perturbed metabolic network

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902902-7

7 January 2021

Signal transduction as a drug-discovery platform

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902902-7

7 January 2021

Global approaches to protein-protein interactions

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902902-7

7 January 2021

The tandem affinity purification (TAP) method: a general procedure of protein complex purification

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902902-7

7 January 2021

Functional organization of the yeast proteome by systematic analysis of protein complexes

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902902-7

7 January 2021

Protein complexes and proteome organization from yeast to man.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902902-7

7 January 2021

A generic protein purification method for protein complex characterization and proteome exploration

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902902-7

7 January 2021

Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902902-7

7 January 2021

The study of macromolecular complexes by quantitative proteomics

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902902-7

7 January 2021

A proteomics strategy to elucidate functional protein-protein interactions applied to EGF signaling

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902902-7

7 January 2021

The Fanconi anaemia/BRCA pathway

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902902-7

7 January 2021

A Growing Network of Cancer-Susceptibility Genes

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902902-7

7 January 2021

Evolution of enzyme cascades from embryonic development to blood coagulation

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902902-7

7 January 2021

New drug targets for type 2 diabetes and the metabolic syndrome

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902902-7

7 January 2021

Mitochondrial respiratory-chain diseases

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902902-7

7 January 2021

Proteomics: quantitative and physical mapping of cellular proteins

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902902-7

7 January 2021

Mass spectrometry-based proteomics

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902902-7

7 January 2021

AU binding proteins recruit the exosome to degrade ARE-containing mRNAs

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902902-7

7 January 2021

Akt phosphorylates the Yes-associated protein, YAP, to induce interaction with 14-3-3 and attenuation of p73-mediated apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902902-7

7 January 2021

Targeting signal transduction with large combinatorial collections

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902902-7

7 January 2021

Chemogenomic approaches to drug discovery

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902902-7

7 January 2021

A receptor for the immunosuppressant FK506 is a cis-trans peptidyl-prolyl isomerase

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902902-7

7 January 2021

Quantitative chemical proteomics for identifying candidate drug targets

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902902-7

7 January 2021

Discovery of novel targets of quinoline drugs in the human purine binding proteome

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902902-7

7 January 2021

Synthetic small molecules that control stem cell fate

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902902-7

7 January 2021

Discovering potent and selective reversible inhibitors of enzymes in complex proteomes

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902902-7

7 January 2021

Intracellular targets of cyclin-dependent kinase inhibitors: identification by affinity chromatography using immobilised inhibitors.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902902-7

7 January 2021

A mammalian histone deacetylase related to the yeast transcriptional regulator Rpd3p

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902902-7

7 January 2021

In the pursuit of industrial proteomics

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902902-7

7 January 2021

10.1016/S1359-6446(03)02902-7

Identifiers

DOI

1 reference

9 August 2017

1 reference

PubMed ID

14693466