(Q35620302)

English

A polymorphism in the interleukin-4 receptor affects the ability of interleukin-4 to regulate Th17 cells: a possible immunoregulatory mechanism for genetic control of the severity of rheumatoid arthritis

scientific article published on 4 February 2011

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

A polymorphism in the interleukin-4 receptor affects the ability of interleukin-4 to regulate Th17 cells: a possible immunoregulatory mechanism for genetic control of the severity of rheumatoid arthritis (English)

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

rheumatoid arthritis

1 reference

based on heuristic

inferred from title

6

object named as

Emily C Somers

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

author name string

Susan K Wallis

1

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

Laura A Cooney

2

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

Judith L Endres

3

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

Min Jie Lee

4

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

Jennifer Ryu

5

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

David A Fox

7

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

publication date

4 February 2011

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

Arthritis Research and Therapy

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

13

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

1

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

R15

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

https://scigraph.springernature.com/pub.10.1186/ar3239

0 references

The role of T helper type 17 cells in inflammatory arthritis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3241359

12 July 2018

Angiogenesis and its targeting in rheumatoid arthritis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3241359

12 July 2018

IL-17 and Th17 Cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3241359

12 July 2018

Lack of association or interactions between the IL-4, IL-4Ralpha and IL-13 genes, and rheumatoid arthritis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3241359

12 July 2018

Th17 cells in human disease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3241359

12 July 2018

Intra-articular injection of interleukin-4 decreases nitric oxide production by chondrocytes and ameliorates subsequent destruction of cartilage in instability-induced osteoarthritis in rat knee joints

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3241359

12 July 2018

Interleukins 1beta and 6 but not transforming growth factor-beta are essential for the differentiation of interleukin 17-producing human T helper cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3241359

12 July 2018

Development, cytokine profile and function of human interleukin 17-producing helper T cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3241359

12 July 2018

Inhibition of angiogenesis by interleukin-4 gene therapy in rat adjuvant-induced arthritis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3241359

12 July 2018

Th17: an effector CD4 T cell lineage with regulatory T cell ties

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3241359

12 July 2018

Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3241359

12 July 2018

Transforming growth factor-beta induces development of the T(H)17 lineage

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3241359

12 July 2018

Association of the IL4R single-nucleotide polymorphism I50V with rapidly erosive rheumatoid arthritis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3241359

12 July 2018

TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3241359

12 July 2018

Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3241359

12 July 2018

A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3241359

12 July 2018

Blocking of interleukin-17 during reactivation of experimental arthritis prevents joint inflammation and bone erosion by decreasing RANKL and interleukin-1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3241359

12 July 2018

IL-23 drives a pathogenic T cell population that induces autoimmune inflammation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3241359

12 July 2018

Divergent pro- and antiinflammatory roles for IL-23 and IL-12 in joint autoimmune inflammation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3241359

12 July 2018

Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3241359

12 July 2018

Dendritic cells genetically engineered to express IL-4 inhibit murine collagen-induced arthritis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3241359

12 July 2018

Contribution of interleukin 17 to synovium matrix destruction in rheumatoid arthritis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3241359

12 July 2018

Adenoviral vector-mediated overexpression of IL-4 in the knee joint of mice with collagen-induced arthritis prevents cartilage destruction.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3241359

12 July 2018

IL-17 in synovial fluids from patients with rheumatoid arthritis is a potent stimulator of osteoclastogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3241359

12 July 2018

Cutting edge: dominant effect of Ile50Val variant of the human IL-4 receptor alpha-chain in IgE synthesis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3241359

12 July 2018

IL-4 blocks M-CSF-dependent macrophage proliferation by inducing p21Waf1 in a STAT6-dependent way.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3241359

25 September 2018

Effect of interleukin-4 on vascular endothelial growth factor production in rheumatoid synovial fibroblasts.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3241359

25 September 2018

An IL-4R alpha allelic variant, I50, acts as a gain-of-function variant relative to V50 for Stat6, but not Th2 differentiation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3241359

25 September 2018

Effect of a treatment strategy of tight control for rheumatoid arthritis (the TICORA study): a single-blind randomised controlled trial

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3241359

25 September 2018

Altered memory T cell differentiation in patients with early rheumatoid arthritis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3241359

25 September 2018

The polymorphisms S503P and Q576R in the interleukin-4 receptor alpha gene are associated with atopy and influence the signal transduction

1 reference

https://pubmed.ncbi.nlm.nih.gov/21294892

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interleukin-17 as a molecular target in immune-mediated arthritis: immunoregulatory properties of genetically modified murine dendritic cells that secrete interleukin-4

1 reference

https://pubmed.ncbi.nlm.nih.gov/21294892

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interleukin-4 inhibition of osteoclast differentiation is stronger than that of interleukin-13 and they are equivalent for induction of osteoprotegerin production from osteoblasts

1 reference

https://pubmed.ncbi.nlm.nih.gov/21294892

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interleukin-4 regulates proteoglycan-induced arthritis by specifically suppressing the innate immune response

1 reference

https://pubmed.ncbi.nlm.nih.gov/21294892

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Polymorphisms of interleukin (IL)-4 receptor alpha and signal transducer and activator of transcription-6 (Stat6) are associated with increased IL-4Ralpha-Stat6 signalling in lymphocytes and elevated serum IgE in patients with Graves' disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/21294892

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effective treatment of inflammatory disease models with exosomes derived from dendritic cells genetically modified to express IL-4

1 reference

https://pubmed.ncbi.nlm.nih.gov/21294892

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clinical and radiographic outcomes of four different treatment strategies in patients with early rheumatoid arthritis (the BeSt study): A randomized, controlled trial

1 reference

https://pubmed.ncbi.nlm.nih.gov/21294892

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of Th17 cells in human autoimmune arthritis

1 reference

https://pubmed.ncbi.nlm.nih.gov/21294892

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of IL-4 in regulation of murine collagen-induced arthritis

1 reference

https://pubmed.ncbi.nlm.nih.gov/21294892

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

V75R576 IL-4 receptor alpha is associated with allergic asthma and enhanced IL-4 receptor function

1 reference

https://pubmed.ncbi.nlm.nih.gov/21294892

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of hormone and cytokine-stimulated osteoclastogenesis and bone resorption by interleukin-4 and interleukin-13 is associated with increased osteoprotegerin and decreased RANKL and RANK in a STAT6-dependent pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/21294892

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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Europe PubMed Central

PubMed publication ID

9 August 2017

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PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

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