(Q35621081)

English

FGF2 gene transfer restores hippocampal functions in mouse models of Alzheimer's disease and has therapeutic implications for neurocognitive disorders

scientific article published on 31 October 2011

In more languages

Statements

scholarly article

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22042871%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

FGF2 gene transfer restores hippocampal functions in mouse models of Alzheimer's disease and has therapeutic implications for neurocognitive disorders (English)

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22042871%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

Alzheimer's disease

0 references

corrigendum / erratum

Correction for Kiyota et al., FGF2 gene transfer restores hippocampal functions in mouse models of Alzheimer's disease and has therapeutic implications for neurocognitive disorders

0 references

5

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22042871%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

author name string

Tomomi Kiyota

1

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22042871%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

Kaitlin L Ingraham

2

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22042871%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

Michael T Jacobsen

3

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22042871%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

Huangui Xiong

4

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22042871%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

language of work or name

0 references

publication date

31 October 2011

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22042871%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

Proceedings of the National Academy of Sciences of the United States of America

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22042871%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

108

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22042871%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

49

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22042871%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

E1339-48

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22042871%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

AAV serotype 2/1-mediated gene delivery of anti-inflammatory interleukin-10 enhances neurogenesis and cognitive function in APP+PS1 mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3241747

12 July 2018

Prevalence of asymptomatic vasogenic edema in pretreatment Alzheimer's disease study cohorts from phase 3 trials of semagacestat and solanezumab

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3241747

12 July 2018

HIV-1 reduces Abeta-degrading enzymatic activities in primary human mononuclear phagocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3241747

12 July 2018

γ-secretase inhibitors and modulators for the treatment of Alzheimer's disease: disappointments and hopes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3241747

12 July 2018

Actin interaction and regulation of cyclin-dependent kinase 5/p35 complex activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3241747

12 July 2018

CNS expression of anti-inflammatory cytokine interleukin-4 attenuates Alzheimer's disease-like pathogenesis in APP+PS1 bigenic mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3241747

12 July 2018

Allopregnanolone reverses neurogenic and cognitive deficits in mouse model of Alzheimer's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3241747

12 July 2018

Real-time imaging and quantification of amyloid-beta peptide aggregates by novel quantum-dot nanoprobes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3241747

12 July 2018

CCL2 accelerates microglia-mediated Abeta oligomer formation and progression of neurocognitive dysfunction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3241747

12 July 2018

The FGF-2/FGFRs neurotrophic system promotes neurogenesis in the adult brain.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3241747

12 July 2018

AAV1/2-mediated CNS gene delivery of dominant-negative CCL2 mutant suppresses gliosis, beta-amyloidosis, and learning impairment of APP/PS1 mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3241747

12 July 2018

Fibroblast growth factor receptor-1 (FGFR1) nuclear dynamics reveal a novel mechanism in transcription control

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3241747

12 July 2018

Neuroprotective effects of brain-derived neurotrophic factor in rodent and primate models of Alzheimer's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3241747

12 July 2018

Computational influence of adult neurogenesis on memory encoding

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3241747

12 July 2018

Spatial learning impairment, enhanced CDK5/p35 activity, and downregulation of NMDA receptor expression in transgenic mice expressing tau-tubulin kinase 1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3241747

12 July 2018

Behavior of neural stem cells in the Alzheimer brain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3241747

12 July 2018

Cognitive function over time in the Alzheimer's Disease Anti-inflammatory Prevention Trial (ADAPT): results of a randomized, controlled trial of naproxen and celecoxib

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3241747

12 July 2018

Therapeutic potential of CERE-110 (AAV2-NGF): targeted, stable, and sustained NGF delivery and trophic activity on rodent basal forebrain cholinergic neurons

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3241747

12 July 2018

Integrative nuclear signaling in cell development--a role for FGF receptor-1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3241747

12 July 2018

Interferon-gamma and tumor necrosis factor-alpha regulate amyloid-beta plaque deposition and beta-secretase expression in Swedish mutant APP transgenic mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3241747

12 July 2018

Alzheimer's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3241747

12 July 2018

Decreased adult hippocampal neurogenesis in the PDAPP mouse model of Alzheimer's disease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3241747

12 July 2018

Overexpression of monocyte chemotactic protein-1/CCL2 in beta-amyloid precursor protein transgenic mice show accelerated diffuse beta-amyloid deposition

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3241747

12 July 2018

Passive immunotherapy against Abeta in aged APP-transgenic mice reverses cognitive deficits and depletes parenchymal amyloid deposits in spite of increased vascular amyloid and microhemorrhage

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3241747

12 July 2018

Neurodegenerative diseases: a decade of discoveries paves the way for therapeutic breakthroughs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3241747

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3241747

12 July 2018

Enhanced neurogenesis in Alzheimer's disease transgenic (PDGF-APPSw,Ind) mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3241747

12 July 2018

Pathways towards and away from Alzheimer's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3241747

12 July 2018

Efficacy of doublecortin as a marker to analyse the absolute number and dendritic growth of newly generated neurons in the adult dentate gyrus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3241747

12 July 2018

Hippocampal synaptic dysfunction in a murine model of human immunodeficiency virus type 1 encephalitis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3241747

12 July 2018

Epitope and isotype specificities of antibodies to beta -amyloid peptide for protection against Alzheimer's disease-like neuropathology

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3241747

12 July 2018

Measurements of vector-derived neurotrophic factor and green fluorescent protein levels in the brain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3241747

12 July 2018

Alzheimer's disease is a synaptic failure

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3241747

12 July 2018

Phagocytotic removal of apoptotic, inflammatory lymphocytes in the central nervous system by microglia and its functional implications

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3241747

12 July 2018

Deficient neurogenesis in forebrain-specific presenilin-1 knockout mice is associated with reduced clearance of hippocampal memory traces

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3241747

12 July 2018

Neurogenesis in the adult is involved in the formation of trace memories

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3241747

12 July 2018

Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3241747

12 July 2018

Molecular basis of the neurodegenerative disorders

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3241747

12 July 2018

Gene therapy vectors based on adeno-associated virus type 1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3241747

12 July 2018

Epidermal growth factor and fibroblast growth factor-2 have different effects on neural progenitors in the adult rat brain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3241747

12 July 2018

Gene transfer by adeno-associated virus vectors into the central nervous system

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3241747

12 July 2018

FGF2 concentration regulates the generation of neurons and glia from multipotent cortical stem cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3241747

12 July 2018

Increased amyloid-beta42(43) in brains of mice expressing mutant presenilin 1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3241747

12 July 2018

Correlative Memory Deficits, Abeta Elevation, and Amyloid Plaques in Transgenic Mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3241747

12 July 2018

A role for immediate-early transcription factors in learning and memory

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3241747

12 July 2018

Immediate-early genes, neuronal plasticity, and memory

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3241747

12 July 2018

A beta peptide vaccination prevents memory loss in an animal model of Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1102349108

21 January 2018

Set back to Alzheimer vaccine studies.

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1102349108

21 January 2018

Nerve inflammation halts trial for Alzheimer's drug.

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1102349108

21 January 2018

A phase 1 clinical trial of nerve growth factor gene therapy for Alzheimer disease

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1102349108

21 January 2018

AAV2/5-mediated NGF gene delivery protects septal cholinergic neurons following axotomy

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1102349108

21 January 2018

Neurogenesis and aging: FGF-2 and HB-EGF restore neurogenesis in hippocampus and subventricular zone of aged mice

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1102349108

21 January 2018

Influence of EGF/bFGF treatment on proliferation, early neurogenesis and infarct volume after transient focal ischemia

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1102349108

21 January 2018

Fibroblast growth factor-2 gene delivery stimulates axon growth by adult retinal ganglion cells after acute optic nerve injury

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1102349108

21 January 2018

Adeno-associated viruses containing bFGF or BDNF are neuroprotective against excitotoxicity

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1102349108

21 January 2018

Creating a neurogenic environment: the role of BDNF and FGF2.

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1102349108

21 January 2018

Trophic factors counteract elevated FGF-2-induced inhibition of adult neurogenesis.

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1102349108

21 January 2018

Neuritic involvement within bFGF immunopositive plaques of Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1102349108

21 January 2018

Tissue plasminogen activator induction in Purkinje neurons after cerebellar motor learning.

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1102349108

21 January 2018

Deficits in synaptic transmission and learning in amyloid precursor protein (APP) transgenic mice require C-terminal cleavage of APP.

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1102349108

21 January 2018

Neural stem cells improve memory in an inducible mouse model of neuronal loss.

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1102349108

21 January 2018

Disruption of neurogenesis by amyloid beta-peptide, and perturbed neural progenitor cell homeostasis, in models of Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1102349108

21 January 2018

The presenilin-1 familial Alzheimer disease mutant P117L impairs neurogenesis in the hippocampus of adult mice

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1102349108

21 January 2018

cAMP-induced differentiation of human neuronal progenitor cells is mediated by nuclear fibroblast growth factor receptor-1 (FGFR1).

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1102349108

21 January 2018

Memantine protects hippocampal neuronal function in murine human immunodeficiency virus type 1 encephalitis.

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1102349108

21 January 2018

Antibodies against beta-amyloid slow cognitive decline in Alzheimer's disease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3241747

25 September 2018

Fos expression in the rostral thalamic nuclei and associated cortical regions in response to different spatial memory tests.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3241747

25 September 2018

Stimulation of neonatal and adult brain neurogenesis by subcutaneous injection of basic fibroblast growth factor.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3241747

25 September 2018

In vivo neurogenesis is inhibited by neutralizing antibodies to basic fibroblast growth factor.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3241747

25 September 2018

Thresholds for synaptic activation of transcription factors in hippocampus: correlation with long-term enhancement

1 reference

https://pubmed.ncbi.nlm.nih.gov/22042871

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Correlations between immediate early gene induction and the persistence of long-term potentiation

1 reference

https://pubmed.ncbi.nlm.nih.gov/22042871

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nuclear localization of functional FGF receptor 1 in human astrocytes suggests a novel mechanism for growth factor action

1 reference

https://pubmed.ncbi.nlm.nih.gov/22042871

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1073/PNAS.1102349108

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22042871%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

2011PNAS..108E1339K

0 references

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22042871%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22042871%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

ResearchGate publication ID

0 references

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

Retrieved from "https://www.wikidata.org/w/index.php?title=Q35621081&oldid=2017130213"