(Q35624717)

9 August 2017

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title

CTLA-4 and tolerance: the biochemical point of view (English)

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9 August 2017

Shunsuke Chikuma

1

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9 August 2017

Jeffrey A Bluestone

series ordinal

2

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9 August 2017

publication date

1 January 2003

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9 August 2017

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9 August 2017

volume

28

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9 August 2017

issue

3

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9 August 2017

page(s)

241-253

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https://scigraph.springernature.com/pub.10.1385/ir:28:3:241

9 August 2017

exact match

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cites work

Structural analysis of CTLA-4 function in vivo

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12 December 2020

CTLA4Ig prevents lymphoproliferation and fatal multiorgan tissue destruction in CTLA-4-deficient mice

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12 December 2020

CTLA-4 regulates the requirement for cytokine-induced signals in T(H)2 lineage commitment

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12 December 2020

Regulation of cytotoxic T lymphocyte-associated molecule-4 by Src kinases.

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12 December 2020

Molecular basis of T cell inactivation by CTLA-4

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12 December 2020

CD28-mediated signalling co-stimulates murine T cells and prevents induction of anergy in T-cell clones

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12 December 2020

Identification and characterization of an alternative cytotoxic T lymphocyte-associated protein 4 binding molecule on B cells

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12 December 2020

Analysis of lymphocyte costimulation in vivo using transgenic and 'knockout' mice

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12 December 2020

Pleiotropic Effects of Deleterious Alleles at the “Motheaten” Locus

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12 December 2020

T cell receptor signaling precedes immunological synapse formation

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12 December 2020

The role of CTLA-4 in induction and maintenance of peripheral T cell tolerance

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12 December 2020

Involvement of SHP-1 tyrosine phosphatase in TCR-mediated signaling pathways in lipid rafts

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12 December 2020

Intracellular trafficking of CTLA-4 and focal localization towards sites of TCR engagement

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12 December 2020

The roles of Fas/APO-1 (CD95) and TNF in antigen-induced programmed cell death in T cell receptor transgenic mice.

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12 December 2020

Lymphoproliferative disorder in CTLA-4 knockout mice is characterized by CD28-regulated activation of Th2 responses

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12 December 2020

Dynamics of the immunological synapse: finding, establishing and solidifying a connection

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12 December 2020

The amplification of TCR signaling by dynamic membrane microdomains

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12 December 2020

CTLA-4 ligation suppresses CD28-induced NF-kappaB and AP-1 activity in mouse T cell blasts

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12 December 2020

Lymphoproliferative disorders with early lethality in mice deficient in Ctla-4

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12 December 2020

Cytolytic T lymphocyte-associated antigen-4 and the TCR zeta/CD3 complex, but not CD28, interact with clathrin adaptor complexes AP-1 and AP-2

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12 December 2020

Normal responsiveness of CTLA-4-deficient anti-viral cytotoxic T cells

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12 December 2020

Blockade of T cell activation using a surface-linked single-chain antibody to CTLA-4 (CD152).

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12 December 2020

Regulation of T cell receptor signaling by tyrosine phosphatase SYP association with CTLA-4

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12 December 2020

Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease

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12 December 2020

CTLA4 ligation attenuates AP-1, NFAT and NF-kappaB activity in activated T cells

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12 December 2020

Regulation of surface and intracellular expression of CTLA-4 on human peripheral T cells

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12 December 2020

Interaction of CTLA-4 with AP50, a clathrin-coated pit adaptor protein

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12 December 2020

CTLA-4: a negative regulator of autoimmune disease.

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12 December 2020

Protein phosphatase 2A forms a molecular complex with Shc and regulates Shc tyrosine phosphorylation and downstream mitogenic signaling

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12 December 2020

Surface cytotoxic T lymphocyte-associated antigen 4 partitions within lipid rafts and relocates to the immunological synapse under conditions of inhibition of T cell activation

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12 December 2020

Janus kinase 2 is associated with a box 1-like motif and phosphorylates a critical tyrosine residue in the cytoplasmic region of cytotoxic T lymphocyte associated molecule-4.

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12 December 2020

Src family tyrosine kinases associate with and phosphorylate CTLA-4 (CD152).

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12 December 2020

B7-1 or B7-2 is required to produce the lymphoproliferative phenotype in mice lacking cytotoxic T lymphocyte-associated antigen 4 (CTLA-4)

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12 December 2020

Enhancement of antitumor immunity by CTLA-4 blockade

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12 December 2020

T-cell regulation by CD28 and CTLA-4.

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12 December 2020

Activation of CD4+ T cells by delivery of the B7 costimulatory signal on bystander antigen-presenting cells (trans-costimulation).

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12 December 2020

Cutting edge: lipid raft integrity affects the efficiency of MHC class I tetramer binding and cell surface TCR arrangement on CD8+ T cells

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12 December 2020

CTLA-4-Mediated inhibition of early events of T cell proliferation.

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12 December 2020

Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4

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12 December 2020

TCR ligand discrimination is enforced by competing ERK positive and SHP-1 negative feedback pathways

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12 December 2020

The role of tyrosine phosphorylation and PTP-1C in CTLA-4 signal transduction.

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12 December 2020

PD-1: an inhibitory immunoreceptor involved in peripheral tolerance

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12 December 2020

Human B7-1 (CD80) and B7-2 (CD86) bind with similar avidities but distinct kinetics to CD28 and CTLA-4 receptors

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12 December 2020

Thymocyte development in the absence of pre-T cell receptor extracellular immunoglobulin domains

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12 December 2020

CD28 costimulation prevents cell death during primary T cell activation

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12 December 2020

T lymphocyte costimulation mediated by reorganization of membrane microdomains

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12 December 2020

CTLA-4 can function as a negative regulator of T cell activation

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12 December 2020

Crystal structure of the B7-1/CTLA-4 complex that inhibits human immune responses

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12 December 2020

Cytotoxic T lymphocyte antigen-4 accumulation in the immunological synapse is regulated by TCR signal strength

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12 December 2020

CTLA-4 suppresses proximal TCR signaling in resting human CD4(+) T cells by inhibiting ZAP-70 Tyr(319) phosphorylation: a potential role for tyrosine phosphatases

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12 December 2020

Inhibition of CTLA-4 function by the regulatory subunit of serine/threonine phosphatase 2A

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12 December 2020

Structural basis for co-stimulation by the human CTLA-4/B7-2 complex

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12 December 2020

Segregation of leading-edge and uropod components into specific lipid rafts during T cell polarization

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12 December 2020

Role of CD28-B7 interactions in generation and maintenance of CD8 T cell memory

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12 December 2020

Antigen-induced translocation of PKC-theta to membrane rafts is required for T cell activation

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12 December 2020

Specific SHP-2 partitioning in raft domains triggers integrin-mediated signaling via Rho activation.

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12 December 2020

Cytotoxic T lymphocyte antigen 4 (CTLA-4) interferes with extracellular signal-regulated kinase (ERK) and Jun NH2-terminal kinase (JNK) activation, but does not affect phosphorylation of T cell receptor zeta and ZAP70.

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12 December 2020

Membrane lipid rafts: new targets for immunoregulation

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12 December 2020

Tyrosine phosphorylation of Blk and Fyn Src homology 2 domain-binding proteins occurs in response to antigen-receptor ligation in B cells and constitutively in pre-B cells

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12 December 2020

Negative regulation of T cell receptor-lipid raft interaction by cytotoxic T lymphocyte-associated antigen 4.

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12 December 2020

Different initiation of pre-TCR and gammadeltaTCR signalling

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12 December 2020

Interaction of CTLA-4 with the clathrin-associated protein AP50 results in ligand-independent endocytosis that limits cell surface expression

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12 December 2020

The phosphotyrosine phosphatase SHP-2 participates in a multimeric signaling complex and regulates T cell receptor (TCR) coupling to the Ras/mitogen-activated protein kinase (MAPK) pathway in Jurkat T cells

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12 December 2020

Cellular distribution and costimulatory function of rat CD28. Regulated expression during thymocyte maturation and induction of cyclosporin A sensitivity of costimulated T cell responses by phorbol ester

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12 December 2020

The CD28 and CTLA-4 receptors associate with the serine/threonine phosphatase PP2A.

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12 December 2020

Surface expression of the IFN-gamma R2 chain is regulated by intracellular trafficking in human T lymphocytes

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12 December 2020

Organization of plasma membrane functional rafts upon T cell activation

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12 December 2020

Identifiers

DOI

10.1385/IR:28:3:241

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Dimensions Publication ID

9 August 2017

1028910203

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